AndrzejADlugoszMD

PubMed

• Development of a Multiplex Immunofluorescence Assay for Tumor Microenvironment Studies of Human and Murine Merkel Cell Carcinoma.
  Lei Sun, Monique E Verhaegen, Jake McGue, Alberto C Olivei, Andrzej A Dlugosz
  Laboratory Investigation; a Journal of Technical Methods and Pathology. 2024-10-01
• Corrigendum to "Characterizing the Therapeutic Potential of a Potent BET Degrader in Merkel Cell Carcinoma" [Neoplasia, Volume 21, Issue 3 (2019) 322-330].
  Jae Eun Choi, Monique E Verhaegen, Sahr Yazdani, Rohit Malik, Paul W Harms
  Neoplasia. 2024-09-01
• Identification of Meibomian gland stem cell populations and mechanisms of aging.
  Xuming Zhu, Mingang Xu, Celine Portal, Yvonne Lin, Alyssa Ferdinand
  Biorxiv. 2024-08-10

Journal Articles

• Circulating Cell-Free miR-375 as Surrogate Marker of Tumor Burden in Merkel Cell Carcinoma  
  Andrzej Dlugosz, MD, Clinical Cancer Research
• Merkel cell carcinoma dependence on Bcl-2 family members for survival  
  Verhaegen ME, Mangelberger D, Weick JW, Vozheiko TD, Harms PW, Nash KT, Quintana E, Baciu P, Johnson TM, Bichakjian CK, Dlugosz AA, J Invest Dermatol, 3/1/2014
• Multiple Shh signaling centers participate in fungiform papilla and taste bud formation and maintenance  
  Liu HX, Ermilov A, Grachtchouk M, Li L, Gumucio DL, Dlugosz AA, Mistretta CM, Dev Biol, 10/1/2013
• Transgenic expression of interferon in mouse stomach leads to inflammation, metaplasia, and dysplasia  
  Syu LJ, El-Zaatari M, Eaton KA, Liu Z, Tetarbe M, Keeley TM, Pero J, Ferris J, Wilbert D, Kaatz A, Zheng X, Qiao X, Grachtchouk M, Gumucio DL, Merchant JL, Samuelson L..., Am J Pathol, 12/1/2012
• Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells  
  Eberl M, Klingler S, Mangelberger D, Loipetzberger A, Damhofer H, Zoidl K, Schnidar H, Hache H, Bauer HC, Solca F, Hauser-Kronberger C, Ermilov AN, Verhaegen ME, Bicha..., EMBO Mol Med, 3/1/2012
• A transgenic mouse for imaging caspase-dependent apoptosis within the skin  
  Khanna D, Hamilton CA, Bhojani MS, Lee KC, Dlugosz A, Ross BD, Rehemtulla A, J Invest Dermatol, 7/1/2010
• Transient activation of beta-catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice  
  Van Mater D, Kolligs FT, Dlugosz AA, Fearon ER, Genes Dev, 5/1/2003
• Macrophage-stimulating protein induces proliferation and migration of murinekeratinocytes  
  Wang MH, Dlugosz AA, Sun Y, Suda T, Skeel A, Leonard EJ, Exp Cell Res, 7/1/1996
• Regulating normal skin function by polypeptide growth factors  
  Glick AB, Dlugosz AA and Yuspa S, Cosmetics and Toiletries, 1/1/1994
• Interactions between IF's, microtubules and myofibrils in fibrogenic and myogenic cells  
  Holtzer H, Forry-Schaudies S, Dlugosz A, Antin P and Dubyak G, Ann NY Acad Sci, 1/1/1985
• The relationship between stress fiber-like structures and nascent myofibrils in cultured cardiac myocytes  
  Dlugosz AA, Antin PB, Nachmias VT, Holtzer H, J Cell Biol, 12/1/1984
• Properties of cell lineages as indicated by the effects of ts-RSV and TPA on the generation of cell diversity  
  Holtzer H, Pacifici M, Croop J, Boettiger D, Toyama Y, Payette R, Biehl J, Dlugosz A and Holtzer S, Fortsch. Zool, 1/1/1981
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Books/Book Chapters

• Fitzpatrick’s Dermatology in General Medicine 
  Chapter: Chemical Carcinogenesis 
  Glick AB and Dlugosz AAEditors: Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, and Wolff K.McGraw-Hill, Inc., New YorkEdition 8th,2012
• Fitzpatrick’s Dermatology in General Medicine 
  Chapter: Carcinogenesis: Chemical 
  Dlugosz AA and Yuspa SHEditors: Wolff K, Goldsmith, LA, Katz, SI, Gilchrest BA, Paller, AS, and Leffell, DJ.McGraw-Hill, Inc., New YorkEdition 7th,2008
• Skin Cancer: Mechanisms and Human Relevance 
  Chapter: Biochemical regulation of keratinocyte differentiation and neoplastic transformation 
  Dlugosz AAEditors: Mukhtar H.CRC Press, Boca Raton, FL1995
• Dermatology in General Medicine 
  Chapter: Carcinogenesis: Chemical 
  Dlugosz AA and Yuspa SHEditors: Fitzpatrick TB, Eisen AZ, Wolff K, Freedberg IA and Austen KF.McGraw-Hill, Inc., New YorkEdition 4th,1993
• Physiology Biochemistry and Molecular Biology of The Skin 
  Chapter: Cutaneous carcinogenesis: natural and experimental 
  Yuspa SH and Dlugosz AAEditors: Goldsmith L.Oxford University Press, New York1991
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Abstracts/Posters

