Bruce A Lessey MD PhD

PubMed

• Endometrial scratching before euploid embryo transfer: a case-control study.
  Sophia M K Lindekugel, Lexi Rose Frankel, Jeffrey L Deaton, Allan Dong, Rebekah Lassiter
  Journal of Assisted Reproduction and Genetics. 2025-03-01
• Inflammatory Changes after Medical Suppression of Suspected Endometriosis for Implantation Failure: Preliminary Results.
  Bruce A Lessey, Allan Dong, Jeffrey L Deaton, Daniel Angress, Ricardo F Savaris
  International Journal of Molecular Sciences. 2024-06-22
• 2 citations
  Transcriptomic changes in eutopic endometrium and ectopic lesions during endometriosis progression in a mouse model.
  Rong Li, Dinh Nam Tran, Bruce A Lessey, Steven L Young, Tae Hoon Kim
  F&S Science. 2024-05-01

Journal Articles

• Effects of histone methyltransferase inhibition in endometriosis  
  Colon-Caraballo M, Torres-Reveron A, Soto-Vargas JL, Young SL, Lessey BA, Mendoza A, Urrutia R, Flores I, Biology of Reproduction, 1/1/2018
• Postmenopausal Deep Infiltrating Endometriosis of the Colon: Rare Location and Novel Medical Therapy  
  Snyder BM, Beets JW, Lessey BA, Horton SR, Abrams GA, Case Reports in Gastrointestinal Medicine, 1/1/2018
• Sperm Motility Index and Intrauterine Insemination Pregnancy Outcomes  
  Bonds, CL; Roudebush, WE; Lessey BA, GHS Proc, 1/1/2017
• Primary Efficacy and Safety Results from Two Double-Blind, Randomized, Placebo-Controlled Studies Of Elagolix, an Oral Gonadotropin-Releasing Hormone Antagonist, in Wo...  
  Singh SS, Taylor HS, Giuduce LC, Lessey BA, Abrao MS, Kotarski J, Duan WR, Schwefel B, Thomas J, Chwalisz K, JOGC, 1/1/2017
• The Use of Resveratrol as an Adjuvant Treatment of Pain in Endometriosis: A Randomized Clnical Trial  
  Mendes da Silva DM, Gross LA, Neto EG, Lessey BA, Savaris RF, J Endocrine Society, 1/1/2017
• Do I Really Need to Stop Taking Estrogen?  
  Fox C, Lessey BA, Miller PB, GHS Proc, 1/1/2016
• Yolk Sac Diameter in Multiple Gestations  
  Fox C, Fru K, Lessey BA, GHS Proc, 1/1/2016
• Proteomics of the human endometrial glandular epithelium and stroma from the proliferative and secretory phases of the menstrual cycle  
  Hood BL, Liu B, Alkhas A, Shoji Y, Challa R, Wang G, Ferguson S, Oliver J, Mitchell D, Bateman NW, Zahn CM, Hamilton CA, Payson M, Lessey B, Fazleabas AT, Maxwell GL, ..., Biol Reprod, 1/1/2015
• Guidelines for the design, analysis and interpretation of �omics� data: focus on human endometrium  
  Signe Altmae, Francisco J. Esteban, Anneli Stavreus-Evers, Carlos Sim�n, Linda Giudice, Bruce A. Lessey, Jose A. Horcajadas, Nick S. Macklon, Thomas D�Hooghe, Cristina..., Hum Reprod Update, 1/1/2014
• Endometriosis and the enigmatic question of progression  
  Savaris RF, Nichols C, Lessey BA, Journal of Endometriosis, 1/1/2014
