BruceKalmanRubinMDMEngr, MBA, FRC

Pediatric Pulmonology • Richmond, VA

Pediatric Asthma Pulmonology

Professor and Chair of Pediatrics; Physician in Chief Children's Hospital of Richmond at VCU

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Office
1000 E Broad St
Richmond, VA 23219
Phone+1 804-828-2467

Fax+1 804-828-9439

Summary

Dr. Bruce Rubin is a pediatric pulmonologist in Richmond, VA and is affiliated with multiple hospitals in the area, including Children's Hospital of Richmond at VCU-Brook Road Campus and Children's Hospital of Richmond at VCU.

Education & Training

Wake Forest University Babcock School of ManagementMBA, Management, 2002 - 2004
Wake Forest UniversityM.B.A., 2004
Tulane UniversityResidency, Pediatrics, 1981 - 1981
Tulane UniversityResidency, Pediatrics, 1980 - 1980
Oxford UniversityFellowship, 1978 - 1980
Oxford UniversityNo degree, Bioengineering, 1978 - 1980
Tulane University School of MedicineClass of 1979
Tulane UniversityMEngr, Biomedical Engineering, 1974 - 1977
Oxford UniversityNo degree, Biomedical Engineering, 1977
Tulane UniversityBS, Mathematics and Physics, cum laude, 1972 - 1975
Oxford UniversityB.S., Physics, Mathematics, and Computer Science, Cum Laude, 1975
North Miami Senior High SchoolDiploma, 1972
Toronto Sick KidsPediatric Pulmonology, Residency and Fellowship

Certifications & Licensure

VA State Medical License 2009 - 2026
MD State Medical License 2014 - 2016
NC State Medical License 1997 - 2010
LA State Medical License 1979 - 1995
American Board of Pediatrics Pediatrics
American Board of Pediatrics Pediatric Pulmonology
Royal College of Physicians of CanadaFRCPC

Awards, Honors, & Recognition

Eagle Scout (gold palm) Boy Scouts of America
Fellow (FAAP) American Academy of Pediatrics
Whos Who in Medicine and Healthcare Marquis Whos Who
Alpha Omega Alpha Medical Academic Honor Society Tulane University
America's Top Doctors Castle Connolly, 2009-2014
Professor of Pediatrics (honorary) Wenzhou Medical University, 2014
Jimmy Young Medalist American Association for Respiratory Care, 2012, 2012
Past President’s Award International Congress of Pediatric Pulmonology (CIPP), 2012
Robert A Bageant Award for service to the VSRC Virginia Society for Respiratory Care, 2011
President’s Award for service to the MSRC and keynote speaker Missouri Society for Respiratory Care, 2010
Forrest M. Bird Lifetime Scientific Achievement Award American Association for Respiratory Care, 2008
Prix Extraordinaire International Congress of Pediatric Pulmonology (CIPP), 2008
International Lifetime Achievement Award for Disease State Management American Association for Respiratory Care (AARC), 2007
Al Soffer Award for Editorial Excellence American College of Chest Physicians, 2004
Resident Teaching Award Wake Forest University Pediatrics, 1997, 1999, 1999-2000, 2000, 2004, 2004
Fellow Academy of Medical Sciences of the Bahamas (FAMS), 2003
Listed in Guide to America’s Top Pediatricians 2003
Listed in Who’s Who in American Education 2003
Listed in Castle Connolly Top Doctors in America 2002
Fellow American Association for Respiratory Care (FAARC), 2001
Listed in Who’s Who in America 2000
Listed in Who’s Who in Medicine and Healthcare 2000
Listed in Who’s Who in America: Science and Engineering 1998
Listed in The Best Doctors in America 1996, 2002
Professor of Pediatrics (honorary) Charles University and Motol Children’s Hospital, 1995
Honorary Consultant Government of the Bahamas and Princess Margaret Hospital, 1994
Outstanding teacher in the Department of Pediatrics St. Louis University, 1993
Listed in American Men and Women of Science 1993
Du Pont Critical Care Research Award ACCP, 1990, 1990
Alfred Soffer Research Award ACCP, 1990, 1990
Finalist (1 of 3) for the Cecile Lehman Mayer Research Award ACCP, 1990
Du Pont Young Investigator Award American College of Chest Physicians, 1989, 1989
American College of Chest Physicians University of Alberta, 1989
Faculty teaching award Queen’s University Medical School, 1985, 1985
Listed in Canadian Who’s Who 1985
Owl Club Outstanding Teacher Award Tulane Medical students, 1981
Rhodes Scholar 1978
Ralph L. Longden Scholar 1973
Scholar Tulane University, 1972
Elected Honorary Member American Association for Respiratory Care, 2016
Past President’s Award International Congress of Pediatric Pulmonology, 2012
Robert A Bageant Award Virginia Society for Respiratory Care, 2011
Memorial Honor Lecture American Association for Respiratory Care, 2011
President’s Award Missouri Society for Respiratory Care, 2010
Scientific Achievement Award American Association for Respiratory Car, 2008
Lifetime Achievement Award for Disease State Management American Association for Respiratory Care (AARC), 2007
Al Soffer Award for Editorial Excellence American College of Chest Physicians, 2004
Listed in Who’s Who in American Education Marquis Who’s Who, 2003
Elected Fellow Academy of Medical Sciences of the Bahamas, 2003
Listed in Guide to America’s Top Pediatricians SLD Industries, 2003
Elected Fellow American Association for Respiratory Care (FAARC), 2001
Member American Pediatric Society, 2000
Listed in Who’s Who in Medicine and Healthcare Marquis Who’s Who, 2000
Listed in Who’s Who in America Marquis Who’s Who, 2000
Listed in Who’s Who in America: Science and Engineerin Marquis Who’s Who, 1998
The Best Doctors in America National edition, 1997
Listed in The Best Doctors in America: Central Region 1996
Honorary Consultant Government of the Bahamas and Princess Margaret Hospital, 1994
Outstanding teacher Department of Pediatrics, St. Louis University, 1993
Cecile Lehman Mayer Research Award ACCP, 1990
Resident teaching award University of Alberta, 1989
Outstanding Teacher Award Owl Club, 1981
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Clinical Trials

