Brian Jesse Debosch MD PhD

PubMed

• Protocol to evaluate fasting metabolism and its relationship to the core circadian clock in mice.
  Jiameng Sun, Brian J DeBosch
  STAR Protocols. 2025-03-21
• Beyond Scratching the Surface: A Nonpruritogenic Novel Bile Acid Derivative That Ameliorates Cholestatic- and Diet-Induced Liver Injury.
  Rebecca Haeusler, Brian J Debosch
  Gastroenterology. 2025-03-07
• A New Tool to Study the DREADDed Peripheral Nervous System.
  Amber L Alhadeff, Brian J DeBosch
  Gastroenterology. 2025-02-01

Abstracts/Posters

• Transmissible Protection From Fructose Induced Hepatic Steatosis Using Microbiota From Mice With Defective Intestinal Chylomicron Production
  Yan Xie, Hitoshi Matsumoto, Susan Kennedy, Brian J. DeBosch, Kelle H. Moley, Yanjiao Zhou, Phillip I. Tarr, Nicholas O. Davidson, American Gastroenterological Association Digestive Diseases Week, San Diego, CA, 1/1/2016
• GLUT8 (SLC2A8) Is a Mammalian Trehalose Transporter Required for Trehalose-Induced Autophagy.
  Brian DeBosch, Allyson L Mayer, Monique R Heitmeier, Paul Hruz and Cassandra B Higgins., American Gastroenterological Association Digestive Diseases Week, San Diego, CA, 1/1/2016
• Trehalose inhibits SLC2A Proteins to induce autophagy and prevent hepatic steatosis.
  BJ DeBosch, M Heitmeier, AL Mayer, CB Higgins, M Chi, K Yarasheski, J Crowley, Z Chen, BN Finck, PW Hruz, KH Moley., Midwest DDRCC Symposium, Washington University, St. Louis, MO, 1/1/2015
• GLUT8/SLC2A8 Regulates Fasting-Induced Hepatic Steatosis
  Allyson Mayer, Emily Feng, Cassandra Higgins, Paul Hruz, Kelle Moley and Brian DeBosch, FASEB Summer Research Conferences - Glucose Transport: Gateway to Systems Biology, Huntley Lodge, Big Sky, MT, 1/1/2015
• Trehalose inhibits SLC2A proteins to induce hepatic autophagy and prevent hepatic steatosis.
  BJ DeBosch, M Heitmeier, AL Mayer, CB Higgins, M Chi, K Yarasheski, J Crowley, Z Chen, BN Finck, PW Hruz, KH Moley, FASEB Summer Research Conferences: Glucose transport - gateway to systems biology, Big Sky, MT, 1/1/2015
• Early-onset metabolic syndrome in mice lacking the enterocyte urate transporter, SLC2A9
  Brian DeBosch and Kelle Moley, Midwest DDRCC Alliance, University of Michigan, Ann Arbor, 1/1/2014
• GLUT8 is required for fructose-induced hepatic macrosteatosis.
  Brian DeBosch and Kelle Moley, North American Society for Pediatric Gastroenterology, Hepatology & Nutrition: Fellows' Conference, Scottsdale, AZ, 1/1/2013
• GLUT8 is essential for fructose-induced NAFLD.
  Brian DeBosch and Kelle Moley, Glucose Transport: Gateway to Systems Biology: Federation for American Societies for Experimental Biology, Snowmass, CO, 1/1/2013
• Glut8 Regulates Enterocyte Fructose Transport and Global Fructose Metabolism.
  Brian DeBosch and Kelle Moley, American Gastroenterological Association: Digestive Disease Week, San Diego, CA, 1/1/2012
• TRB3 Function in Cardiac Endoplasmic Reticulum Stress.
  Anthony Muslin, Joan Avery and Brian DeBosch., American Heart Association Scientific Sessions, New Orleans, LA, 1/1/2008
• Akt2 regulates cardiomyocyte survival and glucose metabolism.
  Anthony Muslin and Brian DeBosch, International Society for Heart Research Scientific Sessions, San Francisco, CA, 1/1/2007
• Akt2 is dispensible for IGF-1- induced cardiac growth, but is essential for cardiac glucose uptake and metabolism.
  Brian DeBosch, Morris Birnbaum and Anthony Muslin., American Heart Association Scientific Sessions, Dallas, TX, 1/1/2005
• Akt1 Promotes Physiologic, But Antagonizes Pathologic, Cardiac Hypertrophy.
  Brian DeBosch, Stefan Lupu and Anthony Muslin, American Heart Association, New Orleans, LA, 1/1/2004
• Enhancement of EGF-stimulated AKT and MAP kinase pathways by phosphatidylinositol-4-phosphate-5-kinase.
  Brian DeBosch, Alejandro Barbieri, Colin Heath and Phillip Stahl., FASEB Scientific Sessions, New Orleans, LA, 1/1/2002
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Lectures

• Trehalose, Cellular Action and Therapeutic Possibilities 
  1/1/2016
• Treatment for Pediatric NAFLD: Sweet new therapies are coming through the portal! 
  Washington University School of Medicine - 1/1/2015
• Spontaneous, Early-Onset Metabolic Syndrome in Mice Lacking the Enterocyte Urate Transporter 
  1/1/2014