BarryWilliamFestoffMD

Neurology • Kansas City, MO

Neuromuscular Medicine, Neurorehabilitation

"President and Founder pHLOGISTIX LLC Professor of Neurology, University of Kansas Medical Center"

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Office
pHLOGISTIX LLC
1714 Holmes Street, Suite 4
Kansas City, MO 64108
Phone+1 816-679-2915

Fax+1 888-368-2880

Summary

Dr. Barry Festoff is a neurologist in Kansas City, MO who retired from the Kansas City Veterans Affairs Medical Center in 2010 where he had a large research laboratory and established the Muscle & Nerve Clinic. He also retired as Professor of Neurology at The University of Kansas Medical Center where he established the first ALS Clinic and Center in 2024. He received his medical degree from University of Miami Miller School of Medicine and has practiced neurology for more than 50 years. He specialized in neuromuscular medicine and neurorehabilitation and is experienced in concussion neurodiagnostics and drug discovery to treat neuroinflammation in neurodegeneration and neurotrauma. To approach the development of trauma-induced neuroinflammation evolving into neurodegeneration he started the biotechnology company PHLOGISTIX.

PHLOGISTIX LLC

At PHLOGISTIX we research critical pathways involving neuro-coagulation and neuroinflammation to develop novel new drugs to help athletes, soldiers and others.

Education & Training

University of Miami/Jackson Health SystemResidency, Neurology, 1969 - 1971
Duke University HospitalResidency, Internal Medicine, 1966 - 1969
University of Miami Leonard M. Miller School of MedicineClass of 1966, M.D.
University of FloridaBA, 1958 - 1962

Certifications & Licensure

MO State Medical License 1980 - 2025
American Board of Psychiatry and Neurology Neurology

