CharlesDSmithMD

PubMed

• Spiking neural networks fine-tuning for brain image segmentation.
  Ye Yue, Marc Baltes, Nidal Abuhajar, Tao Sun, Avinash Karanth
  Frontiers in Neuroscience. 2023-01-01
• 3 citations
  A clinicopathologic study of malignancy in VCP-associated multisystem proteinopathy.
  Alyaa Shmara, Mari Perez-Rosendahl, Kady Murphy, Ashley Kwon, Charles Smith
  Orphanet Journal of Rare Diseases. 2022-07-15
• 3 citations
  Development of a protocol to assess within-subject, regional white matter hyperintensity changes in aging and dementia.
  Ahmed A. Bahrani, Charles D. Smith, Justin M. Barber, Omar M. Al-Janabi, David K. Powell
  Journal of Neuroscience Methods. 2021-08-01

Journal Articles

• Genotype‐Phenotype Study in Patients with Valosin‐Containing Protein Mutations Associated with Multisystem Proteinopathy  
  V Kimonis, T Mozaffar, C Smith, A K Wang, Clinical Genetics
• A Case Report Comparing Clinical, Imaging and Neuropsychological Assessment Findings in Twins Discordant for the Vcp PR155c Mutation  
  Surampalli, A, Gold, BT, Smith, C, Castellani, RJ, Khare, M, Yu, H, Nguyen, C, Lan, M, Wencel, M, Wigal, S, Caiozzo, V, and Kimonis, V, Neuromuscul Disord, 1/1/2015
• Reversible Cognitive, Motor, and Driving Impairments in Severe Hypothyroidism  
  Smith, CD, Grondin, R, LeMaster, W, Martin, B, Gold, BT, and Ain, KB, Thyroid, 1/1/2015
• Abcc9 Gene Polymorphism Is Associated with Hippocampal Sclerosis of Aging Pathology  
  Nelson, PT, Estus, S, Abner, EL, Parikh, I, Malik, M, Neltner, JH, Ighodaro, E, Wang, WX, Wilfred, BR, Wang, LS, Kukull, WA, Nandakumar, K, Farman, ML, Poon, WW, Corra..., Acta Neuropathol, 1/1/2014
• Self-Reported Head Injury and Risk of Late-Life Impairment and Ad Pathology in an Ad Center Cohort  
  Abner, EL, Nelson, PT, Schmitt, FA, Browning, SR, Fardo, DW, Wan, L, Jicha, GA, Cooper, GE, Smith, CD, Caban-Holt, AM, Van Eldik, LJ, and Kryscio, RJ, Dement Geriatr Cogn Disord, 1/1/2014
• White Matter Integrity Is Associated with Cerebrospinal Fluid Markers of Alzheimer's Disease in Normal Adults  
  Gold, BT, Zhu, Z, Brown, CA, Andersen, AH, LaDu, MJ, Tai, L, Jicha, GA, Kryscio, RJ, Estus, S, Nelson, PT, Scheff, SW, Abner, E, Schmitt, FA, Van Eldik, LJ, and Smith, CD, Neurobiol Aging, 1/1/2014
• Self-Reported Memory Complaints: Implications from a Longitudinal Cohort with Autopsies  
  Kryscio, RJ, Abner, EL, Cooper, GE, Fardo, DW, Jicha, GA, Nelson, PT, Smith, CD, Van Eldik, LJ, Wan, L, and Schmitt, FA, Neurology, 1/1/2014
• Hippocampal Sclerosis of Aging, a Prevalent and High-Morbidity Brain Disease  
  Nelson, PT, Smith, CD, Abner, EL, Wilfred, BJ, Wang, WX, Neltner, JH, Baker, M, Fardo, DW, Kryscio, RJ, Scheff, SW, Jicha, GA, Jellinger, KA, Van Eldik, LJ, and Schmit..., Acta Neuropathol, 1/1/2013
