Alfredo A Sadun MD

PubMed

• 5 citations
  Elamipretide Topical Ophthalmic Solution for the Treatment of Subjects with Leber Hereditary Optic Neuropathy: A Randomized Trial.
  Rustum Karanjia, Alfredo A Sadun
  Ophthalmology. 2024-04-01
• 5 citations
  Choriocapillaris and Retinal Vascular Alterations in Presymptomatic Alzheimer's Disease.
  Giulia Corradetti, Deniz Oncel, Shin Kadomoto, Xianghong Arakaki, Robert A Kloner
  Investigative Ophthalmology & Visual Science. 2024-01-02
• 10 citations
  Childhood-Onset Leber Hereditary Optic Neuropathy-Clinical and Prognostic Insights.
  Piero Barboni, Chiara La Morgia, Maria Lucia Cascavilla, Eun Hee Hong, Marco Battista
  American Journal of Ophthalmology. 2023-05-01

Journal Articles

• Mitochondrial optic neuropathies: additional facts and concepts - response.  
  Sadun AA, La Morgia C, Carelli V, Experimental Opthalmol, 6/18/2013
• Optic nerve histopathology in a case of Wolfram Syndrome: A mitochondrial pattern of axonal loss.  
  Ross-Cisneros FN, Pan BX, Silva RA, Miller NR, Albini TA, Tranebjaerg L, Rendtorff ND, Lodahl M, Moraes-Filho MN, Moraes MN, Salomao SR, Berezovsky A, Belfort R Jr, Ca..., Mitochondrion, 6/6/2013
• The Pupil Light Reflex in Leber's Hereditary Optic Neuropathy: Evidence for Preservation of Melanopsoin-Expressing Retinal Ganglion Cells.  
  Moura AL, Nagy BV, La Morgia C, Barboni P, Oliveira AG, Salomão SR, Berezovsky A, de Moraes-Filho MN, Chicani CF, Belfort R Jr, Carelli V, Sadun AA, Hood DC, Ventura DF, Invest Ophthalmol Vis Sci, 6/4/2013
• Drug-related mitochondrial optic neuropathies.  
  Wang MY, Sadun AA, J Neuroophthalmol, 6/1/2013
• Are we there yet? Is neuro-ophthalmology at the cusp of a paradigm shift? Lessons from leber hereditary optic neuropathy.  
  Sadun AA, J Neuroophthalmol, 6/1/2013
• Neuro-ophthalmology Safer Than MRI?  
  Sadun AA, Chu ER, Boisvert CJ, Opthalmology, 4/1/2013
• Beckman Initiative for Macular Research Classification Committee.Clinical Classification of Age-related Macular Degeneration.  
  Ferris FL 3rd, Wilkinson CP, Bird A, Chakravarthy U, Chew E, Csaky K, Sadda SR, Ophthalmology, 4/1/2013
• Mitochondrial optic neuropathies: our travels from bench to bedside and back again An expansion of the 35(th) Susan Alper Memorial lecture by Alfredo A. Sadun, MD, PhD...  
  Sadun AA, Morgia CL, Carelli V, Clin Experiment Ophthalmol, 2/21/2013
• Microcystic macular degeneration from optic neuropathy: not inflammatory, not trans-synaptic degeneration.  
  Barboni P, Carelli V, Savini G, Carbonelli M, La Morgia C, Sadun AA, Brain, 2/8/2013
• Mitochondrial dysfunction in optic neuropathies: animal models and therapeutic options.  
  Carelli V, La Morgia C, Sadun AA, Curr Opin Neurol, 2/1/2013
• Mouse mtDNA mutant model of Leber hereditary optic neuropathy.  
  Lin CS, Sharpley MS, Fan W, Waymire KG, Sadun AA, Carelli V, Ross-Cisneros FN, Baciu P, Sung E, McManus MJ, Pan BX, Gil DW, Macgregor GR, Wallace DC, Proc Natl Acad Sci U S A, 12/4/2012
• Visual improvement with the use of idebenone in the treatment of wolfram syndrome.  
