AmirToorMD

Hematologic Oncology

Professor of Medicine, UTSW, Dallas, TX; Director of Allogeneic Stem Cell Transplantation; Affiliate Professor, Internal Medicine, Virginia Commonwealth University, Richmond, VA.

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Office
5323 Harry Hines Blvd
UTSW
Dallas, TX 75390
Phone+1 610-402-8000

Summary

Dr. Amir Toor is a hematopoietic cell transplant and cellular therapy physician in Allentown, PA and is affiliated with Lehigh Valley Health Network. He is an affiliate Professor of Internal Medicine and Pediatrics at the VCUHS. He received his medical degree from King Edward Medical University and has been in practice 22 years after completing a fellowship in Hematology, Oncology and Bone Marrow Transplantation at University of Minnesota in 1999. He specializes in hematopoietic cell transplantation for hematologic malignancies and is experienced in managing acute and chronic leukemias, myelodysplasia, myelofibrosis, and multiple myeloma. He has served on School of Medicine and Department of Medicine Promotion and Tenure Committees. Dr. Toor has received the School of Medicine and Department of Medicine Distinguished Mentor Awards in 2021 and 2017 respectively. He has more than 75 peer-reviewed publications and over 100 scientific abstracts and received the Department of Medicine Distinguished Scholarship Award in 2016. His peer-reviewed publications may be found at; https://www-ncbi-nlm-nih-gov.proxy.library.vcu.edu/myncbi/12AlD9qomzV5r/bibliography/public/

Medical Grand Rounds 20230404

Patt Endowed lectureship @Lehigh Valley Health Network, "Demystifying Transplant and Cellular Therapy; On the Crossroads of Immunology and Oncology".

Reed Whitener - VCU Massey Cancer Center

“Reed is a living example of taking what we learn from clinical trials and putting that knowledge to work improving care for the next patient,” said Amir Toor..

Amir A. Toor, M.D. School of Medicine Distinguished Mentor Award.

Amir Toor, M.D., is Professor of Medicine in the Division of Hematology, Oncology & Palliative Care, Department of Internal Medicine (DOIM).

VCU Massey researchers harness the immune system to improve stem cell transplant

Dr. Amir Toor from VCU Massey Cancer Center explains NCT01050790, a clinical trial evaluating epigenetic induction of adaptive immune responses in MM (2012).

Finding Order in Biologic Systems: Amir Toor at TEDxRVA 2013

Dr. Amir Toor is an associate professor of medicine in the Bone Marrow Transplant Program at Virginia Commonwealth University.

Education & Training

University of MinnesotaFellowship, Hematology and Medical Oncology, 1996 - 1999
University of ConnecticutResidency, Internal Medicine, 1993 - 1996
Flushing Hospital Medical CenterInternship, Internal Medicine, 1992 - 1993
King Edward Medical UniversityClass of 1990

Certifications & Licensure

TX State Medical License 2024 - 2025
PA State Medical License 2023 - 2024
VA State Medical License 2007 - 2024
IL State Medical License 2001 - 2008
AR State Medical License 1999 - 2001
CT State Medical License 1995 - 1996
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Hematology

Awards, Honors, & Recognition

Distinguished Mentor Award Virginia Commonwealth University School of Medicine, 2021
Outstanding Mentor Award Department of Medicine, Virginia Commonwealth University, 2017
Distinguished Scholarship Award Department of Medicine, Virginia Commonwealth University, 2016
Regional Top Doctor Castle Connolly, 2014
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Clinical Trials

Stem Cell Transplantation in Individuals With Multiple Myeloma (BMT CTN 0102) Start of enrollment: 2003 Dec 01
Completed
Phase 3
Reduced Intensity Total Body Irradiation + Thymoglobulin Followed by Allogeneic PBSCT Start of enrollment: 2008 Jul 21
Completed
Phase 2
Lenalidomide + Azacitidine for Adaptive Immunotherapy -> Auto SCT in Multiple Myeloma Start of enrollment: 2010 Jan 01
Completed
Not Applicable
Adoptive Immunotherapy in Relapsed Hematological Malignancy: Early GVHD Prophylaxis Start of enrollment: 2015 Nov 04
Completed
Phase 2
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Publications & Presentations

