BrianLouisSamuelsMD

PubMed

• 407 citations
  Efficacy and Safety of Trabectedin in Patients With Advanced or Metastatic Liposarcoma or Leiomyosarcoma After Failure of Prior Anthracyclines and Ifosfamide: Results ...
  George D. Demetri, Sant P. Chawla, Margaret von Mehren, Paul S. Ritch, Laurence H. Baker
  Journal of Clinical Oncology. 2009-09-01
• 75 citations
  SARC009: Phase 2 study of dasatinib in patients with previously treated, high‐grade, advanced sarcoma
  Scott M. Schuetze, J. Kyle Wathen, David R. Lucas, Edwin Choy, Brian L. Samuels
  Cancer. 2016-03-15
• 504 citations
  Randomized phase II study of gemcitabine and docetaxel compared with gemcitabine alone in patients with metastatic soft tissue sarcomas
  Robert G. Maki, J. Kyle Wathen, Shreyaskumar Patel, Dennis A. Priebat, Scott H. Okuno
  Journal of Clinical Oncology. 2007-07-01

Journal Articles

• SARC 009: Phase II study of dasatinib in patients with previously-treated, high-grade advanced sarcoma  
  Scheutze SM, Wathen K, Lucas DR, Choy E, Samuels BL, Staddon AP, Ganjoo KN, von Mehren M, Chow WA, Loeb D, Thomas D, Chugh R, Reinke D, Baker LH, Cancer, 1/1/2016
• Clinical outcomes and safety with trabectedin therapy in patients with advanced soft tissue sarcomas following failure of prior chemotherapy: results of a worldwide ex...  
  B. L. Samuels, S. Chawla, S. Patel, M. von Mehren, J. Hamm, P. E. Kaiser, S. Schuetze, J. Li, A. Aymes, G. D. Demetri, Ann Oncol, 1/1/2013
• Sarcoma Alliance for Research through Collaboration (SARC) Efficacy of imatinib in aggressive fibromatosis: Results of a phase II multicenter Sarcoma Alliance for Rese...  
  Chugh R, Wathen JK, Patel SR, Maki RG, Meyers PA, Schuetze SM, Priebat DA, Thomas DG, Jacobson JA, Samuels BL, Benjamin RS, Baker LH, Clin Cancer Res, 1/1/2010
• Efficacy and Safety of Trabectedin in Patients with Advanced or Metastatic Liposarcoma or Leiomyosarcoma After Failure of Prior Anthracyclines and Ifosfamide:Results o...  
  Demetri, GD, Chawla, S, Gómez, J, von Mehren M, Ritch, P, Baker, L, Blay, JY, Hande, K, Keohan, ML, Samuels, BL, Schuetze S Lebedinsky C, Elsayed YA, Izquierdo MA, Gom..., J Clin Oncol, 1/1/2009
• BL Phase II Multicenter Trial of Imatinib in 10 Histologic Subtypes of Sarcoma Using a Bayesian Hierarchical Statistical Model  
  Chugh, R, Wathen, JK, Maki, RG, Benjamin, RS, Patel, S, Myers, P, Priebat, DA, Reinke, DK, Thomas, DG, Keohan, ML, Samuels, BL, and Laurence H. Baker, LH, J Clin Oncol, 1/1/2009
• Randomized phase II study of gemcitabine and docetaxel compared with gemcitabine alone in patients with metastatic soft tissue sarcomas  
  Maki RG, Wathen JK, Patel S,. Priebat DA, Okuno SH, Samuels BL, Fanucchi M, Harmon DC, Schuetze SM, Reinke D, Thall PF, Benjamin RS, Baker LH, Hensley ML, J Clin Oncol, 1/1/2007
• Mitomycin-C/5-fluorouracil/leucovorin and hyperfractionated radiation therapy for rectal carcinoma: a phase II study with long-term follow-up  
