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Office
399 Binney Street
Cambridge, MA 02142
Summary
- I'm a physician-scientist and Head of Clinical Development focused on growing and nurturing an incredibly smart and hard-working team of physicians and scientists in the Clinical Development, Clinical Science, Translational Medicine, Pharmacovigilance and Medical Writing groups at Relay Therapeutics. Our goal is to bring transformational new therapies to patients living with cancers and rare diseases through seamless clinical development from phase one to registration.
My experiences span solid tumors and heme malignancies, from INDs and first-in-human phase ones to registrational Phase 2 and 3 randomized trials and an sNDA. I have driven clinical development and publication strategy, advisory boards, interacted with FDA, EMA and country level authorities in Europe and Asia, been involved with analyst interactions, business development/diligence and portfolio management. My research background includes genomics, targeted therapies, precision oncology molecular and computational biology.
Education & Training
- Boston Children’s Hospital/Boston Medical CenterFellowship, Pediatric Hematology/Oncology, 2009 - 2012
- New York Presbyterian Hospital (Columbia Campus)Residency, Pediatrics, 2006 - 2009
- University of Illinois College of MedicineClass of 2006
Certifications & Licensure
- MA State Medical License 2009 - 2019
- NY State Medical License 2007 - 2009
Publications & Presentations
PubMed
- 7 citationsDiscovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3Kα Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia.Andreas Varkaris, Ermira Pazolli, Hakan Gunaydin, Qi Wang, Levi Pierce
Cancer Discovery. 2024-02-08 - 1 citationsIntegration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma.Jonathan Paolino, Boris Dimitrov, Beth Apsel Winger, Angelica Sandoval-Perez, Amith Vikram Rangarajan
Clinical Cancer Research. 2023-11-14 - 12 citationsAvapritinib versus Placebo in Indolent Systemic Mastocytosis.Jason Gotlib, Mariana Castells, Hanneke Oude Elberink, Frank Siebenhaar, Karin Hartmann
NEJM Evidence. 2023-06-01
Journal Articles
- PPM1D Truncating Mutations Confer Resistance to Chemotherapy and Sensitivity to PPM1D Inhibition in Hematopoietic CellsPeter G Miller, Brenton Mar, Benjamin L Ebert, Shaunt Fereshetian, Anthony Letai, Siddhartha Jaiswal, Blood
Press Mentions
- Genetic Profiling Can Guide Stem Cell Transplantation for Patients with Myelodysplastic Syndrome, Study FindsFebruary 9th, 2017
- Genetic Profiling Can Guide Stem Cell Transplantation for Patients with Myelodysplastic Syndrome, Study FindsFebruary 8th, 2017
- Genetic Profiling Can Guide Stem Cell Transplantation for Patients with Myelodysplastic Syndrome, Study FindsFebruary 8th, 2017
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