Carlos MFerrarioMD

Summary

• Dr. Carlos M Ferrario is an cardiologist in Winston Salem, NC and is affiliated with Wake Forest Baptist Medical Center. His research has advanced understanding and treatment of high blood pressure and vascular disease.
  Dr. Ferrario’s research identified the mechanisms of action of angiotensin in the brain through his discovery of the area postrema as a site for the action of the hormone (7, 8), the role of the heart in the development of arterial hypertension (10, 15, 18), and discovered new endocrine pathways leading to the formation and action of angiotensin peptides. Pioneering research in the renin-angiotensin system includes the discovery of the antihypertensive function of angiotensin-(1-7) (4-6, 17), the role of angiotensin converting enzyme 2 as a component of the opposing arm of the renin angiotensin system, and the furthering of understanding as to how inhibitors of angiotensin converting enzyme and angiotensin receptor antagonists act on the body’s nervous and endocrine mechanisms to regulate blood pressure. His studies on the role of angiotensin II in the pathogenesis of atherosclerosis lead to increased recognition on the interaction between lipids and angiotensin II in the evolution of atherosclerosis. The newer studies identifying the function of angiotensin-(1-12) as a novel tissue substrate forming angiotensin II directly by chymase rather than angiotensin converting enzyme are underscoring the important of species differences in characterizing the mechanisms accounting for the pathogenesis of heart and vascular disease.
  Dr. Ferrario has published over 500 papers, 74 book chapters, and 5 books. He has mentored over 61 physicians, many of which have become major medical leaders in the USA, Japan, and Latin America.