AnthonyW.TolcherMD

Oncology • San Antonio, TX

Breast Cancer, Sarcoma

Director of Clinical Research at START; Associate Editor of The Journal of New Anticancer Agents

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Office
2829 Babcock Rd
Ste 300
San Antonio, TX 78229
Phone+1 210-580-9500

Fax+1 210-568-4397

Education & Training

University of British ColumbiaClass of 1986

Certifications & Licensure

TX State Medical License 1998 - 2025
American Board of Internal Medicine Medical Oncology

Clinical Trials

Chemotherapy in Treating Patients With Advanced Solid Tumors Start of enrollment: 1998 Jul 01
Completed
Phase 1
Chemotherapy in Treating Patients With Advanced Solid Tumors Start of enrollment: 1998 Oct 01
Completed
Phase 1
Olimersen and Irinotecan in Treating Patients With Metastatic or Recurrent Colorectal Cancer Start of enrollment: 2000 Jun 01
Completed
Phase 1, Phase 2
Trastuzumab Plus R115777 in Treating Patients With Advanced or Metastatic Cancer Start of enrollment: 2000 Jun 01
Completed
Phase 1
Erlotinib in Treating Patients With Advanced Kidney Cancer Start of enrollment: 2002 Jun 01
Completed
Phase 2
Combination Chemotherapy and Oblimersen in Treating Patients With Advanced Colorectal Cancer Start of enrollment: 2002 Oct 01
Completed
Phase 1, Phase 2
Study of Vinorelbine Liposomes Injection for Advanced Solid Tumors, Non-Hodgkin's Lymphoma or Hodgkin's Disease Start of enrollment: 2006 Jul 01
Completed
Phase 1
Safety Study of CALAA-01 to Treat Solid Tumor Cancers Start of enrollment: 2008 May 01
Terminated
Phase 1
A Dose Escalation Study of OMP-59R5 in Subjects With Solid Tumors Start of enrollment: 2010 Dec 01
Completed
Phase 1
Phase I Dose-Escalation, Safety, Pharmacokinetic and Pharmacodynamic Study of BVD-523 in Patients With Advanced Malignancies Start of enrollment: 2013 Mar 01
Completed
Phase 1, Phase 2
Phase I Study to Assess the Safety, Tolerability and Pharmacokinetics of CUDC-427 When Given to Patients With Advanced and Refractory Solid Tumors or Lymphoma Start of enrollment: 2013 Jul 01
Terminated
Phase 1
Phase I, Multicenter, Dose Escalation Study of DCR-MYC in Patients With Solid Tumors, Multiple Myeloma, or Lymphoma
TERMINATED
PHASE1
Phase 1 of EC1169 In Patients With Recurrent MCRPC Start of enrollment: 2014 May 01
Completed
Phase 1
A Safety and Pharmacokinetic Study of TRX-818 Administered Orally to Patients With Advanced Cancer Start of enrollment: 2015 Sep 01
Completed
Phase 1
Phase 1 Study Evaluating VT1021 in Patients With Advanced Solid Tumors Start of enrollment: 2017 Nov 28
Active, not recruiting
Phase 1
A Safety and Pharmacokinetic Study of NBM-BMX Administered Orally to Patients With Advanced Cancer Start of enrollment: 2018 Oct 16
Completed
Phase 1
TTX-030 Single Agent and in Combination With Immunotherapy or Chemotherapy for Patients With Advanced Cancers Start of enrollment: 2019 Apr 10
Completed
Phase 1
Phase 1, First in Human, Open-Label, Dose-Escalation Study of 609A Start of enrollment: 2019 May 01
Recruiting
Phase 1
Study of TST005 in Patients With Locally Advanced or Metastatic Solid Tumors Start of enrollment: 2021 Jun 11
Terminated
Phase 1
Roles: Contact
A Study Evaluating the Safety and Efficacy of HB0036 in Subjects With Advanced Solid Tumors Start of enrollment: 2022 Aug 25
RECRUITING
PHASE1, PHASE2
Roles: Contact
A Study of APG-115 in as a Monotherapy or Combination With Pembrolizumab in Patients With Metastatic Melanomas or Advanced Solid Tumors Start of enrollment: 2018 Aug 29
RECRUITING
PHASE1, PHASE2
Roles: Contact, Principal Investigator
A Study of Injection HB0025 in Patients With Advanced Solid Tumors Start of enrollment: 2021 Mar 10
Recruiting
Phase 1
Roles: Contact
Tuvusertib (M1774) in Participants With Metastatic or Locally Advanced Unresectable Solid Tumors (DDRiver Solid Tumors 301) Start of enrollment: 2019 Dec 20
ACTIVE_NOT_RECRUITING
PHASE1
Roles: Principal Investigator
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Publications & Presentations

