CharlesPatrickBurnsMD

Oncology • Hilton Head Island, SC

Physician

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Office
15 Northridge Dr
Hilton Head Island, SC 29926
Phone+1 843-681-6612

Fax+1 843-681-6614

Education & Training

Case Western Reserve University/University Hospitals Cleveland Medical CenterResidency, Internal Medicine, 1966 - 1970
Mount Sinai Medical Center of ClevelandInternship, Transitional Year, 1963 - 1964
University of Kansas School of MedicineClass of 1963
University of KansasBA, 1959

Certifications & Licensure

IA State Medical License 1971 - 2023
SC State Medical License 2006 - 2023
KS State Medical License 1964 - 2014
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Hematology
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

Distinguished Emeritus Member American Society of Hematology AND Royal Society of Medicine
Master, American College of Physicians American College of Physicians, 2011
Fellow Royal Society of Medicine, London, 1980
Listed Guide to America’s Top Physicians, Consumer’s Research Council of America, 2003
Above and Beyond the Call of Duty UIHC, 2002
U.S. Public Health Service Career Development Award 1978
Alpha Omega Alpha Honorary Medical Society
Listed Who's Who in America
Listed Who's Who in the World
Listed Who’s Who in Medicine and Healthcare
Fellow American College of Physicians
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Publications & Presentations

PubMed

37 citations
Effects of Lipids on Cancer Therapy
C. Patrick Burns, Arthur A. Spector
Nutrition Reviews. 2009-04-27
9 citations
Inactivation of anthracyclines by serum heme proteins.
Brett A. Wagner, Lynn M. Teesch, Garry R. Buettner, Bradley E. Britigan, C. Patrick Burns
Chemical Research in Toxicology. 2007-05-12
66 citations
Doxorubicin increases intracellular hydrogen peroxide in PC3 prostate cancer cells
Brett A. Wagner, Crystal B. Evig, Krzysztof J. Reszka, Garry R. Buettner, C. Patrick Burns
Archives of Biochemistry and Biophysics. 2005-08-15

