AnneFSchottMD

Oncology • Ann Arbor, MI

Breast Cancer

Professor, Hematology/Oncology; Associate Director for Clinical Research, University of Michigan Rogel Cancer; Center Vice-Chair, Institutional Review Board Medicine

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Office
1500 E Medical Center Dr
Ann Arbor, MI 48109
Phone+1 734-936-4000

Education & Training

University of MichiganFellowship, Hematology and Medical Oncology, 1993 - 1996
University of Virginia Medical CenterResidency, Internal Medicine, 1989 - 1992
University of South Alabama College of MedicineClass of 1989
University of South AlabamaBS, 1981 - 1985

Certifications & Licensure

MI State Medical License 1993 - 2027
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

Best Doctors in America Best Doctors, 2015
Academiae Laureati Medici of the Department of Internal Medicine 2015
Best Doctors in America Best Doctors, Inc., 2014
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013
Mark Roth Memorial Award 1995
ASH Scholar Award 1994
John Watson Donald Memorial Surgical Award 1989
Alpha Omega Alpha 1988
Outstanding Chemistry Graduate University of South Alabama, 1984
Alpha Epsilon Delta Medical Student Honor Society 1983
Phi Eta Sigma Freshman Honor Society 1982
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Clinical Trials

S0430 Cyclophosphamide and Capecitabine in Treating Women With Stage IV Breast Cancer Start of enrollment: 2005 Aug 01
Completed
Phase 2
UMCC 9901: Phase II Study of Tailored-Dose Docetaxel + Trastuzumab in Her-2 Positive Metastatic Breast Cancer Start of enrollment: 1999 Mar 01
Completed
Phase 2
Phase II Study of Tailored-Dose Docetaxel in Metastatic Breast Cancer Start of enrollment: 1999 Mar 01
Completed
Phase 2
Evaluation of Tumor Factors in Breast Cancer Treated With Docetaxel and Capecitabine Start of enrollment: 2003 Jul 01
Completed
Not Applicable
Tissue Procurement Protocol for Patients Undergoing Neoadjuvant Systemic Therapy for Breast Cancer Start of enrollment: 2005 May 01
Completed
S0622, Dasatinib in Treating Patients With Stage IV Breast Cancer That Has Spread to the Bone Start of enrollment: 2007 Mar 01
Completed
Phase 2
Phase I/II Study of MK-0752 Followed by Docetaxel in Advanced or Metastatic Breast Cancer Start of enrollment: 2008 Mar 01
Completed
Phase 1, Phase 2
Use of Trastuzumab to Induce Increased ER Expression in ER-negative/Low, Her-2/Neu Positive Breast Cancer Start of enrollment: 2008 Jul 01
Terminated
Phase 1, Phase 2
Radiation Therapy With or Without Trastuzumab in Treating Women With Ductal Carcinoma In Situ Who Have Undergone Lumpectomy Start of enrollment: 2008 Nov 10
Active, not recruiting
Phase 3
A Phase III Randomized Trial of Metformin vs Placebo in Early Stage Breast Cancer Start of enrollment: 2010 Aug 13
Completed
Phase 3
Tamoxifen Citrate, Letrozole, Anastrozole, or Exemestane With or Without Chemotherapy in Treating Patients With Invasive RxPONDER Breast Cancer Start of enrollment: 2011 Jan 15
Active, not recruiting
Phase 3
Chemotherapy With or Without Trastuzumab After Surgery in Treating Women With Invasive Breast Cancer Start of enrollment: 2011 Jan 06
Active, not recruiting
Phase 3
S1202: Duloxetine Hydrochloride for Muscle/Joint Pain in Early-Stage Breast Cancer Receiving Hormone Therapy Start of enrollment: 2013 May 15
Completed
Phase 3
S1207 Hormone Therapy With or Without Everolimus in Treating Patients With Breast Cancer Start of enrollment: 2013 Sep 12
Active, not recruiting
Phase 3
Pilot Study to Evaluate Reparixin With Weekly Paclitaxel in Patients With HER 2 Negative Metastatic Breast Cancer (MBC) Start of enrollment: 2012 Feb 27
Completed
Phase 1
Testing MK-3475 (Pembrolizumab) as Adjuvant Therapy for Triple Receptor-Negative Breast Cancer Start of enrollment: 2017 Jan 18
Active, not recruiting
Phase 3
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Publications & Presentations

