ChristopherWilliamsMDPhD

PubMed

• 551 citations
  Host cyclooxygenase-2 modulates carcinoma growth
  Christopher S. Williams, Masahiko Tsujii, Jeff Reese, Sudhansu K. Dey, Raymond N. DuBois
  The Journal of Clinical Investigation. 2000-06-01
• 276 citations
  Celecoxib Prevents Tumor Growth in Vivo without Toxicity to Normal Gut: Lack of Correlation between in Vitro and in Vivo Models
  Christopher S. Williams, Alastair J.M. Watson, Hongmiao Sheng, Rania A. Helou, Jinyi Shao
  Cancer Research. 2000-11-01
• 32 citations
  A Cyclooxygenase-2 Inhibitor (SC-58125) Blocks Growth of Established Human Colon Cancer Xenografts
  Christopher S. Williams, Hongmiao Sheng, Jeffrey A. Brockman, Radhika Armandla, Jinyi Shao
  Neoplasia. 2001-01-01

Journal Articles

• Loss of Solute Carrier Family 7 Member 2 Exacerbates Inflammation-Associated Colon Tumorigenesis  
  Lori A Coburn, M Kay Washington, Keith T Wilson, Christopher S Williams, Nature
• Competition between the Brain and Testes under Selenium Compromised Conditions: Insight into Sex Differences in Selenium Metabolism and Risk of Neurodevelopmental Disease  
  Pitts MW, Kremer, PM, Hashimoto AC, Torres DJ, Byrns CN, Williams CS, Berry MJ, J Neurosci, 1/1/2015
• Anti-mtg16 antibodies reveal mtg16 subcellular distribution and nucleocytoplasmic transport in erythroleukemia cells  
  Nguyen H, Mariotti J, Bareyan D, Carnahan R, Williams CS, Engel ME, Antibody Tech J, 1/1/2015
• Deletion of cationic amino acid transporter 2 exacerbates dextran sulfate sodium colitis and leads to an il-17- predominant T cell response  
  Singh K, Coburn LA, Barry DP, Asim M, Scull BP, Allaman MM, Lewis ND, Washington MK, Rosen MJ, Williams CS, Chaturvedi R, Wilson KT, Am J Phys Gastro, 1/1/2013
• L-arginine supplementation improves responses to injury and inflammation in dextran sulfate sodium colitis  
  Coburn LA, Gong X, Singh K, Asim M, Scull BP, Allaman MA, Williams CS, Rosen MJ, Washington MK, Barry DP, Piazuelo MB, Casero RA, Chaturvedi R, Zhao Z, Wilson KT, PLoS One, 1/1/2012
• Tumor suppressor function of the plasma glutathione peroxidase Gpx3 in colitis-associated carcinoma  
  Barrett CB, Ning W, Motley AK, Washington MK, Hill KE, Coburn LA, Chaturvedi R, Wilson KT, Burk RF, Williams CS, Cancer Res, 1/1/2012
• BVES regulates EMT in human corneal and colon cancer cells and is silenced via promoter methylation in human colorectal carcinoma  
  Williams CS, Zhang B, Smith JJ, Jayagopal A, Barrett CW, Pino C, Russ P, Presley SH, Peng D, Rosenblatt DO, Haselton FR, Yang JL, Washington MK, Chen X, Eschrich S, Ye..., J Clin Invest, 1/1/2011
• MTGR1 is required for tumorigenesis in the murine AOM/DSS colitis-associated carcinoma model  
  Barrett CW, Fingleton B, Williams A, Ning W, Steapleton M, Washington MK, Chaturvedi R, Wilson KT, Hiebert SW, Williams CS, Cancer Res, 1/1/2011
• Bves modulates tight junction associated signaling  
  Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS, PLoS One, 1/1/2011
• Murine colitis modeling using dextran sulfate sodium (DSS)  
  Whitten CW, Williams AD, Williams CS, J Vis Exp, 1/1/2010
• Increased expression and cellular localization of Spermine Oxidase in ulcerative colitis and relationship to disease activity  
  Hong SS, Chaturvedi R, Delgado AG, Piazuelo MB, Coburn LA, Williams CS, Casero RA, Schwartz DA, Wilson KT, Inflamm Bowel Dis, 1/1/2010
• Inactivation of the p19(ARF) tumor suppressor affects intestinal epithelial proliferation and integrity  
  Farmer TE, Williams CS, Washington, MK, Hiebert SW, J Cell Biochem, 1/1/2008
• Myeloid Translocation Gene family members associate with T-cell factors (TCFs) and influence TCF-dependent transcription  
  Moore AC, Amann JM, Williams CS, Tahinci E, Ellis T, Martinez JA, Yang G, Luce S, Lee E, Hiebert SW, Mol Cell Biol, 1/1/2008
• Deletion of Mtgr1 sensitizes the colonic epithelium to dextran sodium sulfate-induced colitis  
  Martinez JA, Williams CS, Amman JM, Ellis TC, Moreno-Miralles I, Washington MK, Gregoli P, Hiebert SW, Gastroenterology, 1/1/2006
• Diagnosis and treatment of chronic gastroparesis and chronic intestinal pseudo-obstruction  
  Smith DS, Williams CS, Ferris CD, Gastroenterol Clin North Am, 1/1/2003
• Acute pulmonary embolectomy: a contemporary approach  
  Aklog L, Williams CS, Byrne JG, Goldhaber SZ, Circulation, 1/1/2002
• A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established human colon cancer xenografts  
  Williams CS, Sheng HM, Brockman JA, Armandla R, Shao J, Washington MK, Elkahloun AG, DuBois RN, Neoplasia, 1/1/2001
• Targeting Cyclooxygenase 2 and HER-2/neu pathways inhibits colorectal carcinoma growth  
  Mann M, Sheng H, Shao J, Williams CS, Pisacane PS, Sliwkowsku, PX, DuBois RN, Gastroenterology, 1/1/2001
• Regulation of cyclooxygenase 2 expression in hepatocytes by CCAAT/enhancer-binding proteins  
  Callejas NA, Boscá L, Williams CS, DuBois RN, Martín-Sanz P, Gastroenterology, 1/1/2000
• Host cyclooxygenase-2 modulates carcinoma growth  
  Williams CS, Tsujii M, Reese J, Dey SK, DuBois RN, J Clin Invest, 1/1/2000
• Transforming Growth Factor-beta1 enhances Ha-ras- induced expression of Cyclooxygenase-2 in intestinal epithelial cells via stabilization of mRNA  
  Sheng H, Shao J, Dixon DA, Williams CS, Prescott SM, DuBois RN, Beauchamp RD, J Biol Chem, 1/1/2000
• Celecoxib prevents tumor growth in vivo without toxicity to normal gut: lack of correlation between in vitro and in vivo models  
  Williams CS, Watson AJ, Sheng HM, Helou R, Shao J, DuBois RN, Cancer Res, 1/1/2000
• Sulindac sulfide, but not sulindac sulfone, inhibits colorectal cancer growth  
  Williams CS, Goldman AP, Sheng HM, Morrow JD, DuBois RN, Neoplasia, 1/1/1999
• The role of cyclooxygenases in inflammation, cancer, and development  
  Williams CS, M. Mann, DuBois RN, Oncogene, 1/1/1999
• The role of COX-2 in intestinal cancer  
  Williams CS, R. L. Shattuck-Brandt, DuBois RN, Ann N Y Acad Sci, 1/1/1999
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Books/Book Chapters

