AnnCMcKeeMD

Neurodegenerative, Dementia & Geriatrics

William Fairfield Warren Distinguished Professor of Neurology & Pathology, CTE Center Director, ADC Center Associate Director, AD & CTE Center Neuropathology Core Director

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Office
200 Springs Road
182B
Bedford, MA 01730
Phone+1 781-687-2913

Fax+1 781-687-3515

Education & Training

Massachusetts General HospitalFellowship, Neuropathology, 1986 - 1989
UMass Chan Medical SchoolResidency, Neurology, 1984 - 1985
Case Western Reserve University/University Hospitals Cleveland Medical CenterResidency, Neurology, 1982 - 1983
The MetroHealth System/Case Western Reserve UniversityResidency, Internal Medicine, 1979 - 1981
Case Western Reserve University School of MedicineClass of 1979
University of Wisconsin-ExtensionBS, 1975

Certifications & Licensure

MA State Medical License 1986 - 2025
OH State Medical License 1979 - 1986
American Board of Pathology Neuropathology
American Board of Psychiatry and Neurology Neurology

Awards, Honors, & Recognition

Time 100 most influential people Time magazine, 2018
Henry Wisniewski, Lifetime achievement award Alzheimer’s association, 2018
Bostonian of the Year Boston Globe, 2017
Ethos Award Santa Clara University, Institute of Sports Law and Ethics, 2014
Pamela Warden Lectureship Defense and Veterans Brain Injury Center, 2014
Zimmerman Lectureship in Neuropathology Montefiore and Albert Einstein Medical Centers, 2013
John Groves Lectureship in Neuropathology McMaster University, 2013
Patriot Award Appleton East High School, 2012
Gabriele Zu Rhein Lectureship in Neuropathology University of Wisconsin, Madison, 2011
Impact Award Sports Legacy Institute, 2011
Harold Alfond Sports Medicine Lectureship 2011
Blythe Memorial Lectureship University of North Carolina Medical Center, 2010
Moore Award, Honorable Mention American Association of Neuropathologists, 2006, 2009
Merit Award Department of Veterans Affairs, U.S. Government, 1994, 2012
Moore Award American Association of Neuropathologists, 1990
Career Investigator Development Award National Institute of Neurological and Communicative Disorders and Stroke, 1989
Cleveland Neuroscience Research Award 1984
Resident Research Award Cleveland Metropolitan General Hospital, 1984
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Publications & Presentations

PubMed

Chronic Traumatic Encephalopathy, Family History of Mental Illness, and Aggression in Brain Donors With Repetitive Head Impact Exposure.
Madeline Uretsky, Evan Nair, Rebecca Burton, Shea W Cronin, Danielle Rousseau
Neurology. 2024-12-24
Neurodegeneration in the cortical sulcus is a feature of chronic traumatic encephalopathy and associated with repetitive head impacts.
Raymond Nicks, Arsal Shah, Spiro Anthony Stathas, Daniel Kirsch, Sarah M Horowitz
Acta Neuropathologica. 2024-12-06
Duration of Ice Hockey Play and Chronic Traumatic Encephalopathy.
Bobak Abdolmohammadi, Fatima Tuz-Zahra, Madeline Uretsky, Raymond Nicks, Sydney Mosaheb
JAMA Network Open. 2024-12-02