Awards, Honors, & Recognition

Visiting Professor Consumer’s Research Council of America; Visiting Professor, University of British Columbia, Vancouver, 2010
Visiting Professor University of Calgary, 2010
Visiting Professor Florida International University, 2009
Visiting Professor Sackler Medical School, Tel Aviv University, Sheba Medical Cente, 2006
Visiting Neuroscientist Experimental Neuropharmacology, Oxford University, Oxford, UK, 2005
Scientific Advisory Committee Western ALS (WALS) Consortium, 2004
Elected to ASIA American Spinal Injury Association, 2004
Chair ymposium on PARs in CNS Development, Sydney, Australia, 2002
Colloquium Chair on PARs in the Nervous System American Society for Neurochemistry, Palm Beach, FL, 2002
Invited Speaker 2nd International Society for Proteolysis Congress, Munich, Germany, 2001
Session Chair and Speaker Thrombin, PARs and Neurodegeneration, FASEB Summer Research Conf, 2001
Faculty Research Investigator Award University of Kansas Medical Center, 2001
Invited speaker ransglutaminases and Neurodegeneration Symposium, American Society for Neurochemistry, Chicago, 2000
Organizer and invited speaker Congress on Neuroprotection and Neurorepair, Magdeburg, Germany, 2000
Invited speaker Fondation Ipsen, Symposium on Protein Aggregation in Neurodegeneration, Paris, 2000
Inducted University of Miami School of Medicine Hall of Fame, 1999
VA National Research Middleton Award Chancellor's Club Research University of Kansas, 1999
Poste Verte Visiting Scientist, Laboratoire de Plasticité Cérébrale, Université de Montpellier II, Montpellier, FRANCE;, 1998
Session chair Neurobiology and Beyond, Thrombin and Vascular Medicine, FASEB Summer Research Conference, Saxton's River, VT; Symposium speaker, Neuronal Cell Death During Development and Disease, 3rd International Society of African Neuroscience, Capetown, South Af, 1997
Session chair Extravascular Effects of Thrombin, FASEB Summer Research Conference, Newer Aspects of Thrombin, Copper Mountain, CO; Special Emphasis Panel, NHLBI, NIH, Bethesda, 1995
Professeur et Chaire de l'Académie des Sciences Française French Academy of Sciences, Institut de France, Paris, FRANCE, 1994
Behavioral and Neuroscience Special Emphasis Panel, NLS3-1 Study Section, NIH, DRG, Bethesda, MD; Short Term Fellow, Somatic Cell and Molecular Genetics Course, Eleanor Roosevelt University of Colorado Medical Center, 1993
Member Credentialing and Publications Committees, American Society for Neurorehabilitation, 1992
Invited Speaker, International Symposium on Space Biology and Medicine COSMOS, Leningrad, USSR, 1991
Member eurobiology Merit Review Panel, Veterans Affairs, 1990
Chair Working Group on Defining Biochemical and Molecular Biology Limits of ALS, 1990
Organizer and Director, Advanced Research Workshop "Regulation of Extravascular Fibrinolytic Enzymes and Their Inhibitors, the Serpins, in the Nervous System" NATO, 1989
Named as Long Term representative American Academy of Neurology to Council of Medical Sub-Specialty Societies, 1988
Scientific Advisory Board nternational ALS.MND Research Foundation Monteggio, 1987
National Advisory Board ALS/Neuromuscular Disease Research Foundation Pacific Medical Center, San Francisco, CA, 1987
Biographical listing Who's Who in the Midwest, 1986
Career Development Awardee, Medical Investigatorship Award Veterans Administration, 1985
Elected Member The American Society for Clinical Investigation, 1984
Visiting Scientist (Maitre de Recherche, 1 Classe) Institut National de la Santé et de la Recherche Medicale (I.N.S.E.R.M.), 1984
Elected, Member of The Corporation Marine Biological Laboratory, Woods Hole, MA, 1984
American Academy of Neurology National ALS Foundation, 1983
Elected Fellow American Academy of Neurology, 1982
Elected Member American Neurological Association, 1980
Elected Member Elected to American Society of BiAmerican Society of Molecular Biology and Biochemistry, 1980
Elected to American Neurological Association National Amyotrophic Lateral Sclerosis Foundation, 1980
Elected to American Society of Biological Chemists merican Society of Molecular Biology and Biochemistry, 1980
Organizing Committee Symposium on Clinical Management of Patients with Amyotrophic Lateral Sclerosis, 1979
Examiner Neurology, American Board of Psychiatry and Neurology, 1977
Mary Jennifer Selznick Fellow Workshop on Huntington's and other Genetic Disease, 1976
Chairman Session on Phospholipids, American Society for Neurochemistry Annual Meeting, 1976
Chairman Neurochemistry Session, Sixth Annual Meeting, Society for Neuroscience, 1976
Principal Proponent Veterans Administration, 1976
A.F.Bennett Basic Research Award Society of Biological Psychiatry, 1969
National Multiple Sclerosis postdoctoral Fellowship, Molecular Neurobiology Lab Duke University, 1968
NIH postdoctoral Fellowship, Research Training Program in Molecular Biology Duke University, 1967
Medical School Research Award, 2nd Prize Peninsula Life Insurance Scholarship, 1966
Roche Medical Student Award Peninsula Life Insurance Scholarship, 1966
Dr. Joseph Collins Foundation Scholarship, 1966
Elected Alpha Omega Alpha Medical Honorary Society, 1965
Freshman Anatomy Award 1963
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Publications & Presentations

PubMed

36 citations
Bioenergetic dysfunction and inflammation in Alzheimer's disease: a possible connection
Heather M. Wilkins, Steven M. Carl, Alison C. S. Greenlief, Barry W. Festoff, Russell H. Swerdlow
Frontiers in Aging Neuroscience. 2014-11-10
140 citations
Microglial activation, increased TNF and SERT expression in the prefrontal cortex define stress-altered behaviour in mice susceptible to anhedonia
Yvonne Couch, Daniel C. Anthony, Oleg V. Dolgov, Alexander Revischin, Barry W. Festoff
Brain, Behavior, and Immunity. 2013-03-01
45 citations
β-Synuclein Reduces Proteasomal Inhibition by α-Synuclein but Not γ-Synuclein
Heather Snyder, Kwame Mensah, Cindy H. Hsu, Makoto Hashimoto, Irina Surgucheva
The Journal of Biological Chemistry. 2005-03-04