PubMed

Feasibility of intravenous vitamin C supplementation in allogeneic hematopoietic cell transplant recipients.
Gary L Simmons, Roy Sabo, Rehan Qayyum, May Aziz, Erika Martin
Ejhaem. 2024-10-01
Increased donor inhibitory KIR are associated with reduced GVHD and improved survival following HLA-matched unrelated donor HCT in paediatric acute leukaemia.
Elizabeth Krieger, Rehan Qayyum, Amir Toor
British Journal of Haematology. 2024-05-01
1 citations
Defining and Grading Infections in Clinical Trials Involving Hematopoietic Cell Transplantation: A Report From the BMT CTN Infectious Disease Technical Committee.
Zainab Shahid, Aaron M Etra, John E Levine, Marcie L Riches, Aliyah Baluch
Transplantation and Cellular Therapy. 2024-05-01

Journal Articles

DNA Nanomapping Using CRISPR-Cas9 as a Programmable Nanoparticle
Amir Toor, MD, Nature
Treatment of Acute Fibrinous Organizing Pneumonia Following Hematopoietic Cell Transplantation with Etanercept
K Miller, W B Clark, J M McCarty, A A Toor, H M Chung, Nature
Fractal Organization of the Human T Cell Repertoire in Health and Following Stem Cell Transplantation
Meier J, Roberts C, Avent K, Hazlett A, Berrie J, Payne K, Hamm D, Desmarais C, Sanders C, Hogan KT, Archer KJ, Manjili MH, Toor AA, Biol Blood Marrow Transplant, 1/10/2013
Anti-thymocyte globulin for conditioning in matched unrelated donor hematopoietic cell transplantation provides comparable outcomes to matched related donor recipients
Portier DA, Sabo RT, Roberts CH, Fletcher DS, Meier J, Clark WB, Neale MC, Manjili MH, McCarty JM, Chung HM, Toor AA, Bone Marrow Transplant, 12/1/2012
Epigenetic induction of adaptive immune response in multiple myeloma: sequential azacitidine and lenalidomide generate cancer testis antigen-specific cellular immunity
Toor AA, Payne KK, Chung HM, Sabo RT, Hazlett AF, Kmieciak M, Sanford K, Williams DC, Clark WB, Roberts CH, McCarty JM, Manjili MH, Br J Haematol, 9/1/2012
Favorable Outcomes in Patients with High Donor-Derived T Cell Count after in Vivo T Cell-Depleted Reduced-Intensity Allogeneic Stem Cell Transplantation
Toor AA, Sabo RT, Chung HM, Roberts C, Manjili RH, Song S, Williams DC Jr, Edmiston W, Gatesman ML, Edwards RW, Ferreira-Gonzalez A, Clark WB, Neale MC, McCarty JM, Ma..., Biol Blood Marrow Transplant, 5/1/2012
Randomized Phase III Trial of Pegfilgrastim versus Filgrastim After Autologus Peripheral Blood Stem Cell Transplantation
Gerds A, Fox-Geiman M, Dawravoo K, Rodriguez T, Toor A, Smith S, Kiley K, Fletcher-Gonzalez D, Hicks C, Stiff P, Biol Blood Marrow Transplant, 5/1/2012
Immunotherapy of cancer: reprogramming tumor-immune crosstalk
Payne KK, Toor AA, Wang XY, Manjili MH, Clin Dev Immunol, 1/1/2012
Distinct Oligoclonal T Cells Are Associated With Graft Versus Host Disease After Stem-Cell Transplantation
Berrie JL, Kmieciak M, Sabo RT, Roberts CH, Idowu MO, Mallory K, Chung HM, McCarty JM, Borrelli CA, Detwiler MM, Kazim AL, Toor AA, Manjili MH, Transplantation, 1/1/2012
Activated NKT Cells and NK Cells Render T Cells Resistant to Myeloid-Derived Suppressor Cells and Result in an Effective Adoptive Cellular Therapy against Breast Cance...
Kmieciak M, Basu D, Payne KK, Toor A, Yacoub A, Wang XY, Smith L, Bear HD, Manjili MH, J Immunol, 7/15/2011
Comment on "Cutting Edge: CD8+ T Cell Priming in the Absence of NK Cells Leads to Enhanced Memory Responses
Manjili MH, Toor A, J Immunol, 6/1/2011