Journal Articles

Astrocytic Degeneration in Chronic Traumatic Encephalopathy
David L Brody, Thor D Stein, Ann C McKee, Acta Neuropathologica
Frequency of head impact related outcomes by position in NCAA Division I collegiate football players
Baugh CM, Kiernan PT, Kroshus E, Daneshvar DH, Montenigro PH, McKee AC, Stern R, J Neurotrauma, 8/26/2014
Proteins recruited to exosomes by tau overexpression implicate novel cellular mechanisms linking tau secretion with Alzheimer's disease
Saman S, Lee NC, Inoyo I, Jin J, Li Z, Doyle T, McKee AC, Hall GF, J Alzheimers Dis, 1/1/2014
1R-flurbiprofen improves tau, but not Abeta pathology in a triple transgenic model of Alzheimer's disease
Carreras I, McKee AC, Choi JK, Aytan N, Kowall NW, Jenkins BG, Dedeoglu A, Brain Res, 12/1/2013
Lexical retrieval in discourse: An early indicator of Alzheimer's dementia
Pekkala S, Wiener D, Himali JJ, Beiser AS, Obler LK, Liu Y, McKee A, Auerbach S, Seshadri S, Wolf PA, Au R, Clin Linguist Phon, 8/28/2013
Clinical presentation of chronic traumatic encephalopathy
Stern RA, Daneshvar DH, Baugh CM, Seichepine DR, Montenigro PH, Riley DO, Fritts NG, Stamm JM, Robbins CA, McHale L, Simkin I, Stein TD, Alvarez VE, Goldstein LE, Buds..., Neurology, 8/21/2013
Reitz C, Jun G, Naj A, Rajbhandary R, Vardarajan BN, Wang LS, Valladares O, Lin CF, Larson EB, Graff-Radford NR, Evans D, De Jager PL, Crane PK, Buxbaum JD, Murrell JR..., JAMA, 4/1/2013
Multiple mechanisms of extracellular tau spreading in a non-transgenic tauopathy model
Le M, Kim W, Lee S, McKee A, Hall G, Am J Neurodegeneration, 11/25/2012
Expression of Taurine Transporter (TauT) is Modulated by Heat Shock Factor 1 (HSF1) in Motor Neurons of ALS
Jung MK, Kim KY, Lee NY, Kang YS, Hwang YJ, Kim Y, Sung JJ, McKee A, Kowall N, Lee J, Ryu H, Mol Neurobiol, 11/23/2012
Chronic traumatic encephalopathy: neurodegeneration following repetitive concussive and subconcussive brain trauma
Baugh CM, Stamm JM, Riley DO, Gavett BE, Shenton ME, Lin A, Nowinski CJ, Cantu RC, McKee AC, Stern RA, Brain Imaging Behav, 6/1/2012
Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature Review
Nelson PT, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns NJ, Castellani RJ, Crain BJ, Davies P, Del Tredici K, Duyckaerts C, Frosch MP, Haroutunian V, Hof PR, Hulet..., J Neuropathol Exp Neurol, 5/1/2012
Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease
Saman S, Kim W, Raya M, Visnick Y, Miro S, Saman S, Jackson B, McKee AC, Alvarez VE, Lee NC, Hall GF, J Biol Chem, 2/1/2012
Long-term consequences of repetitive brain trauma: chronic traumatic encephalopathy Review
Stern RA, Riley DO, Daneshvar DH, Nowinski CJ, Cantu RC, McKee AC, PMR, 10/1/2011
Tar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue
Liu-Yesucevitz L, Bilgutay A, Zhang YJ, Vanderwyde T, Citro A, Mehta T, Zaarur N, McKee A, Bowser R, Sherman M, Petrucelli L, Wolozin B, PLoS One, 10/1/2011
Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington's disease mice
Lee J, Kosaras B, Del Signore SJ, Cormier K, McKee A, Ratan RR, Kowall NW, Ryu H, Acta Neuropathol, 4/1/2011
The Epidemiology of Sports-Related Concussion
Daneshvar D, Nowinski C, McKee A, Cantu R, Clinics in Sports Medicine, 1/1/2011
Chronic Traumatic Encephalopathy: A Potential Late Effect of Sport-Related Concussive and Subconcussive Head Trauma
Gavett B, Stern R. McKee A, Clinics in Sports Medicine, 1/1/2011
Helmets and Mouth guards: The Role of Personal Equipment in Preventing Sports Related Concussions
Daneshvar D, Nowinski C, McKee A, Stern R, Cantu R, Clinics in Sports Medicine, 1/1/2011
Mild traumatic brain injury: A risk factor for neurodegeneration
Gavett, B, Stern R, Cantu R, Nowinski C, McKee A, Alzheimer's Research and Therapy, 6/1/2010
TDP-43 Proteinopathy and Motor Neuron Disease in Chronic Traumatic Encephalopathy
McKee A, Gavett B, Stern R, Nowinski C, Cantu R, Kowall N, Perl D, Hedley-Whyte E, Price B, Sullivan C, Morin P, Lee H-S, Kubilus C, Daneshvar D, Wulff M, Budson A, Journal Neuropathol Exp Neurol, 1/1/2010
Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease
Mastroeni D, McKee A, Grover A, Rogers J, Coleman PD, PLoS One, 8/1/2009
Chronic Traumatic Encephalopathy in Athletes: Progressive Tauopathy following Repetitive Head Injury
McKee AC, Cantu RC, Nowinski CJ, Hedley-Whyte ET, Gavett BE, Budson AE, Santini VE, Lee H-Y, Kubilus CA, Stern RA, J Neuropath Exp Neurol, 1/1/2009
Ibuprofen reduces intraneuronal ABeta, prevents hyperphosphorylated tau and ameliorates cognitive deficits in young triple transgenic Alzheimer mice
McKee AC, Carreras I, Hossain L, Ryu H, Klein W, Oddo S, LaFerla F, Jenkins B, Kowall N, Dedeoglu A, Brain Research, 5/1/2008
Sepiapterin reductase expression is increased in Parkinson's disease brain tissue
Tobin JE, Cui J, Wilk J, Latourelle J, Laramie J, McKee A, Guttman M, Karamohamed S, DeStefano A, Myers R, Brain Research, 1/1/2007
Insulin degrading enzyme is localized predominantly in the cell surface of polarized and unpolarized human cerebrovascular endothelial cultures
Lynch JA, George AM, Eisenhauer PB, Conn K, Gao W, Carreras I, Wells J, McKee A, Ullman D, Fine RE, J Neurosci Res, 5/1/2006
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Books/Book Chapters

