AlfredoSadunMD

PubMed

• 206 citations
  Efficient mitochondrial biogenesis drives incomplete penetrance in Leber's hereditary optic neuropathy.
  Carla Giordano, Luisa Iommarini, Luca Giordano, Alessandra Maresca, Annalinda Pisano
  Brain. 2014-02-01
• 2 citations
  Mitochondrial retinopathies and optic neuropathies: The impact of retinal imaging on modern understanding of pathogenesis, diagnosis, and management.
  Enrico Borrelli, Francesco Bandello, Camiel J F Boon, Valerio Carelli, Guy Lenaers
  Progress in Retinal and Eye Research. 2024-07-01
• 7 citations
  Alzheimer's disease pathophysiology in the Retina.
  Bhakta Prasad Gaire, Yosef Koronyo, Dieu-Trang Fuchs, Haoshen Shi, Altan Rentsendorj
  Progress in Retinal and Eye Research. 2024-07-01

Journal Articles

• Further Discussion of Vitrectomy for Floaters  
  Sebag J, Sadun AA, Retina, 11/10/2014
• Considerations on Vitrectomy for Floaters  
  Sebag J, Yee KM, Sadun AA, Retina, 9/23/2014
• Inner Retinal Optic Neuropathy - Vitreo-Macular Surgery Associated Disruption of the Inner Retina  
  Pan BX, Yee KM, Ross-Cisneros FN, Sadun AA, Sebag J, Invest Ophthalmol Vis Sci, 9/18/2014
• Medical Management of Hereditary Optic Neuropathies  
  La Morgia C, Carbonelli M, Barboni P, Sadun AA, Carelli V, 7/31/2014
• Comparing EPI-743 Treatment in Siblings with Leber's Hereditary Optic Neuropathy Mt14484 Mutation  
  Chicani CF, Chu ER, Miller G, Kelman SE, Sadun AA, Can J Ophthalmol, 10/1/2013
• Mitochondrial Optic Neuropathies: Additional Facts and Concepts  
  Sadun AA, La Morgia C, Carelli V, Clin Experiment Ophthalmol, 6/18/2013
• Beckman Initiative for Macular Research Classification CommitteeClinical Classification of Age-related Macular Degeneration  
  Ferris FL 3rd, Wilkinson CP, Bird A, Chakravarthy U, Chew E, Csaky K, Sadda SR, Ophthalmology, 4/1/2013
• Mitochondrial Optic Neuropathies: Our Travels from Bench to Bedside and Back Again an Expansion of the 35(th) Susan Alper Memorial Lecture by Alfredo A Sadun, MD, PhD ...  
  Sadun AA, Morgia CL, Carelli V, Clin Experiment Ophthalmol, 2/21/2013
• Mitochondrial Dysfunction in Optic Neuropathies: Animal Models and Therapeutic Options  
  Carelli V, La Morgia C, Sadun AA, Curr Opin Neurol, 2/1/2013
• The Pupil Light Reflex in Leber's Hereditary Optic Neuropathy: Evidence for Preservation of Melanopsoin-Expressing Retinal Ganglion Cells  
  Moura AL, Nagy BV, La Morgia C, Barboni P, Oliveira AG, Salomao SR, Berezovsky A, de Moraes-Filho MN, Chicani CF, Belfort R Jr, Carelli V, Sadun AA, Hood DC, Ventura DF, Invest Ophthalmol Vis Sci, 1/1/2013
• Visual Improvement with the Use of Idebenone in the Treatment of Wolfram Syndrome  
  Bababeygy SR, Wang MY, Khaderi KR, Sadun AA, J Neuroophthalmol, 12/12/2012
• Mouse mtDNA Mutant Model of Leber Hereditary Optic Neuropathy  
  Lin CS, Sharpley MS, Fan W, Waymire KG, Sadun AA, Carelli V, Ross-Cisneros FN, Baciu P, Sung E, McManus MJ, Pan BX, Gil DW, Macgregor GR, Wallace DC, Proc Natl Acad Sci U S A, 12/4/2012
• Bilateral Vision Loss Responsive to Corticosteroids  
  Lee MD, Song BJ, Odel JG, Sadun AA, Surv Ophthalmol, 11/12/2012
• Mathematically Modeling the Involvement of Axons in Leber's Hereditary Optic Neuropathy  
  Pan BX, Ross-Cisneros FN, Carelli V, Rue KS, Salomao SR, Moraes-Filho MN, Moraes MN, Berezovsky A, Belfort R Jr, Sadun AA, Invest Ophthalmol Vis Sci, 11/9/2012
• Are Melanopsin Cells Blocked by Filtering IOLs?  