Ex vivo Expansion of Tumor-reactive T Cells by Means of Bryostatin 1/Ionomycin and the Common Gamma Chain Cytokines Formulation
Kmieciak M, Toor A, Graham L, Bear HD, Manjili MH, J Vis Exp, 1/14/2011
Rearrangements of the MLL gene are influenced by DNA secondary structure, potentially mediated by topoisomerase II binding
Le H, Singh S, Shih SJ, Du N, Schnyder S, Loredo GA, Bien C, Michaelis L, Toor A, Diaz MO, Vaughan AT, Genes Chromosomes Cancer, 9/1/2009
Dose intense therapy for relapsed lymphoproliferative disorders: the more things change, the more they are the same
Toor AA, Leuk Lymphoma, 5/1/2009
Impaired NHEJ function in multiple myeloma
Yang C, Betti C, Singh S, Toor A, Vaughan A, Mutat Res, 1/15/2009
Feasibility of conditioning with thymoglobulin and reduced intensity TBI to reduce acute GVHD in recipients of allogeneic SCT
Amir A. Toor, Tulio Rodriguez, Michael Bauml, Najeeb Mohideen, Herbert Mathews, Ameet Kini, David Senitzer, Mala Parthasarathy, Scott Smith, Jared Klein, Patrick Stiff, Bone Marrow Transplant, 12/1/2008
Posaconazole Salvage Therapy Allows Successful Allogeneic Hematopoietic Stem Cell Transplantation in Patients With Refractory Invasive Mold Infections
Mullane K, Toor A, Rodriguez T, Kalnicky C, Klein J, Stiff P, Transpl Infect Dis, 6/1/2007
Tandem autologous stem cell transplantation for patients with primary refractory or poor risk recurrent Hodgkin lymphoma
Fung HC, Stiff P, Schriber J, Toor A, Smith E, Rodriguez T, Krishnan A, Molina A, Smith D, Ivers B, Kogut N, Popplewell L, Rodriguez R, Somlo G, Forman SJ, Nademanee A, Biol Blood Marrow Transplant, 5/1/2007
Alefacept in Corticosteroid Refractory Graft vs Host Disease; Early Results Indicate Promising Activity
Amir A. Toor, Patrick J. Stiff, Brian Nickoloff & Kenneth B. Gordon, Journal of Dermatological, 1/1/2007
Autologous hematopoietic stem cell transplants that utilize total body irradiation can safely be carried out entirely on an outpatient basis
Stiff P, Mumby P, Miler L, Rodriguez T, Parthswarthy M, Kiley K, Porter N, Batiste R, Wojtowitz S, Lichtenstein S, Fox-Geiman M, Toor A, Bone Marrow Transplant, 12/1/2006
Analysis of Expression of Heat Shock Protein-90 (HSP90) and the effects of HSP90 Inhibitor (17-AAG) in Multiple Myeloma
J. Duus, H.I. Bahar, G Venkataraman, F Ozpuyan, K. F. Izban, H. Al-Masri, T. Maududi, A. Toor, S. Alkan, Leuk Lymphoma, 7/1/2006
Patients' understanding of disease status and treatment plan at initial hematopoietic stem cell transplantation consultation
Stiff PJ, Miller LA, Mumby P, Kiley K, Batiste R, Porter N, Potocki K, Volle M, Lichtenstein S, Wojtowicz S, Zakrzewski S, Toor A, Rodriguez T, Bone Marrow Transplant, 3/1/2006
Cardiac Nonamyloidotic Immunoglobulin Deposition Disease
Amir A. Toor, Ben A.Ramdane, Jacob Joseph, Maria Thomas, Carl O'Hara, Bart Barlogie, Patrick Walker, Lija Joseph, Mod Pathol, 2/1/2006
The administration of polymerized human hemoglobin (Pyridoxylated) to a Jehovah's Witness after submyeloablative stem cell transplantation complicated by delayed graft...
Smith SE, Toor A, Rodriguez T, Stiff P, Compr Ther, 1/1/2006
Second allografts for relapsed hematologic malignancies: feasibility of using a different donor
Duus JE, Stiff PJ, Choi J, Parthasarathy M, Rodriguez T, Toor AA, Bone Marrow Transplant, 2/1/2005
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Abstracts/Posters