PubMed

2986 citations
ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome.
Christophe Ginestier, Min Hee Hur, Emmanuelle Charafe-Jauffret, Florence Monville, Julie Dutcher
Cell Stem Cell. 2007-11-15
17 citations
Sonographic evaluation of early-stage breast cancers that undergo neoadjuvant chemotherapy.
Marilyn A. Roubidoux, Gerald L. LeCarpentier, J. Brian Fowlkes, Brett H. Bartz, Deepa Pai
Journal of Ultrasound in Medicine. 2005-07-01
100 citations
Clinical and Radiologic Assessments to Predict Breast Cancer Pathologic Complete Response to Neoadjuvant Chemotherapy
Anne F. Schott, Marilyn A. Roubidoux, Mark A. Helvie, Daniel F. Hayes, Celina G. Kleer
Breast Cancer Research and Treatment. 2005-08-01

Journal Articles

Assessment of Clinical Benefit of Integrative Genomic Profiling in Advanced Solid Tumors
Erin F Cobain, Francis Worden, Scott M Schuetze, Mark M Zalupski, Vaibhav Sahai, Ajjai Alva, Anne F Schott, Moshe Talpaz, JAMA Oncology
Adjuvant exemestane with ovarian suppression in premenopausal breast cancer
Pagani O, Regan MM, Walley BA, Fleming GF, Colleoni M, Lang I, Gomez HL, Tondini C, Burstein HJ, Perez EA, Ciruelos E, Stearns V, Bonnefoi HR, Martino S, Geyer CE Jr, ..., N Engl J Med, 1/1/2014
Adjuvant ovarian suppression in premenopausal breast cancer
Francis PA, Regan MM, Fleming GF, Lang I, Ciruelos E, Bellet M, Bonnefoi HR, Climent MA, Da Prada GA, Burstein HJ, Martino S, Davidson NE, Geyer CE Jr, Walley BA, Cole..., N Engl J Med, 1/1/2014
A randomized placebo-controlled phase III study of duloxetine for treatment of aromatase inhibitor (AI)-associated musculoskeletal symptoms in women with early-stage b...
Henry NL, Unger JM, Schott A, Hansen L, Lew D, Wade JL, Moinpour C, Hortobagyi GN, Meyskens FL, J Clin Oncol, 1/1/2014
Targeting Intrinsically-Resistant Breast Cancer Stem Cells with Gamma-Secretase Inhibitors
Chang J, Landis M, Schott A, Pavlic A, Dobrolecki L, Korkaya H, Zhang X, Froehlich A, Rodriguez A, Rimawi M, Wicha M, Lewis M, Hayes D, Cancer Res, 1/1/2009
Book Review, 2nd edition, Bland K and Copeland E, editors
Schott AF, Oncology, 1/1/2001
Herceptin: an example of the success of translational research
Schott AF and Ethier SP, Michigan Oncology Journal, 1/1/1999
Leukemia and lymphoma
Schott AF, Primary Care Update, 1/1/1997
Bcl-XL protects cancer cells from p53-mediated apoptosis
Schott AF, Apel I J, Nunez G, Clarke M F, Oncogene, 1/1/1995
Anion Affinity of Carbonylbis (triphenylphosphine Rhodium (I)) in CH2Cl2; Fluoride vs its Halide Analogs
Branan DM, Hoffman MW, McElroy EA, Miller NC, Ramage DL, Schott AF, and Young SH, Inorganic Chemistry, 1/1/1987
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Books/Book Chapters

Adjuvant Therapy of Cancer VIII
Chapter: Section VII: Conference Summary, Adjuvant therapy of cancer VIII: concluding perspectives.
Page 289 - 298Schott A and Baker LHEditors: JH Glick, RD Gerber, A Goldhirsch, H-J Senn.Lippincott-Raven Publishers, Philadelphia, PA1997

