Basil T. Darras MD

Child Neurology•Boston, MA

Professor of Neurology, Boston Children's Hospital and Harvard Medical School

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300 Longwood AveFegan 11Boston, MA 02115
Phone+1 617-355-8235
Fax+1 617-730-0279

Education & Training

Yale-New Haven HospitalPost-Doctoral Fellowship, 1985 - 1988
Tufts Medical CenterFellowship, Child Neurology, 1982 - 1985
Nassau University Medical CenterResidency, Pediatrics, 1979 - 1982
University of AthensClass of 1977

Certifications & Licensure

MA State Medical License 1982 - 2025
American Board of Medical Genetics and Genomics Clinical Genetics
American Board of Pediatrics Pediatrics
American Board of Psychiatry and Neurology Neurology with Special Qualification in Child Neurology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2002-2014
Boston Magazine Castle Connolly, 2008-2013
Boston Herald Castle Connolly, 2005
Super Doctor SuperDoctors.com
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Clinical Trials

Finding the Optimum Regimen for Duchenne Muscular Dystrophy Start of enrollment: 2013 Jan 01
Completed
Phase 3
Prospective, Longitudinal Study of the Natural History and Functional Status of Patients With Myotubular Myopathy (MTM) Start of enrollment: 2014 Feb 01
Completed
A Study to Assess the Efficacy and Safety of Nusinersen (ISIS 396443) in Infants With Spinal Muscular Atrophy Start of enrollment: 2014 Aug 19
Terminated
Phase 3
Extracellular RNA Biomarkers of Duchenne Muscular Dystrophy Start of enrollment: 2019 Nov 30
Recruiting
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Publications & Presentations

PubMed

Analysis of human urinary extracellular vesicles reveals disordered renal metabolism in myotonic dystrophy type 1.
Preeti Kumari, Lauren M Sullivan, Zhaozhi Li, E Parker Conquest, Elizabeth Cornforth
Nature Communications. 2025-03-05
Characterization of swallowing biomechanics and function in untreated infants with spinal muscular atrophy: A natural history dataset.
Katlyn Elizabeth McGrattan, Robert J Graham, Alicia Hofelich Mohr, Anna Miles, Jacqui Allen
Journal of Neuromuscular Diseases. 2025-02-20
1 citations
Spinal Muscular Atrophy Update in Best Practices: Recommendations for Treatment Considerations.
Mary K Schroth, Jennifer Deans, Diana X Bharucha Goebel, W Bryan Burnette, Basil T Darras
Neurology. Clinical Practice. 2025-02-01

