ChristopherVDeSimoneMDPhD

PubMed

• A comparative meta-analysis of addition of ganglionic plexus ablation versus no ganglionic plexus ablation to pulmonary vein isolation for atrial fibrillation.
  Ashish Kumar, Mariam Shariff, Jose Carlos Pachon, Juan C Zerpa Acosta, Christopher V DeSimone
  Journal of Interventional Cardiac Electrophysiology. 2024-11-26
• Sex differences in atrial fibrillation ablation outcomes in patients with heart failure.
  Siddharth Agarwal, Kassem Farhat, Muhammad Salman Khan, Christopher V DeSimone, Abhishek Deshmukh
  Journal of Interventional Cardiac Electrophysiology. 2024-11-01
• Early insights on adverse events associated with PulseSelect™ and FARAPULSE™: analysis of the MAUDE database.
  Pragyat Futela, Gurukripa N Kowlgi, Christopher V DeSimone, Ammar M Killu, Konstantinos C Siontis
  Journal of Interventional Cardiac Electrophysiology. 2024-10-23

Journal Articles

• Blood Pressure Responses to Endovascular Stimulation: A Potential Therapy for Autonomic Disorders with Vasodilatation  
  Naksuk N, Killu AM, Yogeshwaran V, DeSimone CV, Suddendorf S, Ladewig D, Madhavan M, Cha YM, Kapa S, Asirvatham SJ, J Cardiovasc Electrophysiol, 1/28/2016
• Cardiac Implantable Electronic Device Lead Vegetation and Atrial Fibrillation Ablation: A Case-based Illustration of Peri-Procedural Anticoagulation Management Strategies  
  Lenz CJ, DeSimone CV, Ponamgi SP, Sugrue A, Sinak L, Chandrasekaran K, Packer DL, Asirvatham SJ, J Interv Card Electrophysiol, 1/22/2016
• Ischemic Stroke or Systemic Embolism following Transseptal Ablation of Arrhythmias in Patients with Cardiac Implantable Electronic Devices  
  Madhavan M, Yao X, Sangaralingham LR, Asirvatham SJ, Friedman PA, McLeod CJ, DeSimone CV, Noseworthy PA, J Am Heart Assoc, 1/13/2016
• Innovative Approaches to Assess the Impact and Decrease the Neurological Consequences of Ablation  
  Ponamgi SP, Yasin OZ, Padmanabhan D, DeSimone CV, Asirvatham SJ, Journal of Innovations in Cardiac Rhythm Management, 1/1/2016
• Atrial Fibrillation and Stroke- Increasing Stroke Risk with Intervention  
  DeSimone CV, Madhavan M, Ebrille E, Rabinstein AA, Friedman AA, Asirvatham SJ, Journal of Atrial Fibrillation, 1/1/2014
• Different Strokes  
  Konecny T, DeSimone CV, Sehar N, Asirvatham SJ, Journal of Innovations in Cardiac Rhythm Management, 1/1/2014
• Percutaneous Autonomic Neural Modulation: A Novel Technique to Treat Cardiac Arrhythmia  
  DeSimone CV, Madhavan M, Venkatachalam KL, Knudson MB, Asirvatham SJ, Cardiovasc Revasc Med., 1/1/2013
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Books/Book Chapters

• Catheter ablation of cardiac arrhythmias 
  Chapter: Cardiac anatomy for catheter mapping and ablation of arrhythmias 
  Page 85 - 105Liang JJ, DeSimone CV, Lachman N, Noheria A, Nanda S, Asirvatham SJEditors: Stephen Huang S, Miller JM.Elsevier Saunders, Philadelphia, PAEdition 3rd,2015

