Christine Edry Seidman MD
Adult Congenital Heart Disease
Thomas W. Smith Professor of Medicine, Brigham and Women's Hospital
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77 Avenue Louis PasteurHarvard Medical School Department Of GeneticsBoston, MA 02115
Phone+1 617-432-7871
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Education & Training
Mass General Brigham/Massachusetts General HospitalResidency, Internal Medicine, 1982 - 1986
Johns Hopkins UniversityResidency, Internal Medicine, 1978 - 1981
George Washington University School of Medicine and Health SciencesClass of 1978
Certifications & Licensure
MA State Medical License 1986 - 2025
MD State Medical License 1981 - 1991
American Board of Internal Medicine Internal Medicine- American Board of Internal Medicine Cardiovascular Disease
Awards, Honors, & Recognition
- Joseph A. Vita Award American Heart Associations, 2016
- 21st Annual Glorney-Raisbeck Award The New York Academy of Medicine, 2009
- Le Grande Prix for Cardiovascular Research Academie de Science, - Institut de France, 2007
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Clinical Trials
- Identification of Genetic Causes of Bicuspid Aortic Valve Disease Start of enrollment: 2009 Dec 01
- Congenital Heart Disease GEnetic NEtwork Study (CHD GENES) Start of enrollment: 2010 Nov 15
Publications & Presentations
PubMed
- Efficient identification of de novo mutations in family trios: a consensus-based informatic approach.Mariya Shadrina, Özem Kalay, Sinem Demirkaya-Budak, Charles A LeDuc, Wendy K Chung
Life Science Alliance. 2025-06-01 - GLP1R upregulation in mitral regurgitation observed at a single nucleus level.Sameeksha Tiwari, Martin Beyer, Sary F Aranki, Meraj Neyazi, Gavin Y Oudit
Journal of Molecular and Cellular Cardiology. 2025-04-08 - Genomic analysis of 11,555 probands identifies 60 dominant congenital heart disease genes.Michael C Sierant, Sheng Chih Jin, Kaya Bilguvar, Sarah U Morton, Weilai Dong
Proceedings of the National Academy of Sciences of the United States of America. 2025-04-01
Journal Articles
- Association of Damaging Variants in Genes with Increased Cancer Risk Among Patients with Congenital Heart DiseaseDaniel Quiat, Richard P Lifton, Christine E Seidman, JAMA Cardiology
- Telomere Shortening Is a Hallmark of Genetic CardiomyopathiesChristine E Seidman, John T Hinson, Gerhard Weber, Euan Ashley, John W Day, Joseph C Wu, Proceedings of the National Academy of Sciences
- A Gene-Centric Strategy for Identifying Disease-Causing Rare Variants in Dilated CardiomyopathyAmy Roberts, Christine E Seidman, Nature
Press Mentions
Hidden Genetic Causes of Congenital Heart Disease IdentifiedFebruary 20th, 2025- American College of Cardiology (ACC) Champions Distinguished Awards Winners at ACC.23/WCC ConvocationMarch 12th, 2023
- VIDEO: Using Genetics in Cardiology to Enable Earlier InterventionsJanuary 5th, 2023
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Grant Support
- Identifying unrecognized genetic causes of congenital heart diseaseBRIGHAM AND WOMEN'S HOSPITAL2024–2028
- Genomic Effects on Right Ventricular Function, Clinical Features and Outcomes in CHDBOSTON CHILDREN'S HOSPITAL2009–2025
- Defining Genetic Architecture and Pathways of DCMHARVARD MEDICAL SCHOOL2005–2025
- Using Genetics For Early Phenotyping &Prevention Of Hypertrophic CardiomyopathyNational Heart, Lung, And Blood Institute2010–2011
- Human Mutations That Cause Tetralogy Of FallotNational Heart, Lung, And Blood Institute2004–2008
- Specialized Center Of Research In Heart FailureNational Heart, Lung, And Blood Institute2000–2004
- Clinical And Genetic Diversity Of Familial Dilated CardiomyopathyNational Heart, Lung, And Blood Institute2000–2002
- Genetic Analysis Of Inherited Congenital Heart DiseasesNational Heart, Lung, And Blood Institute1999–2002
- SCOR In Heart FailureNational Heart, Lung, And Blood Institute1998–1999
- Identification Of Gene Defects That Cause Familial Dilated CardiomyopathiesNational Heart, Lung, And Blood Institute1995–1999
- Genetics Of Familial Hypocalciuric HypercalcemiaNational Institute Of Diabetes And Digestive And Kidney Diseases1993–1997
- Digitails--Mechanism And Reversal StudiesNational Heart, Lung, And Blood Institute1994
- Genetic Analysis Of Familial Hypertrophic CardiomyopathyNational Heart, Lung, And Blood Institute1990–1994
- Digitalis: Mechanism And Reversal StudiesNational Heart, Lung, And Blood Institute1993
- Training Program In Cardiovascular ResearchNational Heart, Lung, And Blood Institute1985–1993
- Digitalis--Mechanism And Reversal StudiesNational Heart, Lung, And Blood Institute1992
- Short-Term Training In Health Professional SchoolsNational Heart, Lung, And Blood Institute1990–1992
- Development Of Stable Cardiac Cell LinesNational Heart, Lung, And Blood Institute1988–1992
- Digitals: Mechanism And Reversal StudiesNational Heart, Lung, And Blood Institute1990–1991
- Digitals: Mechanism And Reversal StudiesNational Heart, Lung, And Blood Institute1989
- Digitals: Mechanism And Reversal StudiesNational Heart, Lung, And Blood Institute1985–1988
- Students In Health Professional SchoolsNational Heart, Lung, And Blood Institute1985–1987
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