Hematopoietic Cell Yield During Apheresis Declines Predictably Over Time
Allison Hazlet, Elaine Wang, Jennifer Anderson, Harold Chung, William Clark, John McCarty, Catherine Roberts and Amir Toor, Biology of Blood and Marrow Transplantation, annual meeting of American Society of Blood and Marrow Transplantation, 2/1/2013
Fractal Organization of the Human T Cell Repertoire in Health and Following Stem Cell Transplantation
Jeremy Meier, Allison F Hazlett, Kassi Avent, Jennifer Berrie, Kyle Payne, David Hamm, Cindy Desmarais, Catherine Sanders, Kevin T Hogan, Steven Grant, Kellie J Archer..., Blood, ASH Annual Meeting Abstracts, 11/1/2012
Optimizing Outcomes in Multiple Myeloma Using Risk Stratified Allocation to Single Versus Tandem Autologous SCT
Matthew Risendal, Roy T Sabo, Allison F Hazlett, Priscilla Mpasi, Joan Bolling, William B Clark, John M McCarty, Harold M Chung, Catherine H Roberts, and Amir A Toor, Blood, ASH Annual Meeting Abstracts, 11/1/2012
Favorable Outcomes in Patients with High Donor-Derived T Cell Count Following In Vivo T Cell Depleted Reduced Intensity Allogeneic Stem Cell Transplantation
Amir A Toor, Roy T Sabo, Harold M Chung, Catherine H Roberts, Rose H Manjili, Shiyu Song, David C. Williams, Jr., William Clark, Masoud H Manjili, and John M McCarty, Blood, ASH Annual Meeting Abstracts, 11/1/2011
Adaptive Immunotherapy In Multiple Myeloma: Epigenetic Modification and Immunomodulation by Sequential Azacitidine and Lenalidomide to Generate Cancer Testis Antigen S...
Amir A Toor, Kyle Payne, Harold M Chung, Catherine H Roberts, Roy T Sabo, Maciej Kmieciak, William Clark, Christy McLaughlin, Angela Buskey, Jennifer Anderson, Rose H ..., Blood, ASH Annual Meeting Abstracts, 11/1/2011
Feasibility of allogeneic stem cell transplantation conditioned with thymoglobulin and reduced-intensity total body irradiation
A. Toor, H. Chung, C. Roberts, R. Sabo, A. Ferreira-Gonzalez, S. Song, R. Edwards, J. Lamberta, M. Gatesman, S. Rabie, V. Buckovich, W. Clark, M. Manjili, J. McCarty, 2011 EBMT Meeting, 1/1/2011
Distinct Oligoclonal T Cells are Associated with GVHD or GVHD-Free Responses in Patients with Hematologic Malignancies Following Stem Cell Transplantation
Amir A Toor, Maciej Kmieciak, Jennifer L Berrie, Katherine L Mallory, Catherine H Roberts, Roy Sabo, Michael Idowu, Harold M Chung, Bucovich Veronica, William B Clark..., 2011 BMT Tandem Meeting, 1/1/2011
Use Of Rabbit Anti-Thymocyte Globulin For Conditioning In Matched Unrelated Donor Hematopoietic Cell Transplantation Provides Comparable Dose Dependant Outcomes To Mat...
David A Portier, Roberts H Catherine, Devon S Fletcher, Roy Sabo, Sherrie Rabie, William B Clark, Masoud Manjili, Jeffery M Tessier, Harold M Chung, John M McCarty, an..., 2011 BMT Tandem Meeting, 1/1/2011
Impact of ATG on the development of late complications following unrelated donor bone marrow transplant
Adess M, Rodriguez T, Klein J, Stiff P, Parthasarathy M, Toor A, 2006 BMT Tandem Meeting, 1/1/2006
Posaconazole (POS) Salvage Therapy Allows Successful Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) in Patients With Refractory Zygomycosis
Mullane K, Toor A, Rodriguez T, Kalnicky C, Klein J, Stiff P, 2005 BMT Tandem Meeting, 1/1/2005
Alefacept for management of steroid-refractory graft-versus-host disease (GVHD) in patients undergoing allogeneic hematopoietic stem cell transplantation
A Toor, PJ Stiff, BJ Nickoloff and KB Gordon, Dermatology, 1/1/2005
Allogeneic Stem Cell Transplantation (SCT) Using Rabbit-ATG (Thymoglobulin®) And Low Dose Total Body Irradiation (TBI): Favorable Outcomes with Unrelated Donors (URD)
