CeciliaBlairLevandowskiMDPhD(She/Her)

Oncology • Chapel Hill, NC

Hematology/Oncology Fellow

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Office
UNC Hospitals
101 Manning Dr
Chapel Hill, NC 27514

Summary

eRNA production and p53 activity

The Δ40p53 isoform inhibits p53-dependent eRNA transcription and enables regulat

Using an innovative approach, this study reveal delat40p53 isoform tempers WTp53 activity by blocking p53 eRNA production to allow input from other TFs.

Education & Training

University of North Carolina HospitalsResidency, Internal Medicine, 2022 - 2024
University of Colorado School of Medicine Anschutz Medical CampusClass of 2022, MD
University of Colorado BoulderPhD, Biochemistry, 2014 - 2020
Davidson CollegeBS, Biology, 2004 - 2008

Certifications & Licensure

NC State Medical License 2022 - 2025

Publications & Presentations

PubMed

208 citations
Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts
Kan Cao, Cecilia D. Blair, Dina A. Faddah, Julia E. Kieckhaefer, Michelle Olive
The Journal of Clinical Investigation. 2011-07-01
1 citations
Mediator kinase inhibition impedes transcriptional plasticity and prevents resistance to ERK/MAPK-targeted therapy in KRAS-mutant cancers.
Daniel P Nussbaum, Colin A Martz, Andrew M Waters, Alejandro Barrera, Annie Liu
NPJ Precision Oncology. 2024-05-31
17 citations
The Δ40p53 isoform inhibits p53-dependent eRNA transcription and enables regulation by signal-specific transcription factors during p53 activation.
Cecilia B. Levandowski, Taylor Jones, Margaret Gruca, Sivapriya Ramamoorthy, Robin D. Dowell
Plos Biology. 2021-08-05

Journal Articles

Suppression of p53 response by targeting p53–Mediator binding with a stapled peptide.
Allen, B.L., Quach, K., Levandowski, C.B., Jones, T., Ebmeier, C.C., Rubin, J.D., Read, T., Dowell, R.D., Schepartz, A., Taatjes, D.J., Cell Reports