Journal Articles

Microglial activation, increased TNF and SERT expression in the prefrontal cortex define stress-altered behaviour in mice susceptible to anhedonia
Couch, Y., Anthony, D. C., Dolgov, O., Revischin, A., Festoff, B., Santos, A. I., Steinbusch, H. W. and Strekalova, T., Brain Behavior and Immunity, 3/2013
Localization of apoliporotein E to neuromuscular synapses in rat, mouse and man.
Akaaboune, M., Festoff, B.W., Villanova, M. and Hantaï, D, FEBS Lett
Insulin-like growth factor binding protein-1 is pre-synaptic at mouse neuromuscular synapses and is transported in nerve.
Ma, J.Y., Yang, S.X., Ho, G.J. and Festoff, B.W, Neurochem
Sérine protéases et leurs inhibiteurs: leur rôle dans la différenciation du système neuromusculaire.
Hantaï, D., Akaaboune, M., Verdière-Sahuqué, M., Lachkar, S. et Festoff, B.W, Compte Rendu Soc
Effects of sub-lethal injection of botulinum toxin on ultraterminal nerve sprouts and plasminogen activators in mouse skeletal muscle.
Tian, W.-H., Festoff, B.W., Blot, S., Diaz, J. and Hantaï, D, Synapse
Efficacy of recombinant insulin-like growth factor I in a double-blind, placebo-controlled, randomized, parallel treatment trial in amyotrophic lateral sclerosis.
Lai, E.C., Felice, K.J., Festoff, B.W., Gawel, M.J., Gelinas, D.F., Kratz, R., Murphy, M.F., Natter, H.M., Norris, F.H., Jr., and Rudnicki, S.A, Neurology
Active thrombin and prothrombin levels in the cerebrospinal fluid of patients with degenerative, malignant and traumatic disorders.
Smirnova, I.V., Salazar, A.M., Handler, M., Glatt, S., Citron, B.A., Gregory, E., Arnold, P.M. and Festoff, B.W, Thromb
Protein crosslinking, tissue transglutaminase, alternative splicing and neurodegeneration.
Citron, B.A., Suo, Z., SantaCruz, K.S., Davies, P.J. A., Qin, F. and. Festoff, B.W, Neurochem
Spinal cord injury and neuronal cell death: apoptosis and implications for future treatment.
Citron B.A, Arnold, P.M., Ameenuddin, S. and Festoff, B.W, Sem
Persistent protease- activated receptor 4 signaling mediates thrombin-induced microglial activation.
Suo, Z., Wu, M., Citron, B.A., Gao, C., Festoff, B.W, J Biol
Proteinase-activated receptors in the nervous system: Roles in neuroplasticity and neurotrauma.
Festoff, B.W, Drug Dev
Magnetic resonance imaging of mouse spinal cord.
Bilgen, M., Al-Hafez, B., Berman, N.E. and Festoff, B.W, Magn. Reson
Novel mutation in VCP gene causes atypical amyotrophic lateral sclerosis.
González-Pérez, P., Cirulli, E.T., Drory, V.E., Dabby, R., Nisipeanu, P., Carasso, R.L., Sadeh, M., Fox, A., Festoff, B.W., Sapp, P.C., McKenna-Yasek, D., Goldstein,..., Neurology
Soluble thrombomodulin levels in plasma of multiple sclerosis patients and their implication.
estoff, B.W., Li, C-Y, Woodhams, B., Lynch, S, J. Neurolog
Role of thrombomodulin’s lectin-like domain in recovery after spinal cord injury in mice.
Vogeti, S., Chou, C-T, Conway, E.M. and Festoff, B.W, in review
Transcriptional activity of neurodegeneration in cultured motor neurons and wobbler mice.
Citron B.A., Schramp, M., Wong, A., Ameenudin, S. and Festoff B.W, in review
Upregulation of spinal cord dorsal horn proteinase-activated receptor 2 in neuroinflammatory pain models in rats.
Festoff, B.W., Oriti, L.A., McCarson, K. and Citron, B.A, in review
Phenytoin and the "safety margin" of neuromuscular transmission.
Franco, L.F. and Festoff, B.W, Trans. Amer. Neurol.Assoc
Adenylate cyclase system of human skeletal muscle. Characteristics of catecholamine stimulation and nucleotide regulation.
Reddy, N.B., Oliver, K.L., Festoff, B.W. and Engel, W.K, Biochim. Biophys
Adenylate cyclase system of human skeletal muscle. Subcellular distribution and general properties.
Reddy, N.B., Oliver, K.L., Festoff, B.W. and Engel, W.K, Biochim. Biophys
Neurotrophic regulation of 16S acetylcholinesterase at the vertebrate neuromuscular junction
Fernandez, H.L., Duell, J.J., and Festoff, B.W, J. Neurobiol
Insulin receptor on monocytes of MyD patients.
Festoff, B.W. and Moore, W.V., Jr, Trans. Am. Neurol. Assoc
Circulating protease inhibitors in ALS: Reduced alpha-2- macroglobulin.
Festoff, B.W, Trans. Amer. Neurol. Assoc
Trismus: A new sign in polymyositis.
Chikarmane, A., Singer, P.A. and Festoff, B.W, Trans. Amer. Neurol. Assoc
amilial myasthenia with marked type II atrophy and negative antibody studies.
Chikarmane, A., Kepes, J., Singer, P.A. and Festoff, B.W, Trans. Amer. Neurol. Assoc
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Books/Book Chapters