  Bababeygy SR, Sadun AA, Int Ophthalmol, 11/6/2012
• Neuron-specific Enolase Is Elevated in Asymptomatic Carriers of Leber's Hereditary Optic Neuropathy  
  Yee KM, Ross-Cisneros FN, Lee JG, Da Rosa AB, Salomao SR, Berezovsky A, Belfort R Jr, Chicani F, Moraes-Filho M, Sebag J, Carelli V, Sadun AA, Invest Ophthalmol Vis Sci, 9/21/2012
• Patterns of Ganglion Cell Complex and Nerve Fiber Layer Loss in Nonarteritic Ischemic Optic Neuropathy by Fourier-domain Optical Coherence Tomography  
  Aggarwal D, Tan O, Huang D, Sadun AA, Invest Ophthalmol Vis Sci, 7/3/2012
• Bilateral Oedipism  
  Bababeygy SR, Sadun AA, Ophthal Plast Reconstr Surg, 6/8/2012
• Retinal Nerve Fiber Layer Thickness Variability in Leber Hereditary Optic Neuropathy Carriers  
  Barboni P, Savini G, Feuer WJ, Budenz DL, Carbonelli M, Chicani F, Ramos CD, Salomao SR, De Negri A, Parisi V, Carelli V, Sadun AA, Eur J Ophthalmol, 5/4/2012
• Is Leber Hereditary Optic Neuropathy Treatable? Encouraging Results with Idebenone in Both Prospective and Retrospective Trials and an Illustrative Case  
  Sabet-Peyman EJ, Khaderi KR, Sadun AA, J Neuroophthalmo, 3/1/2012
• Effect of EPI-743 on the Clinical Course of the Mitochondrial Disease Leber Hereditary Optic Neuropathy  
  Sadun AA, Chicani CF, Ross-Cisneros F, Barboni P, Thoolen M, Shrader WD, Kubis K, Carelli V, Miller G, Arch Neurol, 3/1/2012
• Studies of the Ocular Complications of Aids Research Group Association between Retinal Nerve Fiber Layer Thickness and Abnormalities of Vision in People with Human Im...  
  Kalyani PS, Holland GN, Fawzi AA, Arantes TE, Yu F, Sadun AA, Am J Ophthalmol, 1/12/2012
• Impending Anterior Ischemic Optic Neuropathy with Elements of Retinal Vein Occlusion in a Patient on Interferon for Polycythemia Vera  
  Rue KS, Hirsch LK, Sadun AA, Clin Ophthalmol, 1/1/2012
• Secondary Post-Geniculate Involvement in Leber's Hereditary Optic Neuropathy  
  Rizzo G, Tozer KR, Tonon C, Manners D, Testa C, Malucelli E, Valentino ML, La Morgia C, Barboni P, Randhawa RS, Ross-Cisneros FN, Sadun AA, Carelli V, Lodi R, PLoS One, 1/1/2012
• Accuracy of Funduscopy to Identify True Edema versus Pseudoedema of the Optic Disc  
  Carta A, Favilla S, Prato M, Marzoli SB, Sadun AA, Mora P, Invest Ophthalmol Vis Sci, 11/22/2011
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Books/Book Chapters

• Optical Coherence Tomography in Central Nervous System Diseases 
  Chapter: Optical Coherence Tomography in Alzheimer's Disease 
  Gianluca Coppola, Vincenzo Parisi, Gianluca Manni, Francesco Pierelli, Alfredo A. SadunEditors: Andrzej Grzybowski.Springer Verlag2015
• The Vitreous 
  Chapter: Vitreous Floaters and Vision: Current Concepts and Management Paradigms 
  Page 771 - 788Huang LC, Yee KMP, Wa CA, Nguyen JN, Sadun AA, and Sebag JEditors: J Sebag.Springer Science + Business Media, New York2014
• The Vitreous 
  Chapter: Macular Hote and Macular Pucker Surgery with Special Emphasis on Reoperations 
  Page 613 - 627Pan BX, Yee KMP, Ross-Cisneros F, Sadun AA, and Sebag JEditors: J Sebag.Springer Science + Business Media, New York2014
• The Vitreous 