  Nabhan C, Ragam A, Samuels B, Milton DT, Prasad L, Hooberman A, Hartsell W, Anthony A, Weisman R, Bitran JD, Clinical Colorectal Cancer, 1/1/2007
• Androgen and c-Kit receptors in desmoplastic small round cell tumors resistant to chemotherapy: novel targets for therapy  
  Fine RL, Shah SS, Moulton TA, Yu IR, Fogelman DR, Richardson M, Burris HA, Samuels BL, Assanasen C, Gorroochurn P, Hibshoosh H, Orjuela M, Garvin J, Goldman FD, D..., Cancer Chemotherapy and Pharmacology, 1/1/2007
• A phase II trial of O6-benzylguanine and carmustine in patients with advanced soft tissue sarcoma  
  Ryan CW, Dolan ME, Brockstein BB, McLendon R, Delaney SM, Samuels BL, Agamah ES, Vokes EE, Cancer Chemotherapy and Pharmacology, 1/1/2006
• Phase II studies of bryostatin-1 in patients with advanced sarcoma and advanced head and neck cancer  
  Brockstein B, Samuels BL, Humerickhouse R, Arietta R, Fishkin P, Wade J, Sosman J, Vokes EE, Investigational New Drugs, 1/1/2001
• Management of recurrent desmoid tumor after surgery and radiation: role of cytotoxic and non-cytotoxic therapies  
  Samuels BL, Surgical Oncology, 1/1/1999
• Phase II trial of uracil/tegafur (UFT) plus leucovorin in patients with advanced biliary carcinoma  
  Mani S, Sciortino D, Samuels BL, Arrietta R, Schilsky RL, Vokes EE, Benner S, Investigational New Drugs, 1/1/1999
• Modulation of vinblastine resistance in metastatic renal cell carcinoma with cyclosporine A or tamoxifen: a CALGB study  
  Samuels BL, Hollis DR, Rosner GL, Trump DL, Shapiro CL, Vogelzang NJ, and Schilsky RL, Clin. Cancer Res., 1/1/1998
• A phase I-II study of paclitaxel, ifosfamide and vinorelbine with filgrastim (rhG-CSF) support in advanced non-small cell lung cancer  
  Masters GA, Mauer AM, Hoffman PC, Wyka D, Samuels BL, Krauss SA, Watson S, Golomb HM, and Vokes EE, Ann Oncol, 1/1/1998
• Phase II trial of uracil/tegafur (UFT) plus leucovorin in patients with advanced hepatocellular carcinoma  
  Mani S, Schiano T, Garcia JC, Ansari RH, Samuels BL, Sciortino DF, Tembe S, Shulman KL, Baker A, Benner SE, Vokes EE, Investigational New Drugs, 1/1/1998
• Dihydro-5-azacytidine and cisplatin in the treatment of malignant mesothelioma: a phase II study by the CALGB  
  Samuels BL, Herndon JE, Harmon DC, Carey R, Aisner J, Corson JM, Suzuki, Green MR, and Vogelzang NJ, Cancer, 1/1/1998
• Phase I study of vinorelbine and ifosfamide in advanced non-small cell lung cancer  
  Masters GA, Hoffman PC, Hsieh A, Drinkard LC, Mick R, Samuels BL, Guaspari A, Golomb HM, and Vokes EE, J. Clin. Oncol., 1/1/1997
• Ifosfamide plus paclitaxel in advanced non-small cell lung cancer: a phase I studies  
  Hoffman PC, Masters GA, Drinkard LC, Krauss SA, Samuels BL, Golomb HM, and Vokes EE, Ann. Oncol, 1/1/1996
• Her2/neu overexpression is associated with treatment failure in women with high-risk stage II and IIIA breast cancer (>10 involved lymph nodes) treated with high do...  