Macrolide Antibiotic Therapy for Patients With Cystic Fibrosis Start of enrollment: 2000 Dec 01
Completed
Phase 2
Study of Expectorant Activity of Oral N-acetylcystein (NAC) in Patients With Stable Chronic Bronchitis Start of enrollment: 1997 Jan 01
Completed
Phase 2
An Observational Study to Evaluate The Relationship of Nasal Mucus Properties and Symptoms Start of enrollment: 2012 Mar 01
Completed
The Effect of Humidification on Mucus Rheology Start of enrollment: 2012 Jul 01
Completed
International Plastic Bronchitis Registry Start of enrollment: 2012 Jul 01
Terminated
Evaluating High Flow Humidification Therapy in Patients With Cystic Fibrosis Start of enrollment: 2015 May 01
Completed
Not Applicable
sPLA2 in EBC During Acute Chest Syndrome Start of enrollment: 2018 Jan 19
Completed
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Publications & Presentations

PubMed

240 citations
Mucins, Mucus, and Goblet Cells
Jonathan Ma, Bruce K. Rubin, Judith A. Voynow
Chest. 2017-11-21
19 citations
Cough in the Athlete: CHEST Guideline and Expert Panel Report.
Louis-Philippe Boulet, Julie Turmel, Richard S. Irwin, Kenneth W. Altman, Alan F. Barker
Chest. 2017-02-01
28 citations
Methodologies for the development of the management of cough: CHEST guideline and expert panel report.
Sandra Zelman Lewis, Rebecca L. Diekemper, Cynthia T. French, Philip M. Gold, Richard S. Irwin
Chest. 2014-11-01