  Chapter: Vitreo-Papillary Adhesion and Traction 
  Page 299 - 310Wang MY, Sadun AA and Sebag JEditors: J Sebag.Springer Science + Business Media, New York2014
• The Vitreous 
  Chapter: Vitreous Cytokines and Regression of the Fetal Hyaloid Vasculature 
  Page 41 - 55Yee KMP, Feener EP, Gao B, Aiello LP, Madigan MC, Provis J, Ross-Cisneros F, Sadun AA, and Sebag JEditors: J Sebag.Springer Science + Business Media, New York2014
• Ophthalmology 
  Editors: Yanoff M and Duker JS: Sadun AA (Section Eds).Harcourt, LondonEdition 4th,2013
• Visual Fields: Examination and Interpretation 
  Chapter: Acquired Optic Nerve Diseases 
  Chicani F, Quiros P, Sadun AAEditors: Thomas J. Walsh.Oxford Univ. PressEdition 3rd,2010
• Visual Fields: Examination and Interpretation 
  Chapter: Inherited or Congenital Optic Nerve Disease 
  Quiros P, Chicani F, Sadun AAEditors: Thomas J. Walsh.Oxford Univ. PressEdition 3rd,2010
• Ophthalmology 
  Chapter: Papilledema and Raised Intracranial Pressure 
  Page 960 - 963Sadun AAEditors: Yanoff & Duker.London, UKEdition 3rd,2009
• Neuro-ophthalmology 
  Chapter: A Case of Giant Cell Arteritis, in Curbside Consultations 
  Sadun AAEditors: Andrew Lee.Slack2009
• Ophthalmology 
  Chapter: Anatomy and Physiology 
  Page 950 - 953Sadun AAEditors: Yanoff & Duker.London, UKEdition 3rd,2009
• Ophthalmology 
  Chapter: Differentiation of Opic Nerve from Retinal Macular Disease 
  Page 954 - 955Sadun AA, Patel VEditors: Yanoff & Duker.London, UKEdition 3rd,2009
• Ophthalmology 
  Chapter: Hereditary, Nutritional, and Toxic Optic Atrophies 
  Page 976 - 979Sadun AA, Gurkan S, Patel VEditors: Yanoff & Duker.London, UKEdition 3rd,2009
• Ophthalmology 
  Chapter: Optic Chiasm, Parasellar Reigon, and Pituitary Fossa 
  Page 986 - 994Ruben RM, Sadun AA, Piva AEditors: Yanoff & Duker.London, UKEdition 3rd,2009
• Ophthalmology 
  Chapter: Tumors, Infections, Inflamations, and Neurodegeneration 
  Page 1069 - 1075Saadati HG, Sadun AAEditors: Yanoff & Duker.London, UKEdition 3rd,2009
• Ophthalmology 
  Chapter: Ocular Myopathies 
  Page 1032 - 1039Ruben RM, Sadun AAEditors: Yanoff & Duker.London, UKEdition 3rd,2009
• Ophthalmology 
  Editors: Yanoff M and Duker JS: Sadun AA (Section Eds).Harcourt, LondonEdition 3rd,2009
• Duane's Clinical Ophthalmology 
  Chapter: Anatomy of the Visual Sensory System 
  Sadun AA, Glaser J, Bose S2008
• Principals and Practices of Ophthalmology 
  Chapter: Optic Atrophy and Papilledium 
  Page 4108 - 4116Sadun AAEditors: Albert, Jakobies, Azer, Gragoudas.Edition 3rd,2008
• Current Ocular Therapy 
  Chapter: Ischemic Optic Neuropathies 
  Sadun AASaundersEdition Six,2008
• Ophthalmology 
  Editors: Yanoff M and Duker JS: Sadun AA (Section Eds).Harcourt, LondonEdition 2nd,2004
• BCSC Section 13 
  Chapter: Epidemic Optic Neuropathy in Cuba 
  Sadun AA2002
• Encyclopedia for Neurological Sciences 
  Chapter: Optic Nerve, Cranial Nerve II 
  Sadun AA2002
• Neuroprotection: Implication for the Eye Disease 
  Lam, TT and Sadun AADoheney Eye Institute, Los Angeles, CA2002
• Ophthalmology 
  Editors: Yanoff M and Duker JS: Sadun AA (Section Eds).Mosby International, London1999
