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Office
Division of Neurosurgery
1500 East Duarte Road
Duarte, CA 91010Phone+1 626-256-4673Fax+1 626-471-7344
Summary
- I am a board certified neurosurgeon and current vice chair & professor, Department of Surgery and chief, Division of Neurosurgery at City of Hope in Duarte, California. I am also the director of the Brain Tumor Program at City of Hope.
I am an expert in the field of surgical neuro-oncology, and our Brain Tumor Program and Division of Neurosurgery is leading groundbreaking research into nanotechnology as a tool for delivering cancer-fighting drugs directly into tumors, in a minimally invasive manner.
Education & Training
- UCLA David Geffen School of Medicine/UCLA Medical CenterResidency, Neurological Surgery, 1990 - 1996
- UCLA David Geffen School of Medicine/UCLA Medical CenterInternship, Transitional Year, 1989 - 1990
- David Geffen School of Medicine at UCLAClass of 1989
Certifications & Licensure
- CA State Medical License 1991 - 2026
- WI State Medical License 1996 - 2007
- American Board of Neurological Surgery Neurological Surgery
Awards, Honors, & Recognition
- America's Top Doctors Castle Connolly, 2009-2014
- Top Doctors:LA Area Castle Connolly, 2013
- America's Top Doctors for Cancer Castle Connolly, 2005-2013
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Clinical Trials
- Phase I Study of Cellular Immunotherapy for Recurrent/Refractory Malignant Glioma Using Intratumoral Infusions of GRm13Z40-2, An Allogeneic CD8+ Cytolitic T-Cell Line Genetically Modified to Express the IL 13-Zetakine and HyTK and to be Resistant to Glucocorticoids, in Combination With Interleukin-2 Start of enrollment: 2010 May 01
- Genetically Modified T-cells in Treating Patients With Recurrent or Refractory Malignant Glioma Start of enrollment: 2015 May 18
- Memory-Enriched T Cells in Treating Patients With Recurrent or Refractory Grade III-IV Glioma Start of enrollment: 2018 Aug 14
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Publications & Presentations
PubMed
- 237 citationsReporter gene imaging of targeted T cell immunotherapy in recurrent glioma.Khun Visith Keu, Timothy H. Witney, Shahriar S. Yaghoubi, Jarrett Rosenberg, Anita Kurien
Science Translational Medicine. 2017-01-18 - 37 citationsLocoregional delivery of IL-13Rα2-targeting CAR-T cells in recurrent high-grade glioma: a phase 1 trial.Christine E Brown, Jonathan C Hibbard, Darya Alizadeh, M Suzette Blanchard, Heini M Natri
Nature Medicine. 2024-04-01 - 25 citationsChimeric antigen receptor T-cell therapy for glioblastoma.Analiz Rodriguez, Christine E. Brown, Behnam Badie
Translational Research. 2017-09-01
Press Mentions
- Mustang Bio Announces City of Hope, University of Alabama at Birmingham and Nationwide Children’s Hospital Abstract Accepted for Late-Breaker Poster Presentation at the American Association for Cancer Research (AACR) Annual Meeting 2022March 9th, 2022
- Mustang Bio Announces City of Hope, University of Alabama at Birmingham and Nationwide Children’s Hospital Abstract Accepted for Late-Breaker Poster Presentation at the American Association for Cancer Research (AACR) Annual Meeting 2022March 9th, 2022
- City of Hope Physicians and Scientists Present New Immunotherapy Research at ASCO Virtual ConferenceJune 3rd, 2021
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Grant Support
- Novel Cell Delivery Method for Brain Tumor TherapyNational Cancer Institute (NCI)2014–Present
- Dynamic Magnetic Targeting of Activated Brain Macrophages for Glioma TherapyNINDS2013–Present
- Role Of Receptor For Advanced Glycation END Product (RAGE) Pathway In Brain TumorNational Cancer Institute2011
- Application Of Carbon Nanotubes For Macrophage Activation In Brain Tumor ModelsNational Cancer Institute2009–2010
Professional Memberships
- Member
- Fellow
Other Languages
- Farsi
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