Amir A Toor, Tulio Rodriguez, Najeeb Mohideen, Micheal Bauml, Scott E Smith, Mala Parthasarathy, John Norton, Jared Klein, Patrick J Stiff, Blood, 47th annual meeting of ASH, 1/1/2005
Allogeneic Stem Cell Transplantation (SCT) Using Rabbit-ATG (Thymoglobulin) And 2-Gy Total Body Irradiation (TBI): Reliable Early Engraftment With Minimal Acute Graft ...
Amir A Toor, Tulio Rodriguez, Najeeb Mohideen, Mala Parthasarathy, and Patrick J Stiff, Blood, 46th annual meeting of ASH, 1/1/2004
Rabbit-ATG (Thymoglobulin) and 2-Gy Total Body Irradiation (TBI) Followed by Allogeneic Stem Cell Transplantation (SCT): Engraftment without Associated Acute Graft vs....
Amir A. Toor, Najeeb Mohideen, Tulio Rodriguez, Mala Parthasarathy, Sheila Wojtowich, Patrick J. Stiff, Blood, 1/1/2003
Analysis of Risk Factors for Re-Mobilization Success in Patients Undergoing Autologous Stem Cell Transplants Who Fail an Initial Mobilization
Patrick J. Stiff, Sally Boeve, Joan Strupeck, Mary Fox-Geiman, Karen Kiley, Catherine Shipp, Amir Toor, Tulio Rodriguez, Shelia Wojtowicz, Steven Creech, Blood, 1/1/2002
Low-Dose Total Body Irradiation and Thymoglobulin®, Followed by Allogeneic Peripheral Blood Stem Cell Transplantation: Mixed T-Cell Chimerism Associated with GVH and A...
Amir Toor, N. Mohideen, T. Rodriguez, C. Petrowski, S. Wojtowicz, R. Batiste, N. Porter, M. Parthasarathy, P. Stiff, Blood, 1/1/2002
Second Allogeneic Transplant for Relapsed High-Grade Hematologic Malignancies: Early Results on the Feasibility of Using a Different Donor
J. Choi, J. Duus, P. Stiff, M. Parthasarathy, M. Volle, S. Creech, J. Strupeck, K. Potocki, T. Rodriguez, A. Toor, Blood, 1/1/2002
Impaired Non-Homologous End Joining (NHEJ) of DNA Double Strand Breaks (DSB) in Multiple Myeloma (MM) Cell Lines: Implications for Karyotypic Instability in Multiple M...
Amir Toor, C. Betti, A. Vaughan, Blood, 1/1/2002
Allogeneic Transplantation in Hodgkin Disease for Patients Who Fail Autologous Transplantation Is Safe and Effective
Julian P. Cooney, Amir A. Toor, Marla Parthasarathy, Patrick J. Stiff, Blood, 1/1/2001
Central Nervous System (CNS) Involvement in Multiple Myeloma (MM)
A. Fassas, F. Muwalla, R. Bemradane, A. Badros, A. Toor, M. Zangari, C. Morris, E. Anaissie, S. Mathew, L. Joseph, B. Barlogie, G. Tricot, Blood, 1/1/2001
TBI-Based Autologous Stem Cell Transplants Can Safely Be Performed on an Outpatient Basis
Patrick J. Stiff, Joseph Camarda, Mala Parthasarathy, Joan Strupeck, Amir Toor, Blood, 1/1/2001
A Phase I/II Multi-Center Study of Troxatyl ™ in Patients with Refractory Chronic Lymphocytic Leukemia (CLL), Lymphoma or Multiple Myeloma (MM)
Francis Giles, R. Belanger, Amir Toor, Peter McLaughlin, Luis Fayad, Milsolav Beran, Maher Albitar, Julie Vose, Blood, 1/1/2001
ABO Mismatch May Affect Engraftment in Multiple Myeloma (MM) Patients (pts) Receiving Non-Myeloablative Conditioning
Ashraf Badros, Guido Tricot, Amir Toor, Christopher Morris, Bart Barlogie, Maurizio Zangari, Nikhil Munshi, Michele Cottler-Fox, Blood, 1/1/2001
Autologous Peripheral Blood Stem Cell (PBSC) Transplantation in Multiple Myeloma (MM); Results with Busulfan (Bu) and Cyclophosphamide (Cy) Based Conditioning Regimen
Amir A. Toor, Mala Parthasarathy, Julian Cooney, Steve Creech, Patrick J. Stiff, Blood, 1/1/2001
Melphalan-Based High Dose Therapy (HDT) with Peripheral Blood Stem Cell (PBSC) Support is Safe and Effective in Multiple Myeloma (MM) with Renal Failure (RF,Creatinine...
A. Badros, E. Siegel, G. Tricot, M. Zangari, R. Desikan, C. Morris, C. Langmaid, A. Toor, E. Anaissie, B. Barlogie, Blood, 1/1/2000
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Lectures