  Bababeygy SR, Wang MY, Khaderi KR, Sadun AA, J Neuroophthalmol, 12/1/2012
• Bilateral Vision Loss Responsive to Corticosteroids.  
  Lee MD, Song BJ, Odel JG, Sadun AA, Surv Ophthalmol, 11/12/2012
• Mathematically Modeling the Involvement of Axons in Leber's Hereditary Optic Neuropathy.  
  Pan BX, Ross-Cisneros FN, Carelli V, Rue KS, Salomao SR, Moraes-Filho MN, Moraes MN, Berezovsky A, Belfort R Jr, Sadun AA, Invest Ophthalmol Vis Sci, 11/9/2012
• Are melanopsin cells blocked by filtering IOLs?  
  Bababeygy SR, Sadun AA, Int Ophthalmol, 11/6/2012
• Neuron-specific enolase is elevated in asymptomatic carriers of leber's hereditary optic neuropathy.  
  Yee KM, Ross-Cisneros FN, Lee JG, Da Rosa AB, Salomao SR, Berezovsky A, Belfort R Jr, Chicani F, Moraes-Filho M, Sebag J, Carelli V, Sadun AA, Invest Ophthalmol Vis Sci, 9/21/2012
• Patterns of ganglion cell complex and nerve fiber layer loss in nonarteritic ischemic optic neuropathy by fourier-domain optical coherence tomography.  
  Aggarwal D, Tan O, Huang D, Sadun AA, Invest Ophthalmol Vis Sci, 7/3/2012
• Bilateral Oedipism.  
  Bababeygy SR, Sadun AA, Ophthal Plast Reconstr Surg, 6/8/2012
• Is Leber Hereditary Optic Neuropathy treatable? Encouraging results with idebenone in both prospective and retrospective trials and an illustrative case.  
  Sabet-Peyman EJ, Khaderi KR, Sadun AA, J Neuroophthalmol, 3/1/2012
• Effect of EPI-743 on the Clinical Course of the Mitochondrial Disease Leber Hereditary Optic Neuropathy.  
  Sadun AA, Chicani CF, Ross-Cisneros F, Barboni P, Thoolen M, Shrader WD, Kubis K, Carelli V, Miller G, Arch Neurol, 3/1/2012
• Studies of the Ocular Complications of Aids Research Group. Association between retinal nerve fiber layer thickness and abnormalities of vision in people with Human I...  
  Kalyani PS, Holland GN, Fawzi AA, Arantes TE, Yu F, Sadun AA, Am J Ophthalmol, 1/12/2012
• Impending anterior ischemic optic neuropathy with elements of retinal vein occlusion in a patient on interferon for polycythemia vera.  
  Rue KS, Hirsch LK, Sadun AA, Clin Ophthalmol, 1/1/2012
• Secondary Post-Geniculate Involvement in Leber's Hereditary Optic Neuropathy.  
  Rizzo G, Tozer KR, Tonon C, Manners D, Testa C, Malucelli E, Valentino ML, La Morgia C, Barboni P, Randhawa RS, Ross-Cisneros FN, Sadun AA, Carelli V, Lodi R, PloS One, 1/1/2012
• Accuracy of funduscopy to identify true edema versus pseudoedema of the optic disc.  
  Carta A, Favilla S, Prato M, Marzoli SB, Sadun AA, Mora P, Invest Ophthalmol Vis Sci, 11/22/2011
• Retinal Nerve Fiber Layer Thickness in Dominant Optic Atrophy Measurements by Optical Coherence Tomography and Correlation with Age.  
  Barboni P, Savini G, Parisi V, Carbonelli M, La Morgia C, Maresca A, Sadun F, De Negri AM, Carta A, Sadun AA, Carelli V, Opthalmol, 10/1/2011
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Books/Book Chapters

• Ophthalmology. 
  Mosby International, Harcourt, LondonEdition 4th ,2012
• Visual Fields: Examination and Interpretation. 
  Chapter: Acquired optic nerve diseases. 