Serine Proteases and Their Serpin Inhibitors in the Nervous System: Roles in Development and Malignant and Degenerative Disease.
Chapter: Serpins and brain tumors: roles in pathogenesis
Page 301 - 312Rao, J.S., Suzuki, R. and Festoff, B.WEditors: Festoff, B.W.Plenum Press, New York
The Spinal Cord.
Chapter: Amyotrophic lateral sclerosis: The syndrome, its pathophysiology and approach to treatment
Page 607 - 664Festoff, B.WEditors: R.A. Davidoff.Marcel Dekker, New YorkEdition 5,
Encyclopedia of Neuroscience.
Chapter: Muscular Dystrophies, dystrophies
Page 723 - 724Festoff, B.W. and Rao, J.SEditors: Adelman, G.Birkhauser, Boston
Realities in Coping with Progressive Neuromuscular Diseases.
Chapter: The decision-making process in amyotrophic lateral sclerosis
Cobb, A.C., Hamera, E. and Festoff, B.WEditors: Charash, L.I., Lovelace, R.E., Wolf, S.G., Kutscher, A.H., Roye, D.P. and Leach, C.F.The Charles Press, Philadelphia, PA
Advances in Neuromuscular Diseases.
Chapter: Therapeutic trial of recombinant human growth hormone in amyotrophic lateral sclerosis
Page 117 - 126Festoff, B.W., Melmed, S., and Smith, R.AEditors: Serratrice, G., Pellissier, J-F., Desnuelle, C. and Pouget, J.Expansion Scientifique Française, Paris
Progress in Clinical Trials. Amyotrophic Lateral Sclerosis.
Chapter: The future of clinical trials in amyotrophic lateral sclerosis: the recombinant era
Page 1 - 14Festoff, B.WEditors: F.C. Rose.Demos Publications, New York
Progress in Clinical Trials. Amyotrophic Lateral Sclerosis.
Chapter: The influence of compliance and other human factors on treatment trials
Page 45 - 52Smith, R.A., Jacoby, S. and Festoff, B.W., Peterson, L., Melmed, S., Molnar, G., Sherman, B. and Frane, JEditors: F.C. Rose.Demos Publications, New York
Serine Proteases and Their Serpin Inhibitors in the Nervous System: Roles in Development and Malignant and Degenerative Disease.
Chapter: Plasminogen activators in development, injury and pathology of the neuromuscular system
Page 219 - 228Hantaï, D., Soria, C., Soria, J., Blondet, B., Barlovatz-Meimon, G., Rao, J.S. and Festoff, B.WEditors: Festoff, B.W.Plenum Press, New York
Serine Proteases and Their Serpin Inhibitors in the Nervous System: Roles in Development and Malignant and Degenerative Disease.
Chapter: A cascade approach to synapse formation based on thrombogenic and fibrinolytic models
Page 245 - 254Festoff, B.W., Rao, J.S., Reddy, B.R. and Hantaï, DEditors: Festoff, B.W.Plenum Press, New York
Molecular Neurobiology.
Chapter: Muscle adhesive basement membrane proteins are degraded by plasminogen activator in the presence of plasminogen
Page 167 - 171Hantaï, D. and Festoff, B.WEditors: Levi-Montalcini, R., Calissano, P., Kandel, E. and Maggi, A.Springer-Verlag, Berlin
Handbook of Amyotrophic Lateral Sclerosis.
Chapter: Protease cascade dysregulation and synaptic degeneration: A unifying pathogenetic hypothesis for amyotrophic lateral sclerosis
Page 661 - 685Festoff, B.WEditors: Smith, R.A.Marcel Dekker, New York
ALS--From Charcot to the present and into the future.
Chapter: The insulin-like growth factor signaling system and therapeutic potential of recombinant IGF-I in amyotrophic lateral sclerosis
Page 239 - 251Festoff, B.W., Al-Arabi, A., Iqbal, M. and Yang, S.X.Editors: Rose, F.C.Smith-Gordon, London
