ClayFSemenkovichMD

Endocrinology • Saint Louis, MO

Diabetes, Lipid Metabolism

Professor of Medicine, Washington University St Louis

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Office
4921 Parkview Pl
# Dv
Saint Louis, MO 63110
Phone+1 314-362-3500

Fax+1 314-230-1119

Education & Training

Washington University/B-JH/SLCH ConsortiumResidency, Internal Medicine, 1986 - 1987
Washington University/B-JH/SLCH ConsortiumFellowship, Endocrinology, Diabetes, and Metabolism, 1984 - 1986
Washington University/B-JH/SLCH ConsortiumResidency, Internal Medicine, 1981 - 1984
Washington University in St. Louis School of MedicineClass of 1981

Certifications & Licensure

IL State Medical License 2021 - 2026
MO State Medical License 1982 - 2026
TX State Medical License 1987 - 2007
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Endocrinology, Diabetes and Metabolism

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2002-2014
CMS Meaningful Use Stage 1 Certification Allscripts Enterprise EHR, Allscripts, 2012
St. Louis Magazine: Top Doctors Castle Connolly, 2001
Elected Member The American Society for Clinical Investigation, 1999
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Clinical Trials

Chloroquine to Treat People With Metabolic Syndrome Aim2 (ARCH-MS) Start of enrollment: 2004 Sep 01
Completed
Phase 2
Atheroma Reduction With Chloroquine in Patients With the Metabolic Syndrome (ARCH-MS) Start of enrollment: 2006 Apr 01
Completed
Not Applicable
Metabolic Effects of Hydroxychloroquine Start of enrollment: 2012 Mar 01
Terminated
Not Applicable
Composition & Function of Sarcoplasmic Reticulum in Persons With the Metabolic Syndrome Start of enrollment: 2014 Mar 01
Active, not recruiting
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Publications & Presentations

PubMed

De novo lipid synthesis in cardiovascular tissue and disease.
Tariq J Khan, Clay F Semenkovich, Mohamed A Zayed
Atherosclerosis. 2025-01-01
Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress.
Ekaterina D Korobkina, Camila Martinez Calejman, John A Haley, Miranda E Kelly, Huawei Li
Nature Metabolism. 2024-11-01
5 citations
Liver ACOX1 regulates levels of circulating lipids that promote metabolic health through adipose remodeling.
Dongliang Lu, Anyuan He, Min Tan, Marguerite Mrad, Amal El Daibani
Nature Communications. 2024-05-17

Lectures

Muscle Phospholipid Synthesis Regulates Insulin Sensitivity and Contractile Function
St. Louis, MO - 6/14/2014
Physiologic and Genetic Evidence Links Hemopexin to Adipocytes in Obesity
St. Louis, MO - 6/15/2014

Press Mentions

Researchers Link Certain Genes to Obesity Complications in WomenFebruary 16th, 2023
Diabetes and Obesity, Washington University in St. Louis Discovers One of the Causes That Relate Them – Gasseta MedicaJanuary 31st, 2023
Uncovering the Link Between Obesity and Diabetes RiskJanuary 12th, 2023
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Grant Support

Animal Model Research CoreNational Institute Of Diabetes And Digestive And Kidney Diseases2011–2012
Obesity, Adipogenesis, And Lipid LigandsNational Institute Of Diabetes And Digestive And Kidney Diseases2010–2012
DE Novo Lipogenesis And Metabolic DiseaseNational Institute Of Diabetes And Digestive And Kidney Diseases2007–2012
Macrophage Fatty-Acid Synthase Deficiency Decreases Diet-Induced AtherosclerosisNational Center For Research Resources2011
Building Interdisciplinary Careers In Women'S HealthEunice Kennedy Shriver National Institute Of Child Health &Human Development2010–2011
Diabetes And Related Metabolic DiseasesNational Institute Of Diabetes And Digestive And Kidney Diseases2007–2011
Genotoxic Stress, Atherosclerosis And Metabolic SyndromeNational Heart, Lung, And Blood Institute2007–2010
Sccor In Metabolic Syndrome And Vascular DiseaseNational Heart, Lung, And Blood Institute2006–2010
Interdisciplinary Research Careers In Women'S HealthEunice Kennedy Shriver National Institute Of Child Health &Human Development2007–2009
Diabetes Research And Training CenterNational Institute Of Diabetes And Digestive And Kidney Diseases2007
Insulin Resistance And AtherosclerosisNational Center For Research Resources2007
Chloroquine And The Metabolic SyndromeNational Center For Research Resources2005–2007
Animal Model Research Core CNational Institute Of Diabetes And Digestive And Kidney Diseases2006
Genotoxic Stress, Atherosclerosis And Metabolic SyndromNational Heart, Lung, And Blood Institute2006
Administrative CoreNational Heart, Lung, And Blood Institute2006
Mouse Phenotyping CoreNational Institute Of Diabetes And Digestive And Kidney Diseases2004–2006
Insulin Resistance And GlucocorticoidsNational Center For Research Resources2004–2006
Uncoupling, Aging And AtherosclerosisNational Institute On Aging2002–2006
Chloroquine And The Metabolic SyndromeNational Center For Research Resources2005
Atherosclerosis, Diabetes And LPLNational Heart, Lung, And Blood Institute1998–2005
Core--Mouse PhenotypingNational Institute Of Diabetes And Digestive And Kidney Diseases2003
Sarcopenia, TNF Alpha And Lpl--Effects Of Aging/ExerciseNational Institute On Aging1999–2003
Sarcopenia, TNF And Lpl--Effects Of Aging And ExerciseNational Center For Research Resources2000–2002
Core--Animal Model ResearchNational Institute Of Diabetes And Digestive And Kidney Diseases1999–2002
Leptin Response To ExerciseNational Center For Research Resources1999–2002
Effects Of Catecholamines On Skeletal Muscle Lipoprotein Lipase After ExerciseNational Center For Research Resources1998–2002
Intermediary Metabolism And A Novel RNA Binding ProteinNational Institute Of Diabetes And Digestive And Kidney Diseases1998–2001
Mystery Of Diabetes &Atherosclerosis Time For New PlotNational Center For Research Resources1997
Muscle Lipoprotein Lipase Mass, Activity And MRNA Response To Acute ExerciseNational Center For Research Resources1996
Nutritional And Genetic Regulation Of Lipoprotein LipaseNational Heart, Lung, And Blood Institute1994–1995
Nutritional &Genetic Regulation Of Lipoprotein LipaseNational Heart, Lung, And Blood Institute1992–1993
Regulation Of Lipoprotein Lipase SynthesisNational Institute Of Diabetes And Digestive And Kidney Diseases1990–1991
Regulation Of Lipoprotein Lipase SynthesisNational Institute Of Diabetes And Digestive And Kidney Diseases1987–1989