Carl J Pepine MD

Cardiology•Gainesville, FL

Adult Congenital Heart Disease, Preventive Cardiology

Professor of Medicine, University Fla College of Medicine

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1329 SW Archer RoadSuite 5130, Room 5231Gainesville, FL 32610
Phone+1 352-273-9082
Fax+1 352-392-3606

Education & Training

Naval Regional Medical CenterResidency, Internal Medicine, 1968 - 1971
Sidney Kimmel Medical College at Thomas Jefferson University/TJUHResidency, Internal Medicine, 1967 - 1968
Allegheny Health Network Medical Education Consortium (AGH)Internship, Internal Medicine, 1966 - 1967
Rutgers New Jersey Medical SchoolClass of 1966

Certifications & Licensure

FL State Medical License 1974 - 2026
PA State Medical License 1967 - 1984
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Cardiovascular Disease

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2002-2014
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013
Women's Health Castle Connolly, 2008
Men's Health Castle Connolly, 2007
Top Doctors: Florida Castle Connolly, 2000
Elected Member The American Society for Clinical Investigation, 1982
Whos Who in Medicine and Healthcare Marquis Whos Who
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Clinical Trials

Asymptomatic Cardiac Ischemia Pilot (ACIP) Study Start of enrollment: 1990 Nov 01
Completed
Phase 3
Women's Ischemia Syndrome Evaluation (WISE) Start of enrollment: 2001 May 01
Completed
Phase 3
INVEST: INternational VErapamil SR Trandolapril STudy Start of enrollment: 1997 Sep 01
Completed
Phase 4
QWISE - Study of Quinapril in Women With Chest Pain, Coronary Flow Reserve Limitations and Evidence of Myocardial Ischemia Start of enrollment: 2000 May 01
Completed
Phase 4
EWISE: Study of Eplerenone in Women With Chest Pain, Coronary Vascular Dysfunction and Evidence of Myocardial Ischemia Start of enrollment: 2004 Aug 01
Completed
Phase 4
WISE ARIC: Retinal Photography in Women With Chest Pain Start of enrollment: 2003 Jun 01
Completed
Women's Ischemia Syndrome Evaluation (WISE) Coronary Vascular Dysfunction Start of enrollment: 2008 Sep 17
ACTIVE_NOT_RECRUITING
IK-5001 for the Prevention of Remodeling of the Ventricle and Congestive Heart Failure After Acute Myocardial Infarction Start of enrollment: 2012 Apr 01
Completed
Not Applicable
Treatment With Ranolazine in Microvascular Coronary Dysfunction (MCD): Impact on Angina Myocardial Ischemia Start of enrollment: 2011 May 01
Completed
Not Applicable
Allogeneic Heart Stem Cells to Achieve Myocardial Regeneration Start of enrollment: 2012 Nov 13
Terminated
Phase 1, Phase 2
Safety and Feasibility Trial of Adipose-Derived Regenerative Cells in the Treatment of Chronic Myocardial Ischemia Start of enrollment: 2012 Jun 01
Completed
Phase 2
Patients With Intermittent Claudication Injected With ALDH Bright Cells Start of enrollment: 2013 Jun 01
Completed
Phase 2
Study 1: Effect of Minocycline Treatment on Drug-Resistant Hypertensive Patients Start of enrollment: 2014 Oct 01
Recruiting
Phase 4
The Role of Gut Microbiota in Hypertension Start of enrollment: 2014 Jul 01
Active, not recruiting
Combination of Mesenchymal and C-kit+ Cardiac Stem Cells as Regenerative Therapy for Heart Failure Start of enrollment: 2015 Oct 01
Completed
Phase 2
Stem Cell Injection in Cancer Survivors Start of enrollment: 2016 Aug 01
Completed
Phase 1
The Role of Gut Microbiota in Heart Failure and Pre-Heart Failure With Preserved Ejection Fraction Start of enrollment: 2016 Oct 01
Recruiting
Gut Organoid Study Start of enrollment: 2021 Mar 05
COMPLETED
Phase 1 Study of ULSC in Patients With Polymyositis (PM) and Dermatomyositis (DM) Start of enrollment: 2021 Oct 06
COMPLETED
EARLY_PHASE1
Roles: Principal Investigator, Contact
MCG As a Noninvasive Diagnostic Strategy for Suspected INOCA (MICRO2) Start of enrollment: 2024 Jun 03
RECRUITING
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

Rationale and design of the women's ischemia syndrome evaluation mechanisms of coronary microvascular dysfunction leading to preheart failure with preserved ejection f...
Tatsunori Takahashi, Janet Wei, Ana C Iribarren, Martha Gulati, Galen Cook-Wiens
American Heart Journal. 2025-06-01
Intracoronary acetylcholine for vasospasm provocation in women with ischemia and no obstructive coronary artery disease.
Benita Tjoe, Christine Pacheco, Nissi Suppogu, Bruce Samuels, Panteha Rezaeian
American Heart Journal Plus. 2025-05-01
Myocardial biomarkers in coronary microvascular dysfunction: Response to ranolazine.
Katherine E Hampilos, Anum Asif, Puja K Mehta, Daniel S Berman, Galen Cook-Wiens
American Heart Journal Plus. 2025-04-01

Journal Articles

Gut Microbiota and Serum Metabolite Differences in African Americans and White Americans with High Blood Pressure☆
Carl Pepine, MD, International Journal of Cardiology

Lectures

Refractory Angina: Options for Patients With 'No Options
2019 ACC Scientific Session & Expo, New Orleans - 3/18/2019

Authored Content

Invasive Functional Assessment in Patients with Angina and Coronary Microvascular Dysfunction A Plea for MoreMay 2020
Invasive Functional Assessment in Patients with Angina and Coronary Microvascular Dysfunction A Plea for MoreMay 2020
Hypertension Across a Woman’s Life CycleApril 2018

Press Mentions

CardiAMP-HF Trial Data Presented for BioCardia Cardiac Cell Therapy for HFrEFApril 7th, 2025
HMN 2025: How Women with Chest Ache Could Not Want Intensive Medical RemedyApril 1st, 2025
Biocardia Phase 3 CardiAMP-HF Trial of Novel Cardiac Cell Therapy for Ischemic Heart Failure Shows Increased Survival, Decreased Cardiac Events, and Improved Quality of Life at Two YearsMarch 31st, 2025
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Grant Support

Antihypertensive Mechanisms of Minocycline in Resistant Hypertension: Role of the gut microbiota-brain-immune axisUNIVERSITY OF FLORIDA2023–2029
Ufrcc For Cardiovascular Cell Therapy Research NetworkNational Heart, Lung, And Blood Institute2012
Women'S Ischemia Syndrome Evaluation (WISE) Coronary Vascular DysfunctionNational Heart, Lung, And Blood Institute2008–2011
Ancillary Functional Studies For The CctrnNational Heart, Lung, And Blood Institute2008–2011
Ufcc For Cardiovascular Cell Therapy Research NetworkNational Heart, Lung, And Blood Institute2007–2011
Renin Angiotensin For Coronary Microvascular DysfunctionNational Heart, Lung, And Blood Institute2001–2005
Scientific Review And Evaluation GrantNational Heart, Lung, And Blood Institute2001–2002
Ischemic Heart Disease In Women--Clinical CenterDivision Of Heart And Vascular Diseases1996–2001
Exercise Induced Ischemia In Patients With Stable Exertional AnginaNational Center For Research Resources1997–1999
DMP 754 In Patients With Chronic Stable Coronary Artery DiseaseNational Center For Research Resources1997