Dr. Silk is on Doximity
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Office
Dana-Farber Cancer Institute
450 Brookline Ave
Boston, MA 02215Phone+1 617-632-6571
Education & Training
- University of MichiganFellowship, Hematology and Medical Oncology, 2011 - 2014
- UPMC Medical EducationResidency, Internal Medicine, 2008 - 2011
- University of Pittsburgh School of MedicineClass of 2008
- Swarthmore CollegeBA, Biology, 1997 - 2001
- Swarthmore CollegeB.S., Biology (concentration in Environmental Studies), 2001
- University of Pittsburgh School of MedicineM.S., Clinical Research
Certifications & Licensure
- MA State Medical License 2018 - 2025
- NJ State Medical License 2014 - 2019
- MI State Medical License 2011 - 2014
- PA State Medical License 2008 - 2011
Awards, Honors, & Recognition
- Project Member Team Award (PMTA) National Institutes of Health (NIH) Cancer Therapeutics and Evaluation, 2015
- Excellence in Research Award, Hematology/ Oncology Fellowship Program University of Michigan, 2014
- Outstanding Clinical Research Paper Award University of Michigan, 2013
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Clinical Trials
- A Phase 1 Study of the Clinical and Immunologic Effects of ALT-803 in Patients With Advanced Solid Tumors Start of enrollment: 2014 May 01
- Intratumoral CAVATAK (CVA21) and Pembrolizumab in Patients With Advanced Melanoma (VLA-011 CAPRA) Start of enrollment: 2015 Dec 17
- Aldesleukin and Pembrolizumab in Treating Patients With Stage III-IV Melanoma Start of enrollment: 2017 Mar 21
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Publications & Presentations
PubMed
- Changes in Merkel cell oncoprotein antibodies after radiation therapy in curatively treated Merkel cell carcinoma and association with recurrence.Kevin X Liu, Kee-Young Shin, Manisha Thakuria, Jonathan D Schoenfeld, Roy B Tishler
Cancer. 2024-12-15 - Circulating Tumor DNA Assay Detects Merkel Cell Carcinoma Recurrence, Disease Progression, and Minimal Residual Disease: Surveillance and Prognostic Implications.Tomoko Akaike, Manisha Thakuria, Ann W Silk, Daniel S Hippe, Song Youn Park
Journal of Clinical Oncology. 2024-09-10 - A phase 2 open-label study of cemiplimab in patients with advanced cutaneous squamous cell carcinoma (EMPOWER-CSCC-1): Final long-term analysis of groups 1, 2, and 3, ...Brett G M Hughes, Alexander Guminski, Samantha Bowyer, Michael R Migden, Chrysalyne D Schmults
Journal of the American Academy of Dermatology. 2024-09-07
Journal Articles
- Phase I Trial of ALT-803, a Novel Recombinant Interleukin-15 Complex, in Patients with Advanced Solid TumorsJeffrey S Miller, Shernan G Holtan, Sylvia M Lee, Chihiro Morishima, Ann W Silk, Clinical Cancer Research
- Clinical characterization of colitis arising from anti-PD-1 based therapyWang DY, Mooradian MJ, Kim DW, Shah NJ, Fenton SE, Conry RM, Mehta R, Silk AW, Zhou A, Compton ML, Al-Rohil RN, Lee S, Voorhees AL, Ha L, McKee S, Norrell JT, Mehnert ..., OncoImmunol, 1/1/2018
- Adjuvant Nivolumab versus Ipilimumab in Resected Stage III or IV MelanomaWeber J, Mandala M, Del Vecchio M, and the CheckMate 238 Collaborators (Silk AW), N Engl J Med, 1/1/2017
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Books/Book Chapters
Abstracts/Posters
- Safety and pharmacodynamics of the DRD2 antagonist ONC201 in advanced solid tumor patients with weekly oral administration.Stein MN, Malhotra J, Malhotra U, Silk AW, Chan N, Rodriguez-Rodriguez L, Aisner J, Aiken R, Newman J, Sadimin E, Saunders T, Frankel M, Kareddula A, El-Deiry WS, Tara..., J Clin Oncol, 1/1/2018
- A Phase II Study of Talimogene laherparepvec Followed by Talimogene laherparepvec + Nivolumab in Refractory T Cell and NK Cell Lymphomas, Cutaneous Squamous Cell Carci...Silk AW, LeBoeuf NR, Rabinowits G, Puzanov I, Burgess MA, Devata S, Moore D, Goydos JS, Chen HX, Kaufman H, Zloza A, Mehnert JM, ASCO-SITC Clinical Immuno-Oncology Symposium; New Jersey Cancer Retreat, San Francisco, CA, 1/1/2018
- A Phase I Study to Evaluate the Safety of Trigriluzole (BHV-4157) in Combination with PD-1 Blocking Antibodies.Silk AW, Berman R, Coric V, Ruggiero L, Reitz AB, Shih W, Kane MP, Mehnert JM, Pelletier JC, Zloza A, Goydos JS, ASCO-SITC Clinical Immuno-Oncology Symposium; New Jersey Cancer Retreat, San Francisco, CA, 1/1/2018
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Lectures
- Oncolytic Viral Therapy in Melanoma and Merkel Cell Carcinoma: What�s Good for the Goose is Good for the GanderUniversity of Pittsburgh Medical Center, Pittsburgh, PA - 1/1/2018
- Oncolytic Viral TherapyRutgers Robert Wood Johnson Medical School - 1/1/2018
- Practical Radiology for FellowsRutgers Robert Wood Johnson Medical School - 1/1/2018
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Press Mentions
- What Is Basal Cell Carcinoma, the Skin Cancer Biden Just HadMarch 3rd, 2023
- Novel Vaccine Approach Halts Disease After 23 Years of Breast CancerNovember 18th, 2022
- Society for Immunotherapy of Cancer (SITC) Publishes Clinical Practice Guideline on Immunotherapy for the Treatment of Nonmelanoma Skin CancerAugust 3rd, 2022
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Grant Support
- Combination oncolytic virus and PD-1 blockade for melanoma treatmentGateway for Cancer Research2016–2018
Professional Memberships
- Member
- Society for the Immunotherapy of Cancer (SITC)Member
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