ClaytonASmithMD

PubMed

• 391 citations
  Isolation of primitive human hematopoietic progenitors on the basis of aldehyde dehydrogenase activity.
  Robert W. Storms, A P Trujillo, J B Springer, L Shah, O M Colvin
  Proceedings of the National Academy of Sciences of the United States of America. 1999-08-03
• 179 citations
  AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells
  Shanshan Pei, Mohammad Minhajuddin, Biniam Adane, Nabilah Khan, Brett M. Stevens
  Cell Stem Cell. 2018-07-05
• 184 citations
  Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells.
  Courtney L Jones, Brett M Stevens, Angelo D'Alessandro, Julie A Reisz, Rachel Culp-Hill
  Cancer Cell. 2018-11-12

Journal Articles

• Venetoclax with Azacitidine Disrupts Energy Metabolism and Targets Leukemia Stem Cells in Patients with Acute Myeloid Leukemia  
  Daniel A Pollyea, Jonathan A Gutman, Enkhtsetseg Purev, Clayton Smith, Nature
• ALDHs in hematopoietic stem cells and leukemagenesis  
  Smith C, Gasparetto M, Jordan CT, Pollyea DA, Humphries KH, Vasiliou V, NYAS, 1/1/2014
• Fludarabine and cytarabine in patients with relapsed actute myeloid leukemia  
  McLaughlin B, Im A, Raptis A, Hou JZ, Redner R, Duggal S, Lin Y, Smith C, Boyiadzis M, Int J Hematol, 1/1/2012
• Aldehyde Dehydrogenases: From eye crystallins to metabolic disease and stem cells  
  Vasillis V, Smith C, Thompson D, Mayumi F, Chen Y, Chem Biol Interact, 1/1/2012
• The significance of varying levels of aldehyde dehydrogenase activity in murine marrow  
  Gasparetto M, Sekulovic S, Zakaryan A, Kent DG, Humphries RK, and Smith C, Exp Heme, 1/1/2012
• ALDH3A1 compensates for loss of ALDH1A1 in hematopoiesis and influences hematopoietic stem cell numbers, cell cycle status and early B-cell development  
  Gasparetto M, Sekulovic S, Brocker C, Tang P, Zakaryan A, Xiang P, Kuchenbauer F et al, Exp Heme, 1/1/2011
• Properties of CD34+ CML stem/progenitor cells that correlate with different clinical responses to imatinib mesylate  
  Jiang X, Forrest D, Nicolini F, Turhan A, Guilhot F, Yip C, Holyoake T, Jorgensen H, Lambie K, Saw KM, Pang E, Vukovic R, Lehn P, Ringrose A, Yu M, Brinkman R, Smith C..., Blood, 1/1/2010
• A role for E2F activities in determining the fate of Myc-induced lymphoagenesis  
  Rempel R, Mori S, Gasparetto M, Glozak M, Andrechek ER, Adler SB, Laakso NM, Lagoo AS, Storms R, Smith C and Nevins JR, PLOS Genetics, 1/11/2009
• Cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia are correlated with Sokal risk scores and duration of therapy but not trough ...  
  Forrest DL, Trainor S, Brinkman RR, Barnett MJ, Hogge DE, Nevill TJ, Shepherd JD, Nantel SH, Toze CL, Sutherland HJ, Song KW, Lavoie JC, Power MM, Abou-Mourad Y and Sm..., Leuk Res, 1/1/2009
• An approach to the management of chronic myeloid leukemia in British Columbia  
  Forrest DL, Jiang X, Eaves CJ and Smith C, Curr Oncol, 1/1/2008
• Stem cell biomarkers in chronic myeloid leukemia  
  Jiang X, Zhao Y, Forrest D, Smith C, Eaves A and Eaves C, Disease Markers, 1/1/2008
• Improved purification of hematopoietic stem cells based on their elevated aldehyde dehydrogenase activity  