  Chicani F, Quiros P, Sadun AAEditors: Thomas J. Walsh.Oxford University Press2010
• Visual Fields: Examination and Interpretation. 
  Chapter: Inherited or congenital optic nerve disease. 
  Quiros P, Chicani F, Sadun AAEditors: Thomas J. Walsh.Oxford University Press2010
• Curbside consultations in Neuro-ophthalmology. 
  Chapter: A Case of Giant Cell Arteritis. 
  Sadun AAEditors: Andrew Lee.Slack2009
• Ophthalmology. 
  Chapter: Anatomy of Physiology. Ophthalmology. 
  Page 950 - 953Yanoff & DukerLondon, UK.Edition 3rd ,2009
• Ophthalmology. 
  Mosby International, Harcourt, LondonEdition 3rd ,2009
• Ophthalmology. 
  Chapter: Differentiation of Opic Nerve from Retinal Macular Disease. 
  Page 954 - 955Yanoff & DukerLondon, UK.Edition 3rd ,2009
• Ophthalmology. 
  Chapter: Tumors, Infections, Inflamations, and Neurodegeneration. 
  Page 1069 - 1075Yanoff & DukerLondon, UK.Edition 3rd ,2009
• Ophthalmology. 
  Chapter: Ocular Myopathies. 
  Page 1032 - 1039Yanoff & DukerLondon, UK.Edition 3rd ,2009
• Ophthalmology. 
  Chapter: Optic Chiasm, Parasellar Reigon, and Pituitary Fossa. 
  Page 986 - 994Yanoff & DukerLondon, UK.Edition 3rd ,2009
• Ophthalmology. 
  Chapter: Hereditary, Nutritional, and Toxic Optic Atrophies. 
  Page 976 - 979Yanoff & DukerLondon, UK.Edition 3rd ,2009
• Ophthalmology. 
  Chapter: Papilledema and Raised Intracranial Pressure. 
  Page 960 - 963Yanoff & DukerLondon, UK.Edition 3rd ,2009
• Current Ocular Therapy. 
  Chapter: Ischemic Optic Neuropathies. 
  Sadun AASaundersEdition 6th ,2008
• Optic Atrophy and Papilledium in Principals and Practices of Ophthalmology. 
  Chapter: Optic Atrophy and Papilledium in Principals and Practices of Ophthalmology. 
  Page 4108 - 4116Sadun AAEditors: Albert, Jakobies, Azer, Gragoudas.Edition 3rd ,2008
• Duane's Clinical Ophthalmology 2005. 
  Chapter: Anatomy of the Visual Sensory System. 
  Sadun AA, Glaser J, Bose S2008
• Anatomy of the Visual Sensory System in Neuro-ophthalmology. 
  Chapter: Anatomy of the Visual Sensory System in Neuro-ophthalmology. 
  Page 75 - 94Sadun AA, Glaser JEditors: Glaser.JB Lippincott Co, Philadelphia, PA.Edition 4th ,2005
• Ophthalmology. 
  Mosby International, Harcourt, LondonEdition 2nd ,2004
• Opthalmology. 
  Chapter: The Brain: Tumors, infections, inflammations and neurodegenerations. 
  Page 1383 - 1389Yanoff & DukerLondon, UK.2003
• Opthalmology. 
  Chapter: The afferent visual system: hereditary, nutritional and toxic optic neuropathies. 
  Page 1275 - 1278Yanoff & DukerLondon, UK.2003
• Opthalmology. 
  Chapter: The afferent visual system: papilledema and raised intracranial pressure. 
  Page 1259 - 1262Yanoff & DukerLondon, UK.2003
• Opthalmology. 
  Chapter: The afferent visual system: differentiation of optic nerve from retinal macular disease. 
  Page 1253 - 1254Yanoff & DukerLondon, UK.2003
• Opthalmology. 
  Chapter: The afferent visual system: anatomy and physiology. 
  Page 1249 - 1252Yanoff & DukerLondon, UK.2003
• Opthalmology. 
