BethAOvermoyerMD

Oncology • Boston, MA

Breast Cancer, Cancer Genetics/Cancer Risk Assessment, Hematologic Oncology

Assistant Professor of Medicine, Dana Farber Cancer Institute

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Office
44 Binney St
# 220B
Boston, MA 02115
Phone+1 617-632-3427

Fax+1 617-632-1930

Education & Training

University of Pennsylvania Health SystemFellowship, Hematology and Medical Oncology, 1989 - 1993
University of Pennsylvania Health SystemResidency, Internal Medicine, 1986 - 1989
Case Western Reserve University School of MedicineClass of 1986

Certifications & Licensure

MA State Medical License 2007 - 2026
OH State Medical License 1993 - 2010
CT State Medical License 2005 - 2009
PA State Medical License 1987 - 2006
American Board of Internal Medicine Internal Medicine

Awards, Honors, & Recognition

America's Top Doctors for Cancer Castle Connolly, 2016
Fellow (FACP) American College of Physicians, 2005
Super Doctor SuperDoctors.com

Clinical Trials

SU5416 and Doxorubicin in Treating Patients With Stage IIIB or Stage IV Inflammatory Breast Cancer Start of enrollment: 2000 Apr 01
Completed
Phase 1
Combination Chemotherapy in Treating Patients With Advanced Solid Tumors Start of enrollment: 2000 Feb 01
Completed
Phase 1
HER-2 Protein Vaccine in Treating Women With Breast Cancer Start of enrollment: 2003 Jul 01
Completed
Phase 1
Docetaxel, Doxorubicin, and Cyclophosphamide in Treating Women With Advanced Breast Cancer Start of enrollment: 2003 Sep 01
Withdrawn
Phase 1
Vaccination With Autologous Breast Cancer Cells Engineered to Secrete Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) in Metastatic Breast Cancer Patients Start of enrollment: 2006 Jan 01
Completed
Phase 1
Paclitaxel With or Without Carboplatin and/or Bevacizumab Followed by Doxorubicin and Cyclophosphamide in Treating Patients With Breast Cancer That Can Be Removed by Surgery Start of enrollment: 2009 May 15
Active, not recruiting
Phase 2
Autologous Vaccination With Lethally Irradiated, Autologous Breast Cancer Cells Engineered to Secrete GM-CSF in Women With Operable Breast Cancer Start of enrollment: 2006 Jan 01
Completed
Phase 1
Paclitaxel + Trastuzumab + Pertuzumab as Pre-Op for Inflammatory BrCa Start of enrollment: 2013 Aug 01
Active, not recruiting
Phase 2
Ruxolitinib W/ Preop Chemo For Triple Negative Inflammatory Brca Start of enrollment: 2014 Feb 01
Completed
Phase 1, Phase 2
A Phase 2 Study of Eribulin Followed by AC as Preoperative Therapy for HER2-negative Inflammatory Breast Cancer Start of enrollment: 2016 Feb 26
Active, not recruiting
Phase 2
A Phase 1b/2 Study of Rebastinib (DCC-2036) in Combination With Paclitaxel in Patients With Advanced or Metastatic Solid Tumors Start of enrollment: 2018 Oct 25
Completed
Phase 1, Phase 2
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Publications & Presentations

PubMed

25 citations
JAK-STAT Signaling in Inflammatory Breast Cancer Enables Chemotherapy-Resistant Cell States.
Laura E Stevens, Guillermo Peluffo, Xintao Qiu, Daniel Temko, Anne Fassl
Cancer Research. 2023-01-18
1 citations
TBCRC 039: a phase II study of preoperative ruxolitinib with or without paclitaxel for triple-negative inflammatory breast cancer.
Filipa Lynce, Laura E Stevens, Zheqi Li, Jane E Brock, Anushree Gulvady
Breast Cancer Research. 2024-01-31
322 citations
A Phase I pharmacokinetic and translational study of the novel vascular targeting agent combretastatin A-4 phosphate on a single-dose intravenous schedule in patients ...
Afshin Dowlati, Kelly Robertson, Matthew M. Cooney, William P. Petros, Michael Stratford
Cancer Research. 2002-06-15

Journal Articles

Effect of Eribulin with or Without Pembrolizumab on Progression-Free Survival for Patients with Hormone Receptor–Positive, ERBB2-Negative Metastatic Breast Cancer
Sara M Tolaney, Gerburg Wulf, Laura Spring, Beth Overmoyer, Ann H Partridge, Eric P Winer, Ian E Krop, JAMA Oncology
A Pharmacogenetic Prediction Model of Progression‐Free Survival in Breast Cancer Using Genome‐Wide Genotyping Data from CALGB 40502 (Alliance)
Hope S Rugo, Francisco Castillos, Beth Overmoyer, Mark J Ratain, Clinical Pharmacology & Therapeutics

Press Mentions

Breast Cancer: Common, Deadly and Preventable?October 25th, 2022
Enobosarm Shows Clinical Benefit in AR+, ER+ Metastatic Breast CancerJanuary 9th, 2021
Veru Expands Oncology Drug Pipeline; Exclusively Licenses Phase 3 Clinical Stage Targeted Therapy for Endocrine Resistant Metastatic Breast CancerDecember 9th, 2020
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Grant Support

SU5416 And Doxorubicin In Inflammatory Breast CancerNational Center For Research Resources2004
Pegylated Liposomal Doxorubicin + Vinorelbine + Gemcitabine For Solid TumorsNational Center For Research Resources2004
Fenretinide + Paclitaxel + Cisplatin For Advanced Solid TumorsNational Center For Research Resources2004
Bevacizumab And Docetaxel For Locally Advanced Breast CancerNational Center For Research Resources2004
Translational Research In Breast CancerNational Cancer Institute2000–2004
Core--Clinical Trials FacilityNational Cancer Institute2001–2002