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Office
1102 Bates Ave
Houston, TX 77030Phone+1 832-824-1000
Summary
- Dr. Andras Heczey's research focuses on developing novel treatments for children with solid tumors by redirecting the immune system to attack and kill cancer cells by using genetically-engineered T cells and Natural Killer T cells. He developed bispecific T cell engagers and chimeric antigen receptors which specifically target several solid tumors (including hepatoblastoma, hepatocellular carcinoma, yolk sac tumors, Wilms tumor, rhabdoid tumors etc) when expressed in T cells.
As the Director of the Liver Tumor Center, Dr. Heczey developed a strategy to target glypican-3 (GPC3) with genetically-engineered T lymphocytes. His team is currently evaluating Interleukin-15 and GPC3-CAR expressing T cells in children with solid tumors.
His ultimate goal is to cure all patients with solid cancers by effectively translating preclinical findings from bench-to-bedside.
Education & Training
- Baylor College of MedicineFellowship, Pediatric Hematology/Oncology, 2009 - 2012
- Children's Hospital Los AngelesResidency, Pediatrics, 2006 - 2009
- Semmelweis UniversityClass of 2002
Certifications & Licensure
- TX State Medical License 2010 - 2026
- CA State Medical License 2009 - 2025
- American Board of Pediatrics Pediatrics
- American Board of Pediatrics Pediatric Hematology-Oncology
Clinical Trials
- Glypican 3-specific Chimeric Antigen Receptor Expressing T Cells for Hepatocellular Carcinoma (GLYCAR) Start of enrollment: 2019 Mar 28
- GD2 Specific CAR and Interleukin-15 Expressing Autologous NKT Cells to Treat Children With Neuroblastoma Start of enrollment: 2018 Jan 18
- T Cells co- Expressing a Second Generation Glypican 3-specific Chimeric Antigen Receptor With Cytokines Interleukin-21 and 15 as Immunotherapy for Patients With Liver Cancer (TEGAR) Start of enrollment: 2020 Jan 01
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Publications & Presentations
PubMed
- Interleukin-15-armoured GPC3 CAR T cells for patients with solid cancers.David Steffin, Nisha Ghatwai, Antonino Montalbano, Purva Rathi, Amy N Courtney
Nature. 2024-11-27 - The impact of congenital heart disease on treatment and survival of patients with hepatoblastoma: A single-center experience.Andres F Espinoza, Ashley E Montgomery, Nicholas C Maamari, Heather A Dickerson, Andras Heczey
Pediatric Blood & Cancer. 2024-11-01 - Incidence and survival of pediatric and adult hepatocellular carcinoma, United States, 2001-2020.Azlann Arnett, David A Siegel, Shifan Dai, Trevor D Thompson, Jennifer Foster
Cancer Epidemiology. 2024-10-01
Press Mentions
- CAR T Cells Armed with IL-15 Show Promise in Treating Solid CancersNovember 27th, 2024
- Promising Results for CAR-NKT Cell Therapy Against Neuroblastoma in Phase 1 TrialMay 16th, 2023
- CAR-NKT Cell Therapy Shows Promising Results Against Neuroblastoma in Phase 1 Clinical TrialMay 15th, 2023
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