Charles L Loprinzi MD

Oncology•Rochester, MN

Professor of Medicine, Mayo Medical School

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200 1st St SwMayo Clinic, Dept Med OncologyRochester, MN 55905
Phone+1 507-284-2511

Education & Training

University of Wisconsin Hospitals and ClinicsFellowship, Medical Oncology, 1982 - 1984
Creighton University School of Medicine/Maricopa Medical Center (Phoenix)Residency, Internal Medicine, 1979 - 1982
Oregon Health and Science University School of MedicineClass of 1979

Certifications & Licensure

MN State Medical License 1985 - 2026
AZ State Medical License 1988 - 2017
FL State Medical License 1987 - 2005
WI State Medical License 1982 - 1985
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2003-2014
America's Top Doctors for Cancer Castle Connolly, 2005-2013
Fellow (FASCO) American Society of Clinical Oncologists, 2008

Clinical Trials

Aspirin in Treating Patients With Colorectal Cancer That Has Been Surgically Removed Start of enrollment: 1993 May 01
Completed
Phase 3
Shark Cartilage in Treating Patients With Advanced Colorectal or Breast Cancer Start of enrollment: 2001 Aug 01
Completed
Phase 3
Gabapentin in Treating Peripheral Neuropathy in Cancer Patients Undergoing Chemotherapy Start of enrollment: 2002 Feb 01
Completed
Phase 3
Gabapentin in Treating Hot Flashes in Patients With Prostate Cancer Start of enrollment: 2001 Dec 01
Completed
Phase 3
Medroxyprogesterone Compared With Venlafaxine in Treating Hot Flashes in Women Start of enrollment: 2002 Apr 01
Completed
Phase 3
Calcium With or Without Estrogen and/or Risedronate in Preventing Osteoporosis in Patients With Prostate Cancer Start of enrollment: 2002 Nov 01
Completed
Phase 3
Lidocaine Patch in Treating Cancer Patients With Neuropathic Pain After Surgery Start of enrollment: 2004 May 01
Completed
Phase 3
Lamotrigine in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer Start of enrollment: 2004 Feb 01
Completed
Phase 3
Temozolomide and Radiation Therapy in Treating Patients With Stage IV Malignant Melanoma With Measurable and Unresectable Cancer of the Central Nervous System Start of enrollment: 2004 Jan 01
Terminated
Phase 2
(Valerian) for Improving Sleep in Patients With Cancer Receiving Adjuvant Therapy Start of enrollment: 2003 Aug 01
Completed
Phase 3
Low-Dose Testosterone in Improving Libido in Postmenopausal Female Cancer Survivors Start of enrollment: 2004 Apr 01
Completed
Phase 3
Creatine in Treating Patients With Cancer-Associated Weight Loss Start of enrollment: 2004 Dec 01
Completed
Phase 3
Gabapentin With or Without Antidepressants in Treating Hot Flashes in Women Who Have Had Breast Cancer or Have Concerns About Taking Hormone Therapy Start of enrollment: 2004 Nov 01
Completed
Phase 3
Tetracycline in Preventing Skin Rash in Patients Who Are Receiving Drugs Such as Gefitinib and Cetuximab for Cancer Start of enrollment: 2004 Dec 01
Completed
Not Applicable
Everolimus in Treating Patients With Stage IV Melanoma Start of enrollment: 2005 Apr 01
Completed
Phase 2
American Ginseng in Treating Patients With Cancer-Related Fatigue Start of enrollment: 2005 Oct 01
Completed
Not Applicable
Pyridoxine and Topical Urea/Lactic Acid-Based Cream in Preventing Hand-Foot Syndrome in Patients Receiving Capecitabine for Breast Cancer or Other Cancer Start of enrollment: 2006 Jun 01
Completed
Phase 3
Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity Caused By Oxaliplatin in Patients Receiving Combination Chemotherapy for Stage II, Stage III, or Stage IV Colorectal Cancer That Has Been Completely Removed By Surgery Start of enrollment: 2006 Jan 01
Completed
Phase 3
Pilocarpine in Treating Vaginal Dryness in Patients With Breast Cancer Start of enrollment: 2006 Dec 01
Completed
Phase 3
Vitamin E in Preventing Peripheral Neuropathy Caused by Chemotherapy in Patients Receiving Chemotherapy for Cancer Start of enrollment: 2006 Dec 01