Journal Articles

Clinical Pharmacology of Bronchodilator Medications
Bruce Rubin, MD, Respiratory Care
Cystic Fibrosis 2017—the Year in Review
Bruce Rubin, MD, Respiratory Care
Inhibition of IL-13 induced periostin in airway epithelium attenuates cellular protein expression of MUC5AC
Suzaki I, Kawano S, Komiya K, Tanabe T, Akaba T, Asano K, Suzaki H, Izuhara K, MD, Rubin BK, Respirology, 1/1/2017
Airway goblet cells secrete pro-inflammatory cytokines, chemokines and growth factors
Tanabe T, Rubin BK, CHEST, 1/1/2016
A small molecule neutrophil elastase inhibitor, KRP-109, inhibits cystic fibrosis mucin degradation
Chillappagari S, Müller C, Mahavadi P, Guenther A, Nährlich L, Rosenblum J, Rubin BK, Henke MO, J Cyst Fibros, 1/1/2016
Use of management pathways or algorithms in children with chronic cough: systematic reviews
Chang AB, Oppenheimer JJ, Weinberger M, Weir K, Rubin BK, Irwin RS, CHEST, 1/1/2016
Children with chronic wet or productive cough – treatment and investigations: A systematic reviews
Chang AB, Oppenheimer JJ, Weinberger M, Rubin BK, Irwin RS, CHEST, 1/1/2016
Asthma 2015: The year in review
Rubin BK, Respir Care, 1/1/2016
Oxygen with cold bubble humidification is no better than dry oxygen in preventing mucus dehydration, decreased mucociliary clearance, and decline in pulmonary function
Franchini ML, Athanazio R, Amato-Lourenço LF, Carreirão-Neto W, Saldiva PHN, Lorenzi-Filho G, Rubin BK, Nakagawa NK, CHEST, 1/1/2016
Plastic bronchitis
Rubin BK, Clin Chest Med, 1/1/2016
Measurement of eNO with portable analyzer might improve the management of persistent cough at primary care practice in Japan
Watanabe K, Shinkai M, Shinoda M, Hara Y, Yamaguchi N, Rubin BK, Ishigatsubo Y, Kaneko T, Clin Respir J, 1/1/2016
Clarithromycin suppresses CLCA1 and inhibits IL-13-Induced goblet cell hyperplasia in human bronchial epithelial cells
Nagashima A, Shinkai M, Shinoda M, Shimokawaji T, Kimura Y, Mishina K, Sato T, Toda M, Inayama Y, Rubin BK, Kaneko T, Antimicrobial Agents Chemotherapy, 1/1/2016
Prognostic implications of aspiration pneumonia in patients with community acquired pneumonia: A systematic review with meta-analysis
Komiya K, Rubin BK, Kadota JI, Mukae H, Akaba T, Moro H, Aoki N, Tsukada H, Noguchi S, Shime N, Takahashi O, Kohno S, Sci Rep, 1/1/2016
Urban air pollution
Nakagawa NK, AthanazioR, Rubin BK, Chest, 1/1/2016
Somatic Cough Syndrome (previously referred to as psychogenic cough) and Tic Cough (previously referred to as habit cough) in Adults and Children: Chest Guideline and ...
Vertigan AE, Murad MH, Pringsheim T, Feinstein A, Chang AB, Newcombe PA, Rubin BK, McGarvey LP, Weir W, Altman KW, Weinberger M, Irwin RS, on behalf of the CHEST Exper..., CHEST, 1/9./2015
Endotracheal tube performance using a novel biorealistic tracheal model
Rozycki SK, Dixon FP, Yopp MA, Maxvold NJ, Rubin BK, Resp Care, 1/5./2015
Aerosol therapy for children: Unhelpful myths and future directions
Rubin BK, Resp Drug Deliv, 1/1/2015
Biomarkers for staging and evaluating therapy for idiBiomarkers for staging and evaluating therapy for idiopathic pulmonary fibrosisopathic pulmonary fibrosis
Hara Y, Shinkai M, Rubin BK, Clin Pulm Med, 1/1/2015
Secretory phospholipases A2 are secreted from ciliated cells and increase mucin and eicosanoid secretion from goblet cells
Tanabe T, Shimokawaji T, Kanoh S, Rubin BK, CHEST, 1/1/2015
Tools for assessing outcomes in studies of chronic cough: CHEST Guideline and Expert Panel Report
Boulet LP, Coeytaux RR, McCrory DC, French CT, Chang AB, Birring SS, Smith J, Diekemper RL, Rubin B, Irwin RS; CHEST Expert Cough Panel, CHEST, 1/1/2015
Inhalation von Antibiotika bei nicht durch Mukoviszidose bedingter Bronchiektasie
Rubin BK. Williams RW, Karger Kompass Pneumol, 1/1/2015
Clinico-pathological analysis referring hemeoxygenase-1 in acute fibrinous and organizing pneumonia patients
Hara Y, Shinkai M, Kanoh S, Kawana A, Rubin BK, Matsubara O, Kaneko T, Respir Med Case Rep, 1/1/2015
AARC Clinical Practice Guideline: Effectiveness of Pharmacologic Airway Clearance Therapies in Hospitalized Patients
Strickland SL, Rubin BK, Haas CF, Volsko TA, Drescher GS, O'Malley CA, Respir Care, 1/1/2015
Aerosol Medications for Treatment of Mucus Clearance Disorders
Rubin BK, Respir Care, 1/1/2015
Altered protease and antiprotease balance during a COPD exacerbation contributes to mucus obstruction
Chillappagari S, Preuss J, Licht S, Muller C, Mahavadi P, Sarode G, Vogelmeier C, Guenther A, Nahrlich L, Rubin BK, Henko MO, Resp Res, 1/1/2015
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Books/Book Chapters

