ArthurMertzKriegMDFACR

PubMed

• 67 citations
  Overcoming PD-1 Blockade Resistance with CpG-A Toll-Like Receptor 9 Agonist Vidutolimod in Patients with Metastatic Melanoma.
  Antoni Ribas, Theresa Medina, John M. Kirkwood, Yousef Zakharia, Rene Gonzalez
  Cancer Discovery. 2021-07-29
• 130 citations
  Modification of antisense phosphodiester oligodeoxynucleotides by a 5' cholesteryl moiety increases cellular association and improves efficacy.
  Arthur M. Krieg, Tonkinson J, Sara Matson, Qiuyan Zhao, M. Saxon
  Proceedings of the National Academy of Sciences of the United States of America. 1993-02-01
• 96 citations
  An innate immune defense mechanism based on the recognition of CpG motifs in microbial DNA
  Arthur M. Krieg
  The Journal of Laboratory and Clinical Medicine. 1996-08-01

Journal Articles

• CpG Oligonucleotides Protect against Venezuelan Equine Encephalitis Virus Infection in a Route-dependent Manner  
  Rees DG, Phillpotts RJ, Griffin KF, Lukaszewski RA, Laws TR, Atkins HS, Krieg AM, Titball RW, Int J Antimicrob Agents, 12/1/2013
• The Ability of CpG Oligonucleotides to Protect Mice against Francisella Tularensis Live Vaccine Strain but Not Fully Virulent F Tularensis Subspecies Holarctica Is Ref...  
  Rees DG, Hartley MG, Green M, Lukaszewski RA, Griffin KF, Atkins HS, Lyons R, Krieg AM, Titball RW, Microb Pathog, 10/1/2013
• Clinical Evaluation of Safety and Immunogenicity of PADRE-cytomegalovirus (CMV) And Tetanus-CMV Fusion Peptide Vaccines with or without PF03512676 Adjuvant  
  La Rosa C, Longmate J, Lacey SF, Kaltcheva T, Sharan R, Marsano D, Kwon P, Drake J, Williams B, Denison S, Broyer S, Couture L, Nakamura R, Dadwal S, Kelsey MI, Krieg ..., J Infect Dis, 4/15/2012
• Lipid-derived Nanoparticles for Immunostimulatory RNA Adjuvant Delivery  
  Nguyen DN, Mahon KP, Chikh G, Kim P, Chung H, Vicari AP, Love KT, Goldberg M, Chen S, Krieg AM, Chen J, Langer R, Anderson DG, Proc Natl Acad Sci U S A, 4/3/2012
• CpG Still Rocks! Update on an Accidental Drug  
  Krieg AM, Nucleic Acid Ther, 4/1/2012
• Immunostimulatory Potential of Silencing RNAs Can Be Mediated by a Non-uridine-rich Toll-like Receptor 7 Motif  
  Jurk M, Chikh G, Schulte B, Kritzler A, Richardt-Pargmann D, Lampron C, Luu R, Krieg AM, Vicari AP, Vollmer J, Nucleic Acid Ther, 6/1/2011
• Ositive T Cell Co-stimulation by TLR7/8 Ligands Is Dependent on the Cellular Environment  
  Richardt-Pargmann D, Wechsler M, Krieg AM, Vollmer J, Jurk M, Immunobiology, 1/1/2011
• AIMing 2 Detect Foreign DNA  
  Krieg, A.M., Science Signaling, 1/1/2009
• CpG Oligodeoxynucleotide Augment the Murine Immune Response to the Yersinia Pestis F1-V Vaccine in Bubonic and Pneumonic Models of Plague  
  Amemiya, K., Meyers, J.L., Rogers, T.E., Fast, R.L., Bassett, A.D., Worsham, P.L., Powell, B.S., Norris, S.L., Krieg, A.M., Adamovicz, J.J., Vaccine, 1/1/2009
• Sequences Derived from Self-RNA Containing Certain Natural Modifications Act as Suppressors of RNA-mediated Inflammatory Immune Responses  
  Tluk, S., Jurk, M., Forsbach, A., Weeratna, R., Samulowitz, U., Krieg, A.M., Bauer, S., Vollmer, J., International Immunology, 1/1/2009
• Immunotherapeutic Applications of CpG Oligodeoxynucleotide TLR9 Agonists  
  Vollmer, J., Krieg, A.M., Advanced Drug Delivery Reviews, 1/1/2009
• CD14(+) Cells Are Required for IL-12 Response in Bovine Blood Mononuclear Cells Activated with Toll-like Receptor (TLR) 7 and TLR8 Ligands  