Completed
Phase 3
Citalopram in Treating Postmenopausal Women With Hot Flashes Start of enrollment: 2006 Nov 01
Completed
Phase 3
Methylphenidate in Treating Patients With Fatigue Caused by Cancer Start of enrollment: 2008 Feb 01
Completed
Phase 3
Epoetin Alfa or Darbepoetin Alfa in Treating Patients With Anemia Caused by Chemotherapy Start of enrollment: 2007 May 01
Completed
Phase 2
Skin Conduction Device for Measuring Hot Flashes in Postmenopausal Women With Hot Flashes Start of enrollment: 2006 May 01
Completed
Not Applicable
Zoledronate in Treating Osteopenia or Osteoporosis in Postmenopausal Women Receiving Letrozole for Stage I, Stage II, or Stage IIIA Primary Breast Cancer Start of enrollment: 2006 Apr 01
Completed
Not Applicable
Darbepoetin Alfa With or Without Iron in Treating Anemia Caused By Chemotherapy in Patients With Cancer Start of enrollment: 2006 Jan 01
Completed
Phase 3
Pregabalin in Treating Women With Hot Flashes Start of enrollment: 2008 Jun 01
Completed
Phase 3
American Ginseng in Treating Patients With Fatigue Caused by Cancer Start of enrollment: 2008 Oct 01
Completed
Phase 3
Acute Pain Caused by Paclitaxel in Patients With Cancer Start of enrollment: 2009 Feb 01
Completed
Stellate Ganglion Nerve Block in Treating Women With Hot Flashes Start of enrollment: 2009 Apr 01
Completed
Early Phase 1
Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity in Patients With Colon Cancer or Rectal Cancer Receiving Oxaliplatin-Based Combination Chemotherapy Start of enrollment: 2010 Jun 01
Completed
Phase 3
Short-Term Fasting Before Chemotherapy in Treating Patients With Cancer Start of enrollment: 2010 Aug 13
Completed
Not Applicable
Sulfasalazine in Preventing Acute Diarrhea in Patients With Cancer Who Are Undergoing Pelvic Radiation Therapy Start of enrollment: 2011 Apr 01
Completed
Phase 3
Scrambler Therapy in Treating Pain and Peripheral Neuropathy in Patients Previously Treated With Chemotherapy Start of enrollment: 2011 Mar 01
Completed
Scrambler Therapy in Treating Chronic Pain in Patients With Rash From Varicella Zoster Virus Infection Start of enrollment: 2011 Mar 01
Completed
Not Applicable
Magnesium Oxide in Treating Postmenopausal Women With Hot Flashes and a History of Breast Cancer Start of enrollment: 2011 Sep 01
Completed
Phase 2
Testosterone in Treating Postmenopausal Patients With Arthralgia Caused by Adjuvant Aromatase Inhibitor Treatment Start of enrollment: 2013 Sep 10
COMPLETED
PHASE3
Pregabalin in Preventing Acute Pain Syndrome in Patients Receiving Paclitaxel Start of enrollment: 2012 Jan 01
Topical Cryotherapy in Reducing Pain in Patients With Chemotherapy Induced Peripheral Neuropathy or Paclitaxel Induced Acute Pain Syndrome Start of enrollment: 2015 Dec 23
Completed
Not Applicable
Study of Cisplatin-Induced Peripheral Neuropathy in Patients With Germ Cell Tumor Start of enrollment: 2015 Jul 01
Completed
MC5-A Scrambler Therapy or TENS Therapy in Treating Patients With Chemotherapy-Induced Peripheral Neuropathy Start of enrollment: 2016 Apr 13
Completed
Not Applicable
Oxybutynin Chloride in Managing Hot Flashes Start of enrollment: 2016 Dec 09
Completed
Phase 3
Fingolimod in Preventing Paclitaxel-Associated Neuropathy in Patients With Breast Cancer Start of enrollment: 2019 Dec 12
Completed
Phase 1
Fingolimod in Treating Patients With Chemotherapy-Induced Neuropathy Start of enrollment: 2019 May 24
Completed
Early Phase 1
Rose Geranium in Sesame Oil Nasal Spray for the Improvement of Nasal Vestibulitis Symptoms in Cancer Patients Receiving Chemotherapy Start of enrollment: 2020 Nov 13
Completed
Phase 3
PEA for the Relief of Chemotherapy-Induced Peripheral Neuropathy Start of enrollment: 2022 May 16
ACTIVE_NOT_RECRUITING
PHASE2
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