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Abstracts/Posters

• Reducing Post-vitrectomy Cataracts
  Yee K, Wa CA, Nguyen JH, TanS, Lesnik-Oberstein SY, Filas BA, Shul YB, Beebe DC, Sadun AA, Sebag J, ARVO Meeting, 4/30/2014
• Quantitative Ultrasonography of Vitreous Correlates with Contrast Sensitivity in Patients with Floaters
  Wa CA, Yee KM, Mamou J, Silverman RH, Gale J, GantiAK, Kettterling JA, Sadun AA, Sebag J, ARVO Meeting, 4/30/2014
• Multifocal Bioelectrical Cortical Responses in Leber Hereditary Optic Neuropathy
  Parisi V, Ziccardi L, Giannnini D, Sadun AA, De Negri, Savini G, Barboni P, La Morgia C, Carelli, ARVO Meeting, 4/30/2014
• Macular Pucker Lowers Contrast Sensitivity which Improves After Surgery
  Nguyen J, Yee KM, Wa CA, Sadun AA, Sebag J, ARVO Meeting, 4/30/2014
• Cardiac Conduction in Leber's Hereditary Optic Neuropathy
  Frousiakis SE, Karanjia R, Ganti MK, Pouw A, Moraes M, Salomao S, Belfort, Jr. R, Quiros PA, Chicani F, Sadun AA, ARVO Meeting, 4/30/2014
• EPI-743 May Improve Visual Acuity in LHON: Data from a Brazilian Cohort
  Ganti AK, Chu E, Karanjia R, Tran J, Belfort, Jr. R, Moraes M, Berezovsky A, Sadun AA, Miller G, Chicani F, ARVO Meeting, 4/30/2014
• Characterization of a Novel OPA1 Mouse Model by Light and Transmission Electron Microscopy
  Pham AH, Ross-Cisneros F, Pan B, Zaninello M, Scorrano L, Carelli V, Sadun AA, ARVO Meeting, 4/30/2014
• Perimetric Parameters in Unaffected Carriers of Leber's Hereditary Optic Neuropathy (LHON)
  Pouw A, Gale J, Karanjia R, Tran J, Moraes M, Salomao S, Berezovsky A, Chicani F, Quiros PA, Sadun AA, ARVO Meeting, 4/30/2014
• Melanopsin Retinal Ganglion Cells are Spared in Wolfram Syndrome
  Ross-Cisneros F, La Morgia C, Pan B, Hannibal J, Miler N, Carelli V, Sadun AA, ARVO Meeting, 4/30/2014
• The mt11778/ND4 Mutation, in Leber's Hereditary Optic Neuropathy, Is Associated with Less Degeneration in the Peripheral Nerve Compared to the mt3460/ND1 Mutation
  Chu ER, Ross-Cisneros, Pham AH, Gale J, Moraes M, Salomao S, Berezovsky A, Carelli V, Belfort, Jr., Sadun AA, ARVO Meeting, 4/30/2014
• Effects of Pentoxifylline on Blood Flow in Patients with Non-Arteritic Ischemic Optic Neuropathy
  Gale j, Chu ER, Frousiakis SE, Srinivas S, Karanjia R, Tan O, Huang D, Sadda S, Sadun AA, ARVO Meeting, 4/30/2014
• Long-term Safety of Vitrectomy for Patients with Floaters
  Wa C, Yee K, Huang L, Sadun AA, Sebag J, ARVO Meeting, 6/16/2013
• Time Interval Before Re-operation Influences Visual Outcomes in Repeat Macular Hole and Macular Pucker Surgery
  Pan B, Yee K, Ross-Cisneros F, Sadun AA, Sebag J, ARVO Meeting, 6/16/2013
• Subjective Influences on Visual Acuity Testing Performance : A Prospective Study with On-accomodating Intra-ocular Lenses
  Iyer, Arvind, Chu E, Pan B, Tjan B, Sadun AA, Lu K, Udwadia F, ARVO Meeting, 6/16/2013
• Treatment of Leber's Hereditary Optic Neuropathy Patients with EPI-743 Prevents Decline of the Serum Biomarker - Neuron Specific Enolase
  Chu E, Ross-Cisneros, Lee JG, Yee K, Chicani C, Murase K, Thoolen M, Miller G, Sadun AA, ARVO Meeting, 6/16/2013