Abstracts/Posters

• A Novel Means to Successfully Differentiate Wide-Complex Tachycardias Using Mathematically-Synthesized Vectorcardiogram Signals
  Kashou AH, May AM, DeSimone CV, Deshmukh AJ, Noseworthy PA, Minneapolis, MN, 1/1/2018
• Stroke in Patients with Cardiovascular Implantable Electronic Device Infection Undergoing Transvenous Lead Removal
  Lee JZ, Pradyumma A, Pasha AK, C, Tseng AS, Diehl NN, Hodge DO, DeSimone CV, Killu AM, Brady PA, Kancharla K, Kusumoto FM, Srivathsan K, Osborn MJ, Espinosa RE, Rea RF..., HRS, 1/1/2018
• Direct Pulmonary Vein Ablation Without Stenosis: Chronic Efficacy of a Novel Electroporation Technique
  Witt C, Sugrue A, Padmanabhan D, Vaidya V, Gruba S, Rohl J, Killu A, Naksuk N, DeSimone C, Kapa S, Asirvatham SJ, ACC, 1/1/2018
• Use of a Novel Electrogram Filtering Algorithm to Visualize Conduction Tissue Signals in the Ventricle in Sinus Rhythm and Arrhythmia: An Acute Canine Study
  Padmanabhan D, Killu AM, Witt C, Naksuk N, DeSimone CV, Sugrue A, Foxall T, Drakulic B, Ladewig D, Suddendorf S, Powers J, Venkatachalam KL, Asirvatham SJ, BCVS, 1/1/2017
• Assessment of Catheter Position above or below the Aortic Valve by Evaluation of Characteristics of the Local Electrogram: An Acute Canine Study
  Padmanabhan D, Witt C, Naksuk N, Killu AM, DeSimone CV, Sugrue A, Foxall T, Drakulic B, Ladewig D, Suddendorf S, Powers J, Venkatachalam KL, Asirvatham SJ, BCVS, 1/1/2017
• Inducible Arrhythmogenicity of Direct Current Electroporation Ablation: Insight from a Series of Acute Canine Studies
  Sugrue A, Witt C, DeSimone CV, Padnanabhan D, Killu A, Naksuk N, Kapa S, Asirvatham SJ, BCVS, 1/1/2017
• Non-Invasive Remote Monitoring of Potassium in Dialysis Patients Using an Internet-Based Wireless ECG Patch
  Attia Z, Dillon JJ, DeSimone CV, Sapir Y, Somers VK, Dugan JL, Ackerman, Asirvatham SJ, Bukartyk J, Scott CG, Ladewig DJ, Seifert G, Gibson P, Geva A, Sadot D, Friedma..., American Heart Association Scientific Sessions, 1/1/2016
• Novel Insights into the Role of the His-Purkinje System during Electrophysiological Mapping of the Canine Heart in Ventricular Fibrillation
  Asirvatham RS, Tri J, DeSimone CV, Asirvatham SJ, International Dead Seas Symposium (IDSS) on Innovations in Cardiac Arrhythmias and Device Therapy, Tel Aviv, Israel, 1/1/2016
• Beating Heart Validation of Safety and Efficacy of a Percutaneous Pericardiotomy Tool
  Gaba P, Killu AM, Naksuk N, DeSimone CV, Suddendorf S, Powers J, Ladewig D, Lerman L, Borlaug B, Asirvatham SJ, Heart Rhythm, 1/1/2016
• Dose-Response Relationship Between the Direct Current Electroporation and Ablation of Pulmonary Vein Myocardium
  Naksuk N, Killu AM, DeSimone CV, Ladewig DJ, Suddendorf SH, Kapa S, Holmes DR, Asirvatham SJ, Heart Rhythm, 1/1/2016
• Effects of Stepwise Denervation of Stellate Ganglion and Ansa Subclaviae: Novel Insights into Cardiac Sympathetic Denervation from Canine Studies
  DeSimone CV, Wu G, Suddendorf S, Asirvatham R, Asirvatham SJ, Chen PS, Cha YM, Heart Rhythm, 1/1/2016
• An Emerging Non-Thermal Ablation Tool: Electroporation Effectively Abolishes Purkinje Fiber Potentials Without Transmural Myocardial Ablation
  Killu AM, Naksuk N, DeSimone CV, Tri J, Asirvatham R, Maor E, Ladewig D, Suddendorf S, Asirvatham SJ, Heart Rhythm, 1/1/2016