  Bitran JD, Samuels BL, Trujillo Y, Klein L, Schroeder L, and Martinec J, Clin Cancer Res, 1/1/1996
• Tandem high-dose chemotherapy supported by hematopoietic progenitor cells yields prolonged survival in stage IV breast cancer  
  Bitran JD, Samuels BL, Klein L, Hanauer S, Johnson L, Martinec J, Harris E, Kempler J, and White W, Bone Marrow Transplantation, 1/1/1996
• Lovastatin effects on human breast carcinoma cells: Differential toxicity of an adriamycin-resistant derivative and influence on selenocysteine tRNAs  
  Diamond AM, Jaffe D, Murray JL, Safa AR, Samuels BL, and Hatfield D, Biochem. Mol. Biol. Internat., 1/1/1996
• Dose intensification-A phase I study of ifosfamide with vinorelbine: rationale and study design in advanced non small cell lung cancer  
  Drinkard LC, Hoffman PC, Samuels BL, Watson S, Bitran JD, Golomb HM, and Vokes EE, Seminars in Oncology, 1/1/1995
• High dose intravenous melphalan: a review  
  Samuels BL and Bitran JD, J Clin Oncol, 1/1/1995
• Conservative surgery and adjuvant radiation therapy in the management of adult soft tissue sarcoma of the extremities: clinical and radiobiological results  
  Mundt AJ, Awan A, Sibley GS, Simon MA, Rubin SJ, Samuels BL, Wong W, Beckett M, Vijayakumar S, and Weichselbaum RR, Internat J Rad Oncol Biol Phys, 1/1/1995
• Phase I dose escalation study of tumor necrosis factor-alpha and concomitant radiation therapy  
  Hallahan DE, Vokes EE, Rubin SJ, O’Brien SM, Samuels BL, Vijaykumar S, Kufe DW, Phillips RL, and Weichselbaum RR, Cancer J Sci Am, 1/1/1995
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Books/Book Chapters

• Chordomas and Chondrosarcomas of the Skull Base and Spine 
  Chapter: Chemotherapy of Recurrent or Metastatic Disease 
  Page 354.0 - 358.0Samuels BLEditors: Harsh G.Thieme, New York2003
• Atlas of Cancer 
  Chapter: Systemic Therapy for Soft Tissue Sarcomas 
  Page 371.0 - 377.0Samuels BLEditors: Markman M.Lippincott, Williams and Wilkins, Baltimore2003
• Cancer Treatment: An Update 
  Chapter: Hematologic effects of recombinant human Interleukin-6 (rhIL-6) in sarcoma patients receiving MAID chemotherapy: phase I trial 
  Page 875.0 - 879.0Bukowski RM, Isaacs R, Gordon M, Demetri GD, Samuels BL, Young DC, Samuel S, McLain D, and Levitt DEditors: Banzet P, Holland JF, Khayat D, and Weil M.Springer-Verlag, Paris1994
• Comprehensive Textbook of Oncology 
  Chapter: Biological markers of differentiation in the diagnosis of leukemia and lymphoma 
  Page 1191. - 1202.Samuels BL and Ultmann JEEditors: Moosa AR, Robson MC, and Schimpff SC.Williams and Wilkins, BaltimoreEdition 2nd,1991
• Cancer Biology and Medicine Vol 2: The Science of Cancer Treatment 
  Chapter: The detection of minimal disease and implications for cure 
  Page 83.0 - 102.0Samuels BL, Ultmann JEEditors: Ponder BAJ and Waring MJ.MTP Press, Lancaster, England1990
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Abstracts/Posters

• Phase II Study of Pazopanib in Patients With Advanced Intermediate or High-Grade Liposarcoma
  B. Samuels, S. Chawla, N. Somaiah, A, Staddon, K. Skubitz, K. Mulvey, M. Milhelm, P. Kaiser, D. Portnoy, D. Preibat, M. Walker, E. Stepanski, Connective Tissue Oncology Society Meeting, 1/1/2015
• SARC021: A Randomized Phase 3, Multicenter, Open-label Study Comparing TH-302 in Combination with Doxorubicin vs. Doxorubicin Alone in Subjects with Locally Advanced U...
