ArchibaldJMixsonMD

PubMed

• 1 citations
  pH modification of gel mobility shift improves polyplex selection In Vivo.
  Q Leng, A Anand, A James Mixson
  Biochemical and Biophysical Research Communications. 2024-12-17
• pH-Dependent Non-Covalent Release of Chemotherapy from Carriers.
  Qixin Leng, Aishwarya Anand, Archibald James Mixson
  Discovery Medicine. 2024-03-01
• 1 citations
  Delivery of mRNA with Histidine-Lysine Peptides.
  Qixin Leng, Jiaxi He, Aishwarya Anand, A James Mixson
  Methods in Molecular Biology. 2024-01-01

Journal Articles

• Gene therapy with p53 inhibits human breast cancer in vivo.  
  Xu M, Kumar D, Stass S, and Mixson AJ, Molecular Genetics and Metabolism
• Recent advances in systemic gene therapy with p53.  
  Chen QR and Mixson AJ, Frontiers in Bioscience
• Liposomes complexed to angiostatin and endostatin inhibit breast cancer in nude mice.  
  Chen QR, Kumar D, Stass SA, and Mixson AJ, Cancer Research
• Anti-angiogenic Gene Therapy.  
  Zhang L, Chen QR, and Mixson AJ, Current Genomics
• Modified branch peptides with a histidine-rich tail enhance in vitro gene transfection.  
  Leng Q and Mixson AJ, Nucleic Acids Research
• Advances in siRNA Delivery.  
  Leng Q, Woodle MC, Lu PY, Mixson AJ, Drugs of the Future
• Zinc Finger Nucleases: Tailor-made for Gene Therapy.  
  Chou ST, Leng Q, Mixson AJ, Drugs of the Future
• Buffering Capacity and Size of siRNA Polyplexes Influence Cytokine levels.  
  Leng Q, Chou ST, Scaria P, Woodle M, Mixson AJ, Molecular Therapy
• Surface modified HK:siRNA nanoplexes with enhanced pharmacokinetics and tumor growth inhibition.  
  Chou ST, Leng Q, Scaria P, Kahn JD, Tricoli LJ, Woodle M, Mixson AJ, Biomacromolecules
• Differential uptake of pyrroline-5-carboxylate in adriamycin sensitive and resistant tumor cells.  
  Mixson AJ, Yeh GC, Granger AN, and Phang JM, The FASEB Journal
• Inhibitors of pyrroline-5-carboxylate uptake: evidence for a specific carrier protein.  
  Mixson AJ and Phang JM, The FASEB Journal
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Books/Book Chapters

• Localizing mutations in human genes. 
  Chapter: Molecular Endocrinology: Basic Concept and Clinical Correlations 
  Weinstein, L.S. and Mixson, A.JEditors: Weintraub, B.D.Raven Press, New York
• Inhibiting tumor angiogenesis with molecular therapy. 
  Chapter: The Oncogenomics Handbook: Understanding and Treating Cancer in the 21st Century 
  Leng, Q. and Mixson, A.JEditors: Shimkets, R.A. and LaRochelle, W.J.