• Eutopic Endometrium in Women with Endometriosis: Ground Zero for the Study of Implantation Defects  
  Lessey, BA, Lebovic, DL, Taylor, RN, Semin Reprod Med, 1/1/2013
• Assessement of endometrial receptivity  
  Lessey BA, Fertility and Sterility, 1/1/2011
• Clinical assessment and management of the Endometrium in recurrent pregnancy loss  
  Patel, BG.and Lessey BA, Seminars in Reproductive Medicine, 1/1/2011
• Plasma C3a-des-Arg levels in women with and without endometriosis  
  Fassbender A, D'Hooghe T, Mihalyi A, Kyama C, Simsa P, Lessey BA, Fertil Steril, 1/1/2008
• Endometrial Development and Function in Experimentally-Induced Luteal Phase Deficiency  
  Usadi, RS, Groll, JM, Lessey, BA, Lininger R, Zaino R., Fritz, MA, Young, SL, J Clin Endocrinol Metab, 1/1/2008
• Hormone Control and Androgen Receptor Coregulator Mage-11 in Human Endometrium During the Window of Receptivity to Embryo Implantation  
  Bai, Suxia, Grossman, Gail, Yuan, Lingwen, Lessey BA, French, Frank S., Young, Steven L., Wilson, Elizabeth, Mol Hum Reprod, 1/1/2008
• Uterine Receptivity: Alternations Associated with Benign Gynecological Disease  
  Donaghay MS, and Lessey BA, Seminars in Reproductive Medicine, 1/1/2007
• Endometriosis Markers: Immunologic Alterations as Diagnostic Indicators for Endometriosis  
  Bohler HC., Gercel-Taylor C, Lessey BA, Taylor D, Repro Scien, 1/1/2007
• Gene Expression Analysis of Endometrium Reveals Progesterone Resistance and Candidate Susceptibility Genes in Women with Endometriosis  
  Burney RO, Talbi S, Hamilton AE, Vo KC, Nyegaard M, Nezhat CR, Lessey BA, Guidice LC, Endocrinol, 1/1/2007
• Endometrial Expression of Cyr61, A Marker of Estrogenic Activity in Normal and Abnormal Endometrium  
  MacLaughlin SD, Palomino WA, Bilan MO, Lewis TD, Lininger RA, Lessey, BA, Obstel Gynecol, 1/1/2007
• Molecular phenotyping of human endometrium distinquishes menstrual cycle phases and underlying biological processes in normo-ovulatory women  
  Talbi ., Hamilton AE, V, KC, Tulac S, Overgaard MT, Dosiou C, Le Shay N, Nezhat CN, Kempson R, Lessey BA, Nayak NR, Giudice LC, Endocrinology, 1/1/2006
• Estrogen receptor-alpha (ER-alpha) and defects in uterine receptivity in women  
  Lessey BA, Palomino WA, Apparao, KBC, Young SL, Lininger RA, Reprod Bio and Endocrinol, 1/1/2006
• MUCI Is a Scaffold for Selectin Ligands in the Human Uterus  
  Carson DC, Julian J, Lessey BA, Prakobphol A, Fisher, S.J., Front in Bioscien, 1/1/2006
• CC-1 Cells: A Well-Differentiated Steroid-Responsive Endometrial Cell Line with characteristics of Luminal Epithelium  
  Mo B, Vendrov WA, Palomino WA, DuPont BR, Appara, KBC, Lessey BA, Biol Reprod, 1/1/2006
• Reduced Expression of progesterone receptor-B in the endometrium of women with endometriosis and in cocultures of endometrial cells exposed to 2,3,7,9-tetrachlorodiben...  
