Carlyne Cool MD

Pathology•Aurora, CO

Cytopathology, Pulmonary Pathology, Anatomic Pathology, Clinical Pathology

Clinical Professor, University of Colorado Denver

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Department of Pathology, University of Colorado SOMAIP1 - Room 3.003, 12605 E. 16th AvenueAurora, CO 80045
Phone+1 720-848-4421
Fax+1 720-848-4454

Education & Training

University of ColoradoResidency, Pathology-Anatomic and Clinical, 1992 - 1997
University of Colorado School of Medicine Anschutz Medical CampusClass of 1992
North Dakota State UniversityB.S., Civil Engineering, With Honors, 1983

Certifications & Licensure

MD State Medical License 2021 - 2026
CO State Medical License 1995 - 2025
American Board of Pathology Anatomic Pathology & Clinical Pathology

Awards, Honors, & Recognition

Pathology Summit Award for Excellence in Teaching and the Education of Pathologists 2011
Excellence as Unit Director 2001
Excellence as Mentor and Instructor 2001
Robert H. Fennell Award for Excellence in Pathology Residency 1997
Paul E. Strandjord Young Investigator Award 1997
"Excellence in Teaching" Award Medical Student Council Teaching Awards Committee, 1997
Award in Pediatrics Mosby, 1992
Tau Beta Pi Engineering Honor Society, 1981
Alpha Lambda Delta Scholastic Honor Society, 1979
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Clinical Trials

Role of Genetics in Idiopathic Pulmonary Fibrosis (IPF) Start of enrollment: 2008 Jul 01
Recruiting

Publications & Presentations

PubMed

Dendriform pulmonary ossification in military combat veterans: A case series.
Jeremy T Hua, Carlyne D Cool, Tami J Bang, Silpa D Krefft, Richard C Kraus
Respiratory Medicine Case Reports. 2025-01-01
A Murine Model ofInfection Mimics Pathology of Chronic Human Lung Disease.
Kenneth C Malcolm, Alma E Ochoa, Jack H Congel, Patrick S Hume, Jodi M Corley
American Journal of Respiratory Cell and Molecular Biology. 2024-11-26
Case report: A finding of PVOD and PAH in first degree relatives suggests shared heritable risk and overlapping features of both pulmonary vascular diseases.
Roger Winters, Lindsay M Forbes, Dunbar Ivy, Carlyne Cool, Bryan D Park
Respirology Case Reports. 2024-11-01