Clinics in Chest Medicine issue on Rare and Orphan Lung Diseases
Chapter: Plastic Bronchitis
Page 405 - 408Rubin BKEditors: Frank X McCormack and Robert M. Kotloff.Elsevier press2016
Postgraduate Textbook of Pediatrics
Chapter: Inhalational Therapy
Page 1723 - 1725Rubin BK, Williams RWEditors: Piyush Gupta, PSN Menon, Siddarth Ramji Ramji, Rakesh Lodha.2015
Aerosol therapy for the therapy of CF
Williams R, Rubin BKEditors: Diana Bilton, Andrew Bush.2015
Aerosol therapy for the therapy
Williams R, Rubin BKEditors: CF. Diana Bilton, Andrew Bush.2015
ERS Handbook of Paediatric Respiratory Medicine
Chapter: Plastic bronchitis
Page 577 - 581Rubin BK and Moskowitz WBEditors: Ernst Eber, Fabio Midulla.European Respiratory Society Publications, Sheffield, UK2013
Pediatric Bronchoscopy
Chapter: Atelectasis, middle lobe syndrome, plastic bronchitis
Page 149 - 155Priftis KN and Rubin BKKarger, Basil2011
Pediatric Bronchoscopy
Chapter: Atelectasis, middle lobe syndrome, plastic bronchitis
Page 149.0 - 155.0Priftis KN and Rubin BKEditors: K.N. Prifits, M.B. Anthracopoulos, E. Eber, A. A. Koumbourlis, R. E. Wood.Karger, Basel2011
Rau's Respiratory Care Pharmacology
Chapter: Rau's Respiratory Care Pharmacology
Rubin BK, Fink JB, Henke MOEditors: Doug Gardenhire.Elsevier PressEdition 8th,2011
ACCP/AAP Pediatric Pulmonary Medicine Board Review
Chapter: Pulmonary defense mechanisms
Page 249 - 256Rubin BKChicago, ILEdition 1st,2010
Allergy Frontiers, Therapy and Prevention
Chapter: Drug delivery devices and propellants
Page 245 - 258Rubin BK and Fink JBSpringer, Tokyo, Japan2010
Rubin BK and Fink JB
Chapter: Drug delivery devices and propellants
Page 245.0 - 258.0Rubin BK and Fink JBSpringer, Tokyo2010
ACCP/AAP Pediatric Pulmonary Medicine Board Review
Chapter: Pulmonary defense mechanisms
Page 249.0 - 256.0Rubin BKChicagoEdition 1st,2010
Clinical Asthma
Chapter: Treatment delivery systems
Page 303.0 - 312.0Rubin BK and Fink JBEditors: Treatment delivery systems.Elsevier-Mosby2008
Rau's Respiratory Care Pharmacology
Chapter: Mucus-controlling drug therapy
Rubin BK, Fink JB, Henke MOEditors: Doug Gardenhire.Elsevier PressEdition 7th,2008
The Pulmonary Epithelium
Chapter: Pulmonary delivery of novel therapies
Page 411.0 - 427.0Rubin BK and Fink JBEditors: David Proud.John Wiley & Sons, Hoboken, NJ2008
Respiratory Drug Delivery 8
Chapter: Mucus and sputum in chronic lung disease: Biophysical properties and airway clearance
Page 19.0 - 28.0Rubin BKDavis Healthcare Publishing, LLC, River Grove, IL2008
Rau's Respiratory Care Pharmacology
Chapter: Mucus-controlling drug therapy
Rubin BK, Fink JB, Henke MOEditors: Doug Gardenhire.Elsevier PressEdition 8th,2008
Clinical Asthma
Chapter: Treatment delivery systems
Page 303 - 312Rubin BK and Fink JBEditors: Mario Castro and Monica Kraft.Elsevier-Mosby2008
The Pulmonary Epithelium
Chapter: Pulmonary delivery of novel therapies
Page 411 - 427Rubin BK and Fink JBEditors: David Proud.John Wiley & Sons, Hoboken, NJ2008
Respiratory Drug Delivery 8
Chapter: Mucus and sputum in chronic lung disease: Biophysical properties and airway clearance
Page 19 - 28Rubin BKDavis Healthcare Publishing, LLC, River Grove, IL2008
Proceedings of the Scientific Conference Biotechnology and Immuno-Modulatory Drugs 2005: Current Studies of Biotechnology Volume IV
Chapter: Immunomodulatory drugs
Rubin BK2006
Chronic Obstructive Pulmonary Disease
Chapter: Mucolytics for COPD
Rogers DF & Rubin BKEditors: Robert A Stockley, Steven Rennard, Klaus Rabe, Bartolome Celli.Blackwell Publishing, Oxford2006
Proceedings of the Scientific Conference Biotechnology and Immuno-Modulatory Drugs 2005: Current Studies of Biotechnology Volume IV
Chapter: Immunomodulatory drugs
Rubin BK2006
Antibiotics as Anti-inflammatory and Immunomodulatory Agents
Rubin BK and Tamaoki JEditors: Birkhauser Verlag AG.Basel, Switzerland2004
Therapy for Mucus Clearance Disorders
Chapter: Biology of the Lung Series
Rubin BK and van der Schans CPEditors: Claude Lenfant (NIH) Executive editor.Marcel Dekker2004
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Abstracts/Posters