  Chapter: Optic Chiasm, Parasellar Region, and Pituitary Fossa. 
  Page 1286 - 1294Yanoff & DukerLondon, UK.2003
• Opthalmology. 
  Chapter: The efferent visual system: ocular myopathies. 
  Page 1286 - 1349Yanoff & DukerLondon, UK.2003
• Neuroprotection: Implication for the Eye Disease. 
  Lam, TT and Sadun AADoheney Eye Institute, Los Angeles, CA.2002
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Abstracts/Posters

• Visual and Anatomic Findings after Discontinuation of Hydroxychloroquine in Patients Diagnosed with Toxicity.
  Wong B, Jampol LM, Brenner M, Lyon AT, Sadun AA, Fawzi AA, Vis Sci, 1/1/2012
• Contrast sensitivity, but not contrast gain, is affected in asymptomatic carriers of 11778 Leber's Hereditary Optic Neuropathy (LHON) as assessed with the pedestal-&lt...
  Gualtieri M, Hamer RD, Bandeira ML, Bonci DM, Salomao SR, Berezovsky A, Carelli V, Sadun AA, Ventura DF, Vis Sci, 1/1/2012
• Immunohistochemistry Detects Inner Retina in Excised Membranes from Vitreo-Maculopathies with Poor Post-Operative Vision.
  Yee KM, Pan BX, Ross-Cisneros FN, Chu E, Sadun AA, Sebag J, Vis Sci, 1/1/2012
• Posterior Ischemic Optic Neuropathy: Perioperative Risk Factors.
  Wang MY, Brewer JR, Sadun AA, Vis Sci, 1/1/2012
• Secondary Post-geniculate Involvement In Leber's Hereditary Optic Neuropathy.
  La Morgia C, Rizzo G, Tozer KR, Ross-Cisneros FN, Tonon C, Valentino ML, Barboni P, Sadun AA, Lodi R, Carelli V, Vis Sci, 1/1/2012
• Mitochondrial Strain Index: Mathematically Modeling the Susceptibility of Optic Nerve Axons in Leber's Hereditary Optic Neuropathy.
  Pan BX, Ross-Cisneros FN, Tozer KR, Sadun AA, Vis Sci, 1/1/2012
• Not all Inherited Mitochondrial Diseases Produce an Optic Neuropathy.
  Wa CA, Ross-Cisneros FN, Chu ER, Pan BX, Soh HC, Sue C, Carelli V, Sadun AA, Vis Sci, 1/1/2012
• Optic Nerve Histopathology in a Case of Wolfram Syndrome Demonstrates a Mitochondrial Pattern of Axonal Loss.
  Ross-Cisneros FN, Silva RA, Miller NR, Tranebjaerg L, Carelli V, Albini TA, Sadun AA, Vis Sci, 1/1/2012
• Bioinformatic Analysis of Embryonic Human Vitreomics.
  Sebag J, Yee KM, Madigan MC, Aiello LP, Sadun AA, Vis Sci, 1/1/2012
• Localization of Opticin in Fetal Human Eyes.
  Chu ER, Ballard BN, Yee KM, Ross-Cisneros FN, Madigan MC, Le Goff MM, Bishop PN, Sadun AA, Sebag J, Vis Sci, 1/1/2012
• Association between Vision Abnormalities and Increased Retinal Nerve Fiber Layer Thickness Among Individuals Infected with Human Immunodeficiency Virus.
  Kalyani PS, Holland GN, Fawzi AA, Arantes TE, Yu Fei, Sadun AA, Vis Sci, 4/22/2011
• Importance Of History In The Diagnosis Of Neuro-ophthalmic Diseases.
  Wang MY, Sadun AA, Vis Sci, 1/1/2011
• Optic Neuropathy in a Case of Mitochondrial Neurogastrointestinal Encephalomyopathy (MNGIE): Ultrastructural Features and Mitochondrial DNA analysis.
  Ross-Cisneros FN, Giordano C, Carelli V, Sadun AA, Vis Sci, 1/1/2011
• Onset and Progression of Retinal Nerve Fiber Layer Myelination Associated With Optic Nerve Head Drusen.