• Resting Eeg Discrimination of Early Stage Alzheimer’s Disease from Normal Aging Using Inter-Channel Coherence Network Graphs  
  McBride, J, Zhao, X, Munro, N, Smith, C, Jicha, G, and Jiang, Y, Ann Biomed Engr, 1/1/2013
• Adjusting for Mortality When Identifying Risk Factors for Transitions to Mild Cognitive Impairment and Dementia  
  Kryscio, RJ, Abner, EL, Lin, Y, Cooper, GE, Fardo, DW, Jicha, GA, Nelson, PT, Smith, CD, Van Eldik, LJ, Wan, L, and Schmitt, FA, J Alzheimers Dis, 1/1/2013
• White Matter Integrity and Vulnerability to Alzheimer's Disease: Preliminary Findings and Future Directions  
  Gold, BT, Johnson, NF, Powell, DK, and Smith, CD, Biochim Biophys Acta, 1/1/2012
• Structural Imaging in Early Pre-States of Dementia  
  Smith, CD, Biochim Biophys Acta, 1/1/2012
• Genotype-Phenotype Studies of Vcp-Associated Inclusion Body Myopathy with Paget Disease of Bone and/or Frontotemporal Dementia  
  Mehta, S, Khare, M, Ramani, R, Watts, G, Simon, M, Osann, K, Donkervoort, S, Dec, E, Nalbandian, A, Platt, J, Pasquali, M, Wang, A, Mozaffar, T, Smith, C, and Kimonis, V, Clin Genet, 1/1/2012
• Global Gene Profiling of Vcp-Associated Inclusion Body Myopathy  
  Nalbandian, A, Ghimbovschi, S, Radom-Aizik, S, Dec, E, Vesa, J, Martin, B, Knoblach, S, Smith, C, Hoffman, E, and Kimonis, VE, Clin Transl Sci, 1/1/2012
• University of Kentucky Sanders-Brown Healthy Brain Aging Volunteers: Donor Characteristics, Procedures and Neuropathology  
  Schmitt, FA, Nelson, PT, Abner, E, Scheff, S, Jicha, GA, Smith, C, Cooper, G, Mendiondo, M, Danner, DD, Van Eldik, LJ, Caban-Holt, A, Lovell, MA, and Kryscio, RJ, Curr Alzheimer Res, 1/1/2012
• Partial Least Squares for Discrimination in Fmri Data  
  Andersen, AH, Rayens, WS, Liu, Y, and Smith, CD, Magn Reson Imaging, 1/1/2012
• Preclinical Ad Workgroup Staging: Pathological Correlates and Potential Challenges  
  Jicha, GA, Abner, EL, Schmitt, FA, Kryscio, RJ, Riley, KP, Cooper, GE, Stiles, N, Mendiondo, MS, Smith, CD, Van Eldik, LJ, and Nelson, PT, Neurobiol Aging, 1/1/2012
• Radiological Features of Paget Disease of Bone Associated with Vcp Myopathy  
  Farpour, F, Tehranzadeh, J, Donkervoort, S, Smith, C, Martin, B, Vanjara, P, Osann, K, and Kimonis, VE, Skeletal Radiol, 1/1/2012
• Alzheimer's Disease Is Not "Brain Aging": Neuropathological, Genetic, and Epidemiological Human Studies  
  Nelson, PT, Head, E, Schmitt, FA, Davis, PR, Neltner, JH, Jicha, GA, Abner, EL, Smith, CD, Van Eldik, LJ, Kryscio, RJ, and Scheff, SW, Acta Neuropathol, 1/1/2011
• Hippocampal Sclerosis in Advanced Age: Clinical and Pathological Features  
  Nelson, PT, Schmitt, FA, Lin, Y, Abner, EL, Jicha, GA, Patel, E, Thomason, PC, Neltner, JH, Smith, CD, Santacruz, KS, Sonnen, JA, Poon, LW, Gearing, M, Green, RC, Wood..., Brain, 1/1/2011
• End-Stage Neurofibrillary Tangle Pathology in Preclinical Alzheimer's Disease: Fact or Fiction?  