Air and soul: the science and application of aerosol therapy
Rubin BK, Respir Care, 36th Annual Donald Egan Memorial Lecture, 1/1/2010
The interaction between thymosin beta4 and rhDNase on the properties of cystic fibrosis sputum
Rubin BK, CHEST, American College of Chest Physicians, 1/27/1995
Cystic fibrosis and airway disease
Rubin BK, CHEST, American College of Chest Physicians, 1/27/1995
Pulmonary therapy for cystic fibrosis
Rubin BK, CHEST, American College of Chest Physicians, 1/27/1995
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Lectures

Cystic fibrosis and other bronchiectatic syndromes
Pittsburgh, PA
Airway mucus, it’s not just snot
A non-antibacterial, immunomodulatory macrolide
Taverne, Switzerland
Emerging pathogens in the ICU - Lessons from cystic fibrosis
Vilnius, Lithuania
Fatal and near-fatal asthma
Shanghai Children’s Hospital
Current status of macrolide antibiotics as immunomodulatory medications
Tokyo, Japan - 1/31/2016
The diagnosis and therapy of primary ciliary dyskinesia
Tokyo, Japan - 1/31/2016
Anticholinergic therapy for childhood asthma
Naples, Italy - 1/27/2016
Nasal and sinus disease in cystic fibrosis
Naples, Italy - 1/27/2016
Non-CF Bronchiectasis
1/23/2016
Air and Soul – The science and practice of aerosol therapy
1/23/2016
Anticholinergic medications for childhood asthma therapy
1/23/2016
Beyond the guidelines – Fatal and near fatal asthma
1/23/2016
CICU rounds: Asthma dogma myths and mistakes
1/23/2016
Immune modulation by macrolides
1/23/2016
Therapy for non-CF bronchiectasis
1/23/2016
Genetic pulmonary disease and Ethical Dilemmas
1/23/2016
How to read a scientific paper (Paediatric grand rounds)
1/23/2016
How to develop a research proposal and conduct a study
1/23/2016
Atelectasis, plastic bronchitis and the middle lobe syndrome
1/23/2016
Controversies in childhood chronic cough
1/23/2016
Asthma Year in Review 2015
1/21/2016
Aerosol Therapy: Beyond Albuterol and Steroids
Honolulu, HI - 1/21/2016
Childhood cough – Guidelines and controversies
Honolulu, HI - 1/21/2016
Asthma myths, dogma, and controversies
1/20/2016
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Other

