BruceCKoneMDFACP, FAHA, FASN

PubMed

• 3 citations
  Physical and functional interaction of Rnf2 with Af9 regulates basal and aldosterone-stimulated transcription of the α-ENaC gene in a renal collecting duct cell line.
  Zhi Yuan Yu, Qun Kong, Bruce C. Kone
  Bioscience Reports. 2013-10-25
• 19 citations
  Aldosterone reprograms promoter methylation to regulate αENaC transcription in the collecting cuct
  Zhiyuan Yu, Qun Kong, Bruce C. Kone
  American Journal of Physiology. Renal Physiology. 2013-10-01
• 6 citations
  Sp1 trans-activates and is required for maximal aldosterone induction of the αENaC gene in collecting duct cells.
  Zhiyuan Yu, Qun Kong, Bruce C. Kone
  American Journal of Physiology. Renal Physiology. 2013-09-01

Journal Articles

• Protein interactions with nitric oxide synthases: controlling the right time, the right place, and the right amount of nitric oxide.  
  Kone, B.C., Kuncewicz, T., Zhang, W., and Yu, Z, Am. J. Physiol. 285:F178-F190
• Epigenetics and the control of the collecting duct epithelial sodium channel.  
  Kone, B.C, Sem. Nephrol
• 2009 Southern Society for Clinical Investigation presidential address: Opportunity knocks.  
  Kone, B.C, Am. J. Med. Sci. 338:1-2
• Evolving concepts in potassium homeostasis and hypokalemia.  
  Greenlee, M., Wingo, C.S., McDonough, A.A., Youn, J.-H., and Kone, B.C, Ann. Int. Med. (Review), 150:619-625
• Epigenetic control of the epithelial sodium channel in collecting duct.  
  Zhang, D., Yu, Z., Cruz, P., Kong, Q., Li, S., and Kone, B.C, Kidney Int. 75:260-267
• S-Nitrosylation: targets, controls, and outcomes.  
  Kone, B.C, Curr. Gen. 7:301-310
• NO break-ins at water gate.  
  Kone, B.C, Hypertension 48:29-30
• Nitric oxide synthesis in the kidney – isoforms, biosynthesis and function in health.  
  Kone, B.C. and Yu, Z, Seminars in Nephrol. 24:299-315
• Protein-protein interactions involving inducible nitric oxide synthase.  
  Zhang, W., Kuncewicz, T., Yu, Z., Zou, L., Xu, X., and Kone, B.C, Acta Physiol. Scand. 179:137-42
• Advances in genetic detection of kidney disease.  
  Dosekun, A., Foringer, J., and Kone, B.C, Saudi J. Nephrol. Transplant. 14:259-275
• Renal H+-K+-ATPase: structure, function, and regulation.  
  Kone, B.C, Miner. Elect. Metab. 22:349-365
• Molecular biology of natriuretic peptides and nitric oxide synthases.  
  Kone, B.C, Cardiovasc Res. (Review) 15:429-441
• Postinjury multiple organ failure: the role of the gut.  
  Hassoun, H.T., Kone, B.C., Mercer, D.W., Moody, F.G., Weisbrodt, N.W., and Moore, F.A, Shock. 15:1-10
• Protein-protein interactions important for regulation of nitric oxide synthases.  
  Kone, B.C, Acta Physiol. Scand., 168:27-31
• How will gene therapy apply to the kidney in the 21st century?  
  Kone, B.C, Seminars Nephrol. 20:47-59
• Localization and regulation of nitric oxide synthases in the kidney.  
  Kone, B.C, Seminars Nephrol. 19:230-241
• Molecular approaches to renal physiology and therapeutics.  
  Kone, B.C, Seminars Nephrol. 18:102-121
• A “BOLD” new approach to renal oxygen economy.  
  Kone, B.C, Circulation 94:3067-3068
• Nitric oxide in renal health and disease.  
  Kone, B.C, Am. J. Kid. Dis., 30:311-333
• Biosynthesis and homeostatic roles of nitric oxide in the normal kidney.  
  Kone, B.C., and C. Baylis, Am. J. Physiol. 272:F561-578
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Books/Book Chapters

