Babak Razani MD PhD

PubMed

• Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression.
  Isidoro Cobo, Jessica Murillo-Saich, Mohnish Alishala, Stephen Calderon, Roxana Coras
  Immunity. 2025-03-20
• Identification of lysosomal lipolysis as an essential noncanonical mediator of adipocyte fasting and cold-induced lipolysis.
  Yu-Sheng Yeh, Trent D Evans, Mari Iwase, Se-Jin Jeong, Xiangyu Zhang
  The Journal of Clinical Investigation. 2025-03-17
• 1 citations
  Neutrophil CRACR2A Promotes Neutrophil Recruitment in Sterile Inflammation and Ischemic Stroke.
  Jingu Lee, Brett Balzraine, Alexis Schweizer, Vasilisa Kuzmanova, Yousang Gwack
  Circulation. 2025-03-11

Journal Articles

• PPARγ Deficiency Suppresses the Release of IL-1β and IL-1α in Macrophages via a Type 1 IFN–Dependent Mechanism  
  Kassandra J Weber, Joel D Schilling, Babak Razani, The Journal of Immunology
• Ursolic acid enhances macrophage autophagy and attenuates atherosclerosis  
  Leng S, Iwanowycz S, Saaoud F, Wang J, Wang Y, Sergin I, Razani B, and Fan D., J Lipid Res, 1/1/2016
• Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages protect against atherosclerosis  
  Sergin I, Bhattacharya S, Emanuel R, Esen E, Stokes CJ, Evans TD, Arif B, Curci JA, and Razani B., Sci Signal., 1/1/2016
• Degradation and Beyond: The Macrophage Lysosome as a Nexus for Nutrient Sensing and Processing in Atherosclerosis  
  Sergin I, Evans TD, and Razani B., Curr Opin Lipidol, 1/1/2015
• Can the DNA Damage Response be Harnessed to Modulate Atherosclerotic Plaque Phenotype?  
  Razani B and Raines EW., Circ Res, 1/1/2015
• Hypoxia in Plaque Macrophages: A New Danger Signal for Interleukin-1Beta Activation?  
  Sergin I, Evans TD, Bhattacharya S, and Razani B, Circ Res, 1/1/2014
• Self-eating in the Plaque: What Macrophage Autophagy Reveals About Atherosclerosis  
  Sergin I and Razani B., Trends Endocrinol Metab, 1/1/2014
• Induction of a Lysosomal Biogenesis Program in Atherosclerotic Macrophages Can Rescue Lipid-Induced Lysosomal Dysfunction and Downstream Sequelae  
  Emanuel R, Sergin I, Bhattacharya S, Turner J, Epelman S, Settembre C, Diwan A, Ballabio A, and Razani B., Arterioscler Thromb Vasc Biol., 1/1/2014
• Embryonic and adultderived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation  
  Epelman S, Lavine KJ, Beaudin AE, Sojka DK, Carrero JA, Calderon B, Brija T, Gautier EL, Ivanov S, Satpathy AT, Schilling JD, Schwendener R, Sergin I, Razani B, Forsbe..., Immunity, 1/1/2014
• Interleukins and Atherosclerosis: A Dysfunctional Family Grows  
  Spears LD, Razani B, and Semenkovich CF., Cell Metab, 1/1/2013
• Inhibiting adipose tissue lipogenesis reprograms thermogenesis and PPARgamma activation to decrease diet-induced obesity  
  Lodhi IJ, Yin L, Jensen-Urstad AP, Funai K, Coleman T, Baird JH, El Ramahi MK, Razani B, Song H, Fu-Hsu F, Turk J, and Semenkovich CF, Cell Metab., 1/1/2012
• The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy  
  Lei Y, Wen H, Yu Y, Taxman DJ, Zhang L, Widman DG, Swanson KV, Wen KW, Damania B, Moore CB, Giguere PM, Siderovski DP, Hiscott J, Razani B, Semenkovich CF, Chen X, and..., Immunity, 1/1/2012
• Autophagy links inflammasomes to atherosclerotic progression  
  Razani B, Feng C, Coleman T, Emanuel R, Wen H, Hwang S, Ting JP, Virgin HW, Kastan MB, and Semenkovich CF., Cell Metab, 1/1/2012
• Fatty Acid Synthase modulates homeostatic responses to myocardial stress  
  Razani B, Zhang H, Schulze PC, Schilling JD, Verbsky J, Lodhi IJ, Topkara VK, Feng C, Coleman T, Kovacs A, Kelly DP, Saffitz JE, Dorn GW II, Nichols CG, and Semenkovic..., J Biol Chem., 1/1/2011
• Atheroprotective but not insulin sensitizing effects of chloroquine are p53-dependent  
  Razani B, Feng C, and Semenkovich CF., J Lipid Res, 1/1/2010
• Getting away from glucose: stop sugarcoating diabetes  
  Razani B and Semenkovich CF., Nat. Med., 1/1/2009
• Insulin resistance and atherosclerosis  
  Razani B, Chakravarthy MV, and Semenkovich CF, Endocrinol. Metab. Clin. North Am., 1/1/2008
• Combined loss of INK4a and caveolin-1 synergistically enhances cell proliferation and oncogene-induced tumorigenesis: role of INK4a/CAV-1 in mammary epithelial cell hy...  
  Williams TM, Lee H, Cheung MW, Cohen AW, Razani B, Iyengar P, Scherer PE, Pestell RG, and Lisanti MP, J. Biol. Chem, 1/1/2004
• Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice  
  Williams TM, Cheung MW, Park DS, Razani B, Cohen AW, Muller WJ, Di Vizio D, Chopra NG, Pestell RG, and Lisanti MP., Mol Biol Cell., 1/1/2003
• Caveolin-1 Deficient Mice show post-prandial hyper-insulinemia, insulin resistance, and defective Insulin Receptor (IR-{beta}) protein expression in adipose tissue  
  Cohen AW, Razani B, Wang XB, Combs TP, Williams TM, Scherer PE, and Lisanti MP., Am. J. Physiol. Cell Physiol, 1/1/2003
• Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice sh...  
  Lee H, Park DS, Razani B, Russell RG, Pestell RG, and Lisanti MP., Am. J. Path, 1/1/2002
• Caveolae: From cell biology to animal physiology  
  Razani B, Woodman SE, and Lisanti MP., Pharmacol. Rev., 1/1/2002
• Caveolin-1/3 double-knockout mice are viable, but lack both muscle and non-muscle caveolae, and develop a severe cardiomyopathic phenotype  
  Park DS, Woodman SE, Schubert W, Cohen AW, Frank FG, Chandra M, Shirani J, Razani B, Tang B, Jelicks JA, Factor SM, Weiss LM, Tanowitz HB, and Lisanti MP, Am. J. Pathol., 1/1/2002
• Caveolin-1 deficient mice are lean, resistant to diet-induced obesity, and show hyper-triglyceridemia with adipocyte abnormalities  
  Razani B, Combs TP, Wang XB, Frank PG, Park DS, Russell RG, Li M, Tang B, Jelicks LA, Scherer PE, and Lisanti MP., J. Biol. Chem., 1/1/2002
• Caveolin-2 deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae  
  Razani B, Wang XB, Engelman JA, Battista M, Lagaud G, Zhang XL, Knietz B, Hou H Jr, Christ GJ, Edelmann W, and Lisanti MP., Mol. Cell Biol., 1/1/2002
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Lectures