• Blockade of Gli transcriptional activity in mature anagen hair follicles leads to impaired matrix cell proliferation, aberrant differentiation, and defective hair shaf...
  Ermilov AN, Pero J, Wilbert D, Photenhauer A, Zabawa H, Grachtchouk M, Dlugosz AA, J Invest Dermatol, 1/1/2013
• Targeting Merkel cell carcinoma dependence on Bcl-2 family members promotes efficient cell death in vitro and in vivo
  Verhaegen, ME, Weick JW, Vozheiko TD, Mangelberger DM, Pero JC, Johnson TM, Bichakjian, Dlugosz AA, J Invest Dermatol, 1/1/2013
• Lgr5+ stem cells give rise to Hedgehog pathway-driven gastric adenocarcinomas
  Syu LJ, Zhao X, Grachtchouk M, Ermilov A, Greenson J, Zheng X, Kaatz A, Pero J, Wilbert D, Gumucio D, Samuelson L, Merchant J, Dlugosz AA, J Invest Dermatol, 1/1/2013
• Oncogene addiction distinguishes malignant from benign skin tumors caused by deregulated Hedgehog signaling
  Grachtchouk M. Wilbert D, Pero J, Fiehler K, Crowley J, Photenhauer A, Ermilov AN, Dlugosz AA, J Invest Dermatol, 1/1/2013
• Exploiting deregulated apoptotic signaling as a therapeutic strategy for Merkel cell carcinoma
  Verhaegen ME, Bichakjian CK, Vozheiko T, Weick J, Voutsalath M, Johnson TM, Dlugosz AA, J Invest Dermatol, 1/1/2012
• GLI2 engages the mTOR pathway to drive development of malignant peripheral nerve sheath tumors (MPNSTs) in skin
  Ermilov AN, DeLassua E, Ferris J, Hong D, Pero J, Liu J, Grachtchouk M, Conway SJ, Lucas DR, Dlugosz AA, J Invest Dermatol, 1/1/2012
• Basal cell carcinoma tumor subtype is defined by its cell of origin
  Grachtchouk M, Pero J, Ermilov AN, Michael LE, Wilbert D, Lim S, Dlugosz AA, J Invest Dermatol, 1/1/2011
• Oncogene addiction to Merkel cell polyomavirus large T antigen in Merkel cell carcinoma
  Verhaegen ME, Bichakjian CK, Voutsalath M, Weick J, Baciu P, Quintana E, Stromer TD, Pero J, Nash KT, Ayar AE, Johnson TM, Dlugosz AA, J Invest Dermatol, 1/1/2011
• Targeting deregulated HIF1 signaling in human melanoma by conditional HIF1 knockdown promotes tumor progression
  Nash KT, Ayar AE, Verhaegen ME, Johnson TJ, Dlugosz AA, J Invest Dermatol, 1/1/2011
• Deregulated hedgehog signaling in the pathogenesis of Barrett’s disease and gastric adenocarcinoma
  Ermilov, AN, Ferris J, Pero J, Hong D, Dlugosz AA, J Invest Dermatol, 1/1/2010
• Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin in vivo
  Rittie L, Stoll SW, Kang S, Dlugosz AA, Voorhees JJ, Fisher GJ, J Invest Dermatol, 1/1/2009
• Unscheduled melanogenesis in response to oncogenic Hedgehog signaling in skin
  Yang SH, Verhaegen M, Grachtchouk V, Wang A, Liu J, Syu L, Ferris J, Dlugosz AA, J Invest Dermatol, 1/1/2009
• Hedgehog signaling and sebaceous gland maintenance
  Grachtchouk M, Wang A, Gudjonsson J, Liu J, Ferris J, Dlugosz AA, J Invest Dermatol, 1/1/2008
• Obligatory role for Bmi1 in hedgehog-pathway driven medulloblastoma expansion
  Michael LE, Westerman BA, Ermilov AN, Ferris J, Liu J, Blom M. van Lohuizen M, Dlugosz AA, J Invest Dermatol, 1/1/2008
• Hedgehog-driven epitheial bud development is associated with activation of cannonical Wnt signaling
  Yang S, Grachtchouk V, Wang A, Liu J, Syu L, Dlugosz A, J Invest Dermatol, 1/1/2007
• Lack of evidence for activation of the Hedgehog pathway in psoriasis
  Aphale A, Gudjonsson JE, Grachtchouk M, Johnson T, Voorhees JJ, Dlugosz A, Elder JT, J Invest Dermatol, 1/1/2007
• A conditional mouse model defines temporal and spatial requirements for deregulated Hedgehog signaling in medulloblastoma
  Michael LE, Liu J, Wang A, Ferris JE, Grachtchouk M, Ermilov AN, Dlugosz AA, J Invest Dermatol, 1/1/2007
• Cellular context dictates tumorigenic potential of activated Smo in vivo
  Michael LE, Brown JE, Liu J, Wang A, Ermilov AN, Glick AB, Dlugosz AA, J Invest Dermatol, 1/1/2006
• Constitutive Hedgehog signaling activity, via GLI2 expression, is sufficient for salivary gland tumorigenesis
  Ermilov AE, Brown J, Roessler E, Wang A, Liu J, D’Silva N, Ramirez A, Jorcano J, Muenke M, Dlugosz AA, J Invest Dermatol, 1/1/2006
• Hedgehog signaling and sebocyte development
  Grachtchouk M, Liu J, Hutchin M, Wang A, Glick AB, Dlugosz A, J Invest Dermatol, 1/1/2005
• Dominant negative tuberin collaborates with Patched (PTCH) deficiency in the development of neoplasia in transgenic mice
  Govindarajan B, Arbiser JL, Brat DJ, Dlugosz A, J Invest Dermatol, 1/1/2005
• Full-length human GLI2 contains a previously undescribed transcriptional repressor domain
  Ermilov A, Roessler E, Wang A, Grachtchouk M, Dlugosz A, Muenke M, J Invest Dermatol, 1/1/2005
• Deregulated hedgehog signaling in extracutaneous basaloid squamous cell carcinomas
  Grachtchouk M, Wang A, Lei L, Hutchin M, Lowe L, Glick A, and Dlugosz AA, J Invest Dermatol, 1/1/2004
• Defining the Hedgehog-PTHrP signaling axis in the skin
  Gocken T, Sheng H, Gonterman R, Billings SD, Diamond A, Dlugosz AA, and Foley J, J Invest Dermatol, 1/1/2004
• Odontogenic keratocysts in transgenic mice overexpressing the hedgehog signaling effector Gli2
  Grachtchouk M, Wei L, Liu J, Wang A, and Dlugosz AA, J Invest Dermatol, 1/1/2003
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Lectures