Journal Articles

Inactivation of anthracyclines by serum heme proteins
Wagner, B.A., Teesch, L.M., Buettner, G.R., Britigan, B.E. Burns, C.P., Reszka, K.J., Chem.Res. Toxicol., 1/1/2007
The relationship of religiosity and spirituality to quality of life among cancer patients
Rippentrop, A.E., Altmaier, E.M., Burns, C.P., The Journal of Clinical Psychology in Medicine Settings, 1/1/2006
Inactivation of anthracyclines by cellular peroxidase
Reszka, K.J., Wagner, B.A., Teesch, L.M., Britigan, B.E., Spitz, D.R., Burns, C.P., Cancer Res, 1/1/2005
Effects of peroxidase substrates on the amplex red/peroxidase assay: Antioxidant properties of anthracyclines
Reszka, K.J., Wagner, B.A., Burns, C.P., Britigan, B.E., Anal Biochem, 1/1/2005
Doxorubicin increases intracellular hydrogen peroxide in PC3 prostate cancer cells
Wagner, B.A., Evig, C.B., Reszka, K.J., Buettner, G.R., Burns, C.P., Arch Biochem Biophys, 1/1/2005
Role of Thiocyanate, Bromide, And Hypobromous Acid In Hydrogen Peroxide-Induced Apoptosis
Wagner, B.A., Reszka K.J., McCormick, M.L., Britigan, B.E., Evig, C.B., and Burns, C.P., Free Radical Research, 1/1/2004
Successful management with intravenous immunoglobulins of acquired von Willebrand disease associated with monoclonal gammopathy of undetermined significance
Agarwal, N., Klix, M.M., Burns, C.P., Ann Int Med., 1/1/2004
Phase II study of high-dose fish oil capsules for patients with cancer cachexia: A Cancer and Leukemia Group B Study
Burns, C.P., Halabi, S., Clamon, G.H., Kaplan, E. Hohl, R.J., Atkins, M.N., Schwartz, M.A., Wagner, B.A., Pakett, E., Cancer, 1/1/2004
Endogenous production of and exogenous exposure to nitric oxide augment doxorubicin cytotoxicity for breast cancer cells but not cardiac myoblasts
Evig, C.B, Kelley, E.E., Weydert, C.J., Chue, Y., Buettner, G.R., and Burns, C.P., Nitric Oxide, 1/1/2004
Acetaminophen stimulates the peroxidative metabolism of anthracyclines
Reszka, K.J., Britigan, L.H., Rasmussen, G.T., Wagner, B.A., Burns, C.P., and Britigan, B.E., Arch of Biochem and Biophys, 1/1/2004
Overexpression of manganese superoxide dismutase promotes the survival of prostate cancer cells exposed to hyperthermia
Venkataraman, S., Wagner, B.A., Jiang, X., Wang, H.P., Schafer, F.Q., Ritchie, J.M., Burns, C.P., Oberley, L.W., Buettner, G.R., Free Radic Res, 1/1/2004
Role of nitric oxide and membrane phospholipid polyunsaturation in oxidative cell death
Burns, C.P., Kelley, E.E., Wagner, B.A., and Buettner, G.R., Subcell Biochem, 1/1/2002
Hydrogen peroxide induced apoptosis of HL-60 human leukemia cells is mediated by the oxidants hypochlorous acid and chloramines
Wagner, B.A., Britigan, B.E., Reszka, K.J., McCormick, M.L., and Burns, C.P., Arch Biochem Biophys, 1/1/2002
Persistent thrombocytopenia during remission in acute leukemia does not preclude long term disease-free survival
Heckman, K.D., Weiner, G.J. and Burns, C.P., Amer J Hematology, 1/1/2002
Myeloperoxidase is Involved in H2O2-Induced Apoptosis of HL-60 Human Leukemia Cells
Wagner, B.A., Buettner, G.R., Oberley, L.W., Darby, C.J., and Burns, C.P., J. Biol. Chem., 1/1/2000
Phase I Clinical Study of Fish Oil Fatty Acid Capsules for Patients with Cancer Cachexia: A Cancer and Leukemia Group B Study 9473
Burns, C.P., Halabi, S.H., Clamon, G.H., Wagner, B.A., Hars, V., Hohl, R.J., Vinciguerra, V., and Paskett, E., Clin. Cancer Research, 1/1/1999
Nitric Oxide Inhibits Iron-Induced Lipid Peroxidation in HL60 Cells
Kelley, E.E., Wagner, B.A., Buettner, G.R., and Burns, C.P., Arch. Biochem. Biophys., 1/1/1999
Sensitivity of K562 and HL-60 Cells to Edelfosine, An Ether Lipid Drug, Correlates with Production of Reactive Oxygen Species
Wagner, B.A., Buettner, G.R., Oberley, L.W., Burns C.P., Cancer Research, 1/1/1998
Low Pulse Oximeter-Measured Hemoglobin Oxygen Saturations With Hemoglobin Cheverley
Hohl, R.J., Sherburne, A.R., Feeley, J.E., Huisman, T.H.J., Burns, C.P., Amer. J. Hemat., 1/1/1998
Randomized Study of Prophylactic Platelet Transfusion Threshold: 10,000/MuL vs 20,000/MuL
Heckman, K.D., Weiner, G.J., Davis, C.S., Strauss, R.G., Jones, M.P., Burns, C.P., J. Clin. Onc., 1/1/1997
Production of Lipid-Derived Free Radicals in L1210 Murine Leukemia Cells is an Early Oxidative Event in Photodynamic Action of Photofrin
Kelley, E.E., Buettner, G.R., Burns, C.P., Photochem. Photobiol., 1/1/1997
Increased Efficacy of In Vitro Photofrin Photosensitization of Human Oral Squamous Cell Carcinoma by Iron and Ascorbate
Kelly, E.E., Domann, F.E., Buettner, G.R., Oberley, L.W., Burns, C.P., J. Photochem. Photobiol. B: Biology, 1/1/1997
Vitamin E Slows the Rate of Free Radical-Mediated Lipid Peroxidation in Cells
Wagner, B.A., Buettner, G.R., Burns, C.P., Arch. Biochem. Biophys., 1/1/1996
Bone Marrow Morphology During Induction Phase of Therapy for Acute Myeloid Leukemia (AML)
Dick, F.R., Burns, C.P., Weiner, G.J., and Heckman, K.D., Hematol. Pathol., 1/1/1995
A Five-Drug Remission Induction Regimen with Intensive Consolidation for Adults with Acute Lymphoblastic Leukemia: Cancer and Leukemia Group B Study 8811
Larson, R.A., Dodge, R.K., Burns, C.P., et al, Blood, 1/1/1995
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Books/Book Chapters