• The Sodium Pump: Structure, Mechanism, and Regulation. 
  Chapter: A Cell Biologist’s Perspective on Sites of Na, K-ATPase Regulation 
  Page 17 - 30Fambrough, D.M., Wolitzky, B.A., Taormino, J.P., Tamkun, M.M., Takeyasu, K., Sommerville, D., Renaud, K., Lemas, M.V., Lebovitz, R., Kone, B.C., Hamrick, M., Rome, J.,...Editors: J.H. Kaplan and P. DeWeer.The Rockefeller University Press, New York
• Nephrology for the House Officer. 
  Chapter: Disorders of Water Balance 
  Page 87 - 100Kone, B.C., and Wingo, C.SEditors: C.S. Wilcox and C.C. Tisher.Williams and Wilkins, BaltimoreEdition 2,
• Biology of Nitric Oxide, Part 4. 
  Chapter: Molecular Characterization and Localization of Three Nitric Oxide Synthase Isoforms in Rat Kidney 
  Page 137 - 141Mohaupt, M., Madsen, K.M., Wilcox, C.S., and Kone, B.CEditors: S. Moncada, M. Feelisch, R. Busse, and E.A. Higgs.Portland Press, ny
• Nephrology. 
  Chapter: Disorders of Water Balance 
  Page 94 - 107Kone, B.C., and Wingo, C.SEditors: C.S. Wilcox and C.C. Tisher.Williams and Wilkins, BaltimoreEdition 3,
• Acid-Base and Electrolyte Disorders: A Companion to Brenner and Rector’s The Kidney. 
  Chapter: Hypokalemia 
  Page 381 - 394Kone, B.CEditors: L.L. Hamm and T.D. DuBose, Jr.Saunders, Philadelphia
• Contributions to Nephrology, Vol. 141. 
  Chapter: Proteomic Analysis Reveals Novel Protein Targets of S-Nitrosylation In Mesangial Cells 
  Page 221 - 230Kone, B.C., Sheta, E., Goldknopf, I., and Kuncewicz, TEditors: W. Thongboonkerd and J. Klein.Karger
• The Kidney. 
  Chapter: The Metabolic Basis of Solute Transport 
  Page 231 - 260Kone, B.CEditors: B.M. Brenner.Elsevier Science, PhiladelphiaEdition 7,
• Current Topics in Atherosclerosis Research. 
  Chapter: Atherosclerosis in Chronic Kidney Disease 
  Page 103 - 132Jalal, D., and Kone, B.CEditors: Y.-.J Geng.Nova, New York
• Modern Surgical Care: Physiologic Foundations and Clinical Applications. 
  Chapter: Urine Formation: From Normal Physiology to Florid Renal Failure 
  Page 725 - 765Dosekun, A., Foringer, J., and Kone, B.CEditors: T. Miller.Informa Healthcare, New YorkEdition 3,
• Encyclopedic Reference of Molecular Mechanisms of Disease. 
  Chapter: Mesenteric Ischemia 
  Kone, B.CEditors: F. Lang.Springer Verlag, Heidelberg
• The Kidney. 
  Chapter: The Metabolic Basis of Solute Transport 
  Kone, B.CEditors: B.M. Brenner.Elsevier Science, PhiladelphiaEdition 8,
• Pharmacology and Therapeutics: Principles to Practice. 
  Chapter: Fluid and Electrolyte Homeostasis 
  Kone, B.CEditors: S. Waldman and A. Terzic.Elsevier Science, Philadelphia
• Handbook of Nephrology and Hypertension. 
  Chapter: Potassium Disorders 
  Kone, B.C., and Wingo, C.SEditors: C.S. Wilcox and C.C. Tisher.Williams and Wilkins, BaltimoreEdition 6,
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Abstracts/Posters

