CaryOwenHardingMD

Medical Genetics • Portland, OR

Clinical Biochemical Genetics, Clinical Genetics

Associate Professor, Molecular & Medical Genetics, Oregon Health and Science University School of Medicine

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Office
707 SW Gaines St
Portland, OR 97239
Phone+1 503-494-7859

Fax+1 503-494-4447

Education & Training

University of Wisconsin Hospitals and ClinicsResidency, Pediatrics, 1987 - 1990
University of Washington School of MedicineClass of 1987

Certifications & Licensure

OR State Medical License 1999 - 2025
ID State Medical License 2004 - 2024
WI State Medical License 1988 - 1999
American Board of Medical Genetics and Genomics Clinical Biochemical Genetics
American Board of Medical Genetics and Genomics Clinical Genetics and Genomics

Clinical Trials

Longitudinal Study of Urea Cycle Disorders Start of enrollment: 2006 Feb 01
Recruiting
Human Heterologous Liver Cells for Infusion in Children With Urea Cycle Disorders Start of enrollment: 2010 Dec 01
Terminated
Phase 2
Study of Triheptanoin for Treatment of Long-Chain Fatty Acid Oxidation Disorder Start of enrollment: 2011 Sep 01
Completed
Phase 2
Oxidative Stress, Inflammation and Acute Decompensation in Urea Cycle Disorders Start of enrollment: 2012 Feb 01
Terminated
A Study of the Safety, Efficacy and Pharmacokinetics of Glycerol Phenylbutyrate in Pediatric Subjects Under 2 Years of Age With Urea Cycle Disorders Start of enrollment: 2014 Dec 31
COMPLETED
PHASE4
Efficacy and Safety of SYNB1618 and SYNB1934 in Adult Patients With Phenylketonuria Start of enrollment: 2020 Aug 25
Completed
Phase 2
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

D-BHB supplementation before moderate-intensity exercise suppresses lipolysis and selectively blunts exercise-induced long-chain acylcarnitine increase in pilot study ...
Ashley N Gregor, Philippe Delerive, Bernard Cuenoud, Irina Monnard, Karine Redeuil
Molecular Genetics and Metabolism. 2025-04-01
Phenylketonuria in adults: we know plenty, but there is much more to learn.
Cary O Harding, Georgianne Arnold, Gerard T Berry, Shawn E Christ, Dorothy K Grange
The American Journal of Clinical Nutrition. 2025-03-01
Corrigendum to "Evaluating change in diet with pegvaliase treatment in adults with phenylketonuria: Analysis of phase 3 clinical trial data" [Molecular Genetics and Me...
Fran Rohr, Barbara Burton, Anne Dee, Cary O Harding, Joshua Lilienstein
Molecular Genetics and Metabolism. 2024-12-01

Press Mentions

BioMarin Pharmaceutical : , Pioneer in Rare Disease Treatments for Phenylketonuria, Receives FDA Approval of Label ExpansionOctober 15th, 2020
FDA Approves New Drug Tested at OHSU for Phenylketonuria, or PKU - Portland Business JournalMay 25th, 2018
BioMarin Sinks Despite Meeting Primary EndpointMarch 21st, 2016

Grant Support

Hyperphenylalaninemia Disorders Consortium of the Rare Disease Clinical Research NetworkOREGON HEALTH & SCIENCE UNIVERSITY2019–2025
Augmented Phenylalanine Clearance By Muscles As Novel Therapy For PhenylketonuriaEunice Kennedy Shriver National Institute Of Child Health &Human Development2009–2012
AAV2/8 Vector-Mediated Liver Gene Therapy For Phenylketonuria (PKU)National Institute Of Diabetes And Digestive And Kidney Diseases2007–2009
Liver Gene Therapy For Murine Phenyketonuria (PKU)National Institute Of Diabetes And Digestive And Kidney Diseases2006
Intravenous Non-Viral Gene Therapy For Phenylketonuria (PKU)National Institute Of Diabetes And Digestive And Kidney Diseases2006
Stem Cell-Mediated Liver Repopulation For Murine PKUNational Heart, Lung, And Blood Institute2005–2006
DHA Triglyceride Supplementation In Lchadd PatientsNational Center For Research Resources2004–2005
Metabolic Engineering As Therapy For Murine PKUNational Institute Of Diabetes And Digestive And Kidney Diseases2001–2002
Docosahexaenoic Acid Triglyceride Supplementation In LchaddNational Center For Research Resources2000–2002
DHA Triglyceride Supplementation In Long Chain Dehydrogenase Deficiency (LCHADD)National Center For Research Resources1998–2002
Heterologous Gene Therapy For MetabolismNational Institute Of Diabetes And Digestive And Kidney Diseases1999–2000
Aav-Mediated Gene Therapy--Inborn Errors Of MetabolismNational Institute Of Diabetes And Digestive And Kidney Diseases1999
Heterologous Gene Therapy For MetabolismNational Institute Of Diabetes And Digestive And Kidney Diseases1996–1999