Chemotherapy and Other Antineoplastic Drugs
Burns, C.P., Vaena, DAMcGraw-Hill Encyclopedia of Science and TechnologyEdition 10th,2008
Chemotherapy
Burns, C.P.McGraw-Hill Encyclopedia of Science and TechnologyEdition 9th,2002
Subcellular Biochemistry, vol 36, Phospholipid Metabolism in Apoptosis
Chapter: Role of Nitric Oxide and Membrane Phospholipid Polyunsaturation in Oxidative Cell Death
Burns, C. Patrick, Kelley, Eric E., Wagner, Brett A., Buettner, Gary R.Editors: P. Quinn and V. Kagan.Kluwer Academic/Plenum Press, New York2002
Proceedings of the 2nd International Conference on Antioxidants and Free Radicals in Health and Disease
Chapter: Membrane Fatty Acid based Oxidant and Antioxidant Strategies in Antioxidants and Free Radicals in Health and Disease
Page 279.0 - 298.0Burns, C.P.Editors: J. Marwah, A. Kanthasamy.Prominent Press, Scottsdale, AZ2001
Current Therapy in Oncology
Chapter: Myelodysplastic Syndromes
Page 374.0 - 381.0Burns, C.P.Editors: Vose, J., Foley, J., and Armitage, J.A..W.B. SaundersEdition 2nd,1999
Current Therapy in Cancer
Chapter: Myelodysplastic Syndromes
Page 308.0 - 313.0Burns, C.P.Editors: Foley, J., Vose, J., and Armitage, J.A..W.B. Saunders1994
Omega-3 Fatty Acids: Metabolism and Biological Effects
Chapter: Neoplasia and Omega-3 Fatty Acids
Page 305.0 - 314.0Burns, C.P., Wagner, B.A., Kelley, E.E., and Buettner, G.R.Editors: C.A. Drevon, I. Baksaas, H. Krokan.Birkhauser Verlag, Basel1993
Collected Perspectives in Cancer Research 1986-1987
Chapter: Biological and Therapeutic Potential of Membrane Lipid Modification in Tumors
Page 173.0 - 181.0Spector, A.A. and Burns, C.P.Waverly Press, Baltimore1988
Medical Care for the Elderly - Acute and Chronic
Chapter: Acute and Chronic Leukemia in the Aged
Page 83.0 - 91.0Burns, C.P.Editors: Smith, I.S. P. Medical and Scientific Books, New York1982
Prostaglandins and Related Lipids: Volume Two, Protaglandins and Cancer: First International Conference
Chapter: Relationship of Differentiation and Prostaglandin Production in Human Pro-myelocytic Leukemia
Page 487.0 - 491.0Dudley, D.T., Olson, A.L., and Burns, C.P.Editors: Powles, T.J., Brockman, R.S., Honn, R.V., and Ramwell, P..Alan R. Liss1982
1979 Year Book of Cancer
Chapter: Maintenance Therapy of Adult Acute Nonlymphoblastic Leukemia
Armitage, J.O., and Burns, C.P.Editors: R.L. Clark and R.W. Cumley.Year Book Medical Publishers Inc, Chicago1979
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Abstracts/Posters