• Clinical Applications for Selective COX-2 Inhibitors 
  Chapter: Meloxicam inhibits the growth of colorectal cancer cells 
  Page 141 - 148Goldman AP, Williams CS, Lamps LW, Williams VP, Pairet M, Morrow JD, DuBois RNEditors: J. Botting & J. Vane.Kluwer Academic Publishers, Lancaster, UK1999
• Intestinal Mucosa and It’s Diseases – Pathophysiology and Clinics – Falk Symposium 
  Chapter: The role of COX-2 in cancer 
  Page 210 - 215Williams CS, Shattuck-Brandt RL, DuBois RNEditors: Domschke, et al.1999
• Selective COX-2 Inhibitors 
  Chapter: Inhibition of intestinal tumorigenesis via selective inhibition of COX-2 
  DuBois RN, Sheng H, Shao J, Kobyashi O, Williams CS, Beauchamp RDEditors: J. Botting & J. Vane.Kluwer Academic Publishers, Lancaster, UK1998
• New Targets of Inflammation: Inhibitors of COX-2 or adhesion molecules 
  Chapter: Cyclooxygenase-2 and intestinal cancer 
  Page 125 - 130DuBois RN, Radhika A, Shao J, Tsujii M, Sheng H, Kobyashi O, Beauchamp RD, Williams CSEditors: N. Bazan & J. Vane.Kluwer academic publishers, Lancaster, UK1996
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Abstracts/Posters