Other

Approach to the metabolic myopathies
Darras BT
http://www.uptodate.com/contents/approach-to-the-metabolic-myopathies
UpToDate, Wolters Kluwer Health - 2013-03-05
Treatment of Duchenne and Becker muscular dystrophy
Darras BT
http://www.uptodate.com/contents/treatment-of-duchenne-and-becker-muscular-dystrophy
UpToDate, Wolters Kluwer Health - 2013-03-20
Overview of muscular dystrophies
Darras BT
http://www.uptodate.com/contents/overview-of-muscular-dystrophies-beyond-the-basics
UpToDate, Wolters Kluwer Health - 2012-05-27
Oculopharyngeal, distal, and congenital muscular dystrophies
Darras BT
http://www.uptodate.com/contents/oculopharyngeal-distal-and-congenital-muscular-dystrophies
UpToDate, Wolters Kluwer Health - 2012-10-17
Myotonic dystrophy: Prognosis and management
Darras BT, Chad DA
http://www.uptodate.com/contents/myotonic-dystrophy-prognosis-and-management
UpToDate, Wolters Kluwer Health - 2012-10-26
Myotonic dystrophy: Etiology, clinical features, and diagnosis
Darras BT, Chad DA
http://www.uptodate.com/contents/myotonic-dystrophy-etiology-clinical-features-and-diagnosis
UpToDate, Wolters Kluwer Health - 2012-10-25
Limb-girdle muscular dystrophy
Darras BT
http://www.uptodate.com/contents/limb-girdle-muscular-dystrophy
UpToDate, Wolters Kluwer Health - 2013-01-23
Facioscapulohumeral muscular dystrophy
Darras BT
http://www.uptodate.com/contents/facioscapulohumeral-muscular-dystrophy
UpToDate, Wolters Kluwer Health - 2012-11-26
Energy metabolism in muscle
Darras BT
http://www.uptodate.com/contents/energy-metabolism-in-muscle
UpToDate, Wolters Kluwer Health - 2012-11-01
Emery-Dreifuss muscular dystrophy
Darras BT
http://www.uptodate.com/contents/emery-dreifuss-muscular-dystrophy
UpToDate, Wolters Kluwer Health - 2013-02-28
Clinical features and diagnosis of Duchenne and Becker muscular dystrophy
Darras BT
http://www.uptodate.com/contents/clinical-features-and-diagnosis-of-duchenne-and-becker-muscular-dys
UpToDate, Wolters Kluwer Health - 2012-09-30
Causes of metabolic myopathies
Darras BT
http://www.uptodate.com/contents/causes-of-metabolic-myopathies
UpToDate, Wolters Kluwer Health - 2012-06-02
Glycogen branching enzyme deficiency (glycogen storage disease IV, Andersen disease)
Darras BT, Craigen WJ
http://www.uptodate.com/contents/glycogen-branching-enzyme-deficiency-glycogen-storage-disease-iv-an
UpToDate, Wolters Kluwer Health - 2013-02-13
Phosphorylase b kinase deficiency
Darras BT, Craigen WJ
http://www.uptodate.com/contents/phosphorylase-b-kinase-deficiency
UpToDate, Wolters Kluwer Health - 2013-03-25
Phosphoglycerate kinase deficiency and phosphoglycerate mutase deficiency
Darras BT, Craigen WJ
http://www.uptodate.com/contents/phosphoglycerate-kinase-deficiency-and-phosphoglycerate-mutase-defi
UpToDate, Wolters Kluwer Health - 2012-10-23
Phosphofructokinase deficiency (glycogen storage disease VII, Tarui disease)
Darras BT, Craigen WJ
http://www.uptodate.com/contents/phosphofructokinase-deficiency-glycogen-storage-disease-vii-tarui-d
UpToDate, Wolters Kluwer Health - 2012-10-01
Overview of inherited disorders of glucose and glycogen metabolism
Darras BT, Craigen WJ
http://www.uptodate.com/contents/overview-of-inherited-disorders-of-glucose-and-glycogen-metabolism
UpToDate, Wolters Kluwer Health - 2012-11-13
Other disorders of glycogen metabolism: GLUT2 deficiency and aldolase A deficiency
Darras BT, Craigen WJ
http://www.uptodate.com/contents/other-disorders-of-glycogen-metabolism-glut2-deficiency-and-aldolas
UpToDate, Wolters Kluwer Health - 2012-11-13
Muscle phosphorylase deficiency (glycogen storage disease V, McArdle disease)
Darras BT, Craigen WJ
http://www.uptodate.com/contents/muscle-phosphorylase-deficiency-glycogen-storage-disease-v-mcardle-
UpToDate, Wolters Kluwer Health - 2012-10-01
Lysosome-associated membrane protein 2 deficiency (glycogen storage disease IIb, Danon disease)
Darras BT, Craigen WJ
http://www.uptodate.com/contents/lysosome-associated-membrane-protein-2-deficiency-glycogen-storage-
UpToDate, Wolters Kluwer Health - 2012-08-15
Lysosomal acid maltase deficiency (glycogen storage disease II, Pompe disease)
Darras BT, Craigen WJ
http://www.uptodate.com/contents/lysosomal-acid-maltase-deficiency-glycogen-storage-disease-ii-pompe
UpToDate, Wolters Kluwer Health - 2012-12-14
Lactate dehydrogenase deficiency
Darras BT, Craigen WJ
http://www.uptodate.com/contents/lactate-dehydrogenase-deficiency
UpToDate, Wolters Kluwer Health - 2012-10-23
Glycogen debrancher deficiency (glycogen storage disease III)
Darras BT, Craigen WJ
http://www.uptodate.com/contents/glycogen-debrancher-deficiency-glycogen-storage-disease-iii
UpToDate, Wolters Kluwer Health - 2013-01-18
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Press Mentions

Biogen Announces New Updates Across Its SMA Research Program at 2022 MDA ConferenceMarch 14th, 2022
Genentech’s Evrysdi Continues to Improve Motor Function and Survival in Babies with Type 1 Spinal Muscular Atrophy (SMA)April 15th, 2021
PTC Therapeutics to Host A Conference Call to Review Part 2 of the SUNFISH Clinical Trial Data at the SMA Europe ConferenceFebruary 3rd, 2020
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Grant Support

Ninds Next: Children'S Hospital Boston Clinical Research SiteNational Institute Of Neurological Disorders And Stroke2011
Electrical Impedance Myography And Quantitative Ultrasound In Duchenne Muscular DNational Institute Of Arthritis And Musculoskeletal And Skin Diseases2011
Clinical Study Of Spinal Muscular AtrophyNational Center For Research Resources2006–2007
Dichloroacetate In Mitochondrial DiseaseNational Center For Research Resources2004–2006
Molecular Studies Of Sodium Channels In Skeletal MuscleNational Institute Of Neurological Disorders And Stroke1989–1993