Hydrogen Peroxide-induced apoptosis in human HL-60 cell is mediated by chloramines
Wagner, B.A., Britigan, B.E., Reszka, K.J., McCormick, M.L., Burns, C.P., Free Rad Biol Med, 1/1/2001
Hydrogen Peroxide-induced apoptosis in human HL-60 cell is mediated by chloramines
Wagner, B.A., Britigan, B.E., Reszka, K.J., McCormick, M.L. and Burns, C.P., Meeting, Oxygen Society, Research Triangle, North Carolina, 1/1/2001
Apoptosis induced by hydrogen peroxide is mediated by hypochlorous acid in the myeloperoxide-rich HL-60 cell line
Wagner, B.A. and Burns C.P., Free Rad Biol Med, 1/1/2000
Membrane Fatty Acid Based Oxidant and Antioxidant Strategies in Cancer
Burns, C.P., 2nd International Conference on Antioxidants and Free Radicals in Health and Disease, Vancouver, Canada, 1/1/1999
Nitric oxide inhibits Photofrin-induced lipid peroxidation in murine leukemia cells
Kelley, E.E., Wagner, B.A., Buettner, G.R., Burns, C.P., Photochem. Photobiol., 1/1/1999
Nitric oxide inhibits Photofrin-induced lipid peroxidation in HL-60 cells
Kelley, E.E., Wagner, B.A., Buettner, G.R., Burns, C.P., Free Rad Biol Med, Oxygen Society Meeting, 1/1/1999
Nitric oxide inhibits Photofrin-induced lipid peroxidation in murine leukemia cells
Kelley, E.E., Wagner, B.A., Buettner, G.R., Burns, C.P., 27th Annual Meeting, American Society Photobiology, 1/1/1999
In Vivo Photodynamic Therapy with Photofrin Produces Nitric Oxide in L1210 Tumors
Kelley, E.E., Burns, C.P., and Buettner, G.R., Photochem. Photobiol, Twenty-fifth Annual Meeting, Amer. Soc. for Photobiology, St. Louis, 1/1/1997
Increased Efficacy of In Vitro Photodynamic Therapy of Oral Cancer Cells by the Prooxidants, Iron and Ascorbate
Kelley, E.E., Burns, C.P., Oberley, L.W., Domann, F.E., and Buettner, G.R., 44th Ann. Meeting, Radiation Research Society/Radiation Res., Chicago, IL, 1/1/1996
Production of Lipid-Derived free Radicals in the Initial Peroxidative Events of Photophrin Photosensitization of Leukemic Cells
Kelley, E.E., Buettner, G.R., and Burns, C.P., Meeting of the Amer. Soc. Photobiology, Atlanta, GA, 1/1/1996
Membrane Lipid Free Radical Produced from L1210 Murine Leukemia Cells by Photofrin Photo- sensitization: An EPR Spin Trapping Study
Buettner, G.R., Kelley, E.E., and Burns, C.P., Radiation Research Society (43rd Annual Meeting) and NA Hyperthermia Society (15th Annual Meeting), 1/1/1995
Increased Efficacy of Photofrin Photosensitization of Oral Squamous Cell Carcinoma by the Prooxidants Iron and Ascorbate
Domann, F.E., Kelley, E.E., Buettner, G.R., Burns, C.P., Oberley, L.W., The Oxygen Society (2nd Annual Meeting), 1/1/1995
Production of Lipid-Derived Free Radicals in the Initial Peroxidative Events of Photofrin Photosensitization of Leukemic Cells
Kelley, E.E., Buettner, G.R., Burns, C.P., Ann. Meeting, Oxygen Society, Pasadena, CA, 1/1/1995
Relative Antioxidant Deficiency in Leukemia Cells Containing Polyunsaturated Lipids
Burns, C.P., Wagner, B., and Buettner, G., Blood, 1/1/1994
Membrane Lipid Free Radicals Produced from Intact L1210 Murine, Leukemia Cells by Hematoporphyrin Derivative and Light: An EPR Spin Trapping Study
Buettner, G.R., Kelley, E.E., and Burns, C.P., 21st Annual Meeting Amer. Soc. for Photobiology, Photochem. Photobiol., 1/1/1993
Membrane Lipid Free Radicals Produced from L1210 Murine Leukemia Cells by Photofrin Photosensitization: An EPR Spin Trapping Study
Buettner G.R., Kelley, E.E., and Burns, C.P., 1st Annual Meeting of The Oxygen Society, Charleston, South Carolina, 1/1/1993
Free Radical-Mediated Lipid Peroxidation in Cells: Oxidizability is a Function of Cell Lipid Bis-Allelic Hydrogen Content
Buettner, G.R., Wagner, B.A., and Burns, C.P., 1st Annual Meeting of The Oxygen Society, Charleston, South Carolina, 1/1/1993
Randomized Evaluation of the Optimal Platelet Count for Prophylactic Platelet Transfusions in Patients Undergoing Induction Therapy for Acute Myelocytic Leukemia
Heckman, K., Weiner, G.J., Strauss, R.G., Jones, M.P., and Burns, C.P., Blood, 1/1/1993
The Potential Role of the Peroxidation of Omega-3 Fatty Acids in Cancer Therapy
Burns, C.P., and Wagner, B.A., Ann. Meeting, Amer. Oil Chem. Soc., 1/1/1992
A 5-Drug Induction Regimen with Intensive Consolidation for Adult Acute Lymphoblastic Leukemia (ALL): Cancer and Leukemia Group B
Larson, R.A., Burns, C.P., Dodge, R.C., George, S.L., Bloomfield, C.D., Daven, F.R., Hooberman, A.L., Sobol, R.E., and Schiffer, C.A., Proc. ASCO, 1/1/1992
Bone Marrow Morphology During Induction Phase of Therapy for Acute Myeloid Leukemia (AML)
Dick, F.R., Heckman, K.D., Weiner, J.G., and Burns, C.P., Proceedings, Ann. Meeting ASCP/CAP, 1/1/1992
Role of Membrane Lipid Peroxidative Damage in the Mechanism of the Ether Lipid Drugs
Burns, C.P., Wagner, B.A., and Buettner, G.R., Proc. Am. Assoc. Cancer Res., 1/1/1992
The Potential Role of the Peroxidation of w-3 Fatty Acids in Cancer Therapy
Burns, C.P., and Wagner, B.A., INFORM, 1/1/1992
Generation of a Lipid-Derived Free Radical from Intact Leukemic Cells Induced by the Membrane-Active Bone Marrow Purging Drug Edelfosine
Burns, C.P., Buettner, G.R., and Wagner, B.A., Blood, 1/1/1992
Increased Sensitivity of Human and Murine Leukemia Cells to Ether Lipids Resulting from Membrane Fatty Acid Polyunsaturation
Peterson, E.S., and Burns, C.P., Proc. AACR, 1/1/1991
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Lectures