• Blood vessel epicardial substance (BVES)- interacting protein STK17A regulates migration and invasion in colorectal cancer
  Short SP, Ning W, Parang B, Williams CS, Digestive Disease Week, AGA, Orlando, FL, 1/1/2015
• BVES preserves mucosal integrity after colonic injury
  Reddy VK, Choksi YA, Parang B, Bradley A, Barrett CW, Poindexter, SV, Ning W, Wilson KT, Williams CS, Digestive Disease Week, AGA, Orlando, FL, 1/1/2013
• Identification of a Tight Junction/Focal Adhesion Signaling Complex: BVES and BCAR3
  Poindexter SV, Ning W, Parang B, Reddy VK, Near R, Lerner A, Williams CS, Digestive Disease Week, AGA, Orlando, FL, 1/1/2013
• Mtgr1 is required for Notch Inhibitor-induced Paneth cell differentiation
  Parang B, Noah T, Washington MK, Revetta F, Williams CS, Digestive Disease Week, AGA, Orlando, FL, 1/1/2013
• BVES Suppresses Inflammatory Carcinogenesis
  Parang B, Kaz A, Choksi Y, McDonough EM, Poindexter SV, Barrett CW, Williams CS, Digestive Disease Week, AGA, Orlando, FL, 1/1/2013
• Selenoprotein P suppresses tumorigenesis through both its selenium transport and redox activities in a mouse model of colitis-associated carcinoma
  Barrett CW, Motley AK, Lintel MK, Bradley A, McDonough EM, Choksi YA, Ning W, Reddy VK, Williams CS, Digestive Disease Week, AGA, Orlando, FL, 1/1/2013
• Kaiso modifies MTG16-dependent tumor suppression in a murine model of colitis-associated carcinoma
  Barrett CW, Lintel MK, Short SP, McDonough EM, Bradley A, Parang B, Poindexter SV, Choksi YA, Williams CS, Digestive Disease Week, AGA, Orlando, FL, 1/1/2013
• Gpx3 is a tumor modifier in murine inflammatory carcinogenesis
  Ning W, Washington MK, Hill KE, Barrett CW, Coburn LA, Burk RF, Williams CS, Digestive Disease Week, Chicago, IL, 1/1/2011
• ErbB4 promotes epithelial cell survival signals and tumorigenicity
  Williams CS, Bern JK, Polk DB, Frey MR, Digestive Disease Week, Chicago, IL, 1/1/2011
• MTG16 Contributes to Epithelial Integrity in Response to Injury
  Williams CS, Harris E, Washington MK, Watson A, Engel ME, Williams AD, Moreno-Morales I, Hiebert SW, Digestive Disease Week, San Diego, CA, 1/1/2008
• A role for MTGR1 in intestinal epithelial migration and repair
  Williams CS, Moore AC, Amann JM, Engel ME, Ellis TC, Whitehead R, Hiebert SW, Digestive Disease Week, Washington, DC, 1/1/2007
• Susceptibility to DSS Induced Colitis In Myeloid Translocation Gene Related-1 (MTGR1) Deficient Mice
  Williams CS, Ellis TC, Martinez JA, Moreno-Miralles I, Hiebert SW, Stem Cells in Gastrointestinal Development Regeneration and Neoplasia, AGA Institute, Tysons Corner, VA, 1/1/2006
• Mechanisms for Prevention of Colorectal Cancer by NSAIDs
  DuBois RN, Sheng H, Shao J, Tsujii M, Kawano S, Beauchamp R D, Williams CS, NCI-EORTC Symposium on New Drugs in Cancer Therapy, Amsterdam, Netherlands, 1/1/1998
• Meloxicam inhibits the growth of colorectal cancer cells
  Goldman AG, Williams CS, DuBois RN, AGA, Washington, DC, 1/1/1998
• Increased levels of cyclooxygenase-2 in Min mouse tumors
  Williams CS, Loungo, Aramandhla R, Zhang T, Beauchamp DN, DuBois RN, Digestive Disease Weekly, AGA, San Francisco, CA, 1/1/1996
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Lectures

• Loss of epithelial selenoprotein-P impairs epithelial oxidant defenses and enhances colitis-associated carcinogenesis 
  Washington, DC - 1/1/2015
• Selenoproteins: Guardians of the Mucosa 
  1/1/2014
• Junctional dysfunction in CRC and IBD: BVES as a regulator of EMT-like states 
  1/1/2014
• BVES as a modulator of tight junction signaling in colon cancer and colitis associated carcinoma 
  1/1/2013
• MTGs from translocations to cancer associated mutations, the expanding role of transcriptional co-repressors in intestinal biology 
  1/1/2013
• Murine modeling of colitis associated carcinogenesis 
  1/1/2013
• Epithelial injury responses and GI malignancy 
  1/1/2012
• BVES in colorectal cancer 
  1/1/2012
• MTGs in CRC: giving driving research 
  1/1/2012
• BVES butts heads with colon cancer 
  1/1/2011
• MTGs in CRC: funding early career scientists, a critical need 
  1/1/2010
• Philanthropy drives the cure 
  Houston, TX - 1/1/2010
• Philanthropy in the fight against cancer 
  1/1/2010
• Physician-scientist training experiences 
  1/1/2009
• A role for MTGs in colorectal carcinoma 
  1/1/2008
• MTGs in autoimmune disease states 
  1/1/2008
• Transcriptional co-repressors in intestinal integrity and malignant degeneration 
  1/1/2008
• MTG16 protects the intestinal epithelium from inflammatory injury 
  1/1/2007
• MTGs as potential therapeutic targets in IBD 
  Denver, CO - 1/1/2007
• MTGs in intestinal inflammatory carcinogenesis 
  1/1/2006
• MTGR1 in inflammation in the intestine 
  1/1/2006
• Role of Myeloid Translocation Genes (MTGs) in inflammatory bowel disease and normal intestinal function 
  1/1/2006
• Inflammatory bowel disease: a clinical overview 
  Nashville, TN - 1/1/2006
• Myeloid Translocation Genes (MTG) in intestinal biology 
  1/1/2006
• Clostridium difficile infections 
  1/1/2005
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