  Igarashi TM, Bruner-Tran KL, Yearma, GR, Lessey BA, Edwards EP, Eisenberg E, Osteen KG, Fertil Steril, 1/1/2005
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Books/Book Chapters

• Endometriosis Science and Practice 
  Chapter: Chapter 23: Pathophysiology of Infertility in Endometriosis 
  Page 240.0 - 254.0Lessey BA and Young SLEditors: Giudice LC, Evers JLH, Healy DL.Blackwell Publishing, Ltd, Oxford, UKEdition 1st,2012
• Early Pregnancy 
  Chapter: Clinical assessment of the endometrium 
  Page 171.0 - 198.0Holoch KJ, Lessey BAEditors: Farquharson RG, Stephenson MD.Cambridge Press, Cambridge, England2010
• The Endometrium 
  Chapter: The Endometrium of Polycystic Ovary Syndrome 
  Page 683.0 - 690.0Giudice LC, and Lessey BAEditors: Aplin, JDu Giudice LC, Fazleabas, A.Taylor and Francis Publishers, New York, NYEdition 2nd,2008
• The Endometrium 
  Chapter: Endometrial Receptivity 
  Page 305.0 - 318.0Lessey BA, and Glasser SEditors: Aplin, J.D.u, Giudice, L.C., Fazleabas, A.Taylor and Francis Publishers, New York, NYEdition 2nd,2008
• The Endometrium 
  Chapter: The Endometrial Transcriptome 
  Page 193.0 - 222.0Giudice LC, Talbi S, Hamilton A, and Lessey BAEditors: Aplin, J. D., Giudice, L.C. Fazleabas, A.Taylor and Francis Publishers, New York, NYEdition 2nd,2008
• Essential IVF: Basic Research and Clinical Applications 
  Chapter: Determination of endometrial status and the implantation window 
  Page 577.0 - 609.0Seppala M and Lessey BAEditors: Van Blerkom J, Gregory L.Kluwer Academic Publishers, Boston, MA2004
• Cell and Molecular Biology of Endometrial Carcinoma 
  Chapter: Endometrial cancer cells as models to study uterine receptivity 
  Page 267.0 - 279.0Lessey BA, Vendrov, A.E., Yuan, L.Editors: Kuramoto H, and Nishida, M.Springer, Tokyo, Japan2003
• The Endometrium 
  Chapter: The Endometrium Chapter 
  Lessey BAEditors: Glasser SR, Aplin JD, Giudice, LC, and Tabibzadeh S.Taylor and Francis Publishers, New York, NYEdition 1st,2002
• Advances in Infertility Treatment 
  Chapter: Uterine markers and embryo implantation 
  Page 225.0 - 243.0Lessey BAEditors: M. Filicori.Monduzzi Editore, Bologna, Italy2002
• Textbook of Assisted Reproductive Techniques: Laboratory and Clinical Perspectives 
  Chapter: The use of biomarkers for the assessment of uterine receptivity 
  Page 353.0 - 366.0Lessey BAEditors: Gardner, D.K., Weissman, A, Howles, C.M., and Shoham, Z.Martin Dunitz, London2001
• ART and the Human Blastocyst 
  Chapter: Biomarkers and the Assessment of Uterine Receptivity 
  Page 210.0 - 226.0Lessey BAEditors: Gardner D.K., and Lane, M..Springer-Verlag, New York, NY2001
• Handbook of the Assisted Reproduction Laboratory 
  Chapter: Implantation 
  Page 33.0 - 76.0Lessey BA and Lovely LPEditors: Keel, BA, May, J.V., De Jonge, C.J..CRC Press, Boca Raton, FL2000
• Estrogens and Progestogens in Clinical Practice 
  Chapter: Defective Luteal Phase 