• Dissecting the transforming potential of Merkel cell polyomavirus 
  Denver, CO - 3/21/2014
• Basal cell carcinoma drug therapy and side effects: from bench to clinic and back again 
  2/27/2014
• Hedgehog signaling level, tumor phenotype, and oncogene addiction 
  Il Ciocco, Italy - 5/14/2013
• Hedgehog signaling in skin biology and tumorigenesis: where, when and how? 
  Edinburgh, Scotland - 5/10/2013
• Hedgehog functions in skin biology and cancer 
  New Haven, CT - 4/3/2013
• Immunobullous Disease 
  1/1/2013
• Multiple determinants contribute to basal cell carcinoma development 
  Dermatogenetics, Miami, FL - 2/10/2012
• Hedgehog and basal cell carcinoma: where, when and how 
  Skamania Lodge, WA - 10/14/2011
• Mechanism-Based Medical Approaches to Treating Skin Cancer 
  Napa, CA - 9/18/2011
• Hedgehog signaling in non-melanoma skin cancer 
  Tubingen, Germany - 2/17/2011
• Cell of Origin and Basal Cell Carcinoma Subtype: Location, Location, Location 
  1/1/2011
• Hedgehog signaling; current understanding and clinical implications 
  Vienna, Austria - 11/20/2010
• Deregulated Hedgehog signaling in basal cell carcinoma initiation, progression, and maintenance: therapeutic implications 
  Gothenburg, Sweden - 10/8/2010
• From bench to clinic with a Hedgehog: targeted therapeutics for basal cell carcinoma 
  Atlanta, GA - 5/5/2010
• Hedgehog Signaling in Skin Biology and Tumorigenesis 
  10/22/2009
• Defining the cell of origin for Hedgehog-driven cancer 
  University of California, San Diego - 10/22/2009
• Shh signaling in development and disease 
  Gleneden Beach, OR - 10/8/2009
• Hedgehog signaling & skin tumorigenesis: from bench to bedside 
  3/24/2009
• Hedgehog signaling in skin development and cancer 
  11/9/2007
• Hedgehog signaling in cancer initiation 
  Smithville, TX - 11/10/2006
• Hedgehog signaling in skin appendage biology and cancer 
  Infinity Pharmaceuticals, Inc., Cambridge, MA - 3/20/2006
• Hedgehog signaling in tumor initiation and maintenance 
  1/1/2006
• Hedgehog signaling in skin biology and disease 
  Sophia Antipolis, France - 11/21/2005
• Hedgehog Signaling and Sebocyte Development 
  St. Louis, MO - 5/4/2005
• From Lab Bench to Clinic with a Hedgehog 
  3/9/2005
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