Melphalan Transport by L1210 Leukemia Cells
San Diego, CA - 1/1/1980
Analysis of Presenting Features of Adult Acute Leukemia Using the French-American-British Classification
Phoenix, AZ - 1/1/1979
Chronic Lymphocytic Leukemia
University of Iowa Health Sciences Library, Iowa City, Iowa - 1/1/1975
Hairy Cell Leukemia - Clinical and Metabolic Features
University of California, Irvine - 1/1/1974
What's New in Hematology
University of Iowa College of Medicine - 1/1/1974
Problems in Anemia
University of Iowa College of Medicine - 1/1/1974
Biology of the Hairy Cell of Leukemic Reticuloendotheliosis
Tulane Medical School - 1/1/1974
Disseminated Intravascular Coagulation and Abruptio Placentae
Mercy Hospital, Cedar Rapids - 1/1/1974
Acute Leukemia Chemotherapy
Iowa City, Iowa - 1/1/1974
Differences in Free Fatty Acid Metabolism of Leukemic and Normal Leukocytes
1/1/1974
Use of Laminar Air Flow Rooms and White Blood Cell Transfusions in the Supportive Care of Patients with Acute Leukemia
1/1/1973
Problems in Hematology
Cedar Rapids - 1/1/1973
The Metabolism of the Lymphocyte of Infectious Mononucleosis
University of Kansas Medical Center, 1971; University of Iowa College of Medicine, 1971 - 1/1/1971
The Biochemistry of the Atypical Lymphocyte
University of Nebraska Medical Center - 1/1/1970
Membrane Lipid Alterations as an Adjunct to Drug Therapy
Colby-Sawyer College, New London, New Hampshire - 1/18/1988
Current Issues in Chemotherapy
Iowa City - 1/8./1982
Southeastern Cancer Study Group Protocols
Iowa City - 1/19/1983
New Developments in Oncology
Iowa City - 1/8./1984
Adverse Effect of T-Cell Markers in Adult Acute Lymphoblastic Leukemia
Toronto, Canada - 1/8./1984
What's New in Medicine: Oncology
Iowa City, Iowa - 1/2./1984
Role of Membrane Lipids in Experimental Cancer Chemotherapy
Wayne State University and Michigan Cancer Center, Detroit - 1/17/1985
Splenic Presentation of Low-Grade Lymphoma
University of Iowa - 1/22/1985
Membrane Lipid Alteration of Mammalian Tumors and Hyperthermia
Philadelphia, PA - 1/18/1988
Fatty Acid Modification of Subcellular Organelles and Lack of Effect on Doxorubicin Localization
New Orleans - 1/26/1988
Chemotherapy: Current and Future Trends
University of Iowa, Iowa City - 1/1./1982
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Other

Cancer 1973
Burns CP, KWWL-TV
1/1/1973
New Facilities for Patients with Blood Diseases
Burns CP, Dottie Ray Show, KXIC Radio
1/3./1973