ChristosSocratesMantzorosMD

Endocrinology • Boston, MA

Diabetes, Lipid Metabolism

Professor of Medicine, Beth Israel Deaconess Medical Center

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Office
330 Brookline Ave
AN-249
Boston, MA 02215
Phone+1 617-667-8633

Fax+1 617-667-8634

Education & Training

Wayne State University School of MedicineResidency, Internal Medicine, 1990 - 1993
University of AthensClass of 1987

Certifications & Licensure

MA State Medical License 1993 - 2026
MI State Medical License 1990 - 1993
American Board of Internal Medicine Endocrinology, Diabetes and Metabolism

Awards, Honors, & Recognition

Elected Member The American Society for Clinical Investigation, 2007
Fellow (FACP) American College of Physicians, 2002
Whos Who in Medicine and Healthcare Marquis Whos Who
Fellow (FACE) American Association of Clinical Endocrinology
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Clinical Trials

Study of Leptin for the Treatment of Hypothalamic Amenorrhea Start of enrollment: 2010 Apr 01
Completed
Phase 2
Pharmacokinetics of Leptin Administration During Fasting Start of enrollment: 2001 Feb 01
Completed
Phase 1
Role of Leptin in the Neuroendocrine and Immune Response to Fasting Start of enrollment: 2002 Oct 01
Completed
Phase 1, Phase 2
Effects of Caffeinated and Decaffeinated Coffee on Body Weight and Glucose Tolerance Start of enrollment: 2006 May 01
Completed
Not Applicable
Combination of Insulin Sensitizer and Leptin as Treatment for the HAART -Induced Metabolic Syndrome Start of enrollment: 2006 Aug 01
Completed
Phase 2
The Metabolic Effects of Short-term Walnut Consumption in Subjects With the Metabolic Syndrome Start of enrollment: 2007 Feb 01
Completed
Not Applicable
Leptin in the Maintenance of Reduced Body Weight Start of enrollment: 2008 Jul 01
Completed
Phase 2
In Vivo Leptin Signaling in Humans After Acute Leptin Administration Start of enrollment: 2002 Jul 01
Completed
Phase 1
Leptin Signaling in Lean and Obese Humans Start of enrollment: 2011 Apr 01
Withdrawn
Effect of Increased Free Fatty Acids on Leptin Function Start of enrollment: 2011 Nov 01
Completed
Not Applicable
Liraglutide in Obesity and Diabetes: Identification of CNS Targets Using fMRI Start of enrollment: 2012 Mar 01
Completed
Phase 4
Weight Loss Study-Mechanism Underlying the Improvement of Insulin Resistance in Response to Weight Loss Start of enrollment: 2012 Sep 01
Completed
Not Applicable
Physical Health in Midlife: Influences of Adversity and Relationships Over Time Start of enrollment: 2009 Jan 01
Completed
Activation of Brain Centers by Short-term Walnut Consumption in Obesity Start of enrollment: 2016 Jan 01
Completed
Not Applicable
Improvement of Insulin Resistance After Bariatric Surgery Start of enrollment: 2010 Feb 25
Completed
Not Applicable
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Publications & Presentations

PubMed

Successful repurposing of empagliflozin to treat neutropenia in a severe congenital neutropenia patient with G6PC3 mutations.
Grigorios Tsaknakis, Erasmia Boutakoglou, Irene Mavroudi, Christos S Mantzoros, Maria Veiga-da Cunha
Metabolism. 2025-01-01
The effect of lipid-lowering treatment on indices of MASLD in familial hypercholesterolemia patients.
Chrysoula Boutari, Christos V Rizos, George Liamis, Ioannis Skoumas, Loukianos Rallidis
Clinical Nutrition. 2024-12-01
Apolipoprotein C-III in association with metabolic-dysfunction associated steatotic liver disease: A large, multicenter study.
Matina Kouvari, Laura Valenzuela-Vallejo, Valentina Guatibonza-Garcia, Ornella Verrastro, Evangelos Axarloglou
Clinical Nutrition. 2024-12-01