  Buza, J., Benjamin, P., Zhu, J., Wilson, H.L., Lipford G., Krieg, A.M., Babiuk, L.A., Mutwiri, G.K., Veterinary Immunology and Immunopathology, 12/1/2008
• Attenuated Cytokine Responses in Porcine Lymph Node Cells Stimulated with CpG DNA Are Associated with Low Frequency of IFNalpha-producing Cells and TLR9 mRNA Expression  
  Dar, A., Nichani, A.K., Benjamin, P., Lai, K., Soita, H., Krieg, A.M., Potter, A., Babiuk, L.A., Mutwiri, G.K., Veterinary Immunology and Immunopathology, 6/1/2008
• Toll-like Receptor 9 Activation with CpG Oligodeoxynucleotides for Asthma Therapy  
  Kline, J.N., Krieg, A.M., Drug News & Perspectives, 1/1/2008
• Toll-like Receptor 9 Regulates the Lung Macrophage Phenotype and Host Immunity in Murine Pneumonia Caused by Legionella Pneumophila Department of Internal Medicine,...  
  Bhan, Urvashi; Trujillo, Glenda; Lyn-Kew, Kenneth; Newstead, Michael W.; Zeng, Xianying; Hogaboam, Cory M.; Krieg, Arthur M.; Standiford, Theodore J., Infection and Immunity, 1/1/2008
• NK Cells Activated in Vivo by Bacterial DNA Control the Intracellular Growth of Francisella Tularensis LVS  
  Elkins, K.L., Colombini, S.M., Krieg, A.M., De Pascalis, R, Microbes and Infection, 1/1/2008
• Paclitaxel Reduces Regulatory T Cell Numbers and Inhibitory Function and Enhances the Anti-tumor Effects of the TLR9 Agonist PF-3512676 in the Mouse  
  Vicari, A.P., Luu, R., Zhang, N., Patel, S., Makinen, S.R., Hanson, D.C., Weeratna, R.D., Krieg, A.M., Cancer Immunology, Immunotherapy, 1/1/2008
• Immunization with Analog Peptide in Combination with CpG and Montanide Expands Tumor Antigen-specific CD8+ T Cells in Melanoma Patients  
  Fourcade, J., Kudela, P., Andrade Filho, P.A., Janjic, B., Land, S.R., Sander, C., Krieg, A., Donnenberg, A., Shen, H., Kirkwood, J.M., Zarour, H.M., Journal of Immunotherapy, 1/1/2008
• Randomized Phase II Trial of a Toll-like Receptor 9 Agonist Oligodeoxynucleotide, PF-3512676, in Combination with First-line Taxane plus Platinum Chemotherapy for Adva...  
  Manegold, C., Gravenor, D., Woytowitz, D., Mezger, J., Hirsh, V., Albert, G., Al-Adhami, M., Readett, D., Krieg, A.M., Leichman, C.G., Journal of Clinical Oncology, 1/1/2008
• TLR Agonists Regulate Alloresponses and Uncover a Critical Role for Donor APCs in Allogenic Bone Marrow Rejection  
  Taylor, P.A., Ehrhardt, M.J., Lees, C.J., Panoskaltsis-Mortari, A., Krieg, A.M., Sharpe, A.H., Murphy, A.J., Serody, J.S., Hemmi, H., Akira, S., Levy, R.B., Blazar, B.R., Blood, 1/1/2008
• Immunostimulatory Effects of Three Classes of CpG Oligodeoxynucleotides on PBMC from HCV Chronic Carriers  
  Cooper, C.L., Ahluwalia, N.K., Efler, S.M., Vollmer, J., Krieg, A.M., Davis, H.L., Journal of Immune Based Therapies and Vaccines, 1/1/2008
• Identification of RNA Sequence Motifs Stimulating Sequence-specific TLR8-dependent Immune Responses  
  Forsbach, A., Nemorin, J.G., Montino, C., Muller, C., Samulowitz, U., Vicari, A.P., Jurk, M., Mutwiri, G.K., Krieg, A.M., Lipford, G.B., Vollmer, J, The Journal of Immunology, 1/1/2008
• The Toll of Cathepsin K Deficiency  
  Krieg, A.M., Lipford, G.B., Science, 1/1/2008
• Activation of Innate Immunity in Healthy Macaca Mulatta Macaques by a Single Subcutaneous Dose of GMP CpG 7909: Safety Data and Interferon-inducible Protein-10 Kinetic...  
