AlokA.KhoranaMD

Gastrointestinal Cancer, Hematologic Oncology

Professor of Medicine, Cleveland Clinic Lerner College of Medicine; Sondra and Stephen Hardis Endowed Chair in Oncology Research; Director GI Malignancies Program; Vice-Chair (Faculty Development), Taussig Cancer Inst, Cleveland Clinic

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Office
9500 Euclid Ave
Cleveland, OH 44195
Phone+1 216-444-6833

Fax+1 216-444-9423

Summary

Alok A. Khorana, M.D., F.A.C.P, F.A.S.C.O, is Professor of Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, the Sondra and Stephen Hardis Chair in Oncology Research, Vice-Chair for Clinical Services of the Taussig Cancer Institute (part of Case Comprehensive Cancer Center) and Director of the Gastrointestinal Malignancies Program at the Cleveland Clinic, Cleveland, Ohio. His clinical and translational research program focuses on predictive factors and drug development in cancer-associated thrombosis and gastrointestinal cancers and has been funded by grants from the National Cancer Institute, the National Heart, Lung, and Blood Institute, the Hardis Family, the Porter Family Fund, VeloSano, the Cleveland Clinic Center for Excellence, the Scott Hamilton CARES Initiative, Stand Up To Cancer (Colorectal Cancer “Dream Team”) and the V Foundation.

Dr. Khorana received his medical degree from Maharaja Sayajirao University’s Medical College in Baroda (now Vadodara, Gujarat), India. His postdoctoral training included a residency in internal medicine at the University at Buffalo in New York and a fellowship in hematology/oncology at the University of Rochester, New York. He is a Fellow of the American College of Physicians and in 2018 was elected Fellow of the American Society of Clinical Oncology.

Dr. Khorana is Past Chair of the American Society of Clinical Oncology (ASCO) Clinical Practice Guidelines Panel (CPGC), Chair of ASCO CPGC’s Pancreas Cancer Working Group, Co-Chair of ASCO CPGC’s Multisite Advisory Group and Co-Chair of the ASCO Guidelines Panel on Resectable Pancreas Cancer. He is currently Chair of the Medical and Scientific Advisory Board of the National Blood Clot Association. He has also served or serves on the ASCO Scientific Program Committee and multiple Guidelines/Guidance Panels.

Education & Training

University of RochesterFellowship, Hematology and Medical Oncology, 1999 - 2002
University at BuffaloResidency, Internal Medicine, 1996 - 1999
Baroda Medical CollegeClass of 1995

Certifications & Licensure

OH State Medical License 2013 - 2026
NY State Medical License 2002 - 2014
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

Maria and Sam Miller Professional Excellence Award for Scientific Achievement in Clinical Research Cleveland Clinic, 2019
Teacher of the Year (Medical Oncology) Cleveland Clinic, 2018
Meliora Award (Team Award( University of Rochester, 2013
Sondra and Stephen Hardis Endowed Chair in Oncology Research Cleveland Clinic Foundation, 2013
Patient- and Family-Centered Care Award University of Rochester, 2012
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012
Silver Team Award Greater Rochester Quality Council, 2012
Internal Medicine Research Mentoring Award, Department of Medicine University of Rochester, 2007
Teacher of the Year Wilmot Cancer Center, 2005
Fellow American College of Physicians, 2005
James P. Wilmot Cancer Research Fellowship University of Rochester, 2001
Dr Robert Cooper Endowed Fund for Clinical Research University of Rochester, 2001
Cancer Action Grant for Cancer Research University of Rochester, 2001
Faculty Award for Creative Excellence University of Rochester, 2001-2002
Amgen Clinical Fellowship Grant University of Rochester, 2000
Gold Medal for Academic Excellence in Pharmacology Maharaja Sayajirao University, 1993
Dr H. P. Shastry Gold Medal for Academic Excellence; Undergraduate Academy Gold Medal South Gujarat University, 1991
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Clinical Trials

Cancer Associated Thrombosis and Isoquercetin (CATIQ) Start of enrollment: 2015 Jan 01
Completed
Phase 2, Phase 3
CB-839 + Capecitabine in Solid Tumors and Fluoropyrimidine Resistant PIK3CA Mutant Colorectal Cancer Start of enrollment: 2016 Sep 12
Active, not recruiting
Phase 1, Phase 2