  Fritz MA and Lessey BAEditors: Fraser, I.S., Jensen, R.P.S., Lobo, RA, Whitehead MI.Elsevier1999
• Endometrium and Endometriosis 
  Chapter: Integrins in Endometrium and Endometriosis 
  Page 121.0 - 130.0Lessey BA and Young SLEditors: Diamond M.P. and Osteen, K.G..Blackwell Science, Oxford, England1997
• The Endometrium as a Target for Contraception 
  Chapter: Clinical significance of integrin cell adhesion molecules as markers of endometrial receptivity 
  Page 193.0 - 222.0Lessey BA, Castlebaum AJ, Somkuti SG, Yuan L, Chwalisz KEditors: Beier H, Chwalisz K.Schering Press, Berlin1996
• Yen and Jaffe�s Reproductive Endocrinology 
  Chapter: The Structure, Function and Evaluation of the Female Reproductive Tract 
  Page 206.0 - 247.0Lessey BA and Young SLEditors: Strauss, J.F., III and Barbieri.Elsevier, IncEdition 6th,
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Abstracts/Posters

• MUC1, MUC4 and MUC16 Expression in Endometria of Normal Women and Women with Endometriosis
  M Morgado, N Dharmaraj, P Chapela, SM Hawkins, BA Lessey, SL Young, DD Carson, Texas Forum for Reproductive Sciences, Houston, TX, 1/1/2013
• Involvement of T-Regulatory Cells and Basigin in the Endometrial Inflammatory Pathway in Endometriosis Related Infertility in Humans
  M Adur, A Braundmeier-Fleming, A Fazleabas, B Lessey, R Nowak, 1/1/2011
• Aryl Hydrocarbon Receptor Activity is Associated with Endometriosis and Progesterone Insensitivity
  Wise JD, Jacobsen C, Houwing A, Fru KN, Buzzell D, Young SL, Lessey BA, Hestermann EV, Reproductive Sciences, SGI, Glasgow, Scotland, 1/1/2009
• Progesterone Signaling in Full Thickness Human Endometrium Throughout the Cycle
  Lessey BA, Hays S, Young SL, Jeong JW, DeMayo FJ, Palomino WA, Reproductive Sciences, SGI, Glasgow, Scotland, 1/1/2009
• Endometriosis in Women with Polycystic Ovary Syndrome (POCS)
  Holoch K, Forstein DA, Miller PB, Higdon HL, Lessey BA, Carolina Women�s Health, 6th Annual Meeting of the Androgen Excess and PCOS Society, Columbia, SC, 2008; San Francisco, CA, 2008, 1/1/2008
• Insulin and Progesterone Resistance in PCOS Endometrium: a Microarray Analysis in Clomiphene Citrate-treated and Artificial Menstrual Cycles
  Savaris, R, Groll JM, Young SL, Jeong JW, DeMayo FJ, Giudic, LC, Lessey BA, ESHRE 24th Annual Meeting, Barcelona, Spain, 1/1/2008
• Progesterone Resistance in Endometriosos: Examiniation of L-Selectin Ligand in Eutopic and Ectopic Endometrium Using In Vivo and In Vitro Models
  Palomino WA, Likes CE, Mo B, Forstein DA, Miller P., Lessey BA, Fertility and Sterility, 63rd Annual Meeting American Society for Reproductive Medicine, Washington, DC, 1/1/2007
• Measurement of Activated Complement Subunit C3: A Prospective controlled Evaluation of a New Test for Infertility and Implantation Failure
  Lessey BA, Palomino WA, Hucks MA, Mo B, Miller PB, Forstein DA, Fertility and Sterility, 1/1/2006