lzheimer’s disease and other dementias, Behavioral Neuroscience Series
Chapter: The Neuropathology of Dementia
McKee Ann CEditors: Budson, A.2011
Neural Injury and Regeneration
Chapter: The histopathology of degeneration and plasticity in Alzheimer's disease
Kowall NW, McKee ACEditors: Seil F.1993
Atlas of Diagnostic Oncology
Chapter: Neoplasms of the Central Nervous System
McKee ACEditors: Skarin A.Gower Medical Publishing, New York, NYEdition 1st,1990

Lectures

Emerging Concepts in CTE
Cleveland, OH - 10/16/2014
CTE –emerging concepts
Sao Paulo, Brazil - 9/19/2014
CTE: current concepts
Sao Paulo, Brazil - 9/15/2014
Current concepts in CTE
New Orleans, LA - 5/20/2014
Pathology of CTE
Philadelphia, PA - 5/3/2014
What is CTE?
Appleton High School East, Appleton, WI - 4/7/2014
Update on CTE in athletes
Eau Claire, WI - 4/4/2014
Emerging Concepts in Chronic Traumatic Encephalopathy
Vanderbilt University, Nashville, TN - 11/18/2013
Prospective Study of CTE using Neuro Imaging with Post Mortem as a Final Validation/Challenges
Rochester, MN - 10/8/2013
Chronic Traumatic Encephalopathy in Athletes and Veterans
Boston, MA - 5/23/2013
Update on Chronic Traumatic Encephalopathy
Boston, MA - 5/18/2013
Ocular Manifestations of Chronic Traumatic Encephalopathy
Seattle, WA - 5/5/2013
Chronic post-traumatic encephalopathy in professional sport
Hamilton, Ontario, Canada - 4/19/2013
Brain Damage and Recovery
Atlanta, GA - 4/11/2013
What is the pathological evidence for concussion related changes in the brains of retired athletes?
Zurich, Switzerland - 11/2/2012
Chronic Traumatic Encephalopathy 2012
Scottsdale, AZ - 9/28/2012
Chronic Traumatic Encephalopathy in the Military
Fort Lauderdale, FL - 8/15/2012
Chronic Traumatic Encephalopathy: What we have learned from athletes and Veterans
New York, NY - 4/17/2012
The Long-term Consequences of Repetitive Concussion
Appleton High School East, Appleton, WI - 3/5/2012
Mild Traumatic Brain Injury and Chronic Traumatic Encephalopathy: What we have learned from athletes
Oakbrook, IL - 10/29/2011
Recurrent Athletic mTBI, Cerebral Tauopathy, and Chronic Traumatic Encephalopathy
Philadelphia, PA - 10/21/2011
The Long-term Sequelae of Mild Traumatic Brain Injury
Washington, DC - 8/22/2011
Traumatic Brain Injury
Woods Hole, MA - 8/16/2011
Chronic Traumatic Encephalopathy: Your brain on football
Oak Lawn, IL - 5/11/2011
University of Edinboro Concussion Conference
Edinboro, PA - 4/29/2011
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Press Mentions

Former NFL Star, CBS Anchor Irv Cross Had Brain Disease CTEFebruary 28th, 2023
Researchers Find CTE in 345 of 376 Former NFL Players StudiedFebruary 6th, 2023
Demaryius Thomas Diagnosed with Stage 2 CTE in Posthumous Brain StudyJuly 5th, 2022
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Grant Support

Core--NeuropathologyNational Institute On Aging1996–2010
Cytoskeletal Disorganization Alzheimer'S DiseaseNational Institute Of Neurological Disorders And Stroke1989–1993