Journal Articles

Familial idiopathic interstitial pneumonia: histopathology and survival in 30 patients.
Leslie KO, Cool CD, Sporn TA, Curran-Everett D, Steele MP, Brown KK, Wahidi MM, Schwartz DA, Archives of Pathology & Laboratory Medicine, 11/1/2012
Severe pulmonary arterial hypertension induced by SU5416 and ovalbumin immunization.
Mizuno S, Farkas L, al Husseini A, Farkas D, Gomez-Arroyo J, Kraskauskas D, Nicolls MR, Cool CD, Bogaard HJ, Voelkel NF, American Journal of Respiratory Cell & Molecular Biology, 11/1/2012
MicroRNA-199A-5p is associated with hypoxia-inducible factor-1 expression in lungs from patients with COPD.
Mizuno S, Bogaard HJ, Gomez-Arroyo J, Alhussaini A, Kraskauskas D, Cool CD, Voelkel NF, Chest, 9/1/2012
Modern age of pathology of pulmonary arterial hypertension.
Stacher E, Graham BB, Hunt J, Gandjeva A, Groshong SD, McLaughlin VV, Jessup M, Grizzle WE, Aldred MA, Cool CD, Tuder RM, Am J Resp & Crit Care Med, 8/1/2012
Viral infection and pulmonary hypertension: is there an association?
Cool CD, Voelkel NF, Bull T, Expert Review of Respiratory Medicine, 4/1/2011
Hypoxia-inducible factor-1alpha in human emphysema lung tissue.
Yasuo M, Mizuno S, Kraskauskas D, Bogaard HJ, Natarajan R, Cool CD, Zamora M, Voelkel NF, European Respiratory Journal, 4/1/2011
Decreased neprilysin and pulmonary vascular remodeling in chronic obstructive pulmonary disease.
Wick MJ, Buesing EJ, Wehling CA, Loomis ZL, Cool CD, Zamora MR, Miller YE, Colgan SP, Hersh LB, Voelkel NF, Dempsey EC, AJRCCM, 2/1/2011
A 31-year-old woman with hemoptysis and an intrathoracic mass.
Macht M. Mitchell JD. Cool C. Lynch DA. Babu A. Schwarz MI, Chest, 7/1/2010
Formation of plexiform lesions in experimental severe pulmonary arterial hypertension.
Abe K. Toba M. Alzoubi A. Ito M. Fagan KA. Cool CD. Voelkel NF. McMurtry IF. Oka M, Circulation, 6/29/2010
Compartmentalized expression of c-FLIP in lung tissues of patients with idiopathic pulmonary fibrosis.
Cha SI. Groshong SD. Frankel SK. Edelman BL. Cosgrove GP. Terry-Powers JL. Remigio LK. Curran-Everett D. Brown KK. Cool CD. Riches DW, American Journal of Respiratory Cell & Molecular Biology, 2/1/2010
Pathologic patterns and survival in chronic hypersensitivity pneumonitis.
Churg A. Sin DD. Everett D. Brown K. Cool C, American Journal of Surgical Pathology, 12/1/2009
Murine gammaherpesvirus 68 infection of gamma interferon-deficient mice on a BALB/c background results in acute lethal pneumonia that is dependent on specific viral ge...
Lee KS. Cool CD. van Dyk LF, Journal of Virology, 11/1/2009
Minor salivary gland biopsy to detect primary Sjogren syndrome in patients with interstitial lung disease.
Fischer A. Swigris JJ. du Bois RM. Groshong SD. Cool CD. Sahin H. Lynch DA. Gillis JZ. Cohen MD. Meehan RT. Brown KK, Chest, 10/1/2009
Murine gammaherpesvirus 68 infection of IFNgamma unresponsive mice: a small animal model for gammaherpesvirus-associated B-cell lymphoproliferative disease.
Lee KS. Groshong SD. Cool CD. Kleinschmidt-DeMasters BK. van Dyk LF, Cancer Research, 7/1/2009
Immunopathology of chronic rhinosinusitis in young children.
Coffinet L. Chan KH. Abzug MJ. Simoes EA. Cool C. Liu AH, Journal of Pediatrics, 5/1/2009
Neprilysin null mice develop exaggerated pulmonary vascular remodeling in response to chronic hypoxia.
Dempsey EC. Wick MJ. Karoor V. Barr EJ. Tallman DW. Wehling CA. Walchak SJ. Laudi S. Le M. Oka M. Majka S. Cool CD. Fagan KA. Klemm DJ. Hersh LB. Gerard NP. Gerard C. ..., American Journal of Pathology, 3/1/2009
Exposure-related diffuse lung disease.
Rose CS. Lynch DA. Cool CD, Seminars in Respiratory & Critical Care Medicine, 12/1/2008
The cancer paradigm of severe pulmonary arterial hypertension.
Rai PR. Cool CD. King JA. Stevens T. Burns N. Winn RA. Kasper M. Voelkel NF, American Journal of Respiratory & Critical Care Medicine, 9/15/2008
From viral infection to pulmonary arterial hypertension: a role for viral proteins?
Voelkel NF. Cool CD. Flores S, AIDS, 9/1/2008
Clinically significant interstitial lung disease in limited scleroderma: histopathology, clinical features, and survival.
Fischer A. Swigris JJ. Groshong SD. Cool CD. Sahin H. Lynch DA. Curran-Everett D. Gillis JZ. Meehan RT. Brown KK, Chest, 9/1/2008
Abrogation of anti-inflammatory transcription factor LKLF in neutrophil-dominated airways.
Saavedra MT. Patterson AD. West J. Randell SH. Riches DW. Malcolm KC. Cool CD. Nick JA. Dinarello CA, American Journal of Respiratory Cell & Molecular Biology, 6/1/2008
Pulmonary arterial hypertension from a pediatric perspective.
Cool CD. Deutsch G, Pediatric & Developmental Pathology, 5/1/2008
Wheezing and exertional dyspnea in a 25-year-old mountaineer.
Young RL. Mitchell JD. Cool C. Nana-Sinkam SP, Chest, 3/1/2008
VEGF-R blockade causes endothelial cell apoptosis, expansion of surviving CD34+ precursor cells and transdifferentiation to smooth muscle-like and neuronal-like cells.
Sakao, Seiichiro. Taraseviciene-Stewart, Laimute. Cool, Carlyne D. Tada, Yuji. Kasahara, Yasunori. Kurosu, Katsushi. Tanabe, Nobuhiro. Takiguchi, Yuichi. Tatsumi, Koic..., FASEB J, 11/1/2007
Plexiform-like lesions and increased tissue factor expression in a rat model of severe pulmonary arterial hypertension.
White, R James. Meoli, David F. Swarthout, Robert F. Kallop, Dara Y. Galaria, Irfan I. Harvey, Jennifer L. Miller, Christine M. Blaxall, Burns C. Hall, Carla M. Pierce..., Am J Physiol Lung Cell Mol Physiol, 9/1/2007
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Books/Book Chapters