  S. Chawla, K. Ganjoo, L. Cranmer, S. Schuetze, B.A. Van Tine, N. Somaiah, A. Staddo, M. Milhem, B. Samuels, et al, Connective Tissue Oncology Society Meeting, 1/1/2012
• A phase II study of dasatinib for patients with imatinib-resistant gastrointestinal stromal tumor (GIST)
  J. C. Trent, K. Wathen, M. von Mehren, B. L. Samuels, A. P. Staddon, E. Choy, J. E. Butrynski, R. Chugh, W. A. Chow, D. A. Rushing, C. A. Forscher, L. H. Baker, S. Sch..., Proc Am Soc Clin Oncol, 1/1/2011
• 76. Results of a Sarcoma Alliance for Research through Collaboration (SARC) phase II trial of dasatinib in previously treated, high-grade, advanced sarcoma
  Schuetze S, Wathen K, Choy E, Samuels BL, Ganjoo KN, Staddon AP, von Mehren M, Chow WA, Trent JC, Baker LH, Proc Am Soc Clin Oncol, 1/1/2010
• Trabectedin (Tr) as single agent for advanced soft tissue sarcomas (STS) failing standard of care: Interim analysis of 1,400 patients (pts) in an expanded access progr...
  Samuels B. L., Tap W. D., Patel S., von Mehren M., Hamm J. T., Kaiser P. E., Schuetze S., Li J., Bayever E., Demetri G. D., Proc Am Soc Clin Oncol, 1/1/2010
• A randomized phase II study of perifosine plus imatinib for patients with imatinib-resistant gastrointestinal stromal tumor (GIST)
  A. P. Conley, D. Araujo, J. Ludwig, V. Ravi, B. L. Samuels, H. Choi, P. F. Thall, S. Patel, R. Benjamin, J. Trent, Proc Am Soc Clin Oncol, 1/1/2009
• Compassionate use administration of trabectedin in a 24- hour infusion every 3 weeks in pretreated advanced sarcoma patients
  A Yovine; I Robert Judson; J Blay; P Giovanni Casali; J Misset; B Louis Samuels; C Lebedinsky;. J Fernando Perez; P Zintl; P Schoffski, Connective Tissue Oncology Society Meeting, 1/1/2009
• A randomized, phase ii study of perifosine plus imatinib for patients with imatinib-resistant gastrointestinal stromal tumor (GIST)
  A P. Conley; M S. Park; D M. Araujo; J A. Ludwig; V Ravi; B L. Samuels; H Choi; S Patel; R S.Benjamin; J C. Trent, Connective Tissue Oncology Society Meeting, 1/1/2009
• Combination of trabectedin (T) and doxorubicin (D) for the treatment of patients with soft tissue sarcoma (STS): Safety and efficacy analysis
  J. Blay, M. von Mehren, B. L. Samuels, M. P. Fanucchi, I. L. Ray-Coquard, B. Buckley, L. Gilles, C. Lebedinsky, Y. A. Elsayed, A. Le Cesne, Proc Am Soc Clin Oncol, 1/1/2007
• A phase III study of gemcitabine ± docetaxel for metastatic soft tissue sarcoma
  Maki RG, Wathen JK, Patel SR, Priebat DA, Okuno S, Samuels B, Harmon DC, Fanucchi M, Hensley ML, Reinke D, Thall PF, Benjamin RS, Baker LH, Proc Conn Tissue Oncol Soc, 1/1/2005
• Gleevec Therapy In C-kit Negative Soft Tissue Sarcomas: A Molecular Rationale
  DG Thomas ,TJ Giordano, RS Benjamin, DA Priebat, BL Samuels, SS Bacus, LH Baker, Proc Conn Tissue Oncol Soc, 1/1/2005
• Dose-intense preoperative chemotherapy with hypofractionated radiation for high-risk soft-tissue sarcoma
  C. W. Ryan, A. Montag, S. Undevia, J. R. Hosenpud, B. Samuels, J. B. Hayden, A. Y. Hung, Proc Am Soc Clin Oncol, 1/1/2005
• Activity of imatinib mesylate in desmoid tumors: Interim analysis of a Sarcoma Alliance for Research thru Collaboration (SARC) phase II trial
  L. H. Baker, K. Wathen, R. Chugh, D. Thomas, P. F. Thall, R. G. Maki, B. L. Samuels, P. A. Meyers, D. A. Priebat, R. S. Benjamin, Proc Am Soc Clin Oncol, 1/1/2004
• Imatinib mesylate in soft tissue and bone sarcomas: Interim results of a Sarcoma Alliance for Research thru Collaboration (SARC) phase II trial
  R. Chugh, D. Thomas, K. Wathen, P. F. Thall, R. S. Benjamin, R. S. Maki, B. L. Samuels, M. L. Keohan, D. A. Priebat, L. H. Baker, Proc Am Soc Clin Oncol, 1/1/2004
• Randomized phase II study of trabectedin (ET-743) given by two different dosing schedules in patients with leiomyosarcomas or liposarcomas refractory to conventional d...