Authored Content

Could the Endocrine Disruptor Bisphenol-a Be Implicated in the Pathogenesis of Oral and Oropharyngeal Cancer? Metabolic Considerations and Future DirectionsNovember 2018
Obesity and Cancer Risk: Emerging Biological Mechanisms and PerspectivesNovember 2018
Pharmacotherapy of Obesity: Available Medications and Drugs Under InvestigationOctober 2018
Non-Alcoholic Fatty Liver Disease and Colorectal Cancer: A Marker of Risk or Common Causation?August 2018
Omics, Big Data and Machine Learning as Tools to Propel Understanding of Biological Mechanisms and to Discover Novel Diagnostics and TherapeuticsAugust 2018
Potential Impact of Helicobacter Pylori-Related Metabolic Syndrome on Upper and Lower Gastrointestinal Tract Oncogenesis☆☆☆June 2018
The Role of Extracellular and Intracellular Nicotinamide Phosphoribosyl-Transferase in Cancer: Diagnostic and Therapeutic Perspectives and ChallengesApril 2018
Obesity and Cancer Risk: Emerging Biological Mechanisms and PerspectivesFebruary 2018
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Press Mentions

The Mediterranean Diet May Help Ward off COVID-19August 21st, 2024
Safer, More Effective Therapies Could Help Fight the Obesity EpidemicOctober 26th, 2021
Should the Name ‘NAFLD’ Change to Reflect an Emphasis on Dysregulated Metabolism?October 18th, 2021
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Grant Support

Leptin Signaling In HumansVeterans Affairs2011
The Role Of Leptin In The Maintenance Of A Reduced Body WeightNational Institute Of Diabetes And Digestive And Kidney Diseases2008–2011
Leptin And Adipokine PhysiologyNational Institute Of Diabetes And Digestive And Kidney Diseases2008–2011
Role Of Leptin In The Neuroendocrine Response To FastingNational Institute Of Diabetes And Digestive And Kidney Diseases2001–2011
In Vivo Leptin Signaling In Humans After Acute Leptin AdministrationNational Center For Research Resources2008
Clinical Trial: Metabolic Effects Of Short-Term Walnut Consumption In MetabolicNational Center For Research Resources2008
Clinical Trial: Leptin (R-Methuleptin) For The Treatment Of Hypothalamic AmenhorNational Center For Research Resources2008
Clinical Trial: Insulin Sensitizers And Leptin In Haart-Induced LipatrophyNational Center For Research Resources2008
Clinical Trial: Coffee And Glucose ToleranceNational Center For Research Resources2008
Pioglitazone And Leptin In Haart-Induced LipatrophyNational Center For Research Resources2007
Metabolic Effects Of Short-Term Walnut Consumption In Metabolic SydromeNational Center For Research Resources2007
Leptin For The Treatment Of Hypothalamic AmenhorrheaNational Center For Research Resources2007
Coffee And Glucose ToleranceNational Center For Research Resources2006–2007
Leptin Treatment For Hypothalamic AmenorrheaNational Center For Research Resources2006
Role Of Leptin In The Neuroendocrine Response To FastingNational Institute Of Diabetes And Digestive And Kidney Diseases2005
Clinical Trial Of Leptin For Hypothalamic AmenorrheaEunice Kennedy Shriver National Institute Of Child Health &Human Development2005
Role Of Leptin In The Neuroendocrine And Immune Response To Fasting In HumansNational Center For Research Resources2004–2005
Treatment Of HIV Positive Patients W/Protease Inhibitor Induced Metabolic...National Center For Research Resources2004
Leptin In The Reproductive System, Neuroendocrine Function, And Bone MetabolismNational Center For Research Resources2004
Leptin In Protease-Inhibitor-Induced Lipodystrophy And Metabolic Syndrome In HIVNational Center For Research Resources2004
Role Of Leptin In The Neuroendocrine Response To Fasting In HumansNational Center For Research Resources2000–2002
Core--Physiology And AssayNational Institute Of Diabetes And Digestive And Kidney Diseases1999–2002
Zinc Status And T Cell Disorder In Mild Human Zinc DeficiencyNational Center For Research Resources1997