  Abner, EL, Kryscio, RJ, Schmitt, FA, Santacruz, KS, Jicha, GA, Lin, Y, Neltner, JM, Smith, CD, Van Eldik, LJ, and Nelson, PT, J Alzheimers Dis, 1/1/2011
• Prediction of Preclinical Alzheimer's Disease: Longitudinal Rates of Change in Cognition  
  Riley, KP, Jicha, GA, Davis, D, Abner, EL, Cooper, GE, Stiles, N, Smith, CD, Kryscio, RJ, Nelson, PT, Van Eldik, LJ, and Schmitt, FA, J Alzheimers Dis, 1/1/2011
• Task Deactivation Reductions and Atrophy within Parietal Default Mode Regions Are Overlapping but Only Weakly Correlated in Mild Cognitive Impairment  
  Threlkeld, ZD, Jicha, GA, Smith, CD, and Gold, BT, J Alzheimers Dis, 1/1/2011
• The Multiple Faces of Valosin-Containing Protein-Associated Diseases: Inclusion Body Myopathy with Paget's Disease of Bone, Frontotemporal Dementia, and Amyotrophic La...  
  Nalbandian, A, Donkervoort, S, Dec, E, Badadani, M, Katheria, V, Rana, P, Nguyen, C, Mukherjee, J, Caiozzo, V, Martin, B, Watts, GD, Vesa, J, Smith, C, and Kimonis, VE, J Mol Neurosci, 1/1/2011
• Contralateral Optic Neuritis Following Silicone Oil Endotamponade for Retinal Detachment  
  Espinosa, PS, Espinosa, PH, Smith, CD, and Brger, JR, J Neurol Neurophysiol, 1/1/2011
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Books/Book Chapters

• Advances in Medical Physics 
  Chapter: Diffusion Tensor Imaging: Neuroscience Applications 
  Page 173 - 193Powell, DM, and Smith, CDEditors: Wolbarst, A B, Karellas, A, Krupinski, E A and Hendee, W R.Madison, WI, Medical Physics Publishing2012
• The Clinical Spectrum of Alzheimer’s Disease - the Charge toward Comprehensive Diagnostic and Therapeutic Strategies 
  Chapter: Vcp Disease and Familial Alzheimer’s Disease: Contrasts and Overlaps 
  Page 1 - 17Smith, CD, Badadani, M, Nalbandian, A, Dec, E, Vesa, J, Donkervoort, S, Martin, B, Watts, GD, Caiozzo, V, and Kimonis, VKEditors: De La Monte, S.In Tech, Rijeka2011
• Alzheimer’s Disease, Book 2 
  Chapter: Valosin-Containing Protein (VCP) Disease and Familial Alzheimer’s Disease: Contrasts and Overlaps. 
  Page 1 - 17Smith CD, Badadani M, Nalbandian A, Dec E, Vesa J, Donkervoort S, Martin B, Watts GD, Caiozzo V, Kimonis VKTech, Rijeka2011
• Muscle Ageing, Inclusion-Body Myositis and Myopathies. 
  Chapter: Clinical spectrum of VCP myopathy, Paget’s disease and frontotemporal dementia; experimental models and potential treatments. 
  Kimonis VE, Dec E, Badadani M, Nalbandian A, Vesa J, Caiozzo V, Wallace D, Martin B, Smith C, Watts GDEditors: Askanas V, Engel WK.Wiley, Oxford2010
• Muscle Ageing, Inclusion-Body Myositis and Myopathies 
  Chapter: Clinical Spectrum of Vcp Myopathy, Paget’s Disease and Frontotemporal Dementia; Experimental Models and Potential Treatments 
  Kimonis, VE, Dec, E, Badadani, M, Nalbandian, A, Vesa, J, Caiozzo, V, Wallace, D, Martin, B, Smith, C, and Watts, GDEditors: Askanas, V and Engel, W K.Wiley, Oxford2010
• Focus on Neuroimaging: Neurology Self-Assessment. 
  Espinosa, PS, and Smith, CDLippincott Williams & Wilkins, Baltimore, MDEdition 1st,2009
• Focus on Neuroimaging: Neurology Self-Assessment. 