Publications & Presentations

PubMed

Is Early, Postinduction Restaging of Rectal Cancer Undergoing Total Neoadjuvant Therapy Associated With Ultimate Treatment Response?
William C Chapman Jr, Emre Gorgun, Sumeyye Yilmaz, David R Rosen, Michael A Valente
Diseases of the Colon and Rectum. 2025-02-01
What Predicts Complete Response to Total Neoadjuvant Therapy in Locally Advanced Rectal Cancer?
Sumeyye Yilmaz, David Liska, Madison L Conces, Naz Tursun, Doua Elamin
Diseases of the Colon and Rectum. 2025-01-01
Best Practices for Delivering Neoadjuvant Therapy in Pancreatic Ductal Adenocarcinoma.
Jordan M Cloyd, Angela Sarna, Matthew J Arango, Susan E Bates, Manoop S Bhutani
JAMA Surgery. 2024-12-04

Journal Articles

Do Patients with Pancreatic Body or Tail Cancer Benefit from Adjuvant Therapy?A Cohort Study
Alok Khorana, MD, ScienceDirect
An optimized patient-reported ulcerative colitis disease activity measure derived from the Mayo score and the simple clinical colitis activity index
Bewtra Meenakshi, Brensinger Colleen M, Tomov Vesselin T, Hoang Tram B, Sokach Carly E, Siegel Corey A, Lewis James D, Inflammatory Bowel Diseases, 6/1/2014
Diagnosis of Dry Eye Disease and Emerging Technologies
Zeev MS, Miller DD, Latkany R, Clin Opthalmol, 3/1/2014
Arthroscopic Subscapularis Bankart Technique as a Salvage Procedure for Failed Anterior Shoulder Stabilization
Chaudhury S, DelosD, Dines JS, Altchek DW, Dodson CC, Newman AM, O'brien SJ, HSS Journal, 1/1/2014
Patient preferences for surgical versus medical therapy for ulcerative colitis
Bewtra Meenakshi, Kilambi Vikram, Fairchild Angelyn O, Siegel Corey A, Lewis James D, Johnson F Reed, Inflammatory Bowel Diseases, 1/1/2014
Impact of JC Virus Antibody Testing in Patients with Crohn's Disease with Loss of Response to Infliximab: A Markov Model
Scott Frank I, Osterman Mark T, McConnell Ryan A, Lorusso Monica, Aberra Faten, Kerner Caroline, Lichtenstein Gary R, Lewis James D, Inflammatory Bowel Diseases, 11/1/2013
Prevalence and clinical significance of incidental and clinically suspected venous thromboembolism in lung cancer patients
Connolly GC, Menapace L, Safadjou S , Francis CW and Khorana AA, Clin Lung Ca, 7/1/2013
Clinical Predictors of Urgent Findings on Abdominopelvic CT in Emergency Department Patients with Crohn's Disease
Kerner Caroline, Carey Kathleen, Baillie Charles, Mills Angela M, Yang Wei, Hilton Susan, Synnestvedt Marie B, Weiner Mark G, Lewis James D, Inflammatory Bowel Diseases, 5/1/2013
Venous Thromboembolism Prophylaxis and Treatment in Patients with Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update
Lyman GH, Khorana AA, Kuderer NM et al, J Clin Oncol, 5/1/2013
Crohn's disease and ulcerative colitis are associated with elevated standardized mortality ratios: a meta-analysis
Bewtra Meenakshi, Kaiser Lisa M, TenHave Tom, Lewis James D, Inflammatory Bowel Diseases, 3/1/2013
Challenges in IBD research: update on progress and prioritization of the CCFA's research agenda
Denson Lee A, Long Millie D, McGovern Dermot P B, Kugathasan Subra, Wu Gary D, Young Vincent B, Pizarro Theresa T, de Zoeten Edwin F, Stappenbeck Thaddeus S, Plevy Sco..., Inflammatory Bowel Diseases, 3/1/2013
Quality indicators for inflammatory bowel disease: development of process and outcome measures
Melmed Gil Y, Siegel Corey Allan, Spiegel Brennan M, Allen John I, Cima Robert, Colombel Jean-Frederic, Dassopoulos Themistocles, Denson Lee A, Dudley-Brown Sharon, Ga..., Inflammatory Bowel Diseases, 3/1/2013
Update on Depression and Age-Related Macular Degeneration
Casten RC, Rovner BW, Current Opinion in Ophthalmology, 1/1/2013
Contribution of higher risk genes and European admixture to Crohn's disease in African Americans
Wang MH, Okazaki T, Kugathasan S, Cho JH, Isaacs KL, Lewis JD, Smoot DT, Valentine JF, Kader HA, Ford JG, Harris ML, Oliva-Hemker M, Cuffari C, Torbenson MS, Duerr RH,..., Inflamm Bowel Dis, 12/1/2012
Development of an internet-based cohort of patients with inflammatory bowel diseases (CCFA Partners): methodology and initial results
Long Millie D, Kappelman Michael D, Martin Christopher F, Lewis James D, Mayer Lloyd, Kinneer Patricia M, Sandler Robert S, Inflammatory Bowel Diseases, 11/1/2012
Genes Associated with Intestinal Permeability in Ulcerative Colitis: Changes in Expression Following Infliximab Therapy
Toedter G, Li K, Sague S, Ma K, Marano C, Macoritto M, Park J, Deehan R, Matthews A, Wu GD, Lewis JD, Arijs I, Rutgeerts P, Baribaud F, Inflammatory Bowel Diseases, 8/1/2012
Diagnosis of Ectopic Pregnancy
Givens VM, Lipscomb GH, Clin Obstet Gynecol, 6/1/2012
Return to Play After Type II Superior Labral Anterior-Posterior Lesion Repairs in Athletes: A Systematic Review
Sayde WM, Cohen SB, Ciccotti MG, Dodson CC, Clin Orthop Relat Res, 6/1/2012
Medical Management of Ectopic Pregnancy
Lipscomb GH, Clin Obstet Gynecol, 1/1/2012
Cancer-associated thrombosis: updates and controversies
Khorana AA, Hematology Am Soc Hematol Educ Program, 1/1/2012
‘Photography Perspective Project’ Takes Fresh View of Interventions for Adolescent Mood Disorders
Wimbiscus M, Insights, Publication for Behavioral Health: Cleveland Clinic, 1/1/2012
Book review editorial: Besides perpetrators
Ahktar, S, International Journal of Applied Psychoanalytic Studies, 1/1/2012
Cardiovagal autonomic function in HIV infected patients with unsuppressed HIV viremia
Chow D, Wood R, Choi J, Grandinetti A, Gerschenson M, Sriratanaviriyakul N, Nakamoto B, Harrigan R, Shikuma C, Low P, HIV Clinical Trial, 5/1/2011
The Definitive History of the Fight to Cure Cancer
Khorana AA, Health Aff (Millwood), 1/1/2011
Book review editorial: The aftermath of suicide
Ahktar, S, International Journal of Applied Psychoanalytic Studies, 1/1/2011
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Books/Book Chapters