  Bass SJ, Sherman J, Katz BJ, Sadun AA, Panzer A, Vis Sci, 1/1/2011
• A Morphological Study of the Optic Nerve in a Mito-Mouse Model Carrying an ND6 Point Mutation.
  Bedrood S, Ross-Cisneros FN, Tozer KR, Lin CS, Sharpley MS, Carelli V, Wallace DC, Sadun AA, Vis Sci, 1/1/2011
• Pattern of Ganglion Cells and Nerve Fiber Layer Loss in Non-Arteritic Ischemic Optic Neuropathy determined by Fourier Domain Optical Coherence Tomography.
  Aggarwal D, Tan O, Huang D, Sadun AA, Vis Sci, 1/1/2011
• Immunohistochemistry of Human Embryonic Vitreous.
  Yee KM, Ross-Cisneros FN, Ballard BN, Madigan MC, Provis JM, Aiello LP, Sadun AA, Sebag J, Vis Sci, 1/1/2011
• Melanopsin Driven Pupillary Light Response in Leber's Hereditary Optic Neuropathy (LHON).
  Moura AL, Nagy BV, La Morgia C, Salomao SR, Berezovsky A, Chicani CF, Carelli V, Sadun AA, Hood DC, Ventura DF, Vis Sci, 1/1/2011
• Idebenone Treatment In Leber 's Hereditary Optic Neuropathy.
  Carelli V, La Morgia C, Valentino ML, Carbonelli M, Sadun AA, Aggarwal D, Liguori R, Avoni P, Montagna P, Barboni P, 1/1/2011
• Macular Dysfunction and Structure in Macular Pucker with Good Visual Acuity.
  Ahmed KA, Tozer KR, Robison CD, Wang MY, Fink W, Sadun AA, Sebag AA, Vis Sci, 1/1/2011
• Estrogens Ameliorate Mitochondrial Dysfunction in Leber Hereditary Optic Neuropathy.
  Carelli V, Montopoli M, Perli E, Orlandi M, Ross-Cisneros FN, Sadun AA, Ghelli A, d'Amati G, Giordano C, Vis Sci, 1/1/2010
• Asymptomatic Leber's Hereditary Optic Neuropathy Carriers With Subclinical Disease Have Higher Serum Levels of Phosphorylated Neurofilament Heavy Chain.
  Ross-Cisneros FN, Shaw G, Barboni P, Chicani CF, Rosa AB, Yee KM, Dustin LD, Berezovsky A, Salomao SR, Sadun AA, Vis Sci, 1/1/2010
• Contrast Sensitivity to Achromatic Spatial Drifting Gratings in Asymptomatic Carriers of the MtDNA 11778 Mutation Leber's Hereditary Optic Neuropathy (LHON).
  Costa MF, Gualtieri M, Oliveira AGF, Moreira SMCF, Sadun F, Berezovsky A, Salomao SR, Carelli V, Sadun AA, Ventura DF, Vis Sci, 1/1/2010
• Asymptomatic Carriers of Leber's Hereditary Optic Neuropathy Have Elevated Serum Neuron Specific Enolase.
  Yee KM, Ross-Cisneros FN, Lee JG, Rosa AB, Salomao SR, Berezovsky A, Belfort R, Jr, Sebag J, Carelli V, Sadun AA, Vis Sci, 1/1/2010
• Obstructive Sleep Apnea is an Independent Risk Factor for Non-Arteritic Ischemic Optic Neuropathy.
  Nguyen DT, Emoto Y, Emoto H, Sebag J, Wang MY, Levendowski D, Scarfeo D, Westbrook P, Sadun AA, Vis Sci, 1/1/2010
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Lectures

• Are we there yet: A new paradigm in neuro-ophthalmology. 
  Chicago, IL. - 11/1/2012
• Update on Leber's Hereditary Optic Neuropathy. 
  Parma, Italy. - 10/1/2012
• The clinical assessment of papilledema. 