• Building a Better Macrophage to Treat Atherosclerosis and Associated Metabolic Conditions 
  Graz, Austria - 1/9/2016
• Building a Better Macrophage to Treat Metabolic Disease 
  Cedars-Sinai Medical Center, Los Angeles, CA - 1/8/2016
• Harnessing the Autophagy-Lysosomal Biogenesis Response in Macrophages to Treat Atherosclerosis 
  Vail, CO, 2015; Seoul, South Korea, 2015 - 1/12/2015
• The Autophagy-Lysosome System in Macrophages: A Nexus for Lipid Metabolism and Inflammation in Atherosclerosis 
  UCLA, Los Angeles, CA - 1/4/2014
• p62-enriched Inclusion Bodies in Macrophages Play a Protective Role in Atherosclerosis 
  Toronto, ON - 1/2/2014
• p62, Protein Aggregation, and Atherosclerosis 
  Vail, CO - 1/29/2013
• p62- enriched Inclusion Bodies in Macrophages Play a Protective Role in Atherosclerosis 
  Stowe, VT - 1/20/2013
• The AutophagyLysosome System in Macrophages: A Nexus for Lipid Metabolism and Inflammation in Atherosclerosis 
  Cleveland Clinic, Cleveland, OH - 1/6/2013
• Novel Therapies in Atherosclerosis 
  John Cochran VA Medical Center, St. Louis, MO - 1/7/2012
• Genomic Stress and Autophagy: Emerging Themes in Cardiovascular Disease 
  University of Chicago School of Medicine, Chicago, IL - 1/30/2011
• When the Heart Can't Make its Own Fat: Fatty Acid Synthase in Myocardial Dysfunction 
  University of Maryland School of Medicine, Baltimore, MD, 2011; Division of Endocrinology, Universit - 1/28/2011
• Fatty Acid Synthase Modulates Homeostatic Responses to Myocardial Stress 
  Chicago, IL - 1/1/2011
• Autophagy Links Inflammasomes to Atherosclerotic Progression 
  Chicago, IL - 1/1/2011
• Cardiac Fatty Acid Synthase Mediates Survival with Acute Stress 
  Breckenridge, CO - 1/1/2008
• Caveolin-deficient mice: Insights into caveolar function and human disease 
  Lovelace Respiratory Research Institute, Albuquerque, NM - 1/1/2000
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Other

• Orgocards: Organic Chemistry Review. 
  Wang SQ, Razani B, Lee EJK, Wu J, and Berkowitz W.
  1/1/2002