• NF-?B inhibits transcription of the H/K-ATPase a2 subunit gene in mIMCD3 cells: role of histone deacetylase-6.
  Zhang, W. and Kone, B.C, 35th Annual Meeting of the American Society of Nephrology, Chicago, IL
• PI3-kinase and p70/S6 regulate site-specific histone H4 acetylation at the iNOS promoter and to augment cytokine induction of the iNOS gene.
  Yu, Z., and Kone, B.C, 37th Annual Meeting of the American Society of Nephrology, St. Louis, MO
• In vivo expression profile of a human iNOS promoter transgene.
  Yu, Z., Xia, X, and Kone, B.C, 37th Annual Meeting of the American Society of Nephrology, St. Louis, MO
• a-MSH protects against H2O2-induced inhibition of epithelial cell wound restitution via a Syk kinase- and NF-?B-dependent mechanisms.
  Zou, L, Sato, N., and Kone, B.C, 37th Annual Meeting of the American Society of Nephrology, St. Louis, MO
• A novel aldosterone-signaling cascade leading to targeted histone H3K79 methylation and transcriptional activation of ENaC via SGK1-mediated AF9 phosphorylation.
  Zhang, W., Xia, X., Kuncewicz, T., Hemenway, C.S., and Kone, B.C, 37th Annual Meeting of the American Society of Nephrology, St. Louis, MO
• In vivo expression profile of an H/K-ATPase a2 subunit promoter-reporter transgene: molecular basis for differential transcriptional control in collecting duct and dis...
  Zhang, W., Zou, L., and Kone, B.C, 36th Annual Meeting of the American Society of Nephrology, San Diego, CA
• Structure and regulation of the mDot1 gene, a murine histone H3 methyltransferase active in kidney collecting duct cells.
  Zhang, W., Hayashizaki, Y., and Kone, B.C, 36th Annual Meeting of the American Society of Nephrology, San Diego, CA
• STAT3 DNA-binding and coiled-coil domains physically and functionally interact with NF-?B p65 to regulate iNOS transcription in mesangial cells.
  Yu, Z-Y., and Kone, B.C, 36th Annual Meeting of the American Society of Nephrology, San Diego, CA
• CREB family proteins transactivate the murine H/K-ATPase a2 gene in mIMCD3 cells.
  Xu, X., Zhang, W., and Kone, B.C, 36th Annual Meeting of the American Society of Nephrology, San Diego, CA
• Insulin-stimulated cyclic GMP production inhibits vascular smooth muscle cell migration by dephosphorylating and inhibiting Ca/calmodulin-dependent protein kinase II.
  Kahn, AM, Kone, B.C., Yang, Y, and Sang, S, 35th Annual Meeting of the American Society of Nephrology, Chicago, IL
• USF-1 and –2 trans-repress IL-1ß-induced iNOS transcription in mesangial cells.
  Kone, B.C., and Gupta, A.K, 35th Annual Meeting of the American Society of Nephrology, Chicago, IL
• Histone deacetylases augment cytokine induction of the inducible nitric oxide synthase gene.
  Yu, Z-Y., Zhang, W., and Kone, B.C, 35th Annual Meeting of the American Society of Nephrology, Chicago, IL
• S-Nitrosylation of poly (ADP-ribose) polymerase-1 (PARP-1) inhibits Its binding to the iNOS promoter and downregulates iNOS gene transcription in mesangial cells.
  Yu, Z., Kuncewicz, T., and Kone, B.C, 38th Annual Meeting of the American Society of Nephrology, Philadelphia, PA
• Stat3 inhibits transcription of the inducible nitric oxide synthase gene by interacting with NF-?B.
  Yu, Z-Y., Zhang, W., and Kone, B.C, 35th Annual Meeting of the American Society of Nephrology, Chicago, IL
• Proteomic analysis reveals novel protein targets of S-nitrosylated in mesangial cells.
  Kuncewicz, T., Sheta, E., Goldknopf, I, and Kone, B.C, 35th Annual Meeting of the American Society of Nephrology, Chicago, IL
• a-Melanocyte stimulating hormone (a-MSH) reduces intestinal NF-?B and gut I/R injury.
  Hassoun, H.T., Kone, B.C., Kozar, R.A., Snuggs, M., Phan, T., Moore, F.A, Annual Meeting of the Society of University Surgeons
• Stat3? inhibits IL-1ß-mediated activation of the inducible nitric oxide synthase gene in murine mesangial cells.
  Yu, Z-Y., and Kone, B.C, 34th Annual Meeting of the American Society of Nephrology, San Francisco, CA
• Structure, promoter analysis, and chromosomal localization of the murine colonic H,K-ATPase gene.
  Zhang, W., Kuncewicz, T., Higham, S., and Kone, B.C, 34th Annual Meeting of the American Society of Nephrology, San Francisco, CA
• Protein targets of nitric oxide in mesangial cells: proteomic approach to analysis of S-nitrosylated proteins.
  Kuncewicz, T., and Kone, B.C, 34th Annual Meeting of the American Society of Nephrology, San Francisco, CA
• Interaction of Rac2 and inducible nitric oxide synthase (iNOS) augments superoxide and peroxynitrite generation in activated macrophages.
  Kone, B.C., Balakrishnan, P., and Kuncewicz, T, 34th Annual Meeting of the American Society of Nephrology, San Francisco, CA
• Molecular cloning and chromosomal localization of the murine H-K-ATPase a2 subunit gene.
  Kone, B.C., and Kuncewicz, T, 33rd Annual Meeting of the American Society of Nephrology, Toronto, CA
• a-Melanocyte stimulating hormone does not inhibit NF-?B activation in macrophages: role of a novel inducible I?B kinase.
  Kone, B.C., Bender, J., Kuncewicz, T., and Higham, S, 33rd Annual Meeting of the American Society of Nephrology, Toronto, CA
• Interactions of the Rho Family GTPases Rac1 and Rac2 with Nitric Oxide Synthases (NOS).
  Kone, B.C., and Kuncewicz, T, 32nd Annual Meeting of the American Society of Nephrology, Miami Beach, FL
• Enteral arginine modulates the effect of pharmacologic inhibition of AP-1 on iNOS in the postischemic gut.
  Ban, K., Gonzalez, E.A., Kone, B.C, and Kozar, R.A, Shock Society Annual Meeting
• Epigenetic Repression of the epithelial sodium channel a-subunit gene involves promoter methylation and a loss of Sp1 binding.
  Yu, Z., Kong, Q., and Kone, B.C, 45th Annual Meeting of the American Society of Nephrology, San Diego, CA
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Lectures

