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Office
4701 Ogletown Stanton Rd
Helen F Graham Cancer Center
Newark, DE 19713Phone+1 302-623-4205Fax+1 215-955-2340
Education & Training
- National Institutes of Health Clinical CenterFellowship, Hematology and Medical Oncology, 1982 - 1984
- Mayo Clinic College of Medicine and Science (Rochester)Fellowship, Hematology and Medical Oncology, 1980 - 1982
- Mayo Clinic College of Medicine and Science (Rochester)Residency, Internal Medicine, 1977 - 1980
- University of Minnesota Medical SchoolClass of 1976
Certifications & Licensure
- DC State Medical License 1983 - Present
- DE State Medical License 2007 - 2025
- PA State Medical License 1998 - 2024
- MD State Medical License 1983 - 2020
- IA State Medical License 1996 - 2000
- MN State Medical License 1978 - 1987
- TX State Medical License 1985 - 1987
- American Board of Internal Medicine Internal Medicine
- American Board of Internal Medicine Medical Oncology
Clinical Trials
- Rosuvastatin in Treating Patients With Stage I or Stage II Colon Cancer That Was Removed By Surgery Start of enrollment: 2010 Mar 01
Publications & Presentations
PubMed
- 14 citationsAPC mutations in human colon lead to decreased neuroendocrine maturation of ALDH+ stem cells that alters GLP-2 and SST feedback signaling: Clue to a link between WNT a...Tao Zhang, Koree Ahn, Brooks Emerick, Shirin R. Modarai, Lynn M. Opdenaker
Plos One. 2020-10-28 - 22 citationsSomatostatin signaling via SSTR1 contributes to the quiescence of colon cancer stem cellsShirin R. Modarai, Lynn M. Opdenaker, Vignesh Viswanathan, Jeremy Z. Fields, Bruce M. Boman
BMC Cancer. 2016-12-07 - 16 citationsInterdependence of DNA mismatch repair proteins MLH1 and MSH2 in apoptosis in human colorectal carcinoma cell linesSamar Hassen, Akhtar A Ali, Surya P. Kilaparty, Qudes A. Al-Anbaky, Waqar Majeed
Molecular and Cellular Biochemistry. 2016-01-04
Journal Articles
- The Anti-Cancer Effect of Retinoic Acid Signaling in CRC Occurs via Decreased Growth of ALDH+ Colon Cancer Stem Cells and Increased Differentiation of Stem CellsBruce Boman, MD, Oncotarget
Press Mentions
- ChristianaCare Research May Result in 'More Precise' Advanced Colorectal Cancer TreatmentApril 5th, 2023
- Scientists Discover Second Key Pathway in Colon Cancer Stem Cell GrowthOctober 29th, 2020
- Key Signaling Pathway Could Lead to New Targets in Colorectal CancerDecember 20th, 2018
Grant Support
- AP4 Center For Studies On Hereditary Colorectal CancerNational Cancer Institute2004
- Proteomic Analyses For GI Stem Cell Markers &MechanismsNational Institute Of Diabetes And Digestive And Kidney Diseases2003–2004
- Markers For Stem Cell-Like Colonic Crypt Base CellsNational Institute Of Diabetes And Digestive And Kidney Diseases2003–2004
- Characterizing Murine GI Stem Cells: New Molecular ToolsNational Cancer Institute2003–2004
- Core--Gastrointestinal CancerNational Cancer Institute2001–2002
- Approach For Colon Cancer Therapy Using APC PeptidesNational Cancer Institute1996–1998
Professional Memberships
- Member
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