• Development of a Partially Insulated Epicardial Catheter to Confer Directionality during Ablation
  Killu AM, Naksuk N, Syed F, DeSimone CV, Gaba P, Ladewig D, Suddendorf S, Danielson A, Lukasova M, Wolf J, Leinveber P, Novak M, Starek Z, Kara T, Bruce C, Friedman PA..., Heart Rhythm, 1/1/2016
• Epicardial Electroporation Effectively Ablations Myocardium without Compromising Coronary Artery Patency
  Killu AM, Naksuk N, DeSimone CV, Tri J, Asirvatham R, Maor E, Ladewig D, Suddendorf S, Asirvatham SJ, Heart Rhythm, 1/1/2016
• Evaluation of a Novel Defibrillation Unit with Dual-Vector, Quadriphasic Waveform Capabilities: Towards a Miniaturized Defibrillator
  Okamura H, DeSimone CV, Killu A, Gilles EJ, Tri J, Asirvatham R, Ladewig DJ, Suddendorf SH, Powers JM, Wood-Wentz CM, Gray PD, Raymond DM, Bruce CJ, Asirvatham SJ, Fri..., Heart Rhythm, 1/1/2016
• Enhanced Electrophysiology Recording System
  Killu AM, Naksuk N, Venkatachalam KL, DeSimone CV, Fakhar S, Foxall T, Vlajinic B, Drakulic BS, Suddendorf S, Powers J, Ladewig DJ, Asirvatham SJ, IEEE Engineering in Medicine and Biology Society, 1/1/2016
• Beta-hemolytic Streptococcal Infective Endocarditis: Mayo Clinic Experience 2000-2014
  El Rafei A, DeSimone DC, DeSimone CV, Steckelberg JM, Sohail MR, Wilson WR, Baddour LM, Mayo Clinic 12th Annual Infectious Diseases Fellows Forum, Minneapolis, MN, 1/24/2015
• The Impact of Diabetes Mellitus on Outcomes of Streptococcus agalactiae Infective Endocarditis
  El Rafei A, DeSimone DC, DeSimone CV, Steckelberg JM, Sohail MR, Wilson WR, Baddour LM, ICAAC, San Diego, CA, 1/18/2015
• Beta Hemolytic Streptococcal Infective Endocarditis: Clinical presentation, Management, and Outcomes
  El Rafei A, DeSimone DC, DeSimone CV, Lahr BD, Steckelberg JM, Sohail MR, Wilson WR, Baddour LM, IDweek, San Diego, CA, 1/8/2015
• Coincidental impact of transcatheter patent foramen ovale closure on migraine with and without aura - a comprehensive meta-analysis
  Kanwar SM, Noheria A, DeSimone C, Rabinstein A, Asirvatham S, Headache, 1/1/2015
• Beta Hemolytic Streptococcus Infective Endocarditis: Factors Associated with Early Mortality
  El Rafei A, DeSimone DC, DeSimone CV, Lahr BD, Steckelberg JM, Sohail MR, Wilson WR, Baddour LM, Open forum Infectious Disease �IDweek�, 1/1/2015
• Five-Year Mortality of Native versus Prosthetic Valve Endocarditis in a Population-Based Cohort
  El Rafei A, DeSimone DC, DeSimone CV, Steckelberg JM, Sohail MR, Wilson WR, Baddour LM, Open forum Infectious Disease �IDweek�, 1/1/2015
• Risk of Stroke or Systemic Embolism After Transseptal Ablation in Patients With Implanted Cardiac Devices
  Noseworthy P, Madhavan, DeSimone C, McLeod, Sangaralingham L, Asirvatham S, Yao X, Circulation, 1/1/2015
• Reduction in ventricular fibrillation following surgical correction of bileaflet mitral valve prolapse
  Vaidya V, DeSimone CV, Naksuk N, Syed F, Ackerman MJ, Ponamgi S, Suri R, Noseworthy PA, Asirvatham SJ, Heart Rhythm, 1/1/2015
• Catheter-Based Intervention for Pulmonary Vein Stenosis Due to Fibrosing Mediastinitis
  Ponamgi S, DeSimone CV, Lenz CJ, Coylewright M, Asirvatham SJ, Holmes DR, Packer DL, Heart Rhythm, 1/1/2015
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Lectures