  Espinosa PS, Smith CDLippincott, Baltimore, MD2009
• BVMC 
  Chapter: Distribution-Based Level Set Segmentation for Brain Mr Images 
  Page 1 - 10Liu, J, Chelberg, D, Smith, C, and Chebrolu, HEditors: Rajpoot, N M and Bhalerao, A H.British Machine Vision Association, Warwick, United Kingdom2007
• MICCAI 
  Chapter: Automatic Subcortical Structure Segmentation Using Local Likelihood-Based Active Contour 
  Page 91 - 98Liu, J, Smith, C, and Chebrolu, HEditors: Heimann, M, Styner, M and van Ginniken, B.Brisbane, Australia2007
• ISVC 
  Chapter: Autmomatic Subcortical Structure Segmentation Using Probabalistic Atlas 
  Page 170 - 178Liu, J, Chelberg, D, Smith, C, and Chebrolu, HEditors: Bebis, G.Springer-Verlag, Lake Tahoe, NV; Berlin2007
• Cerebral Ischemia and Basic Mechanisms 
  Chapter: Gene Expression and Functional Changes after Acute Ischemia: Age Related Differences in Outcome and Mechanisms 
  Page 301 - 311Carney, JM, Kindy, MS, Smith, CD, Wood, S, Tatsuno, T, Wu, JF, Landrum, WR, and Floyd, RAEditors: Hartmann, A, Yatsu, F and W., K.Springer-Verlag, Berlin, Germany1993
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Abstracts/Posters

• Sickle Cell Trait and Migraine: An Unusual Cause of Stroke in the Young.
  Patterson, EP, Stewart, A, Smith, C, and Robertson, WC, Child Neurology Society 42nd Annual Meeting, Austin, TX, 1/1/2013
• Dopaminergic Modulation of Medial Prefrontal Cortex Deactivation in Parkinson Depression
  Andersen, AH, Smith, CD, Slevin, JT, Kryscio, RJ, Martin, CA, Schmitt, FA, and Blonder, LX, Markesbery Symposium, 3rd Annual, Lexington, KY, 1/1/2013
• Distinct Electrophysiological Patterns of Repetition Effects in Mild Cognitive Impairment and Alzheimer Disease
  Broster, L, Li, J, Smith, CD, Jicha, G, Schmitt, F, McKinley, H, Munro, NB, Hively, LM, and Jiang, Y, Organization fro Human Brain Mapping 19th Annual Meeting, Seattle, WA, 1/1/2013
• Event Related Potentials: A Cognitive Biomarker for Diagnosis of Early-Stage Alzheimer Disease
  Cecci, M, Burkholder, S, Berg, S, Sadowski, C, Solomon, PR, Doraiswami, PM, Smith, CD, Jicha, G, Arnold, SE, Folley, B, Casey, DA, and Budson, AE, International Conference on Alzheimer's Disease, Alzheimer's Association, Boston, MA, 1/1/2013
• Vascular Neuropathology in Dementia Patients Receiving Antipsychotic Therapy
  Jicha, G, Abner, E, Fardo, DW, Kryscio, R, Schmitt, F, Smith, CD, Neltner, JH, Van Eldik, L, Kukull, WA, and Nelson, PT, International Conference on Alzheimer's Disease, Alzheimer's Association, Boston, MA, 1/1/2013
• Self Reported Memory Decline Predicts Cognitive Impairment and Dementia
  Kryscio, RJ, Abner, EA, Fardo, DW, Nelson, PT, Jicha, GA, Smith, CD, Cooper, GE, Caban-Holt, A, Van Eldik, LJ, and Schmitt, FA, International Conference on Alzheimer's Disease, Alzheimer's Association, Boston, MA, 1/1/2013
• Clinical Correlates of Hippocampal Sclerosis of Aging: The U. Kentucky Experience
  Nelson, PT, Abner, E, Smith, CD, Neltner, JH, Jicha, G, Fardo, DW, Van Eldik, L, Kryscio, R, and Schmitt, F, International Conference on Alzheimer's Disease, Alzheimer's Association, Boston, MA, 1/1/2013
• Neuopathologic Substrate of Clinically-Evident Asymmetric Hippocampal in Alzheimer’s Disease
  Pagnuganti, P, Abner, E, Nelson, PT, Schmitt, F, Van Eldik, L, Kryscio, RJ, Smith, CD, and Jicha, G, International Conference on Alzheimer's Disease, Alzheimer's Association, Boston, MA, 1/1/2013
