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Office
Yale New Haven Hospital
20 York St
New Haven, CT 06510
Education & Training
Yale-New Haven Medical CenterResidency, Internal Medicine, 2021 - 2023
University of Mississippi Medical CenterInternship, Internal Medicine, 2020 - 2021
University of Virginia School of MedicineClass of 2020, M.D.
University of VirginiaPh.D., Biophysics, 2011 - 2018- University of VirginiaB.S., Chemistry , Highest Distinction, 2005 - 2009
Certifications & Licensure
CT State Medical License 2021 - 2026
Awards, Honors, & Recognition
- Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral MD/PhD Fellowship (F30) National Institutes of Health: National Heart, Lung, and Blood Institute, 2015-2019
- 1st Place Case Competition University of Virginia Graduate Student Consulting and Beyond Club, 2014
- Merck Index Award University of Virginia, 2009
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Publications & Presentations
PubMed
- 14 citationsCryo-EM structure of an open conformation of a gap junction hemichannel in lipid bilayer nanodiscs.Ali K. Khan, Maciej Jagielnicki, Brad C. Bennett, Michael D. Purdy, Mark Yeager
Structure. 2021-06-11 - 28 citationsA Steric "Ball-and-Chain" Mechanism for pH-Mediated Regulation of Gap Junction Channels.Ali K. Khan, Maciej Jagielnicki, William E. McIntire, Michael D. Purdy, Venkatasubramanian Dharmarajan
Cell Reports. 2020-04-21 - 12 citationsFunction and dynamics of macromolecular complexes explored by integrative structural and computational biology.Michael D. Purdy, Brad C. Bennett, William E. McIntire, Ali K. Khan, Peter M. Kasson
Current Opinion in Structural Biology. 2014-08-01
Abstracts/Posters
- PH-Gating of GAP Junction Channels: Visualization of a “Ball-and-Chain” by Cryo-EMKhan AK, Jagielnicki MJ, Purdy DM, Yeager M, Biophysical Journal, 2/2/2018
- Mechanism of PH Gating in Cx26 Gap Junction Channels Revealed by cryoEM, Crosslinking and HDXJagielnicki M, Khan AK, McIntire WE, Purdy MD, Dharmarajan V, Griffin PR, Yeager M, Biophysical Journal, 2/2/2018
- Pathway for Transmembrane Signaling in the Bacterial Ferric Citrate Transporter FecAMokdad A, Khan AK, Cafiso DS, Biophysical Journal, 2/2/2011
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Authored Content
- Human Connexin-26 Hemichannel (open conformation)May 2021
- Human Connexin-26 (Neutral pH open conformation)April 2020
- Human Connexin-26 (Low pH closed conformation)April 2020
- Human Connexin-26 (Low pH open conformation)April 2020
- Human Connexin-26 (Neutral pH open conformation)April 2020
- Human Connexin-26 (Low pH closed conformation)April 2020
- Human Connexin-26 (Low pH open conformation)April 2020
- Human Connexin-26 (Low pH open conformation)April 2020
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Grant Support
- Structural Studies of the Cardiac Gap Junction Proteins, Cx40 and Cx43National Institutes of Health: National Heart, Lung, and Blood Institute2015–2019
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