PubMed

Accelerating the Future of Oncology Drug Development: The Role of Consortia in the Delivery of Precision Oncology Early Phase Clinical Trials.
Jia Liu, Max Farrow, Lesley Seymour, Jayesh Desai, Herbert H Loong
Journal of Clinical Oncology. 2025-02-20
TIGIT inhibitor M6223 as monotherapy or in combination with bintrafusp alfa in patients with advanced solid tumors: a first-in-human, phase 1, dose-escalation trial.
Aung Naing, Meredith McKean, Anthony Tolcher, Anja Victor, Ping Hu
Journal for Immunotherapy of Cancer. 2025-02-10
1 citations
A First-in-Human Study of Cinrebafusp Alfa, a HER2/4-1BB Bispecific Molecule, in Patients with HER2-Positive Advanced Solid Malignancies.
Sarina Piha-Paul, Shane A Olwill, Erika Hamilton, Anthony Tolcher, Paula Pohlmann
Clinical Cancer Research. 2025-01-17

Lectures

An open label, multicenter, phase 1b/2 study of rebastinib (DCCâ€‘2036) in combination with carboplatin to assess safety, tolerability, and pharmacokinetics in patient...
2019 ASCO Annual Meeting - 6/1/2019
Phase 1 dose escalation study of XMT-1536, a novel NaPi2b-targeting antibody-drug conjugate (ADC), in patients (pts) with solid tumors likely to express NaPi2b.
2019 ASCO Annual Meeting - 6/1/2019

Press Mentions

Alterome Doses First Patient in Phase 1 Study of ALTA3263, a Novel Pan-KRAS Dual ON/OFF Inhibitor, in Advanced Solid TumorsMarch 10th, 2025
Pyxis Oncology Announces Favorable Preliminary PYX-201 Clinical Phase 1 Part 1 DataNovember 20th, 2024
Vial, Working with Top Phase I Oncology SitesApril 19th, 2023
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Grant Support

PH I Study Of EGFR And HER2 Blockade W/ OSI-774, Trastuzumab And PaclitaxelNational Center For Research Resources2006–2007
Phase I Clinical Trials Of Anti-Cancer AgentsNational Cancer Institute2004–2006
PH II PK And Biologic Correlative Study Of OSI-774 In PTS W/ Adv Renal Cell CarcNational Center For Research Resources2005
PH I Study Of EGFR And HER2 Blockade W OSI-774, Trastuzumab And PaclitaxelNational Center For Research Resources2005
Phase I/II Study Of Oblimersen Sodium With LeucovorinNational Center For Research Resources2004
PH II Pharmakokinetic/Biologic Study Of OSI-774 In RCCNational Center For Research Resources2004
Trial Of RPR 116258a--1 HR IV Infusion In Solid TumorsNational Center For Research Resources2000–2002
Pharmacokinetics/Safety Of INGN 201 In Advanced TumorsNational Center For Research Resources2000–2002
Pharmacokinetics Of Sr45023a 7 Day Administration CycleNational Center For Research Resources2000–2002
Pharmacokinetics Of FB 642 In Patients With Advanced TumNational Center For Research Resources2000–2002
Phase I Study Of Cyclic Oral Administration Of Sch61365 (21 Of 28 Days)National Center For Research Resources1999–2002