• Herbal Therapy For Endometriosis: Prunella Vulgaris (Self Heal) Reduces the Size and Number Endometriotic Xenografts in Immuno-deficient RAG-2/GAMMA (C) Knockout Mice
  Collins NH, Lessey EC, Fowler L, Palomino WA, Houwing AM, Lessey BA, Fertility and Sterility, 62nd Annual Mtg of the American Society for Reproductive Medicine, New Orleans, LA, 1/1/2006
• Expression in Normal and Abnormal Endometrium: A Marker of Estrogenic Activity
  MacLaughlan SD, Mo B, Palomino A, Lessey BA, ACOG, Annual meeting, Cabos, San Lucas, 2005; Washington, DC, 2006, 1/1/2006
• Serum diagnosis of endometriosis using autoantibodies against Thomsen-Friedenreich antigen bearing proteins
  Organ EL, Yearman GR, Osteen KG, Lessey BA, McGuinness DH, E.J Obstet Gynecol, IX World Congress on Endometriosis, Maastricht, Netherlands, 1/1/2005
• Decreased expression of progesterone receptor B isoform in the endometrium from patients with endometriosis
  Igarashi TI, Bruner-Tran KB, Yearman GY, Eisenburg EE, Edwards DE, Lessey BA, Liang SL, Ayabe TA, Tsutsumi OT, Taketani YTl, Osteen KO, E.J Obstet Gynecol, IX World Congress on Endometriosis, Maastricht, Netherlands, 1/1/2005
• Dectection and characterization of isolated androgen receptor expression in the human endometrial cell line
  Merritt WM, Mo, Lessey EC, Hansen M, Lessey BA, Am. College OBGYN, District IV, ACOG Annual Meeting, Savannah, GA, 2004; San Francisco, CA, 2005, 1/1/2005
• The Chinese Herb, Prunella Vulgaris, Exhibits Anti-estrogenic Activity and Inhibits Proliferation of the Endometrial Cancer Cell Line
  Lessey EC, Mo B, Yu X and Lessey BA, Soc. Gynecol. Invest. Annual Meeting, Los Angeles, CA, 1/1/2004
• Regulation of Steroid Receptor Isoforms in a Well-Differentiated Endometrial Cancer Line
  Mo B, Hansen MA, Lessey BA, SSR 37th Annual Meeting, Vancouver, British Columbia, Canada, 1/1/2004
• Overexpression of P160 steroid receptor coactivators (SRCs) in endometrial cancer
  Groll JA, Brown AL, Apparao KBC, Gregory CW, Wilson EM, Lessey BA, Fertility and Sterility, 1/1/2003
• Expression Profile Comparisons in Eutopic Endometrium between women with and without Endometriosis
  Kao LC, Tulac S, Imani B, Yang JP, Lessey BA, L.C. Giudice, VIIIth World Congress on Endometriosis, San Diego, CA, 1/1/2002
• Toll-like receptor expression in human endometrium
  Young SL, Lessey BA, Lyddon TD and Misfeldt ML, J. Soc. Gynecol. Invest., 1/1/2002
• Human endometrial adenocarcinoma cell lines, ECC-1 and Ishikawa, exhibit a luminal vs. glandular phenotype, respectively
  Vendrov AE, Apparao KBC, Lininger RA, Young SL and Lessey BA, J Soc Gynecol Invest, 1/1/2002
• Steroid receptor coactivator (p160) expression throughout the menstrual cycle in normal and abnormal endometrium
  Lessey BA, Gregory CW, Wilson EM, Apparao KBC, Lininger RA, Kowalik A, Meyer WR and Fritz MA, J Soc Gynecol Invest, 1/1/2002
• Endometrial estrogen receptor- expression is increased in women with defects in uterine receptivity: A unifying concept for implantation failure?