  Stewart, V.A., McGrath, S., Krieg, A.M., Larson, N.S., Angov, E., Smith, C.L., Brewer, T.G., Heppner, Jr., D.G., Clinical and Vaccine Immunology, 1/1/2008
• Toll-free Vaccines?  
  Krieg, A.M., Nature Biotechnology, 6/1/2007
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Books/Book Chapters

• Antisense Drug Technology: Principles, Strategies, and Applications 
  Chapter: Mechanisms and Therapeutic Applications of Immune Modulatory Oligodeoxynucleotide and Oligoribonucleotide Ligands for Toll-like Receptors 
  Page 747 - 772Vollmer, J., Krieg, A.M.Editors: S. T. Crooke.CRC Press, Boca Raton, FloridaEdition Seco,2008
• Enhancement of Infectious Disease Vaccines through TLR9-dependent Recognition of CpG DNA 
  Chapter: From Innate Immunity to Immunological Memory 
  Page 155 - 178McCluskie, M.J., Krieg, A.M.2006
• Update on Cancer Therapeutics 
  Chapter: Potential Use of CpG ODN for Cancer Immunotherapy 
  Page 49 - 58Weeratna, R. D., Davis, H. L., Medynski, L., and Krieg, A. M.2006
• Vaccine Adjuvants 
  Chapter: CpG ODN as a Th1 Immune Enhancer for Prophylactic and Therapeutic Vaccines 
  Page 87 - 110Krieg, A. M., and Davis, H. L.2006
• Biological Weapons Defense 
  Chapter: Nonspecific Immunomodulator Therapy: CpG 
  Page 317 - 331Rees, D.G. Cerys, Krieg, A. M., and Titball, R. W.Editors: L. E. Lindler; F. J. Lebeda, and G. W. Korch.Biomedical Sciences, Defence Science and Technology Laboratory, Salisbury, Wilts, UK2005
• Antisense Drug Technology 
  Chapter: Immune Stimulation by Oligonucleotides 
  Page 471 - 515Krieg, A.M.Editors: S. T. Crooke.Marcel Dekker, Inc., New York2001
• The Skin and Gene Therapy 
  Chapter: Systematic Modulation of Immune Responses by CpG DNA 
  Page 201 - 218Krieg, A.M.Editors: U.R. Hengge, and B. Volc-Platzer.Springer-Verlag, New York2000
• Therapeutic Vaccination Strategies 
  Chapter: CpG Oligonucleotides as Immune Adjuvants 
  Page 105 - 118Krieg, A.M.Editors: P. Walden, W. Sterry, H. Hennekes.Springer-Verlag, Heidelberg2000
• Lupus: Molecular and Cellular Pathogenesis 
  Chapter: The Immune Effects of Bacterial DNA and their Possible Role in the Pathogenesis of Lupus 
  Page 79 - 100Tuetken, R.S., Yi, A-K., and Krieg, A.M.Editors: G.C. Tsokos and G. Kammer.Humana Press, Totowana, NJ1999
• Applied Antisense Oligonucleotide Technology 
  Chapter: Leukocyte Stimulation by Oligodeoxynucleotides 
  Page 431 - 448Krieg, A.M.Editors: C.A. Stein and A.M. Krieg.Wiley & Sons, Inc., New York1999
• Manual of Antisense Methodology 
  Chapter: How to Exclude Immunostimulatory and Other Nonantisense Effects of Antisense Oligonucleotides 
  Page 79 - 89Krieg, A.M.Editors: S. Endres and G. Hartmann.Kluwer Academic Publishing, Dordrecht, the Netherlands1999
• Applied Oligonucleotide Technology 
  Editors: C.A. Stein and A.M. Krieg.John Wiley and Sons, Inc., New York, NY1998
• Antisense Research and Application 