Abstracts/Posters

• Raf-1 siRNA Inhibits Tumor Growth In Vivo.
  Leng Q and Mixson AJ, 8th Annual Meeting of the American Society of Gene Therapy
• Direct Measurements of Mechanical Properties of Condensed DNA for Gene Delivery Using Optical Tweezers.
  Seog J, Lee A, Karcz A, Tie C, Sucayan S, Kahn J, Mixson A, International Conference of Young Researchers on Advanced Materials
• Modified HK siRNA Polyplexes with Improved Pharmacokinetics Enhance Tumor Inhibition.
  Chou ST, Leng Q, Scaria P, Mixson AJ, American Society of Cellular and Gene Therapy 15th Annual Meeting
• Hydrogen bonding between the imidazole-containing peptide and siRNA mediates greater stability and biological activity of the polyplex.
  Chou ST, Leng Q, Seog J, Kahn JD, Mixson AJ, 8th Annual Oligonucleotide Therapeutic Annual Meeting
• Genetic and clinical features of 100 patients with resistance to thyroid hormone (RTG-) from 39 families followed at the NIH.
  Brucker-Davis F, Skarulix M, Hauser P, Grace M.B, Wiggs E, Mixson AJ, Malley J, and Weintraub BD, 74th Annual Endocrine Meeting
• Allele specific associated polymorphism (ASAP) analysis of point mutations in the human thyroid receptor-beta (HTR-beta) gene associated with resistance to thyroid hor...
  Grace MB, Seto D, Mixson J, Buzard GS, and Weintraub B, 74th Annual Endocrine Meeting
• Systemic Gene Therapy with p53 Interferes with Progression of Breast Cancer in Nude Mice.
  Lesoon-Wood L, Kim WH, Kleinman H., Weintraub B, and Mixson AJ, 86th American Association for Cancer Research Meeting
• Systemic Toxicity with Liposome: p53 Complexes.
  Xu M and Mixson AJ, 2nd Annual New Cancer Strategies Meeting
• Branched Polymers are Efficient Carriers of Plasmids.
  Chen Q-R, Mixson AJ, 3rd International Symposium on Molecular Medicine Meeting
• A DNAzyme Targeting VEGFR2 in Tumors.
  Zhang L, Chen QR, and Mixson AJ, 5th International Symposium on Molecular Medicine Meeting
• Direct Measurements of Mechanical Properties of Condensed DNA Using Optical Tweezers.
  Lee A, Karcz A, Tie C, Sucayan S, Mixson J, Kahn J and Seog J, Biomedical Engineering Society 11th Annual Meeting
• Sequential Changes in Salt Conditions During the HK: Plasmid Formation Markedly Augments Transfection.
  Leng Q and Mixson AJ, Third International Nanomedicine and Drug Delivery Symposium
• Salt Conditions During HK Polyplex Formation significantly Alters Transfection in vivo.
  Leng Q, Kahn J, Zhu J, Scaria P, and Mixson AJ, 9th Annual Meeting of the American Society of Gene Therapy
• Synthetic HK Polyplexes Augments Transfection.
  Leng Q and Mixson AJ, 1st Annual Hormone Response Cancer Meeting
• Effect of Branched Histidine-Lysine (HK) Polymers on Transfection and toxicity in MDA-MB-435 Cancer Cells.
  Goldgeier L. and Mixson, AJ, Student Research Program
• Development of HK Polymers as carriers of antitumor and antiangiogenic nucleic acids.
  Leng Q, Zhu J, and Mixson AJ, 2nd Annual Hormone Response Cancer Meeting
• Systemic Administration of Selective HK siRNA Polyplexes Induce Low Levels of Cytokines.
  Leng Q, and Mixson AJ, 12th Annual Meeting of the American Society of Gene Therapy
• Patterns of HK siRNA Nanoparticles Silenced Tumor Targets.
  Chou ST, Leng Q, Scaria P, Mixson, AJ, Chemistry and biology interface
• Selective Pegylation Patterns of HK siRNA Nanoparticles Influence Ability to Silence Tumor Targets in-vivo.
  Chou ST, Leng Q, Scaria P, and Mixson, AJ, 1st Annual Cancer Biology Research Retreat
• Novel Gene Therapy Approaches Toward Cancer.
  Mixson AJ, Nanomedicine Research Day, Baltimore, MD
• Diverse phenotypes of 11 kindreds with generalized thyroid hormone resistance and novel mutations in the gene encoding the T3 beta receptor.
  Mixson AJ, Parrilla R, Usala SJ, Ransom SC, McClaskey JH, McPherson JA, and Weintraub B.D, Clinical Research
• Language fluency associated with Thyroid Hormone Resistance.
  Mixson AJ, International Symposium on Thyroid Hormone Resistance, Cambridge, England
• Systemic Therapy of Breast Cancer with Liposome: p53 Complexes.
  Mixson AJ, 2nd Annual New Cancer Strategies: p53, Atlanta, GA
• Treatment of Breast Cancer with Antiangiogenic Genes.
  Mixson AJ, Protenomics and Cancer Therapy, NCI, Bethesda, MD
• New Polymer Enhances Transfection.
  Mixson AJ, 3rd International Symposium on Molecular Medicine, Heraklion, Greece
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Lectures

• Liposomal Delivery Systems for Central and Peripheral Hyperalimentation solutions. 
  Cape Sunion Beach, Greece

Other

• Carrier: DNA complexes containing DNA encoding anti-angiogenic peptides and their use in gene therapy. 
  US patent
• Cationic vehicle: DNA complexes and their use in gene therapy. 
  #EPO819758B1
• Branched Histidine copolymers and methods for using the same. 
  US Patent
• Histidine copolymer and methods for using same. 
  US Patent
• Branched Cationic Copolymers and methods for using antimicrobial use. 
  USA Patent
• Highly branched HK peptides as effective carriers of siRNA. 
  US Patent
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