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490 Arsenal WaySuite 210East Watertown, MA 02472
Phone+1 617-872-9174
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Summary
- I am currently the Chief Development Officer at Tectonic Therapeutic in Watertown, MA.
Education & Training
University of California (San Francisco)Fellowship, Cardiovascular Disease, 1987 - 1989
Mass General Brigham/Brigham and Women's HospitalResidency, Internal Medicine, 1984 - 1987
Harvard Medical SchoolClass of 1984, M.D.
Yale UniversityB.A., History, Magna Cum Laude, 1976 - 1980
Certifications & Licensure
MO State Medical License 1994 - 2015
Publications & Presentations
PubMed
- 9 citationsEndothelial-protective effects of a G-protein-biased sphingosine-1 phosphate receptor-1 agonist, SAR247799, in type-2 diabetes rats and a randomized placebo-controlled...Luc Bergougnan, Grit Andersen, Leona Plum-Mörschel, Maria Francesca Evaristi, Bruno Poirier
British Journal of Clinical Pharmacology. 2021-05-01 - 10 citationsFirst-in-human study of the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple oral doses of SAR247799, a selective G-protein-biased sp...Luc Bergougnan, Sara Armani, Georg Golor, Agnes Tardat, Olivier Vitse
British Journal of Clinical Pharmacology. 2021-02-01 - 31 citationsA G protein-biased S1P1 agonist, SAR247799, protects endothelial cells without affecting lymphocyte numbers.Bruno Poirier, Véronique Briand, Dieter Kadereit, Matthias Schäfer, Paulus Wohlfart
Science Signaling. 2020-06-02
Press Mentions
Tectonic Therapeutic Launches with $80 Million Series A Financing to Transform the Discovery of Novel G-protein Coupled Receptor (GPCR)-Targeted TherapiesApril 15th, 2021
Grant Support
- Altered Cardiac Myocyte Signaling In Diabetic Myocardium And Functional SequelaeNational Heart, Lung, And Blood Institute2009
- Principles In Cardiovascular Research Training ProgramNational Heart, Lung, And Blood Institute2006–2009
- MAP Kinase And AKT Signaling In Congestive Heart FailureNational Heart, Lung, And Blood Institute2005–2009
- RGS Protein Function In Cardiac PhysiologyNational Heart, Lung, And Blood Institute2002–2008
- G Protein Coupling Of Lipid Metabolism In Diabetic HeartNational Heart, Lung, And Blood Institute2002–2005
- RGS Protein Function In Cardiac PhysiologyNational Heart, Lung, And Blood Institute2000–2002
- 14-3-3 Protein Function In Cell Growth And MotilityNational Institute Of General Medical Sciences1997–2001
- PDGF Receptor Function In Embryonic DevelopmentNational Heart, Lung, And Blood Institute1994–1996
- PDGF Receptor Function In Embryonic DevelopmentNational Heart, Lung, And Blood Institute1992–1994
- The Role Of The PDGF Receptor In AtherogenesisNational Heart, Lung, And Blood Institute1989–1990
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