  Chapter: Immune Stimulation by Oligodeoxynucleotides 
  Page 243 - 262Krieg, A.M.Editors: S.T. Crooke.Springer-Verlage, Heidesberg, Germany1998
• Applied Oligonucleotide Technology 
  Chapter: Leukocyte Stimulation by Oligodeoxynucleotides 
  Page 431 - 448Krieg, A.M.Editors: C.A. Stein and A.M. Krieg.John Wiley and Sons, Inc., New York, NY1998
• Antisense Technology: A Practical Approach 
  Chapter: Non-Antisense Effects of Oligodeoxynucleotides 
  Stein, C.A. and Krieg, A.M.Editors: C. Lichtenstein and W. Nellen.Oxford University Press, London, England1997
• Vaccines 97 
  Chapter: CpG DNA Protects Mice from Lethal L. Monocytogenes Challenge 
  Page 77 - 79Krieg, A.M., Love-Homan, L.,. Yi, A.-K, and Harty, J.T.Editors: F. Brown, D. Burton, P. Doherty, J. Mekalanos, and E. Norrby.Cold Spring Harbor Laboratory Press, Cold Spring Harbor Laboratory Press1997
• Handbook of Experimental Immunology 
  Chapter: Viruses and Autoimmunity 
  Krieg, A.M., and Venables, P.Editors: L.A. Herzenbert, D.M. Weir, L. Herzenberg and Caroline Blackwell.Blackwell Science Inc., Malden, MA1997
• McGraw-Hill Yearbook of Science & Technology 
  Chapter: Infection 
  Page 242 - 243Krieg, A.M.McGraw-Hill Book Co., New York1996
• The Retroviridae 
  Chapter: Retroviruses and Their Roles in Chronic Inflammatory Diseases and Autoimmunity 
  Page 491 - 603Garry, G.F., Krieg, A.M., Cheevers, W.P., Montelaro, R.C., Golding, H., Fermin, C.D., and Gallaher, W.R.Editors: J. Levy.Plenum Press, New York1995
• Delivery Strategies for Antisense Oligonucleotide Therapeutics 
  Chapter: Uptake and Localization of Phosphodiester and Chimeric Oligodeoxynucleotides in Normal and Leukemic Primary Cells 
  Page 177 - 190Krieg, A.M.Editors: S. Akhtar.CRC Press, Boca Raton, FL1995
• Proceedings of the Second International Congress of SLE 
  Chapter: Cellular and Molecular Basis for SLE II. Thymus, T Cells, and Retroviruses 
  Page 19 - 22Steinberg, A.D., Gause, W.C., Scott, D.E., Gourley, M., Takashi, T., and Krieg, A.M.Editors: M.L. Boey.Professional Postgraduate Services, International Publishers, Singapore1989
• Cellular Basis of Immune Modulation 
  Chapter: Towards an Understanding of Lupus 
  Page 423 - 442Steinberg, A.D., Krieg, A.M., Gause, W.C., Kastner, D.L., Mountz, J.D., and Klinman, D.M.Editors: J.G. Kaplin and D.R. Green.Alan R. Liss, Inc1989
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Abstracts/Posters

• CpG Oligonucleotides as Immune Adjuvants
  Krieg, A.M., Ernst Schering Research Foundation Workshop, 1/1/2000
• Timing of Immunosuppression in the History of Autoimmunity
  Steinberg, A.D., Krieg, A.M., Takashi, T., and Gourley, M.F., Proceedings of the Second International Symposium on Immunomodulation, Paris, France, 1/1/1991
• Towards an Understanding of Lupus
  Proceedings of the Nineteenth International Leukocyte Culture Conference, Banff, 5/1/1989