Barry A Borlaug MD

Cardiology•Rochester, MN

Heart Failure & Transplantation

Associate Professor, Internal Medicine, Mayo Medical School

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200 1st St SwRochester, MN 55905
Phone+1 507-284-2511

Summary

After graduating from medical school at the University of Wisconsin, Dr. Borlaug trained in internal medicine at the Brigham and Women’s Hospital in Boston, Massachusetts and cardiovascular medicine at the Johns Hopkins Hospital in Baltimore, Maryland prior to joining the cardiovascular division of the Mayo Clinic in Rochester, Minnesota where he is currently Associate Professor of Medicine and Director of Circulatory Failure research. Dr. Borlaug’s research interests focus on the pathophysiology, diagnosis and treatment of heart failure, particularly heart failure with preserved ejection fraction, with an emphasis on hemodynamics. He has published over 80 articles in peer reviewed journals on these topics. Dr. Borlaug is an active member of the American College of Cardiology, American Heart Association, Heart Failure Society of America, International Society for Heart and Lung Transplantation, and the Society of Cardiac Angiographers and Interventionalists.

Education & Training

Johns Hopkins UniversityFellowship, Cardiovascular Disease, 2002 - 2005
Mass General Brigham/Brigham and Women's HospitalResidency, Internal Medicine, 1999 - 2002
University of Wisconsin School of Medicine & Public HealthClass of 1999

Certifications & Licensure

MN State Medical License 2006 - 2026
WI State Medical License 2014 - 2017
PA State Medical License 2005 - 2006
American Board of Internal Medicine Advanced Heart Failure and Transplant Cardiology

Awards, Honors, & Recognition

Fellow (FACC) American College of Cardiology

Clinical Trials

Heart Failure and a Preserved Ejection Fraction Start of enrollment: 2007 Apr 01
Completed
Mechanisms in Heart Failure With Normal EF Start of enrollment: 2007 Nov 01
Completed
Study of Exercise and Heart Function in Patients With Heart Failure and Pulmonary Vascular Disease Start of enrollment: 2011 Aug 01
Completed
Acute Effects of Inorganic Nitrite on Cardiovascular Hemodynamics in Heart Failure With Preserved Ejection Fraction Start of enrollment: 2013 Aug 01
Completed
Phase 2
New Methods to Diagnose Constrictive Pericarditis Start of enrollment: 2013 Dec 01
Withdrawn
Not Applicable
Efficacy Study of Pacemakers to Treat Slow Heart Rate in Patients With Heart Failure Start of enrollment: 2014 Apr 07
Completed
Not Applicable
Inhaled Sodium Nitrite on Heart Failure With Preserved Ejection Fraction Start of enrollment: 2014 Oct 01
Completed
Phase 2
Inorganic Nitrite to Amplify the Benefits and Tolerability of Exercise Training in Heart Failure With Preserved Ejection Fraction (HFpEF) (INABLE-Training) Start of enrollment: 2016 Sep 01
Completed
Phase 2
Pericardial Resection to Treat Heart Failure Start of enrollment: 2017 Mar 20
Completed
Not Applicable
Myeloperoxidase (MPO) Inhibitor A_Zeneca for Heart Failure With Preserved Ejection Fraction (HFpEF) Start of enrollment: 2018 Jul 01
COMPLETED
PHASE1, PHASE2
Minimally Invasive Pericardiotomy as a New Treatment for Heart Failure Start of enrollment: 2019 May 01
Completed
Not Applicable
Pulmonary Hemodynamics During Exercise - Research Network Start of enrollment: 2018 Dec 01
Recruiting
Roles: Contact
Assessment of Pulmonary Congestion During Cardiac Hemodynamic Stress Testing Start of enrollment: 2019 Nov 08
Terminated
Not Applicable
Dapagliflozin (DAPA) Effects in HFpEF Start of enrollment: 2021 Feb 24
Completed
Phase 2
Pulmonary Hypertension in Left Heart Disease Start of enrollment: 2023 Jul 20
RECRUITING
Roles: Contact, Principal Investigator
Contrast Echocardiography During Exercise to Assess Pulmonary Blood Volume Start of enrollment: 2024 Jul 30
RECRUITING
Roles: Contact, Principal Investigator
CArdioMEtabolic Function and Reserve Capacity in Healthy Adults: The CAMERA Study Start of enrollment: 2025 Oct 01
RECRUITING
NA
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