• Treatment of Leber's Hereditary Optic Neuropathy (LHON): Results Using a Novel Quinone, EPI-743
  Chicani C, Chu E, Ross-Cisneros F, Rockwell, Katsuyuki M, Thoolen, Miller G, Sadun AA, ARVO Meeting, 6/16/2013
• Linkage Analysis in Leber's Hereditary Optic Neuropathy (LHON): Failure to Locate Significant Loci in a Very Large Family Indicates a Polygenic/Environmental Complex C...
  Carelli V, Caporali L, Maresca A, Valentino M, Salomao S, Sadun AA, d'Adamo P, ARVO Meeting, 6/16/2013
• A Histopathologic and Morphometric Analysis of Degenerating Melanopsin Retinal Ganglion Cells in Alzheimer's Disease
  Ross-Cisneros F, La Morgia C, Pan B, Hannibal J, Carelli V, Sadun AA, ARVO Meeting, 6/16/2013
• Prospective Study of Vitrectomy for Floaters: Improvement in Contrast Sensitivity and Standardized VFQ Testing
  Yee K, Huang L, Wa C, Sadun AA, Sebag J, ARVO Meeting, 6/16/2013
• Visual and Anatomic Findings after Discontinuation of Hydroxychloroquine in Patients Diagnosed with Toxicity
  Wong B, Jampol LM, Brenner M, Lyon AT, Sadun AA, Fawzi AA, Vis. Sci, 1/1/2012
• Contrast Sensitivity, but Not Contrast Gain, Is Affected in Asymptomatic Carriers of 11778 Leber's Hereditary Optic Neuropathy (LHON) As Assessed with the Pedestal-{De...
  Gualtieri M, Hamer RD, Bandeira ML, Bonci DM, Salomao SR, Berezovsky A, Carelli V, Sadun AA, Ventura DF, Vis. Sci, 1/1/2012
• Immunohistochemistry Detects Inner Retina in Excised Membranes from Vitreo-Maculopathies with Poor Post-Operative Vision
  Yee KM, Pan BX, Ross-Cisneros FN, Chu E, Sadun AA, Sebag J, Vis. Sci, 1/1/2012
• Posterior Ischemic Optic Neuropathy: Perioperative Risk Factors
  Wang MY, Brewer JR, Sadun AA, Vis. Sci, 1/1/2012
• Secondary Post-geniculate Involvement In Leber's Hereditary Optic Neuropathy
  La Morgia C, Rizzo G, Tozer KR, Ross-Cisneros FN, Tonon C, Valentino ML, Barboni P, Sadun AA, Lodi R, Carelli V, Vis. Sci, 1/1/2012
• Mitochondrial Strain Index: Mathematically Modeling the Susceptibility of Optic Nerve Axons in Leber's Hereditary Optic Neuropathy
  Pan BX, Ross-Cisneros FN, Tozer KR, Sadun AA, Vis. Sci, 1/1/2012
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Lectures

• The Cuban Epidemic of Optic Neuropathy and Conversations with Castro 
  Salt Lake City, Utah - 9/1/2014
• The Canary in the Coal Mine: MOS and the Optic Nerve 
  University of Utah School of Medicine. Salt Lake City, Utah - 9/1/2014
• An Epidemic of Optic and Peripheral Neuropathy in Cuba 
  Salt Lake City, Utah - 9/1/2014
• Why the Papillo-macular Bundle of the Optic Nerve Is Most Susceptible to Mitochondrial Disease 
  Salt Lake City, Utah - 9/1/2014
• CDistinguishing Maculopathy from Optic Neuropathy 
  Palo Alto, CA - 7/1/2014
• When Glaucoma Looks like Other Optic Neuropathies 
  Jules Stein Eye Institute. Los Angeles, CA - 6/1/2014
• Neuro-ophthalmology: Past, Present and Future 
  New York, NY - 5/1/2014
• Why the Optic Nerve Succumbs First in Mitochondrial Optic Neuropatheis 
  Rochester University. Rochester, NY - 3/1/2014
• New Treatments for LHON 
  Rochester University. Rochester, NY - 3/1/2014
• The Canary in the Coal Mine for MON: Why the Optic Nerve? Why the PMB? 