On Freud’s ‘The Unconscious’.
Ahktar, S. and O’neil, M.K.IPA/Karnac Books, London, United Kingdom2013
The Electrified Mind: Personality Development, Psychopathology, and Treatment in the Era of Cell Phones and the Internet.
Chapter: The cell phone-internet lexicon: overview and implications.
Page 1 - 20Ahktar, S. and Nayar, K.Editors: Ahktar, S.Jason Aronson, Lanham, MD2011
Cecil Essentials of Medicine
Chapter: Cancer Biology.
Khorana AA and Burtness BAEditors: Andreoli et al.Edition 8th,2010
The Unbroken Soul: Tragedy, Trauma, and Resilience.
Chapter: The biopsychosocial miracle of human resilience: an overview.
Page 1 - 20Ahktar, S. and Wrenn, GEditors: H. Parens, H. Blum, and S. Akhtar.Jason Aronson, Lanham, MD2008
Cecil’s Essentials of Medicine
Chapter: Principles of Cancer Therapy.
Khorana AA and Burtness BAEditors: Andreoli et al.Edition 7th,2007
Yearbook of Obstetrics, Gynecology and Women’s Health 2007.
Chapter: Ectopic Pregnancy.
Lipscomb GHEditors: Shulman LP, Arias R, Barnes R, Hurteau J, Lipscomb GH van Vugt JMH.Mosby, Philadelphia, PA2007
Freud Along the Ganges: Psychoanalytic Reflections on the People and Culture of India.
Chapter: Bollywood and the Indian unconscious.
Page 139 - 175Ahktar, S., Choksi, K.Editors: S. Akhtar.Other Press, New York, NY2005
Brothers and Sisters: Developmental, Dynamic, and Technical Aspects of the Sibling Relationship.
Chapter: Beyond the parental orbit: brothers, sisters, and others.
Page 3 - 24Ahktar, S., Kramer, S.Editors: S. Akhtar and S. Kramer.Jason Aronson, Northvale, NJ1999
The Seasons of Life: Separation-Individuation Perspectives.
Ahktar, S., Kramer, S.Jason Aronson, Northvale, NJ1997
The Internal Mother: Conceptual and Technical Aspects of Object Constancy.
Ahktar, S., Kramer, S., Parens, H.Jason Aronson, Northvale, NJ1996
The Book of Psychiatric Books: The Classics Revisited.
Chapter: Otto Kernberg's 'Borderline Conditions and Pathological narcissism: A re-evaluation.’
Page 341 - 351Ahktar, S., Gruenberg, A.Editors: S. Crown and H. Freeman.Jason Aronson, Northvale, NJ1994
Textbook of Geriatric Neuropsychiatry
Chapter: Neuropsychiatry in Nursing Homes.
Rovner BW, Katz IREditors: Coffey CE and Cummings JL.APA Press, Inc.1994
Dementia.
Chapter: A North American View of Services for Dementia.
Zisselman M, Rovner BWEditors: Burns A & Levy R.Chapman & Hall Medical, London, United Kingdom1993
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Abstracts/Posters