  Christ, O, Lucke K, Imren S, Leung K, Hamilton M, Eaves A, Smith C and Eaves C, Haematologica, 1/1/2007
• Data quality assessment in high throughput flow cytometry experiments  
  Le Meur N, Rossini A, Gasparetto M, Smith C, Brinkman R and Gentleman R, Cytometry A, 1/1/2007
• High content flow cytometry to determine predictors of GvHD following allogeneic transplantation  
  Brinkman R, Gasparetto M, Lee J and Smith C, Biology of Blood and Marrow Transplantation, 1/1/2007
• The challenges of targeting chronic myeloid leukemia stem cells  
  Jiang X, Smith C, Eaves A and Eaves C, Clinical Lymphoma and Myeloma, 1/1/2007
• Predictive value of karyotype on outcome of autotransplants for acute myeloid leukemia in second remission  
  Song KW, Molllee PN, Hogge DE, Gupta V, Barnett MJ, Forrest DL, Lavoie JC, Nevill TJ, Nantel SH, Shepherd JD, Smith CA, Sutherland HJ, Toze CCI, Crump M and Keating A, Leukemia and Lymphoma, 1/1/2005
• Identification of compounds that enhance the anti-lymphoma activity of rituximab using flow cytometric high-content screening  
  Gasparetto M, Sebti S, Bhalla K and Smith C, J Immunologic Methods, 1/1/2004
• Stem Cells and Transplantation  
  Smith C, Cancer Control, 1/1/2004
• Hematopoietic stem cells and hematopoiesis  
  Smith C, Cancer Control, 1/1/2003
• 4-hydroperoxycyclophosphamide purged peripheral blood stem cells for autologous transplantation in patients with acute myeloid leukemia  
  Rizzieri DA, Talbot JT, Long GW, Vredenburgh JW, Gasparetto C, Smith C, Colvin MO, Adams D, Morris A, Dodge R, Loftis J, Waters-Pick B, Reese M, Carawan H and Chao N, Biol Blood and Marrow Transplant, 1/1/2003
• Hematopoietic progenitors which express high levels of aldehyde dehydrogenase can be counted and enriched from mobilized peripheral blood  
  Fallon P, Kerr W, Gentry T, Balber A, Ludeman S, Storms R and Smith C, Br J Hematology, 1/1/2003
• The hematopoietic defect in PNH is not due to defective stroma or abnormal interactions between bone marrow progenitor cells and stroma  
  Nishimura J, Ware RE, Burnette A, Pendleton AL, Kitano K, Hirota H, Machii T, Kitani T, Smith C and Rosse WF, Blood Cells, Molecules and Diseases, 1/1/2002
• Mobilization of dendritic cells from patients with breast cancer into peripheral blood stem cell leukapheresis samples using Flt-3-ligand and G-CSF or GM-CSF  
  Gasparetto C, Gasparetto M, Vredenberg J, Long G, Rizzieri D, Chao N, Loftis J and Smith C, Cytokine, 1/1/2002
• Retroviral vector gene transfer of the pig-A gene into hematopoietic cells affected by paroxysmal nocturnal hemoglobinuria  
  Nishimura J, Rosse WF, Phillips K and Smith C, Blood, 1/1/2001
• Inhaled steroids as prophylaxis for delayed pulmonary toxicity syndrome in breast cancer patients undergoing high-dose chemotherapy and autologous stem cell transplant...  
  McGaughey DS, Nikcevich DA, Long GD, Vredenburgh JJ, Rizzieri D, Smith CA, Broadwater G, Loftis JS, McDonald C, Moffiss AK, Floz RF and Chao NF, Biol Blood and Marrow Transplant, 1/1/2001
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Books/Book Chapters

