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Office
Yale New Haven Hospital
20 York St
New Haven, CT 06510
Education & Training
Yale-New Haven Medical CenterResidency, Internal Medicine, 2021 - 2023
University of Mississippi Medical CenterInternship, Internal Medicine, 2020 - 2021
University of Virginia School of MedicineClass of 2020, M.D.
University of VirginiaPh.D., Biophysics, 2011 - 2018- University of VirginiaB.S., Chemistry , Highest Distinction, 2005 - 2009
Certifications & Licensure
CT State Medical License 2021 - 2026
Awards, Honors, & Recognition
- Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral MD/PhD Fellowship (F30) National Institutes of Health: National Heart, Lung, and Blood Institute, 2015-2019
- 1st Place Case Competition University of Virginia Graduate Student Consulting and Beyond Club, 2014
- Merck Index Award University of Virginia, 2009
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Publications & Presentations
PubMed
- 28 citationsA Steric "Ball-and-Chain" Mechanism for pH-Mediated Regulation of Gap Junction Channels.Ali K. Khan, Maciej Jagielnicki, William E. McIntire, Michael D. Purdy, Venkatasubramanian Dharmarajan
Cell Reports. 2020-04-21 - 14 citationsCryo-EM structure of an open conformation of a gap junction hemichannel in lipid bilayer nanodiscs.Ali K. Khan, Maciej Jagielnicki, Brad C. Bennett, Michael D. Purdy, Mark Yeager
Structure. 2021-06-11 - 19 citationsLigand-induced structural changes in the Escherichia coli ferric citrate transporter reveal modes for regulating protein-protein interactions.Audrey Mokdad, Dawn Z. Herrick, Ali K. Kahn, Emily Andrews, Miyeon Kim
Journal of Molecular Biology. 2012-11-09
Abstracts/Posters
- PH-Gating of GAP Junction Channels: Visualization of a “Ball-and-Chain” by Cryo-EMKhan AK, Jagielnicki MJ, Purdy DM, Yeager M, Biophysical Journal, 2/2/2018
- Mechanism of PH Gating in Cx26 Gap Junction Channels Revealed by cryoEM, Crosslinking and HDXJagielnicki M, Khan AK, McIntire WE, Purdy MD, Dharmarajan V, Griffin PR, Yeager M, Biophysical Journal, 2/2/2018
- Pathway for Transmembrane Signaling in the Bacterial Ferric Citrate Transporter FecAMokdad A, Khan AK, Cafiso DS, Biophysical Journal, 2/2/2011
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Authored Content
- Human Connexin-26 Hemichannel (open conformation)May 2021
- Human Connexin-26 (Neutral pH open conformation)April 2020
- Human Connexin-26 (Low pH closed conformation)April 2020
- Human Connexin-26 (Low pH open conformation)April 2020
- Human Connexin-26 (Neutral pH open conformation)April 2020
- Human Connexin-26 (Low pH closed conformation)April 2020
- Human Connexin-26 (Low pH open conformation)April 2020
- Human Connexin-26 (Low pH open conformation)April 2020
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Grant Support
- Structural Studies of the Cardiac Gap Junction Proteins, Cx40 and Cx43National Institutes of Health: National Heart, Lung, and Blood Institute2015–2019
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