Patt Endowed lectureship, Demystifying Transplant and Cellular Therapy; On the Crossroads of Immunology and Oncology.
Lehigh Valley Health Network, Cedar Crest Hospital, IM Grand Roundds - 4/4/2023
Finding order in complex biologic systems
TEDxRVA, Richmond, VA - 3/1/2013
Frontiers in Cancer Immunotherapy: Lessons from Stem Cell Transplantation
Department of Medicine Grand Rounds, Virginia Commonwealth University - 1/1/2013
Stem cell transplantation for Non-Hodgkins Lymphoma
11th Shaukat Khanum Memorial Cancer Symposium - 11/1/2012
Allogeneic stem cell transplantation- an update
9th Shaukat Khanum Memorial Cancer Symposium - 11/1/2010
Oligoclonal T Cells Associated with Gvhd Following Allogeneic Stem Cell Transplantation Conditioned with Thymoglobulin and Reduced Intensity Total Body Irradiation
11/1/2009
Adequate Immune Reconstitution in Recipients of Unrelated Donor Hematopoietic Cell Transplants Given Rabbit Anti-Thymocyte Globulin During Conditioning
11/1/2009
Effectiveness of Reduced Toxicity Conditioning Regimen with Intravenous Busulfan Plus Pentostatin (BUPENT) in Patients Older Than 50 Years with Advanced Hematologic Ma...
11/1/2009
Phase III Randomized Stem Cell Mobilization Trial Comparing Standard Vs Double-Dose G-CSF Vs Standard Doses of G-CSF Plus GM-CSF in Hard to Mobilize Patients Undergoin...
11/1/2009
Advances in Hematopoietic Stem Cell Transplantation” and “Multiple Myeloma: Making the Right Treatment Choices in 2006
National Guard Hospital, Riyadh, Saudi Arabia - 9/1/2006
Allogeneic Stem Cell Transplantation Using Thymoglobulin And Low Dose Total Body Irradiation: Reining in Adoptive Immunity
Immunology Division Retreat Loyola University - 2/1/2006
Incidence and Risk Factors for Developing Limbic Encephalitis in Allogeneic Stem Cell Transplantation
2006 ASH Meeting - 1/1/2006
Allogeneic Stem Cell Transplantation Using Thymoglobulin And Low Dose Total Body Irradiation: Favorable Outcomes with Unrelated Donors
Genzyme Scientific Review Committee Meeting, Atlanta, GA - 10/1/2005
Alefacept for management of steroid-refractory graft-versus-host disease (GVHD) in patients undergoing allogeneic hematopoietic stem cell transplantation
66th annual meeting of SID - 1/1/2005
Multiple Myeloma: New frontiers in Biology and Management
Stanford University Medical Center, Blood and Marrow Transplantation Program - 4/1/2004
Etiology Of Ischemic Heart Disease : A Retrospective Study
King Edward Medical College 10th Alumni International Symposium - 1/1/1988
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Press Mentions

Technology Could Modify DNA Sequencing to Diagnose Certain DNA MutationsJanuary 27th, 2021
Computer Model Personalizes Donor Selection for Stem Cell TransplantsAugust 31st, 2016
VCU Scientists Develop Computer Models Simulating Stem Cell Transplant RecoveryMarch 17th, 2016
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Committees

Member, School of Medicine Promotion & Tenure Committee 2017 - 2020
Member, Department of Medicine Promotion & Tenure Committee 2014 - 2016
Member, Massey Cancer Center Protocol Review and Monitoring Committee 2008 - 2016