• Self-Reported Head Injury and Risk of Cognitive Impairment and Alzheimer’s-Type Pathology in a Longitudinal Ad Center Cohort
  Abner, E, Nelson, PT, Schmitt, F, Browning, SR, Fardo, DW, Wan, L, Jicha, G, Cooper, GE, Smith, CD, Van Eldik, L, and Kryscio, R, International Conference on Alzheimer's Disease; Alzheimer's Association, Boston, MA, 1/1/2013
• Early to Mid-Life Formal Training in Music Is Associated with Improved Late-Life Semantic and Episodic Memory among Cognitively Normal Older Adults
  Abner, EL, Schmitt, FA, Kryscio, RJ, Jicha, GA, Cooper, GE, Smith, CD, Swezey, S, Fardo, DW, Van Eldik, LJ, and Gooding, L, International Conference on Alzheimer's Disease; Alzheimer's Association, Boston, MA, 1/1/2013
• Loss of Brain Substance in Ad Is Steady and Predictable: In Vivo Imaging with Validation at Autopsy
  Smith, CD, Abner, E, Jicha, G, Van Eldik, L, Schmitt, F, and Nelson, PT, American Neurological Association 138th Annual Meeting, New Orleans, LA, 1/1/2013
• Automatic Multiple Sclerosis Detection Based on Integrated Square Estimation
  Liu, J, Smith, CD, and Chebrolu, H, Mathematical Methods in Biomedical Image Analysis, Breckenridge, CO, 1/1/2012
• Riemannian Shpe Analysis Based on Meridian Curves
  Xie, S, Liu, J, and Smith, CD, Markesbery Symposium, 2nd Annual, Lexington, KY, 1/1/2012
• Robust and Efficient Point Registration Based on Clusters and Generalized Radial Basis Functions
  Xu, H, Liu, J, and Smith, CD, Markesbery Symposium, 2nd Annual, Lexington, KY, 1/1/2012
• A Multi-Center Clinical Trial to Validate Event-Related Potentials (Erps) as Useful Biomarkers for Early Detection of Alzheimer’s Disease (Ad).
  Jiang, Y, and Smith, C, Clinical Trials on Alzheimer’s Disease 4th Annual Conference, Monte Carlo, Monaco, 1/1/2012
• Vcp-Associated Inclusion Body Myopathy with Paget Disease of Bone and/or Frontotemporal Dementia: Expanding Natural History and Genotype-Phenotype Characterization
  Khare, M, Gargus, M, Mehta, S, Ramani, R, Watts, GD, Martin, B, Simon, M, Osann, KE, Donkervoort, S, Nalbandian, A, Wang, A, Mozaffar, T, Smith, CD, and Kimonis, V, American Society of Human Genetics, San Francisco, CA, 1/1/2012
• Dopaminergic Modulation of Cognition and Affect in Parkinson Depression
  Blonder, L, Slevin, JT, Kryscio, R, Martin, CA, Andersen, A, Smith, CD, and Schmitt, F, 8th International Congress on Mental Dysfunction & Other Non-Motor Features in Parkinson's Disease & Related Disorders, Berlin, Germany, 1/1/2012
• The R155h Vcp Knock-in Mouse Recapitulates the Human Disease: Varied Phenotypes in the Dominant and Homozygous State
  Nalbandian, A, Llewellyn, K, Yin, H, Dec, E, Donkervoort, S, Watts, GD, Martin, B, Smith, CD, Caiozzo, V, Wang, A, Mozaffar, T, and Weiss, J, American College of Medical Genetics Annual Meeting, Vancouver, British Columbia, Canada, 1/1/2011
• Vcp Disease: Inclusion Body Myopathy, Paget and Frontotemporal Dementia: New Insights
  Kimonis, V, Badadani, M, Nalbandian, A, Dec, E, Watts, GD, Caiozzo, V, Martin, B, and Smith, CD, American Society of Human Genetics, Vancouver, British Columbia, Canada, 1/1/2011
• The Cognision™ System: Event-Related Potential as a Useful Biomarker for Alzheimer's Disease Diagnosis
  Casey, DA, Cecci, M, Jicha, G, Solomon, PR, Doraiswamy, PM, and Kulkarni, MV, Clinical Trials on Alzheimer's Disease 4th Conference, San Diego, CA, 1/1/2011