The impact of coadministration of venlafaxine, citalopram or gabapentin on the metabolic activation of tamoxifen.
Stephanie L Safgren, Vera J Suman, Roberto A Leon Ferre, Matthew L Kosel, Vered Stearns
Breast Cancer Research and Treatment. 2025-05-01
Safety and feasibility of concomitant scalp cooling and limb cryocompression to prevent paclitaxel-induced alopecia and neuropathy.
Aishwarya Bandla, Rachel Wong, Priyadharshini Santhanakrishnan, Gayathiri Magarajah, Yang En Yee
Supportive Care in Cancer. 2025-02-12
1 citations
Perceptions of Delayed Alopecia Among Breast Cancer Survivors.
Sarah K Premji, Kathryn J Ruddy, Robert A Vierkant, Nicole Larson, Charles Loprinzi
Clinical Breast Cancer. 2025-02-01

Journal Articles

The Importance of a Cause-Based Protocol to Approach Cancer-Related Nausea and Vomiting—Reply
Charles L Loprinzi, Rudolph M Navari, JAMA Oncology
Olanzapine for the Treatment of Advanced Cancer–Related Chronic Nausea and/or Vomiting
Rudolph M Navari, Costantine Albany, Charles L Loprinzi, JAMA Oncology

Lectures

Scrambler therapy for established chemotherapy-induced neuropathy: A randomized phase II trial.
2018 ASCO Annual Meeting - Chicago, Illinois - 06/4/2018
Mayo Clinic Oncology Review
Mayo School of Continuous Professional Development, Minneapolis, Minnesota - 7/20/2013
MSCO Fellows Dinner Meeting
Minnesota Society of Clinical Oncology (MSCO), Minneapolis, Minnesota - 7/20/2013
18th Annual Network of Oncology Clinicians & Researchers (NOCR) Meeting
Imedex, Las Vegas, Nevada - 2/9/2012
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Other

Clinical features and pathogenesis of cancer cachexia
Loprinzi CL, Jatoi A
http://www.uptodate.com/contents/clinical-features-and-pathogenesis-of-cancer-cachexia
UpToDate, Wolters Kluwer Health - 2012-06-08
Role of erythropoiesis-stimulating agents in the treatment of anemia in patients with cancer
Loprinzi CL, Steensma DP, Schrier SL
http://www.uptodate.com/contents/role-of-erythropoiesis-stimulating-agents-in-the-treatment-of-anemi
UpToDate, Wolters Kluwer Health - 2013-03-04
The role of parenteral and enteral/oral nutritional support in patients with cancer
Loprinzi CL, Jatoi A
http://www.uptodate.com/contents/the-role-of-parenteral-and-enteral-oral-nutritional-support-in-pati
UpToDate, Wolters Kluwer Health - 2013-03-14

Authored Content

Olanzapine for the Treatment of Advanced Cancer–Related Chronic Nausea and/or VomitingMay 2020
Olanzapine for the Treatment of Advanced Cancer–Related Chronic Nausea and/or VomitingMay 2020

Press Mentions

Charles B. Hammond, M.D.,September 30th, 2024
ASCO Voices 2020August 9th, 2020
What Is Peripheral Neuropathy and How Can It Be Prevented or Treated?July 14th, 2020
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Grant Support

Survivorship Research Established Investigator AwardNational Cancer Institute2008–2011
Statistical Support UnitNational Cancer Institute2007–2011
Nursing And PharmacyNational Cancer Institute2007–2011
Community Clinical Oncology ProgramNational Cancer Institute2004–2011
SupplementNational Cancer Institute2007–2008
Operations UnitNational Cancer Institute2007
CapitationNational Cancer Institute2007
AuditNational Cancer Institute2007
AdministrationNational Cancer Institute2007
Ncctg CCOP Research Base - Foreign AccrualNational Cancer Institute2006
Community Clinical Oncology Program - Foreign AccrualNational Cancer Institute2005
Ncctg Foreign AccrualsNational Cancer Institute2004
Foreign Accural - NcctgNational Cancer Institute2003
Cancer Chemoprevention--Role Of Infection/ImmunityNational Cancer Institute1999–2003
Community Clinical Oncology ProgramNational Cancer Institute1994–2003
Inhibition Of Ornithine Decarboxylase By Oral CompoundsNational Cancer Institute1985