Consensus statement: Aerosols and delivery devices
Dolovich MA, MacIntyre NR, Anderson PJ, Camargo CA, Chew N, Cole CH, Dhand R, Fink JB, Gross NJ, Hess DR, Hickey AJ, Kim CS, Martonen TB, Pierson DJ, Rubin BK, Smaldon..., Consensus statement: Aerosols and delivery devices
Administration of Inhaled Controller Therapies
Rubin BK, Asthma Management Planning Group Slide Module 5
Care for the pediatric chronic pulmonary patient
Rubin BK, American Association for Respiratory Care
1/1/2012
Care for the pediatric chronic pulmonary patient
Rubin BK, American Association for Respiratory Care, Professor’s Rounds DVD and CME
1/1/2012
Pediatrics is Magical
Rubin BK, Virginia Commonwealth University Creative Services
1/1/2011
Pediatrics is Magical
Rubin BK, Mediaxa
1/1/2011
Macrolides: properties beyond antimicrobial
Park CS, Shinkai M, Rubin BK, Pulmonary and Critical Care Update (PCCU)
http://www.chestnet.org/educational/online/pccu/vol19/index.php
1/1/2005
Macrolides: properties beyond antimicrobial
Park CS, Shinkai M, Rubin BK, Pulmonary and Critical Care Update (PCCU)
www.chestnet.org/educational/online/pccu/vol19/index.php
1/1/2005
North Carolina Baptist Hospital: Respiratory Care
Rubin BK, Babcock School of Management Teaching Case
1/1/2004
North Carolina Baptist Hospital: Respiratory Care
Rubin BK, Babcock School of Management Teaching Case
1/1/2004
New and emerging pathogens in the ICU
Rubin BK
1/1/2002
Inhaled corticosteroids: Devices and deposition
Rubin BK, North Carolina Respiratory Care Board Newsletter
1/1/2002
Inhaled corticosteroids: Devices and deposition
Rubin BK, North Carolina Respiratory Care Board Newsletter
1/1/2002
New and emerging pathogens in the ICU
Rubin BK, American College of Chest Physicians Journal and CD-ROM
1/1/2002
Why do we say “Ah-Choo" when we sneeze?
Rubin BK, CBC Radio Interview: Program “Why is that?”
1/22/1997
The management of pulmonary disease in patients with cystic fibrosis
Rubin BK, Cystic Fibrosis Foundation
1/1/1996
The management of pulmonary disease in patients with cystic fibrosis
Rubin BK, Cystic Fibrosis Foundation
1/1/1996
A national computer database of pediatric pulmonary job listings
Rubin BK, Pediatric pulmonology
1/1/1994
Feature Columnist for Children’s Health
Rubin BK, Today’s Health Magazine
1/1/1989
Administration of Inhaled Controller Therapies
Rubin BK
1/1/1989
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Press Mentions

Four Children’s Hospital of Richmond at VCU Specialties Nationally Ranked by U.S. News & World ReportJune 17th, 2020
Essential Oils for Newborns and Babies: Everything You Need to Know!September 29th, 2018
Pediatric Inhaler Under Development by Dr. Bruce Rubin and Collaborators Named Prix Galien LaureateOctober 26th, 2017

Committees

Author, American Association for Respiratory Care (AARC) 2015 - Present
Member, Expert Cough Panel, American College of Chest Physicians 2015 - Present

Professional Memberships

American Academy of Pediatrics - AAP
Fellow