Abstracts/Posters

Phase Ib Trial of the Gamma Secretase Inhibitor (GSI), MK-0752 Followed by Docetaxel in Locally Advanced or Metastatic Breast Cancer
Schott AF, Chang JC, Krop IE, Griffith KA, Layman RM, Hayes DF, Wicha MS, Cancer Res, 1/1/2010

Lectures

Management of HER-2/neu Overexpressing Breast Cancer
Plymouth, MI - 1/1/2014
New Trends in Breast Cancer Treatment
Grand Rapids, MI - 1/1/2014
Funding Opportunities Offered by SWOG and The Hope Foundation
Chicago, IL - 1/1/2014
Rare Cancer Research in SWOG
Chicago, IL - 1/1/2014
SWOG Membership Opportunities and Benefits
Chicago, IL - 1/1/2014
Management of Estrogen Receptor Positive Metastatic Breast Cancer
Thompsonville, MI - 1/1/2014
Developing the Cancer Therapies of the Future
Perdido Beach Resort, Orange Beach, AL - 1/1/2014
Challenges in Designing Clinical Trials for Stem Cell Directed Therapies, Targeting Cancer Stem Cells
San Francisco, CA - 1/1/2014
Breast Cancer Her2/ER
Chicago, IL - 1/1/2012
Highlights of the Day: Breast Cancer Her2/ER
Chicago, IL - 1/1/2012
Why Does This Cancer Therapy Work in a Petri Dish and Not in my Patient?
San Antonio, TX - 1/1/2011
Simple oral therapy with capecitabine (CAPE) and cyclophosphamide (CPA) for metastastic breast cancer (MBC)
Chicago, IL - 1/1/2010
Adjuvant Systemic Therapy of Breast Cancer
Boyne Falls, MI - 1/1/2010
Approaches to Metastastic Disease in Breast Cancer
Dearborn, MI - 1/1/2010
Controversies in Breast Cancer Treatment
Troy, MI - 1/1/2010
The Angiotensin Receptor and Breast Cancer
Chicago, IL - 1/1/2009
Adjuvant Therapy of Breast Cancer
Detroit, MI - 1/1/2009
Physical and Psychological Consequences of Breast Cancer Diagnosis and Treatment
Ann Arbor, MI - 1/1/2009
When Breast Cancer Treatment Ends: Helping Survivors Stay Healthy
New York, NY - 1/1/2008
Advances in Adjuvant Systemic Therapy
Dearborn, MI - 1/1/2008
Novel Targeted Treatment of Stage IV Breast Cancer
Detroit, MI - 1/1/2008
Updates on Adjuvant Chemotherapy
Plymouth, MI - 1/1/2007
Breast Cancer - Evolving Clinical Practice
Ann Arbor, MI - 1/1/2006
Phase II Endpoints in Cooperative Group Trials
Dallas, TX - 1/1/2005
Adjuvant Chemotherapy for Breast Cancer
Dearborn, MI - 1/1/2005
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Other

Systemic treatment for HER2-positive metastatic breast cancer.
Schott AF, eChapter, UpToDate
1/1/2017
Systemic treatment of metastatic breast cancer in women: Chemotherapy
Schott AF, eChapter, UpToDate
1/1/2017
A case of thigh swelling in a patient with metastatic breast cancer receiving combination chemotherapy.
Schott AF, Breast Cancer Online
1/1/2006
Recommendations for Comparing Therapeutic Sequences for Patients with Breast, Kidney, and Other Advanced and Metastatic Cancers.
Effectiveness Guidance Document Technical Working Group (TWG), Green Park Collaborataive Version
1/1/2005
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Press Mentions

They Found a Lump. Doctors Said Not to Worry. These Are the Stories of Men with Breast CancerOctober 14th, 2021
Women with Metastatic Breast Cancer Are Surviving Longer, Study FindsMay 18th, 2017
Cancer Center Names Four New LeadersSeptember 28th, 2016