BruceColstonTrapnellMD

Pulmonology • Cincinnati, OH

Critical Care Medicine

Professor, Pediatrics, University of Cincinnati College of Medicine

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Office
222 Piedmont Ave
Ste 6000
Cincinnati, OH 45219
Phone+1 513-475-7521

Fax+1 513-475-7327

Education & Training

Clinical Center at the National Institutes of HealthFellowship, Pulmonary Disease and Critical Care Medicine, 1988 - 1989
Clinical Center at the National Institutes of HealthFellowship, Pulmonary Disease and Critical Care Medicine, 1987 - 1988
Ohio State University HospitalResidency, Internal Medicine, 1984 - 1987
University of Maryland School of MedicineClass of 1984

Certifications & Licensure

OH State Medical License 1998 - 2025
LA State Medical License 2021 - 2022
DC State Medical License 1992 - 1998
MD State Medical License 1987 - 1991
American Board of Internal Medicine Internal Medicine

Clinical Trials

Efficacy and Safety of Sirolimus in LAM Start of enrollment: 2006 Dec 01
Completed
Phase 3
Study Evaluating Fosfomycin/Tobramycin for Inhalation in Cystic Fibrosis Patients With Pseudomonas Aeruginosa Lung Infection Start of enrollment: 2008 Nov 01
Completed
Phase 2
Safety & Efficacy Study of rAAV1-CB-hAAT for Alpha-1 Antitrypsin Deficiency Start of enrollment: 2010 Jun 01
Completed
Phase 2
Inhaled Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) in Hereditary Pulmonary Alveolar Proteinosis (PAP) Start of enrollment: 2012 Aug 01
Completed
Phase 2
A National Registry For Pulmonary Alveolar Proteinosis
RECRUITING
Evaluation of a Single Dose of Inhaled Sargramostim in Patients With Autoimmune Pulmonary Alveolar Proteinosis Start of enrollment: 2017 Jul 13
Completed
Phase 1
Multicenter International Cross-Sectional Evaluation of Pulmonary Alveolar Proteinosis Trial Start of enrollment: 2007 Jul 01
Completed
The Longitudinal Evaluation of Autoimmune Pulmonary Alveolar Proteinosis Start of enrollment: 2018 Apr 19
Completed
Safety and Efficacy of PMT Therapy of hPAP Start of enrollment: 2023 Jun 26
RECRUITING
PHASE1, PHASE2
Roles: Contact
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Publications & Presentations

PubMed

Granulocyte-Macrophage Colony Stimulating Factor Receptor Contributes to Plexiform Neurofibroma Initiation.
Jay Pundavela, Ashley Hall, Samantha Anne Dinglasan, Kwangmin Choi, Tilat A Rizvi
Cancers. 2025-03-06
Circulating and Magnetic Resonance Imaging Biomarkers of Intestinal Fibrosis in Small Bowel Crohn's Disease.
Jonathan R Dillman, Jean A Tkach, Joel G Fletcher, David H Bruining, Aiming Lu
Inflammatory Bowel Diseases. 2025-01-24
Lung immune incompetency after mild peritoneal sepsis and its partial restoration by type 1 interferon: a mouse model study.
Qiuming Meng, Fumiko Seto, Tokie Totsu, Tomoyuki Miyashita, Songfei Wu
Intensive Care Medicine Experimental. 2024-12-20

Journal Articles

Inhaled Molgramostim Therapy in Autoimmune Pulmonary Alveolar Proteinosis
Bruce Trapnell, MD, New England Journal of Medicine

Press Mentions

Savara Announces New Data from Pivotal Phase 3 IMPALA-2 Trial of Molgramostim Nebulizer Solution (Molgramostim) in Patients with Autoimmune Pulmonary Alveolar Proteinosis (aPAP) Were Presented at the European Respiratory Society (ERS) Congress 2024September 8th, 2024
Savara Announces First Patient Dosed in Pivotal Phase 3 Autoimmune Pulmonary Alveolar Proteinosis (aPAP) TrialJune 30th, 2021
New England Journal of MedicineSeptember 8th, 2020
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Grant Support

Technology to understand genetic variant effects in contextUNIVERSITY OF WASHINGTON2019–2029
Versatile, exponentially scalable methods for single cell molecular profilingUNIVERSITY OF WASHINGTON2019–2028
New software tools for differential analysis of single-cell genomics perturbation experimentsUNIVERSITY OF WASHINGTON2023–2027
Human gene transfer & macrophage cell transplantation therapy of hereditary PAP (hPAP)CINCINNATI CHILDRENS HOSP MED CTR2021–2026
Human gene transfer & macrophage cell transplantation therapy of hereditary PAP (hPAP)CINCINNATI CHILDRENS HOSP MED CTR2021–2026
Retrospective Autoimmune PAP Natural History and Patient-Reported Outcomes StudyCINCINNATI CHILDRENS HOSP MED CTR2022–2025
Retrospective Autoimmune PAP Natural History and Patient-Reported Outcomes StudyCINCINNATI CHILDRENS HOSP MED CTR2022–2025
Pathogenesis-Based Diagnostics and Pharmacotherapeutics for PAPCINCINNATI CHILDRENS HOSP MED CTR2007–2025
Pathogenesis-Based Diagnostics and Pharmacotherapeutics for PAPCINCINNATI CHILDRENS HOSP MED CTR2007–2025
Pathogenesis-Based Diagnostics and Pharmacotherapeutics for PAPCINCINNATI CHILDRENS HOSP MED CTR2007–2025
Interdisciplinary Training in Genome SciencesUNIVERSITY OF WASHINGTON1995–2025
Pulmonary Development and Disease Pathogenesis Training ProgramCINCINNATI CHILDRENS HOSP MED CTR1994–2025
Pulmonary Development and Disease Pathogenesis Training ProgramCINCINNATI CHILDRENS HOSP MED CTR1994–2025
Macrophage-Based Human Gene Therapy For Hereditary PAPNational Heart, Lung, And Blood Institute2011–2012
Quantitative Chest Computed Tomography In Alpha-1-Antitrypsin DeficiencyNational Center For Research Resources2008
Anticytokine Autoantibodies/Growth Factors In RARE Lung DiseasesNational Center For Research Resources2005–2008
RARE Lung Disease Clinical Research NetworkNational Center For Research Resources2003–2008
AAT Deficiency &Liver Diseases Caused By ProteinsNational Institute Of Diabetes And Digestive And Kidney Diseases2006
Fourth Annual International Pulmonary Alveolar Proteinosis Research ConferenceNational Heart, Lung, And Blood Institute2006
Regulation Of Alveolar Macrophage PhagocytosisNational Heart, Lung, And Blood Institute2003–2006
Pulmonary Alveolar Proteinosis Research ConferenceNational Heart, Lung, And Blood Institute2005
Conference--Pulmonary Alveolar Proteinosis ResearchNational Heart, Lung, And Blood Institute2004
GM-CSF &Alveolar Macrophage Antiviral Lung DefenseNational Heart, Lung, And Blood Institute2001–2004
Core--Viral VectorsNational Heart, Lung, And Blood Institute1997