Molecular Subtyping to Predict Risk of Venous Thromboembolism in Patients with Advanced Lung Adenocarcinoma: A Cohort Study
Alok A Khorana, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Meta-Analysis and Cost-Effectiveness Analysis of Low-Dose Direct Oral Anticoagulant for the Prevention of Cancer Associated Thrombosis
Alok A Khorana, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Clinical Outcomes of Cancer-Associated Thrombosis Beyond 6 Months of Anticoagulation
Alok A Khorana, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
Identifying miRNA Biomarkers and Predicted Targets Associated with Venous Thromboembolism in Colorectal Cancer Patients
Alok A Khorana, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Risk of Intracerebral Hemorrhage with and without Anticoagulation in Patients with Brain Metastasis: The Cleveland Clinic Experience
Alok A Khorana, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Extended Mutational Profiling By MSK-IMPACTTM Identifies Mutations Predicting Thromboembolic Risk in Patients with Solid Tumor MalignancyClinically Relevant Abstract
Alok A Khorana, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Biomarker Assessment of Venous Thromboembolism in Cancer Patients Receiving Checkpoint Blockade
Alok A Khorana, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
Outcomes of Elbow Dislocations in the National Football League.
Dodson CC, Eastern Orthopaedic Association, Miami, FL, 10/1/2013
Sequential Sectioning of the Ulnar Collateral Ligament of the Elbow in Cadaveric Arms with Ulnohumeral Laxity Assessed by Dynamic Ultrasonography.
Dodson CC, Herodicus Annual Meeting, 7/1/2013
Using Dynamic Elbow Ultrasound to Characterize Ulnar Collateral Ligament Abnormalities in Baseball Pitchers. Podium Presentation
Dodson CC, AAOS Annual Meeting, Chicago, IL, 3/1/2013
Medication Adherence in Patients with Inflammatory Bowel Disease within the CCFA Partners cohort.
Kappelman M, Long M, Martin C, Lewis JD, Kinneer P, Sandler R, Inflammatory Bowel Diseases, 12/1/2011
Quality of life in patients with inflammatory bowel disease within the CCFA Partners cohort.
Long M, Kappelman M, Martin C, Lewis JD, Kinneer P, Sandler R, Inflammatory Bowel Diseases, 12/1/2011
Development of an internet-based Cohort of patients with inflammatory bowel diseases (CCFA Partners): Methodology and Initial Results.
Long M, Kappelman M, Martin C, Lewis JD, Kinner P, Sandler R, Inflammatory Bowel Diseases, 12/1/2011
Status of prevention in Patients with Inflammatory Bowel Disease within the CCFA partners cohort.
Long M, Kappelman M, Martin C, Lewis JD, Kinneer P, Sandler R, Inflammatory Bowel Diseases, 12/1/2011
Complete Triceps Tendon Ruptures Requiring Surgical Repair In Professional Football Players. Podium Presentation
Dodson CC, Eastern Orthopaedic Association Annual Meeting, Kingsmill, VA, 10/1/2011
Biceps Tenotomy Versus Tenodesis: A Comprehensive Review Of Clinical Outcomes. Podium Presentation
Dodson CC, Eastern Orthopaedic Association Annual Meeting, Kingsmill, VA, 10/1/2011
Accuracy Of Intra-Articular Injections Of The Glenohumeral Joint Through An Anterior Approach: Arthroscopic Correlation. Podium Presentation
Dodson CC, Eastern Orthopaedic Association Annual Meeting, Kingsmill, VA, 10/1/2011
The incidence and clinical characteristics of congenital ptosis: A 40-year population-based study.
Mohney BG, Griepentrog, Egyptian Group of Pediatric Eye Surgeons Meeting, Alexandria, 11/4/2009
Low-molecular-weight heparin for venous thromboprophylaxis in ambulatory cancer patients: A meta-analysis.
N. M. Kuderer , A. A. Khorana, C. W. Francis, G. H. Lyman, J Clin Oncol, 1/1/2009
Yolk Sac on Transvaginal Ultrasound as a Prognostic Indicator in the Treatment of Ectopic Pregnancy with Single-Dose Methotrexate
Lipscomb GH, Gomez, IG, Givens VM, Meyer NL, Bran DF, 75th Annual Meeting Central Association of Obstetricians and Gynecologists, New Orleans, LA, 10/22/2008
Yolk Sac on Transvaginal Ultrasound as a Prognostic Indicator in the Treatment of Ectopic Pregnancy with Single-Dose Methotrexate.
Lipscomb GH, Gomez IG, Givens VM, Meyer NL, Bran DF, 75th Annual Meeting Central Association of Obstetricians and Gynecologists, New Orleans, LA, 10/22/2008
The Treatment of Complex Anal Fistulae.
Davis KG, Hospital Esquela, Tegucigalpa, Honduras, 1/17/2008
The natural history of intermittent exotropia. Invited Speaker
Mohney BG, Nusz K, I Curso Internacional de Estrabismo y Oftalmologia Pediatrica, Queretaro, Mexico, 10/6/2006
Assessing control in intermittent exotropia. Invited Speaker
Mohney BG, Homes JM, I Curso Internacional de Estrabismo y Oftalmologia Pediatrica, Queretaro, Mexico, 10/6/2006
Medial Ulnar Collateral Ligament Reconstruction of the Elbow in Throwing Athletes. Podium Presentation
Dodson CC, Eastern Orthopaedic Association Annual Meeting, Boca Raton, FL, 10/1/2006
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Lectures