  Federal Univ. of Sao Paulo, Sao Paulo, Brazil - 2/1/2014
• What Cuba Taught Us about Mitochondrial Diseases 
  Federal Univ. of Sao Paulo, Sao Paulo, Brazil - 2/1/2014
• Optic Neuropathy before and after Surgery 
  Puerto Rico - 2/1/2014
• Lessons from Leber's and the Paradigm Shift in Neuro-ophthalmology 
  Univ. of Wisconsin School of Medicine. Madison, WI - 10/1/2013
• Why Is the Optic Nerve the Canary in the Coal Mine of Mitochondrial Diseases 
  Nice, France - 9/1/2013
• New Concepts of Treatment for Mitochondrial Optic Neuropathies Such as LHON 
  Nice, France - 9/1/2013
• Mitochondrial Optic Neuropathies: A New Way of Looking at Old Diseases 
  Los Angeles, CA - 7/1/2013
• Which Three Letters Matter Most? ATP or ROS? 
  Los Angeles, CA - 6/1/2013
• Bacon Back to Montaigne and Lucretius: Why Size Matters 
  Harvard Medical School, Boston, MA - 6/1/2013
• Lessons from Leber's: Why We Are at the Paradigm Shift? 
  Duke Medical Center. Durham, NC - 4/1/2013
• New Insights from Brazil on LHON 
  New Orleans, LA - 1/1/2013
• An Epidemic of Optic Neuropathy: Cuba, Castro and Converting Sugar to Rum 
  New Orleans, LA - 1/1/2013
• Mitochondrial Optic Neuropathies: Why Antibiotics Can Blind You 
  New Orleans, LA - 1/1/2013
• NAION: Is There Any Treatment? 
  New Orleans, LA - 1/1/2013
• Are We There Yet: A New Paradigm in Neuro-ophthalmology. Acceptance of the 11th Hoyt Prize 
  American Academy of Ophthalmology. Chicago - 11/1/2012
• Update on Leber's Hereditary Optic Neuropathy 
  University of Parma. Parma, Italy - 10/1/2012
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Other

• New Developments in the Diagnosis of Giant Cell Arteritis 
  Sadun, AA, Bradly Katz, AAO Podcast
  Chicago - 11/1/2014
• Toxic and Metabolic Optic Neuropathies 
  Sadun, AA, Golnik, K, AAO Podcast
  New Orleans - 11/1/2013
• Aging and the Eye 
  Sadun AA, Arnold, T, AAO Podcast
  Orlando - 10/1/2012
• Glaucoma IS a Neurodegeneration. Videoconference 
  
  Univ. of Bologna, Italy - 6/1/2012
• Anterior Ischemic Optic Neuropathy 
  Sadun AA, Miller, N, AAO Podcast
  10/1/2011
• Hereditary Optic Neuropathies 
  American Academy of Opthalmology Podcast
  American Academy of Ophthalmology, Atlanta, GA - 11/1/2008
• Neuronal Development and Synaptic Organization in the Red Nucleus of the Cat 
  
  1/1/1976
• Neuronal Development and Synaptic Organization in the Red Nucleus of the Cat, Doctoral Dissertation 
  Sadun AA, Albert Einstein College of Medicine. University Microfilms International
  Books/Book Chapters - 1/1/1976
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