• Renal Microcirculatory Hemodynamics: Molecular, Cellular, Physiologic, Clinical and Integrative Mechanisms. 
  Saxton’s River, VT
• Protein Partners of Nitric Oxide Synthases. 
  The University of Texas Medical School at Houston
• Protein-protein Interactions as Controls of Nitric Oxide Synthases. 
  University of Nebraska College of Medicine
• New Aspects of Nitric Oxide Synthase Regulation. 
  University of Pittsburgh School of Medicine
• HIV-Associated Nephropathy. 
  University of Texas Medical School at Houston, Houston, TX
• Control Points for iNOS Regulation. 
  University of Texas Medical School at Houston, Houston, TX
• Nitric Oxide Synthases in Renal Health and Disease. 
  Baylor College of Medicine, Houston, TX
• Cardiovascular Consequences and Management of Renal Anemia. 
  Saint Louis Baptist Medical Center, St. Louis, MO
• Nitric Oxide Synthases: Regulation and Functions. 
  The University of Texas Health Science Center at Houston
• Nitric Oxide in Renal, Vascular, and Inflammatory Cells: New Insights into Activation and Signaling. 
  33rd Annual Meeting of the American Society of Nephrology, Toronto, Canada
• Tubulointerstitial Nephritis. 
  University of Texas Medical School at Houston, Houston, TX
• Activation and Actions of Nitric Oxide Synthases. 
  The University of Alabama at Birmingham
• Clinicopathological Conference. 
  The University of Texas Medical School at Houston
• Regulation of Inducible Nitric Oxide Synthase. 
  Saxton’s River, VT
• A 49 Year Old Woman with Syncope, Weight Loss, and Proteinuria. 
  University of Texas Medical School at Houston, Houston, TX
• Acute Renal Failure in the ICU. 
  University of Texas Medical School at Houston, Houston, TX
• Thrombotic Microangiopathies and Renal Disease. 
  Internal Medicine Grand Rounds, Baylor College of Medicine, Houston, TX
• Cardiorenal Protection: Reducing Cardiovascular Events and Renal Disease Beyond Standard Risk Reduction Strategies. 
  University of Texas Medical School at Houston, Houston, TX
• Inducible Nitric Oxide Synthase: Activation and Actions. 
  Amelia Island, FL
• Endothelial Dysfunction. 
  American Heart Association: Hypertension Summer School, Williamsburg, VA
• Molecular Mechanisms of NO Action. 
  American Heart Association: Hypertension Summer School, Williamsburg, VA
• Acute Renal Failure. 
  Multiple Locations, 1996, 2002
• Division/Department Finances. 
  American Society of Nephrology, Philadelphia, PA
• Moving into Administrative Roles: Division Head. 
  American Society of Nephrology, Philadelphia, PA
• Functional Roles and Regulation of Inducible Nitric Oxide Synthase. 
  Vascular Biology Center, Medical College of Georgia
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Other

• Message from the Renal Section ‘Sage’ --- Impact of Katrina on Research and Scientific Education. 
  Kone, B.C, APS Renal Section Newsletter
• Sage thoughts from the Sage, the NIH Roadmap and CTSAs. 
  Kone, B.C, APS Renal Section Newsletter
• A different perspective on admissions decisions. 
  Kone, B.C, Acad. Med. 84:289