Cancer Associated Thrombosis Is Associated with Higher Mortality across All Khorana Score Risk Levels
61st Annual American Society of Hematology Meeting - Orlando, FL - 12/7/2019
What's New in VTE? Evaluating the Latest Evidence and Grades of Recommendation
60th American Society of Hematology Annual Meeting - 11/30/2018
Generosity: Normal and Pathological
Weill Cornell Medical School, New York, NY - 10/15/2014
What primary care physicians need to know about IBD.
Boca Raton, FL - 3/1/2014
Multidirectional Instability of the Shoulder.
Philadelphia, PA - 5/1/2013
Actual Death, Psychic Death, and Death Instinct.
Philadelphia, PA - 3/9/2013
From Delight to Wisdom: The Nature and Healing Power of Poetry
University of Virginia, Charlottesville, VA - 2/2/2013
Psychic Unintegration: Normal and Pathological Variants. Plenary Address
Amsterdam, The Netherlands - 12/14/2012
Survival, Vision, and Faith.
Boston University, Boston, MA - 10/7/2012
Workshop on psychoanalytic psychotherapy.
Kolkata, India - 8/11/2012
Esophageal Cancer
University of Rochester - 1/1/2012
Considerations around surgical therapy for IBD.
Phoenix, AZ - 10/1/2011
The Trauma of Geographical Dislocation. Plenary Address
George Washington University, Washington, DC - 5/6/2011
The Remains of the Object: Graves, Ashes, and Things Left Behind
Anna Freud Centre, London, UK - 2/22/2011
The Dream in Urdu Poetry. Inaugural Address
Udaipur, India - 12/10/2010
Revision Anterior Cruciate Ligament Reconstruction.
Thomas Jefferson University, Philadelphia, PA - 12/1/2010
Band Keratopathy following Congenital Glaucoma
Washington, DC - 10/1/2010
Principles of Cancer Therapy
University of Rochester Medical School - 1/1/2010
Be Ready When the Joint Commission Comes Knocking on Your Door. Moderating Panel
Athens, Greece - 9/18/2009
Pediatric Ophthalmology Board Review.
2/18/2009
Colon Cancer
1/1/2008
Airway Management in Ambulatory Anesthesia
Amsterdam, The Netherlands - 4/17/2007
Session on Thrombo-embolism. Moderator
Amsterdam, The Netherlands - 4/17/2007
Sedation
Amsterdam, The Netherlands - 4/17/2007
Preoperative evaluation.
Sevilla, Spain - 4/1/2006
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Other

Vaginal Hysterectomy. Videotape
Ling FW, Shull B, Hurt G, Stovall TG, Porges R, Lipscomb GH, Copyright: Council on Resident Education in Obstetrics and Gynecology
1/1/1995

Press Mentions

Cleveland Clinic Research Reveals Unique Tumor-Related Bacteria Tied to Young-Onset Colorectal CancerFebruary 5th, 2024
‘I’m Terminal’ at 60: Why Are Colorectal Cancer Patients Getting Younger?March 1st, 2023
Blood Test Could Help Predict Which Patients with Colon Cancer Need Chemotherapy After Surgery: StudyJanuary 17th, 2023
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