  Brian L. Samuels, D. Rushing, S. P. Chawla, S. M. Schuetze, M. Von Mehren, M. L. Keohan, M. O'Donovan, X. Wei, L.-A. Sternas, G. D. Demetri, Proc Am Soc Clin Oncol, 1/1/2004
• High-dose Toremefine (T) in the treatment of desmoid tumors (DT)
  Brian L Samuels, Laurel Barbour, Kathleen Tolzien, Alajos Hajba, Proc Am Soc Clin Oncol, 1/1/2002
• Patients with stage IV non-small cell lung cancer (NSCLC) have a high cumulative risk of CNS metastasis
  Jacob D Bitran, Kathy Tolzien, Ryan Engle, Brian Samuels, Arthur Hooberman, Proc Am Soc Clin Oncol, 1/1/2002
• Nanoparticle paclitaxel (ABI-007) in metastatic breast cancer (MBC): efficacy and evidence of dose-dependent activity in two multicenter phase II studies
  Nuhad K Ibrahim, Brian Samuels, Ray Page, Troy Guthrie, G. Ramakrishnan, D. Doval, K. Patel, S. Rao, M. Nair, D. Digumarti, Gabriel N Hortobagyi, Proc Am Soc Clin Oncol, 1/1/2002
• Mitomycin C (MMC), 5-Fluorouracil (5FU), Leucovorin (LVN), and Hyperfractionated Radiation (RT) as Preoperative Therapy for Rectal Carcinoma
  Jacob D. Bitran, Brian L. Samuels, Leela M Prasad, Robert I Weisman, Arthur L Hooberman, William F Hartsell, Paul Schabinger, Charmayne Kelly, Leonard Klein, David Hak..., Proc Am Soc Clin Oncol, 1/1/2001
• A Phase II Trial of O6-Benzylguanine (O6-BG) and BCNU in Patients with Advanced Soft Tissue Sarcoma (STS)
  Christopher W. Ryan, Bruce B. Brockstein, Brian L. Samuels, Edem Agamah, Susan R. Flickinger, Everett E. Vokes, Proc Am Soc Clin Oncol, 1/1/2001
• Phase I Study of Low Dose Continuous Infusion Gemcitabine in Sarcoma Patients
  Brian Samuels, Laurel Barbour, Donna Schiller, Proc Am Soc Clin Oncol, 1/1/2001
• Dose Dense Chemotherapy for Sarcomas Using Whole-Blood Derived Peripheral Stem Cell Rescue
  Samuels Brian , Gale Danielle , Michel Judilyn, Murray Judith , Das Gupta Tapas K, Lad Thomas, Boddie Arthur, Proc Am Soc Clin Oncol, 1/1/1999
• A phase I-II study of paclitaxel, ifosfamide and vinorelbine with G-CSF support in advanced non-small cell lung cancer
  Masters GA, Hoffman PC, Samuels BL, Mauer A, Krauss SA, Golomb HM, and Vokes EE, Proc Am Soc Clin Oncol, 1/1/1997
• Mitomycin, 5-fluorouracil, leucovorin, and hyperfractionated radiation as preoperative therapy for rectal carcinoma
  Samuels BL, Prasad L, Hooberman A, Klein L, Hakimian D, Schabinger P, Phillips R, Gambino A, Bitran J, Proc Am Soc Clin Oncol, 1/1/1996
• Autologous bone marrow transplant for women with stage II and IIIA high risk (>10 involved lymph nodes) breast cancer
  Bitran JD, Samuels BL, Klein LM, Schroeder L, Martinec J, Harris E, Proc Am Soc Clin Oncol, 1/1/1996
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