• Surgical Research 
  Chapter: Hematopoietic stem cells: basic concepts and applications to surgical research. 
  Page 207 - 214Rice H, Storms R, Smith C, and Flake AWEditors: W Souba and D Wilmore.Academic Press2001
• Gene Therapy for HIV Infection 
  Chapter: Hematopoietic stem cell transplantation: Issues in HIV gene therapy 
  Page 139 - 158Smith C and Gasparetto GEditors: Smith C.RG Landis, Inc., Austin, TX1998
• Gene Therapy for HIV Infection 
  Chapter: An overview of HIV gene therapy 
  Page 5 - 11Smith CEditors: Smith C.RG Landis, Inc., Austin, TX1998
• Molecular and Cell Biology of Human Gene Therapeutics 
  Chapter: AIDS and HIV Infection 
  Page 195 - 236Smith C and Sullenger BEditors: G Dickson.Chapman and Hall1995
• HIV: A Practical Approach 
  Chapter: Gene therapy for HIV infection 
  Bohnlein E, Smith C, and Marasco WIRL Press at Oxford University Press1995
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Abstracts/Posters

• Broad Efficacy of the Translation Inhibitor Omacetaxine in Relapsed/Refractory Multiple Myeloma Samples
  Clayton Smith, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• A Phase 2 Study of Glasdegib for the Treatment of Acute Myeloid Leukemia and Myelodysplastic Syndrome Patients with High Risk of Post-Allogeneic Stem Cell Transplantat...
  Clayton Smith, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Outcomes Following Allogeneic Stem Cell Transplantation for AML in First Completion Remission Are Comparable between MRD Negative Patients and MRD Positive Patients Re...
  Clayton Smith, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019

Lectures

• Targeted therapies for hematologic malignancies 
  University of Colorado - 1/1/2016
• Waldenstrom's macroglobulinemia 
  University of Colorado, 2012, 2013, 2014, 2015, 2016 - 1/1/2016
• Amyloidosis 
  University of Colorado, 2012, 2013, 2014, 2015, 2016 - 1/1/2016
• Multiple Myeloma 
  University of Colorado, 2012, 2013, 2014, 2015, 2016 - 1/1/2016
• Hematopoiesis 
  University of Colorado, 2012, 2013, 2014, 2015, 2016 - 1/1/2016
• ALDH targeted therapy in AML 
  Vancouver, BC, Canada - 1/1/2013
• Introduction to Blood and Marrow Transplantation 
  University of Colorado - 1/1/2012
• ALDHs in normal and malignant hematopoietic stem cells 
  University of Rochester - 1/1/2012
• Umbilical cord blood and haploidentical donor transplantation 
  1/1/2011
• Umbilical cord blood transplantation in adults 
  1/1/2010
• Aldehyde dehydrogenase in hematopoiesis and stem cell transplantation 
  University of Pittsburgh Cancer Center - 1/1/2010
• Personalized medicine in acute myeloid leukemia: the need, the promise and the challenges 
  1/1/2010
• Acute leukemia, management and recent advances 
  1/1/2010
• Advances in chronic and acute leukemia 
  1/1/2010
• ALDHs and stem cells 
  1/1/2010
• High throughput, high content flow cytometry for drug discovery, functional genomics and clinical studies 
  San Jose, CA - 1/1/2009
• Umbilical cord blood stem cells and transplantation 
  Vancouver, BC, Canada - 1/1/2008
• Graft versus host disease 
  Toronto, Canada - 1/1/2008
• Aldehyde dehydrogenase and umbilical cord blood transplantation 
  Montreal, Canada - 1/1/2008
• Aldehyde dehydrogenase and E2F gene families in hematopoietic stem cells 
  University of New Mexico - 1/1/2008
• High throughput flow cytometric signatures of graft versus host disease 
  University of Miami - 1/1/2007
• The E2F and ALDH gene families in hematopoietic stem cell biology 
  Penn State Cancer Center - 1/1/2006
• High throughput flow cytometry for developing cellular signatures for GvHD and other diseases 
  BC Cancer Center, Victoria - 1/1/2006
• Assessment of stem cells on the basis of ALDH activity 
  1/1/2006
• Novel methods for isolating hematopoietic stem cells 
  Copper Mountain, CO - 1/1/2004
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