ChristineEdrySeidmanMD

Cardiology • Boston, MA

Adult Congenital Heart Disease

Thomas W. Smith Professor of Medicine, Brigham and Women's Hospital

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Office
77 Avenue Louis Pasteur
Harvard Medical School Department Of Genetics
Boston, MA 02115
Phone+1 617-432-7871

Education & Training

Massachusetts General HospitalResidency, Internal Medicine, 1982 - 1986
Johns Hopkins UniversityResidency, Internal Medicine, 1978 - 1981
George Washington University School of Medicine and Health SciencesClass of 1978

Certifications & Licensure

MA State Medical License 1986 - 2025
MD State Medical License 1981 - 1991
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Cardiovascular Disease

Awards, Honors, & Recognition

Joseph A. Vita Award American Heart Associations, 2016
21st Annual Glorney-Raisbeck Award The New York Academy of Medicine, 2009
Le Grande Prix for Cardiovascular Research Academie de Science, - Institut de France, 2007
Association of American Physicians 2006
National Academy of Sciences 2005
Distinguished Scientist American Heart Association, 2003
National Academy of Medicine 1999
American Society for Clinical Investigation 1992
Investigator Howard Hughes Medical Institute
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Clinical Trials

Identification of Genetic Causes of Bicuspid Aortic Valve Disease Start of enrollment: 2009 Dec 01
Active, not recruiting
Congenital Heart Disease GEnetic NEtwork Study (CHD GENES) Start of enrollment: 2010 Nov 15
Recruiting

Publications & Presentations

PubMed

Efficient identification of de novo mutations in family trios: a consensus-based informatic approach.
Mariya Shadrina, Özem Kalay, Sinem Demirkaya-Budak, Charles A LeDuc, Wendy K Chung
Life Science Alliance. 2025-06-01
Genomic analysis of 11,555 probands identifies 60 dominant congenital heart disease genes.
Michael C Sierant, Sheng Chih Jin, Kaya Bilguvar, Sarah U Morton, Weilai Dong
Proceedings of the National Academy of Sciences of the United States of America. 2025-04-01
Recessive genetic contribution to congenital heart disease in 5,424 probands.
Weilai Dong, Sheng Chih Jin, Michael C Sierant, Ziyu Lu, Boyang Li
Proceedings of the National Academy of Sciences of the United States of America. 2025-03-11

Journal Articles

Association of Damaging Variants in Genes with Increased Cancer Risk Among Patients with Congenital Heart Disease
Daniel Quiat, Richard P Lifton, Christine E Seidman, JAMA Cardiology
Telomere Shortening Is a Hallmark of Genetic Cardiomyopathies
Christine E Seidman, John T Hinson, Gerhard Weber, Euan Ashley, John W Day, Joseph C Wu, Proceedings of the National Academy of Sciences
A Gene-Centric Strategy for Identifying Disease-Causing Rare Variants in Dilated Cardiomyopathy
Amy Roberts, Christine E Seidman, Nature

Lectures

Cardiovascular Genetics in Clinical Practice
Harvard Medical School ,Department Of Continuing Education, Boston, Massachusetts - 10/13/2012

Press Mentions

Hidden Genetic Causes of Congenital Heart Disease IdentifiedFebruary 20th, 2025
American College of Cardiology (ACC) Champions Distinguished Awards Winners at ACC.23/WCC ConvocationMarch 12th, 2023
VIDEO: Using Genetics in Cardiology to Enable Earlier InterventionsJanuary 5th, 2023
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Grant Support

Identifying unrecognized genetic causes of congenital heart diseaseBRIGHAM AND WOMEN'S HOSPITAL2024–2028
Genomic Effects on Right Ventricular Function, Clinical Features and Outcomes in CHDBOSTON CHILDREN'S HOSPITAL2009–2025
Defining Genetic Architecture and Pathways of DCMHARVARD MEDICAL SCHOOL2005–2025
Using Genetics For Early Phenotyping &Prevention Of Hypertrophic CardiomyopathyNational Heart, Lung, And Blood Institute2010–2011
Human Mutations That Cause Tetralogy Of FallotNational Heart, Lung, And Blood Institute2004–2008
Specialized Center Of Research In Heart FailureNational Heart, Lung, And Blood Institute2000–2004
Clinical And Genetic Diversity Of Familial Dilated CardiomyopathyNational Heart, Lung, And Blood Institute2000–2002
Genetic Analysis Of Inherited Congenital Heart DiseasesNational Heart, Lung, And Blood Institute1999–2002
SCOR In Heart FailureNational Heart, Lung, And Blood Institute1998–1999
Identification Of Gene Defects That Cause Familial Dilated CardiomyopathiesNational Heart, Lung, And Blood Institute1995–1999
Genetics Of Familial Hypocalciuric HypercalcemiaNational Institute Of Diabetes And Digestive And Kidney Diseases1993–1997
Digitails--Mechanism And Reversal StudiesNational Heart, Lung, And Blood Institute1994
Genetic Analysis Of Familial Hypertrophic CardiomyopathyNational Heart, Lung, And Blood Institute1990–1994
Digitalis: Mechanism And Reversal StudiesNational Heart, Lung, And Blood Institute1993
Training Program In Cardiovascular ResearchNational Heart, Lung, And Blood Institute1985–1993
Digitalis--Mechanism And Reversal StudiesNational Heart, Lung, And Blood Institute1992
Short-Term Training In Health Professional SchoolsNational Heart, Lung, And Blood Institute1990–1992
Development Of Stable Cardiac Cell LinesNational Heart, Lung, And Blood Institute1988–1992
Digitals: Mechanism And Reversal StudiesNational Heart, Lung, And Blood Institute1990–1991
Digitals: Mechanism And Reversal StudiesNational Heart, Lung, And Blood Institute1989
Digitals: Mechanism And Reversal StudiesNational Heart, Lung, And Blood Institute1985–1988
Students In Health Professional SchoolsNational Heart, Lung, And Blood Institute1985–1987