Final Reports of the U.S. Experiments Flown on the Soviet Biosatellite Cosmos 2044.
Chapter: Changes in muscle serine proteases, serpins and matrix molecules
Page 239 - 254Festoff, B. W., Ilyina-Kakueva, E. I., Rayford, A. R., Burkovskaya, T. E., Reddy, B. R. and Rao, J. SEditors: Connolly, J. P., Grindeland, R. E. and R. W. Ballard.Ames Research Center, Moffett Field, CAEdition 2,
Growth Hormone Releasing Hormone, Growth Hormone and IGF-I: Basic and Clinical Advances.
Chapter: Strategies for the use of recombinant human growth hormone and insulin-like growth factor I in amyotrophic lateral sclerosis
Page 110 - 128Festoff, B.W., Yang, S.X. and Stong, DEditors: Blackman, M.R., Harman, S.M., Roth, J. and Shapiro, J.R.Springer Verlag, New York
he Synapse: In development, health, and disease.
Chapter: hifts in the thrombin:protease nexin I balance in postnatal and degenerative synapse elimination
Page 351 - 375Festoff, B.W., Citron, B.A., and Smirnova, I.VEditors: Festoff, B.W., Guest editor, Hantaï, D., and Citron, B.A.JAI Press, Greenwich, CT
Neuroprotective Signal Transduction.
Chapter: Clinical potential of agents that affect thrombin signaling in degenerative and traumatic neurologic disorders
Page 221 - 241estoff, B.WEditors: Mattson, M.P.Humana Press, Totowa, NJ
Nature Encyclopedia of Life Sciences.
Chapter: Amyotrophic Lateral Sclerosis
Page 1 - 4Festoff, B.WNature Publishing Group, London
Proteases in the Brain.
Chapter: Role of proteinase-activated receptors in brain function: Thrombin signaling and its interacting players in physiologic and pathophysiologic processes
Page 323 - 350Festoff, B.WEditors: Lendeckel, U. and Hooper, N.Kluwer Academic/Plenum, New YorkEdition 3,
Growth and Trophic Factors.
Chapter: Dose-dependent initiation of myogenesis by neurotrophic factor
Page 547 - 567Popiela, H., Ellis, S. and Festoff, B.WEditors: J.R. Perez-Polo, J. de Vellis and B. Haber.Alan R. Liss, New York
Advances in Organ Biology.
Chapter: The Synapse in Development, Health and Disease
Festoff, B.WEditors: Hantaï, D. and Citron, B.A.JAI Press, GreenwichEdition 2,
Pathogenesis of Human Muscular Dystrophies.
Chapter: Genetic alterations in surface membranes
Festoff, B.WEditors: L.P. Rowland. Excerpta Medica, Amsterdam
Maturation of Neurotransmissio.
Chapter: Trophic effects of axonally transported proteins on muscle cells in culture
Page 152 - 158Festoff, B.W., Duell, M.J. and Fernandez, H.LEditors: A. Vernadakis, E. Giacobini and G. Filogamo.S.Karger, Base
Current Topics in Nerve and Muscle Research, (A.J. Aguayo and G. Karpati.
Chapter: Role of cyclic nucleotides in skeletal muscle metabolism
Page 61 - 72Festoff, B.WEditors: A.J. Aguayo and G. Karpati. Excerpta Medica, Amsterdam
Amyotrophic Lateral Sclerosis: Diagnosis and Treatment.
Chapter: Therapeutic trials in amyotrophic lateral sclerosis
Page 337 - 366Festoff, B.W. and Crigger, N.JEditors: D.M. Mulder.Houghton Mifflin, Boston
Diabetic Neuropathy.
Chapter: Correlation of hemoglobin A1 and nerve conduction studies in diabetic patients
Page 331 - 335Singer, P.A., Festoff, B.W., Reeder, A.N., Spencer, L., Hassanein, K. and Hartman, CEditors: Y. Goto, A. Horiuchi and K. Kogure.Excerpta Medica, Amsterdam-Oxford
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Abstracts/Posters