Imaging of Diffuse Lung Disease
Chapter: Pathologic evaluation of interstitial lung disease.
Page 21 - 33Tuder RM, Cool CDEditors: DA Lynch, JD Newell, Jr., JS Lee.BC Decker, Inc., Hamilton, London2000
Interstitial Lung Disease
Chapter: Pulmonary vascular involvement in interstitial lung disease (ILD).
Page 251 - 263Tuder RM, Cool C, Jennings C and Voelkel NFEditors: MI Schwarz, T King, Jr..BC Decker, Inc., OntarioEdition 3rd ,1998

Abstracts/Posters

HHV-8 Expression in Primary Pulmonary Hypertension.
Cool CD, Rai PR, Yeager ME, Serls AE, Bull TM, Brown KK, Routes JM, Tuder RM, Voelkel NF, 3rd World Symposium on Pulmonary Hypertension, Venice, 6/1/2003
Vascular alterations associated with usual interstitial pneumonia (UIP)
Portnoy J, Schwarz MI, Brown KK, Kossack W, Cool CD, ATS International Conference, Seattle, WA, 5/1/2003
Transdifferentiation of Endothelial Cells in Primary Pulmonary Hypertension.
Cool CD, Wood K, Voelkel NF, ATS International Conference, Seattle, WA, 5/1/2003
Increased infections with herpes virus 8 (HHV8) in patients with common variable immunodeficiency (CVID) and lymphoproliferative disorders.
Wheat W. Kirkpatrick C, Brown K, Bates C, Cool C, Serls A, Rai P, Routes J, AAI Meeting, Denver, CO, 3/1/2003
Chronic Rhinosinusitis In Young Children Differs From Adults: A Histopathology Study
KH Chan, MJ Abzug, L Coffinet, EAF Simoes, C Cool, JY Wescott, AH Liu, AAI Meeting, Denver, CO, 3/1/2003
Evidence for plexiform lesions in the lungs of macaques infected with simian immunodeficiency virus.
Marecki, J.C., Cool, C.D., Voelkel, N.F., Carville, A., Flores, S.C., 99th International American Thoracic Society Conference, Seattle, WA, 1/1/2003
An Immunohistochemical Analysis of GM-CSF in Pulmonary Alveolar Proteinosis.
Vourlekis JS, Cool CD, Colby TV, Yousem SA, Schwarz MI, Brown KK, ATS International Conference, Atlanta, GA, 5/1/2002
Determinants of Survival in Fibrotic Hypersensitivity Pneumonitis.
Vourlekis JS, Schwarz MI, Cherniack RM, Durran-Everett D, Cool CD, Tuder RM, King TE, Brown KK, ATS International Conference, Atlanta, GA, 5/1/2002
Does Pulmonary Fibrosis Influence Survival in Hypersensitivity Pneumonitis?
Vourlekis JS, Brown KK, Cool CD, Tuder RM, King Jr. TE, Schwarz MI, ATS International Conference, San Francisco, CA, 5/1/2001
Nonspecific Interstitial Pneumonitis (NSIP) Can Be the Sole Histopathologic Lesion of Hypersensitivity Pneumonitis (HP).
Vourlekis JS, Brown KK, Cool CD, Tuder RM, King Jr. TE, Schwarz MI, ATS International Conference, San Francisco, CA, 5/1/2001
Modeling of intravascular pulmonary endothelial cell proliferation in severe pulmonary hypertension.
Cool CD, Geraci MW, Hoshikawa Y, Kasahara Y, Chan D., Voelkel NF, Tuder RM, ATS International Conference, San Francisco, CA, 5/1/2001
Inflammatory myofibroblastic tumor (IMT) presenting as a component or as a pure type of pulmonary artery sarcoma.
Yi ES, Jacobson D, Sneider W, Cool CD, United States and Canadian Academy of Pathology (USCAP), Boston, MA, 1/1/2001
Recurrent Acute Interstitial Pneumonitis.