  Milan, Italy. - 10/1/2012
• Taking the history in Neuro-Ophthalmology. 
  Conegliano, Italy. - 10/1/2012
• Doing the Neuro-Ophthalmology examination and testing. 
  Conegliano, Italy. - 10/1/2012
• Optic neuropathy as a neuro-degeneration. 
  Rome, Italy. - 10/1/2012
• New developments in the science of LHON. 
  Rome, Italy. - 10/1/2012
• From bed to bedside and back in changing the LHON paradigm. 
  New Haven, CT. - 9/1/2012
• History is but Bayesian analysis. 
  New Haven, CT. - 9/1/2012
• Distinguishing maculopathy from optic neuropathy. 
  Palo Alto, CA. - 7/1/2012
• Leber's Hereditary Optic Neuropathy: A lesson in clinical science from bench to bedside back to bench. 
  Washington Memorial Center - 4/1/2012
• Antibiotics that act as mitochondrial optic neuropathies. 
  Sacramento, CA. - 3/1/2012
• The mechanisms by which mitochondrial optic neuropathys cause RGC loss. 
  Sacramento, CA. - 3/1/2012
• Worst disasters in Neuro-Ophthalmology. 
  Sacramento, CA. - 3/1/2012
• Glaucoma as an optic neuropathy: Use of OCT to discern. 
  Los Angeles, CA. - 3/1/2012
• Ethambutol Optic Neuropathy. 
  Los Angeles, CA. - 3/1/2012
• The evolution of vision. 
  Los Angeles, CA. - 3/1/2012
• (Acquired) Mitochondrial Optic Neuropathies: A new way of looking at old diseases. 
  San Antonio, TX. - 2/1/2012
• Mitochondria as the Cause of Optic Neuropathies. 
  Los Angeles, CA. - 12/1/2011
• Leber Hereditary Optic Neuropathy: Mitochondrial Programming of Cell Death. 
  Orlando, CA. - 10/1/2011
• Mitochondrial programming of apoptosis: Lessons from LHON and acquired mitochondrial optic neuropathies. 
  Los Angeles, CA. - 10/1/2011
• A case of Oedipism. 
  New Haven, CT. - 9/1/2011
• How Evolution made Engineering Tradeoffs for the Eye. 
  Los Angeles, CA. - 6/1/2011
• Altering the natural history of Leber hereditary optic neuropathy with a new treatment agent - EPI-743. 
  Dana Point, CA. - 5/1/2011
• Mitochondrial diseases and the optic nerve: Canary in the coal mine. 
  Los Angeles, CA. - 4/1/2011
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Other

• Glaucoma is a neurodegeneration. 
  Sadun AA
  Videoconference. Univ. of Bologna, Italy - 6/1/2012
• Anterior Ischemic Optic neuropathy. 
  Sadun AA, Miller, N, AAO Podcast
  10/1/2011
• Ocular Diseases in the older Population. 
  Sadun AA, Volpe N, Neuro-ophthalmology Podcast
  http://one.aao.org/audio/ocular-disease-in-older-population-neuroophthalmic
  3/1/2010
• Hereditary Optic Neuropathies: American Academy of Opthalmology Podcast. 
  Sadun AA
  American Academy of Ophthalmology, Atlanta, GA. - 11/1/2008
• An Interactive Guide to Correlating Fundus, Fields, and Neuro-imaging. 
  Sherman, J, Sadun AA, Yannuzzi, Lawrence A, Banfiel Ron, Quigley H
  Visual Fields: Pathways to Interpretation. Northland Graphics Digital Imaging. - 1/1/1997
• ILSI Testing organophosphates toxicity in the visual system. 
  Sadun AA Jensen K, Foran J, Seed J
  10/1/1994
• Light-induced melatonin suppression and neuropathological correlations in hereditary optic neuropathies. 
  La Morgia C, Sancisi E, Ross-Cisneros FN, Munarini A, Barboni P, Salomao SR, Sadun AA, Hannibal J, Mantovani V, Montagna P, Carelli V
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