In vitro in corporation of 14C- glucosamine into membranes of rat brain synaptosomes.
Festoff, B.W., Appel, S.H.and Day, E.E, Fed.Proc
The effect of diphenylhydantoin on synaptosome metabolism.
Festoff, B.W. and Appel, S.H, Neurology
Xeroderma pigmentosum: Neurological and cutaneous abnormalities associated with a defect in DNA repair.
Festoff, B.W. and Kraemer, K.H, Neurology
Muscle plasma membranes: An in vitro approach to evaluation of their general functions and junctional receptor properties.
Festoff, B.W., Sciabbarasi, J.S. and Engel, W.K, Third Annual Meetin
Further in vitro studies of skeletal muscle sarcolemma.
Reddy, N.B., Tsukui, R., Engel, W.K. and Festoff, B.W, Fourth Annual Meeting
Neuromuscular blockade with anti-nerve soluble-protein antibodies.
Festoff, B.W., Rosenbaum, R.B., Kula, R.W. and Engel, W.K, Neurology
Anti-sarcoplasmic reticulum antibodies: differential effects on SR functional properties.
Festoff, B.W., Reddy, N.B. and Engel, W.K, Neurosci
Neurotrophic control of adenylate cyclase in fast and slow twitch skeletal muscles.
Reddy, N.B., Oliver, K.L., Engel, W.K. and Festoff,B.W, Fed. Proc
Membrane proteins of cultured myoblasts and fibroblasts.
Festoff, B.W, J. Cell Biol
Studies of a nerve extract with trophic properties.
Festoff, B.W. and Isreal, R.S, Neurosci
Effects of neurotrophic proteins on muscle cells in culture. Satellite Symposium, International.
Festoff, B.W., Duell, M.J., White, T.G. and Fernandez, H.L, ociety for Neurochemistry, Vincent, Italt
Macromolecular correlates of cell adhesion in surface membranes of primary and clonal muscle cells.
Festoff, B.W., Miller, S. and White, T.G, 6th International Meeting of International Society for Neurochemistry, Copenhagen
Na-K pump ratio in myotonic dystrophy.
Hobbs, A.S. and Festoff, B.W., 11th World Congress of Neurology, Amsterdam
Cell surface protein development in post-mitotic, pre- fusional chick embryo myoblasts.
Festoff, B.W. and Miller, S, Neurosci
Neurotrophic protein(s): Role of axonal transport in their intracellular movement.
Fernandez, H.L., Duell, M.J., White, T.G. and Festoff, B.W, Neurosci
evelopmental changes in the phospholipid composition of C6 astroglioma cells in vitro.
Dorman, R.V. and Festoff, B.W, Neurosci
lteration of muscle phospholipid composition following denervation.
Dorman, R.V., Fernandez, H.L. and Festoff, B.W, Neurochem
Neurotrophic regulation of 16S muscle end-plate acetylcholinesterase.
Fernandez, H.L., Duell, M.J. and Festoff, B.W, IVth International Congress on Neuromuscular Diseases, Montreal
Presence of 16S acetylcholinesterase in neural tissue and its bi-directional transport.
Festoff, B.W., Duell, M.J.and Fernandez, H.L, IVth International Congress on Neuromuscular Diseases, Montreal
Bi-directional axonal transport of macromolecular (16S) acetylcholinesterase.
Festoff, B.W. and Fernandez, H.L, Neurosci
Cellular distribution of 16S acetylcholinesterase in mammalian tissues.
Duell, M.J., Fernandez, H.L., and Festoff, B.W, Neurosci
Developmental appearance of acetylcholinesterase molecular forms in chick muscle culture.
Patterson, M.R., Fernandez, H.L.and Festoff, B.W, Neurosci
Neurotrophic control of 16S acetylcholinesterase at the neuromuscular junction.
Fernandez, H.L. and Festoff, B.W, Neurosci
Two parameter cell sorting of chick spinal cord motor neurons.
Piper, S.T. and Festoff, B.W, Neurochem
Two parameter cell sorting of dissociated chick spinal cord.
Piper, S.T. and Festoff, B.W, Cell Tissue Kinet
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