Temporal changes in prevalence and severity of pulmonary hypertension, and relationship to outcomes in coarctation of aorta.
Ahmed Younis, Yogesh N V Reddy, William R Miranda, Ahmed T Abdelhalim, Barry A Borlaug
International Journal of Cardiology. Heart & Vasculature. 2025-04-01
1 citations
Prevalence, aetiology, and outcomes of native pulmonary regurgitation in the general adult population.
Jwan A Naser, Hossam Ibrahim, Kartik Andi, Christopher G Scott, Patricia A Pellikka
European Heart Journal. Cardiovascular Imaging. 2025-03-27
Interplay of Chronic Kidney Disease and the Effects of Tirzepatide in Patients With Heart Failure, Preserved Ejection Fraction, and Obesity: The SUMMIT Trial.
Milton Packer, Michael R Zile, Christopher M Kramer, Masahiro Murakami, Yang Ou
Journal of the American College of Cardiology. 2025-03-24

Journal Articles

Application of Diagnostic Algorithms for Heart Failure with Preserved Ejection Fraction to the Community
Dalane W Kitzman, Barry A Borlaug, Amil M Shah, JACC: Heart Failure
Clinical Research Central and Peripheral Determinants of Exercise Capacity in Heart Failure Patients with Preserved Ejection Fraction
Sanjiv J Shah, Dalane W Kitzman, Barry A Borlaug, Daniel Burkhoff, ScienceDirect
Effect of Inorganic Nitrite vs Placebo on Exercise Capacity Among Patients with Heart Failure with Preserved Ejection Fraction
Gregory D Lewis, David J Whellan, Martin M LeWinter, Margaret M Redfield, Andrew L Smith, Eugene Braunwald, Michael M Givertz, Adrian F Hernandez, Sanjiv J Shah, Horng..., JAMA
Venous Congestion and Pulmonary Vascular Function in Fontan Circulation: Implications for Prognosis and Treatment
Alexander C Egbe, Barry A Borlaug, International Journal of Cardiology
Exercise Ventilatory Inefficiency in Heart Failure and Chronic Obstructive Pulmonary Disease
Barry Borlaug, MD, International Journal of Cardiology
Heart Failure with Preserved Ejection Fraction Expert Panel Report
Kishan S Parikh, Howard K Surks, Sanjiv J Shah, Marvin A Konstam, Margaret M Redfield, Robert M Califf, Kavita Sharma, Narimon Honarpour, Gregory D Lewis, Scott D Solo..., ScienceDirect
Exercise Unmasks Distinct Pathophysiologic Features in Heart Failure with Preserved Ejection Fraction and Pulmonary Vascular Disease
Barry Borlaug, MD, European Heart Journal
Mini-Focus Issue: Exercise Performance and Cardiac Rehabilitation Relative Impairments in Hemodynamic Exercise Reserve Parameters in Heart Failure with Preserved Eject...
Barry A Borlaug, Dalane W Kitzman, Rohan Khera, Gregory D Lewis, Javed Butler, ScienceDirect
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Lectures

HFpEF: Why Is My Patient Huffing and Puffing? How Can We Help?
2019 ACC Scientific Session & Expo, New Orleans - 3/17/2019
The Connection Between Obesity and HFpEF: More Than What Meets the Eye?
2019 ACC Scientific Session & Expo, New Orleans - 3/17/2019
Exercise Hemodynamics: When to Test and What Do the Numbers Mean?
2019 ACC Scientific Session & Expo, New Orleans - 3/16/2019

Other

Editorial Comment the Other Atrium in Heart Failure∗
Barry Borlaug, MD, ScienceDirect
https://www.doximity.com/articles/14c98790-28ea-42e1-94b3-874d1c080933
UpToDate, Wolters Kluwer Health - 2012-07-25
Clinical Research Hemodynamic Correlates and Diagnostic Role of Cardiopulmonary Exercise Testing in Heart Failure with Preserved Ejection Fraction
Barry Borlaug, MD, ScienceDirect
https://www.doximity.com/articles/a2b890ed-e92c-4eed-bb94-5dffc2d16d21
UpToDate, Wolters Kluwer Health - 2012-11-21

Authored Content

Application of Diagnostic Algorithms for Heart Failure with Preserved Ejection Fraction to the CommunityJuly 2020
Application of Diagnostic Algorithms for Heart Failure with Preserved Ejection Fraction to the CommunityJune 2020
Invasive and Noninvasive Hemodynamic Assessment in Adults with Fontan PalliationDecember 2017

Press Mentions

New GLP-1 Data Reinforce CV BenefitFebruary 21st, 2025
Tirzepatide Helps in HFpEF Across Spectrum of Obesity SeverityFebruary 12th, 2025
NT-proBNP Cutoffs for HFpEF Diagnosis May Need TweakingJanuary 29th, 2025
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