• Essential Anatomy for Ventricular Tachycardia 
  1/1/2018
• Great Cases- Atriofascular Pathways: ECG clues and Mapping and Ablation Str 
  1/1/2018
• Case Studies in Disease Management: Anatomy and Arrhythmias 
  1/1/2017
• Q/A for how to succeed after the MD/PhD program- insights and perspective for residency and fellowship 
  1/9/2016
• Fundamentals of EKG and Practical Interpretation 
  1/1/2016
• Thromboembolic Risk of Right Sided Implantable Devices 
  Tel Aviv, Israel - 1/1/2016
• Case Studies in Disease Management 
  1/1/2016
• Potential for Enhancing Post-MI Risk Stratification and Therapy with Cardiac MRI 
  1/1/2016
• Clinically Oriented Pericardiocentesis 
  1/1/2015
• Patent Foramen Ovale in Patients with Cardiac Implantable Electronic Devices; Trials and Tribulations in Defining Practice 
  1/1/2015
• Basic 12 lead Interpretation 
  1/1/2015
• Cardiac Physiology 
  1/1/2015
• Using Signal-Averaged ECG to Correlate Electrocardiographic Changes with Potassium Changes in Patients Undergoing Hemodialysis: A Novel �Bloodless� Blood Test 
  Mayo Clinic, Rochester, MN - 1/14/2014
• Short and Long-Term ECG Changes after Left Cardiac Sympathetic Denervation in Patients with Long QT Syndrome 
  San Francisco, CA - 1/1/2014
• Patent Foramen Ovale in Patients with Cardiac Implantable Electronic Devices: a High Risk Population That May Benefit from Device Closure? 
  Mayo Clinic, Rochester, MN - 1/4/2013
• Mayo Clinic Department of Internal Medicine Morbidity and Mortality Systems Audit 
  Rochester, MN - 1/14/2012
• Patent Foramen Ovale and Risk of Stroke in Patients with Transvenous Pacemakers and Defibrillators 
  Los Angeles, CA - 1/1/2012
• What is the Action for Non-Compaction? Diagnosis and Management of Left Ventricular Non-Compaction Cardiomyopathy 
  Minneapolis, MN - 1/4/2011
• Binding, Specificity, and Gating Studies of HpTx2 with Kv4.3; the Potassium Channel Responsible for the Cardiac Transient Outward Current Ito 
  Chicago, IL - 1/23/2010
• A Case of Symptomatic Non-Sustained Ventricular Tachycardia with an Unusual Structure as the Underlying Etiology 
  Minneapolis, MN - 1/5/2010
• HpTx2 Binding and Gating Modification of Kv4 channels Are Dependent on Distinct Amino Acids in S3b 
  Buffalo, NY - 1/17/2008
• Binding Studies of the Gating Modifier Toxin rHpTx2 with Kv4.3 
  Rochester, NY - 1/1/2008
• Molecular Determinants of rHpTx2GS Interaction with Kv4.3 
  Chicago, IL - 1/13/2007
• Binding Studies of the Gating Modifier rHpTx2 on Kv4.3 
  Rochester, NY - 1/12/2007
• In Vitro Characterization of the Apoptotic Process Using Photoactive Porphyrins in a Cell-Free Nuclear Extract 
  Geneseo, NY, 2003; Ithaca, NY, 2003 - 1/1/2003
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Other

• New Approach to Chronic Resynchronization Therapy: CRT without LV lead. Invited Commentary 
  DeSimone CV and Asirvatham SJ, Cardiac Rhythm News
  http://www.cxvascular.com/crn-features/cardiac-rhythm-news---features/new-approach-to-cardiac-resynchronisation-therapy-crt-without-left-ventricular-lead
  1/25/2014
• Doctoral Dissertation: Binding Studies of the Gating Modifier toxin HpTx2 with Kv4.3 
  DeSimone CV, The State University at Buffalo School of Medicine and Biomedical Sciences
  1/17/2008
• Porphyrin localization and Apoptosis induction in RIF cells in culture. The Miami Nature Biotechnology Winter Symposium: 50 Years on: From the double helix to molecula... 
  DeSimone CV and Greene RS, Proceedings of the Miami Nature Biotechnology Winter Symposium Short Reports
  http://www.med.miami.edu/mnbws/x26.xml
  1/1/2003
• In Vitro Characterization of the Apoptotic Process Using Photoactive Porphyrins in a Cell-Free Nuclear Extract 
  DeSimone CV, Niagara University
  1/1/2003
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