  Lessey BA, Apparao KBC, Young SL, Lininger RA, Usadi RS, Groll J and Fritz MA, J Soc Gynecol Invest, 1/1/2002
• Distribution of Pinopods in the Secretory Phase: A Prospective, Randomized Assessment in Healthy, Fertile Women
  Usadi R, Bagnal R, Murray MJ, Meyer WR, Fritz MA, Lessey BA, ASRM Annual Meeting, Orlando, FL, 1/1/2001
• Osteopontin normally localized to the apical surface of receptive endoemtrium, is lacking in women with endometriosis and aberrant avbeta3 integrin expression
  Lessey BA, Appa Rao KBC, Chambers AF, Usadi R, Madden V, Bagnell R, ASRM Annual Meeting, Orlando, FL, 1/1/2001
• Discovery of candidate genes for human uterine receptivity by GeneChip Microarray Expression Profiling
  Kao,LC, Yang J, Lessey BA, Giudice LC, ASRM Annual Meeting, Orlando, FL, 1/1/2001
• Differential expression of integrin genes in septal and parietal endometrium of women with recurrent pregnancy loss
  Gargiulo AR, Wang ZC, Lessey BA, Xiao L, Politch J, Hill J, ASRM Annual Meeting, Orlando, FL, 1/1/2001
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Lectures

• Endometriosis, Inflammation and Progesterone Resistance 
  Research Triangle, NC - 1/1/2014
• Endometriosis: What Should the OBGYN Know Today 
  Macon, GA - 1/1/2010
• Implantation Physiology: Understanding the Key to Success 
  Newport, RI - 1/1/2010
• In Vitro Fertilization 
  Greenville, SC - 1/1/2010
• Assessment and Regulation of Endometrial Receptivity 
  Geneva, Switzerland - 1/1/2009
• Endometriosis and Infertility: Diagnosis and Management 
  Greenville Hospital System - 1/1/2009
• Molecular Regulation of Implantation: Why Progesterone is So Important 
  Houston, TX - 1/1/2009
• Understanding Infertility and Defects in Implantation in the Age of Genomics 
  University of Minnesota, Minneapolis, MN - 1/1/2009
• Tissue Bank 
  Washington, DC - 1/1/2009
• Anovulation, IR, and the Endometrium: A Focus on Current or Future Implantation and Pregnancy Loss, Polycystic Ovary Syndrome (PCOS) and Insulin Resistance: Strategi... 
  Asheville, NC - 1/1/2009
• New Insights into Uterine Receptivity: Embryo Implantation 
  Palm Beach, FL - 1/1/2006
• Improving Implantation: Choosing the Right Embryo and Ensuring a Receptive Endometrium 
  New Orleans, LA - 1/1/2006
• PCOS: A Model for Endometrial Dysfunction Endometrial Physiology and Pathology 
  San Francisco, CA - 1/1/2006
• Uterine Receptivity and Implantation: Making Sense of it All 
  Wayne State University, Detroit, MI - 1/1/2006
• Markers of Endometrial Receptivity 
  Cleveland, OH - 1/1/2005
• Non-traditional Markers of Endometrial Receptivity: Are they Ready for the Clinic? 
  Miami, Florida - 1/1/2005
• Estrogen Receptors and Defects in Uterine Receptivity 
  University of Massachusetts Medical School, Department of Physiology - 1/1/2005
• Estrogen Receptors and Uterine Receptivity 
  Portland, OR - 1/1/2005
• Biomarkers of Uterine Receptivity: Where Have We Come From and Where are We Going? 
  Charleston, SC - 1/1/2005
• Valeo Medical Symposium � Moving from Discovery to Validation with a Noninvasive Diagnostic for Endometriosis 
  Maastricht, Netherlands - 1/1/2005
• Markers in Endometriosis: New Perspectives and Directions, Cyr61 expression in normal and abnormal endometrium 
  Cabos, San Lucas, Mexico - 1/1/2005
• Endometrium and Implantation 
  Cleveland, OH - 1/1/2004
• Endometrial Receptivity and Implantation: An Interface between Science and Clinical Medicine 
  Clemson University - 1/1/2004
• Estrogen receptors and Endometrial Receptivity 
  Philadelphia, PA - 1/1/2004
• Endometrial Function and Implantation 
  Hartford, CT - 1/1/2004
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Other

• Video discussion of methylene blue dye for detection of endometriosis 
  Lessey BA
  https://www.youtube.com/watch?v=5EncV3vSiEc
  1/1/2013
• Implantation - The Global Library of Women's Medicine Gynecology and Obstetrics 
  Groll JM, Lessey BA, CD-ROM
  1/1/2008
• Kelley�s Story 
  Lessey BA, Web-based video presentation
  1/1/2008
• Endometriosis 
  Lessey BA, Video infomercial
  1/1/2007
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