Vourlekis JS, Brown KK, King TE Jr., Cool CD, Schwarz MI, Am J Respir Crit Care Med, 1/1/2000
VEGF receptor (KDR) and p27/kip1 3-dimensional mapping in plexiform lesions of pulmonary hypertension.
Cool CD, Stewart JS, Werahera P, Miller G, Voelkel NF and Tuder RM, ATS International Conference, Chicago, IL, 5/1/1998
Monoclonal endothelial cell proliferation is present in primary but not secondary pulmonary hypertension.
Lee S-D, Shroyer KR, Markham NE, Cool CD, Voelkel NF and Tuder RM, ATS International Conference, Chicago, IL, 5/1/1998
Computer-aided 3-dimensional reconstruction study of plexiform lesions in pulmonary hypertension.
Cool CD, Stewart JS, Werahera P, Miller G, Voelkel N and Tuder R, International Academy of Pathology National Meeting, Boston, MA, 3/1/1998
Expression of nitric oxide synthase in endothelium grown in an artificial capillary system - a new model for plexiform lesions found in pulmonary hypertension
Orte C, Bishop AE, Mason NA, Cool CD, Tuder RM, Pollock JS and Polak JM, 1/1/1998
Differentiation of endothelial cells in a novel in vitro flow system.
Cool CD, Kressin D, Hassell K, Welsh C, Voelkel NF and Tuder RM, Am J Respir and Crit Care Med, ATS International Conference, San Francisco, CA, 1/1/1997
Analysis of vascular lesions in familial primary pulmonary hypertension (FPPH): Insights into the endothelial cell as the common denominator of a morphologically heter...
Cool CD, Voelkel NF, Loyd J, Wheeler L and Tuder RM, Am J Respir and Crit Care Med, ATS International Conference, San Francisco, CA, 1/1/1997
Expression of protein kinases in bovine pulmonary endothelial cells in a capillary cell system (CellMax) under conditions of high shear stress.
SD Lee, Cool CD, Wang J, Tuder RM and Voelkel NF, Am J Respir and Crit Care Med, 1/1/1997
Prostacyclin synthase expression is decreased in lungs with severe pulmonary hypertension.
Tuder RM, Wang J, Cool CD, Wright L, Geraci MW, Badesch DB and Voelkel NF, Am J Respir and Crit Care Med, 1/1/1997
Aminopeptidase N (APN) and angiotensin-converting enzyme (ACE) expression in patients with primary pulmonary hypertension (PPH).
Cohen AJ, Miller Y, Cool C, Garg S, Gilman L and Voelkel N, Am J Respir and Crit Care Med, 1/1/1997
Endothelin-1 (ET-1) is upregulated in respiratory bronchiolitis-interstitial lung disease (RB-ILD).
Cohen AJ, King TE, Cool C and Miller YE, Am J Respir and Crit Care Med, 1/1/1997
Low or absent peptidase expression in plexiform lesions of primary pulmonary hypertension (PPH).
Cohen AJ, Cool C, Gilman L, Tuder R, Miller Y and Voelkel N, Aspen Lung Conference, 1/1/1997
Three-dimensional reconstruction of the plexiform lesions in pulmonary hypertension.
Cool CD, Voelkel NF and Tuder RM, Am Rev Respir Dis, ATS International Conference, New Orleans, LA, 6/1/1996
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Other

Idiopathic interstitial pneumonias: Clinical manifestations and pathology
Cool CD
http://www.uptodate.com/contents/idiopathic-interstitial-pneumonias-clinical-manifestations-and-path
UpToDate, Wolters Kluwer Health - 2012-05-08