CaseyLO'ConnellMDFACP

Clotting Disorder, Myeloproliferative Disorder Hematology-Oncology

Associate Professor of Clinical Medicine, Lawrence & Janice Kelly Chair in Hematology, Director, Gehr CURES Myeloid Malignancies Program

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Office
1441 Eastlake Ave
Ste 8302E
Los Angeles, CA 90089
Phone+1 323-865-3105

Fax+1 323-865-0060

Education & Training

University of Southern California/LAC+USC Medical CenterFellowship, Hematology, 2006 - 2007
University of Southern California/LAC+USC Medical CenterFellowship, Medical Oncology, 2005 - 2006
University of Southern California/LAC+USC Medical CenterFellowship, Hematology, 2004 - 2005
University of Southern California/Los Angeles General Medical Center (USC/LA General)Residency, Internal Medicine, 2001 - 2004
George Washington University School of Medicine and Health SciencesClass of 2001

Certifications & Licensure

CA State Medical License 2002 - 2026
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Hematology

Awards, Honors, & Recognition

Super Doctor SuperDoctors.com

Clinical Trials

Guadecitabine and Atezolizumab in Treating Patients With Advanced Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia That Is Refractory or Relapsed Start of enrollment: 2016 Nov 02
Active, not recruiting
Phase 1, Phase 2
Recombinant EphB4-HSA Fusion Protein and Azacitidine or Decitabine for Relapsed or Refractory Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia, or Acute Myeloid Leukemia Patients Previously Treated With a Hypomethylating Agent Start of enrollment: 2017 Apr 20
Terminated
Phase 2
Epigenetics, Vitamin C, and Abnormal Blood Cell Formation - Vitamin C in Patients With Low-Risk Myeloid Malignancies Start of enrollment: 2017 Nov 21
Active, not recruiting
Not Applicable
Pharmacokinetics, Safety, and Efficacy of ASTX727 in Combination With Venetoclax in Acute Myeloid Leukemia (AML) Start of enrollment: 2021 Feb 09
Active, not recruiting
Phase 1, Phase 2
Actuate 1901: 9-ING-41 in Myelofibrosis Start of enrollment: 2020 Aug 20
Completed
Phase 2
Roles: Contact
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Publications & Presentations

PubMed

116 citations
Oral cedazuridine/decitabine for MDS and CMML: a phase 2 pharmacokinetic/pharmacodynamic randomized crossover study
Guillermo Garcia-Manero, Elizabeth A. Griffiths, David P. Steensma, Gail J. Roboz, Richard A. Wells
Blood. 2020-08-06
283 citations
Role of direct oral anticoagulants in the treatment of cancer-associated venous thromboembolism: guidance from the SSC of the ISTH.
Alok A. Khorana, Simon Noble, Agnes Y.Y. Lee, Gerald A. Soff, Guy Meyer
Journal of Thrombosis and Haemostasis. 2018-09-01
152 citations
International Randomized Phase III Study of Elacytarabine Versus Investigator Choice in Patients With Relapsed/Refractory Acute Myeloid Leukemia
Gail J. Roboz, Todd L. Rosenblat, Martha Arellano, Marco Gobbi, Jessica K. Altman
Journal of Clinical Oncology. 2014-06-20

Abstracts/Posters

Landmark Response and Survival Analyses from 206 AML Patients Treated with Guadecitabine in a Phase 2 Study Demonstrate the Importance of Adequate Treatment Duration t...
Casey L. O'Connell, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Persistent Leukocytosis in Polycythemia Vera Is Associated with Disease Evolution but Not Thrombosis: An Analysis from a 520-Patient Retrospective Multi-Center Database
Casey L. O'Connell, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Results from a Phase 2 Study of Navitoclax in Combination with Ruxolitinib in Patients with Primary or Secondary Myelofibrosis
Casey L. O'Connell, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Pharmacokinetic Exposure Equivalence and Preliminary Efficacy and Safety from a Randomized Cross over Phase 3 Study (ASCERTAIN study) of an Oral Hypomethylating Agent ...
Casey L. O'Connell, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
A Randomized, Open-Label, Multicenter, Phase 2 Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of KRT-232 Compared with Ruxolitinib in Patients with Phleb...
Casey L. O'Connell, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Final Results of Prospective Treatment with Pegylated Interferon Alfa-2a for Patients with Polycythemia Vera and Essential Thrombocythemia in First and Second-Line Set...
Casey L. O'Connell, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Landmark Response and Survival Analyses from 102 MDS and CMML Patients Treated with Guadecitabine in a Phase 2 Study Showing That Maximum Response and Survival Is Best...
Casey L. O'Connell, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Durable Remission and Long-Term Survival in Relapsed/Refractory (r/r) AML Patients Treated with Guadecitabine, Median Survival Not Reached for Responders after Long Te...
Casey L. O'Connell, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
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Lectures

Phase I Results of a Multicenter Clinical Trial Combining Guadecitabine, a DNA Methyltransferase Inhibitor, with Atezolizumab, an Immune Checkpoint Inhibitor, in Patie...
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
Long Term Results of a Randomized Phase 2 Dose-Response Study of Guadecitabine, a Novel Subcutaneous (SC) Hypomethylating Agent (HMA), in 102 Patients with Intermediat...
2018 ASH Annual Meeting - San Diego, CA - 12/1/2018