• Nonlinear Analysis of Eeg for Early Detection of Cognitive Decline
  Munro, NB, De Bock, TJ, Das, S, Hively, LM, Li, J, Broster, L, Smith, CD, Jicha, G, and Jiang, Y, Human Brain Mapping 17th Annual Conference, Quebec City, Quebec, Canada, 1/1/2011
• Left Frontal Brain Potentials Differentiate Mild Cognitive Impairment from Normal Aging During a Working Memory Task
  Broster, L, Li, J, Smith, CD, Jicha, J, Munro, NB, Hively, LM, and Jiang, Y, Society for Neuroscience Annual Meeting, Washington, DC, 1/1/2011
• Resting State Brain Networks in Women at High Risk of Alzheimer’s Disease
  Andersen, AH, Gold, BT, and Smith, CD, International Conference on Alzheimer's Disease, Alzheimer's Association, Paris, France, 1/1/2011
• Evaluation of a Handheld Event-Related Potential System as a Useful Biomarker for Alzheimer's Disease
  Casey, DA, Cecci, M, Jicha, G, Arnold, SE, Wolk, DA, Solomon, PR, Doriswami, PM, Smith, CD, and Kulkarni, MV, International Conference on Alzheimer’s Disease, Paris, France, 1/1/2011
• Event-Related Potentials (Erp) as a Useful Biomarker for Central Nervous System (Cns) Disorders
  Kulkarni, MV, Cecci, M, Smith, CD, Jicha, GA, Doriswami, PM, Casey, DA, Arnold, SE, Wolk, DA, and Solomon, PR, New Clinical Drug Evaluation Unit 53rd Annual Meeting, Boca Raton, FL, 1/1/2011
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Lectures

• What Have We Learned from ADNI? 
  University of Miami, Miami, FL - 1/29/2010
• Alzheimer's Disease: Pathogenesis, Early Detection and Prevention 
  Dublin, Ireland - 1/25/2008
• Presymptomatic Brain Alterations Before Mild Cognitive Impairment 
  Jewish Hospital, Louisville, KY - 1/12/2007
• Imaging Presymptomatic Alzheimer's Disease 
  Bethesda, MD - 1/15/2005
• Update on the Alzheimer's Disease Pre-state 
  Medical University of South Carolina, Charleston, SC - 1/13/2005
• Neuroimaging: From Anatomy to Behavior 
  Bethesda, MD - 1/5/2005
• New Developments in Neuroimaging: Anatomy and Behavior 
  Milwaukee, WI - 1/6/2004
• Alzheimer’s Disease Update 
  Lexington, KY - 1/1/2003
• The Non-Alzheimer's Dementias 
  Lexington, KY - 1/1/2003
• Longitudinal Functional Brain Alterations in asymptomatic women at risk for Alzheimer's disease. 
  New Orleans, LA - 1/1/2003
• Structural and Functional MRI in Presympromatic AD 
  Washington, DC - 1/17/2002
• Using fMRI to assess presymptomatic risk of Alzheimer's disease. 
  Washington University, St. Louis, MO - 1/1/2002
• MRI in Primary Lateral Sclerosis 
  West Lebanon, NH - 1/26/2001
• The Alzheimer’s Disease Pre-State. 
  University of New Mexico Medical School, Albuquerque, NM - 1/16/2001
• FMRI in Presymptomatic Alzheimer’s Disease 
  Cleveland Clinic, Cleveland, OH - 1/15/2001
• Risk in Alzheimer’s Disease: functional imaging results. 
  New Jersey Medical School, Newark, NJ - 1/12/2001
• Differences in Functional MRI Activation by Category in a Visual Confrontation Naming Task 
  Boston, MA - 1/1/2000
• Imaging: New Techniques, Old Brains 
  Orlando, FL - 1/9/1995
• Cortical Activation of Brodmann Area 37 in Confrontation Naming 
  Nice, France - 1/1/1995
• Magnetic Resonance Imaging of Acute Stroke 
  Lexington, KY - 1/1/1993
• Magnetic Resonance Imaging in Boxers 
  Montreal, Canada - 1/1/1986
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