AlfredTLookJr.MD

PubMed

• 72 citations
  Discovery of a selective inhibitor of doublecortin like kinase 1
  Fleur M. Ferguson, Behnam Nabet, Srivatsan Raghavan, Yan Liu, Alan L. Leggett
  Nature Chemical Biology. 2020-04-06
• 169 citations
  Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry.
  Adam D. Durbin, Mark W. Zimmerman, Neekesh V. Dharia, Brian J. Abraham, Amanda Balboni Iniguez
  Nature Genetics. 2018-08-20
• 56 citations
  ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry
  Lu Wang, Tze King Tan, Adam D. Durbin, Mark W. Zimmerman, Brian J. Abraham
  Nature Communications. 2019-12-09

Journal Articles

• Selective Gene Dependencies in MYCN-Amplified Neuroblastoma Include the Core Transcriptional Regulatory Circuitry  
  William C Hahn, Todd R Golub, A Thomas Look, Adam D Durbin, Neekesh V Dharia, Kimberly Stegmaier, Nature
• The MCL1-Specific Inhibitor S63845 Acts Synergistically with venetoclax/ABT-199 to Induce Apoptosis in T-cell Acute Lymphoblastic Leukemia Cells  
  Alfred Look Jr., MD, Nature
• SCF(FBW7) Regulates Cellular Apoptosis by Targeting MCL1 for Ubiquitylation and Destruction  
  Inuzuka H, Shaik S, Onoyama I, Gao D, Tseng A, Maser RS, Zhai B, Wan L, Gutierrez A, Lau AW, Xiao Y, Christie AL, Aster J, Settleman J, Gygi SP, Kung AL, Look T, Nakay..., Nature, 1/1/2011
• NOTCH2 Links Protein Kinase C Delta to the Expression of CD23 in Chronic Lymphocytic Leukaemia (CLL) Cells  
  Hubmann R, Duchler M, Schnabl S, Hilgarth M, Demirtas D, Mitteregger D, Holbl A, Vanura K, Le T, Look T, Schwarzmeier JD, Valent P, Jager U, Shehata M, Br. J. Haematol, 1/1/2010
• Down-regulation of the Notch Pathway Mediated by a Gamma-secretase Inhibitor Induces Anti-tumour Effects in Mouse Models of T-cell Leukaemia  
  Tammam J, Ware C, Efferson C, O'Neil J, Rao S, Qu X, Gorenstein J, Angagaw M, Kim H, Kenific C, Kunii K, Leach KJ, Nikov G, Zhao J, Dai X, Hardwick J, Scott M, Winter ..., Br. J. Pharmacol, 1/1/2009
• Zebrafish Modelling of Leukaemias  
  Payne E, Look T, Br. J. Haematol, 1/1/2009
• Identification of Additional Cytogenetic and Molecular Genetic Abnormalities in Acute Myeloid Leukaemia with T(8;21)/AML1-ETO  
  Kuchenbauer F, Schnittger S, Look T, Gilliland G, Tenen D, Haferlach T, Hiddemann W, Buske C, Schoch C, Br. J. Haematol., 1/1/2006
• Evidence for an Age Cutoff Greater than 365 Days for Neuroblastoma Risk Group Stratification in the Children's Oncology Group  
  London WB, Castleberry RP, Matthay KK, Look AT, Seeger RC, Shimada H, Thorner P, Brodeur G, Maris JM, Reynolds CP, Cohn SL, J. Clin. Oncol, 1/1/2005
• Making Waves in Cancer Research: New Models in the Zebrafish  
  Berghmans S, Jette C, Langenau D, Hsu K, Stewart R, Look T, Kanki JP, BioTechniques, 1/1/2005
• Investigator Profile An Interview with A Thomas Look, MD Interview by Vicki Glaser  
  Look AT, Zebrafish, 1/1/2005
• Fusion of NUP214 to ABL1 on Amplified Episomes in T-cell Acute Lymphoblastic Leukemia  
  Graux C, Cools J, Melotte C, Quentmeier H, Ferrando A, Levine R, Vermeesch JR, Stul M, Dutta B, Boeckx N, Bosly A, Heimann P, Uyttebroeck A, Mentens N, Somers R, MacLe..., Nat. Genet., 1/1/2004
• Biological Aspects of Neuroblastomas Identified by Mass Screening in Quebec  
  Brodeur GM, Look AT, Shimada H, Hamilton VM, Maris JM, Hann HW, Leclerc JM, Bernstein M, Brisson LC, Brossard J, Lemieux B, Tuchman M, Woods WG, Med. Pediatr. Oncol., 1/1/2001
• Downregulation of Bim, a Proapoptotic Relative of Bcl-2, Is a Pivotal Step in Cytokine-initiated Survival Signaling in Murine Hematopoietic Progenitors  
  Shinjyo T, Kuribara R, Inukai T, Hosoi H, Kinoshita T, Miyajima A, Houghton PJ, Look AT, Ozawa K, Inaba T, Mol. Cell. Biol., 1/1/2001
• Zebrafish Myelopoiesis and Blood Cell Development  
  Hsu K, Kanki JP, Look AT, Curr. Opin. Hematol, 1/1/2001
• Natural History and Biology of Stage a Neuroblastoma: A Pediatric Oncology Group Study  
  Alvarado CS, London WB, Look AT, Brodeur GM, Altmiller DH, Thorner PS, Joshi VV, Rowe ST, Nash MB, Smith EI, Castleberry RP, Cohn SL, J. Pediatr. Hematol. Oncol., 1/1/2000
• Caspase 8 Is Deleted or Silenced Preferentially in Childhood Neuroblastomas with Amplification of MYCN  
  Teitz T, Wei T, Valentine MB, Vanin EF, Grenet J, Valentine VA, Behm FG, Look AT, Lahti JM, Kidd VJ, Nat. Med, 1/1/2000
• Parental Smoking and Alcohol Consumption and Risk of Neuroblastoma Cancer Epidemiol  
  Yang Q, Olshan AF, Bondy ML, Shah NR, Pollock BH, Seeger RC, Look AT, Cohn SL, Biomarkers Prev., 1/1/2000
• Reduced or Absent Expression and Codon 201Gly/Arg Polymorphism of DCC Gene in Rhabdomyosarcoma and Ewing's Sarcoma/PNET Family  
  Choi SH, Kong XT, Taki T, Tsuchida Y, Kawaguchi H, Kato H, Hanada R, Look AT, Hayashi Y, Int. J. Mol. Med., 1/1/2000
• Identification of Newly Diagnosed Children with Acute Lymphocytic Leukemia at High Risk for Relapse  
  Shuster JJ, Camitta BM, Pullen J, Borowitz MJ, Carroll AJ, Look AT, Mahoney DH, Mahmoud H, Lauer SJ, Land VJ, Cancer Research Therapy and Control, 1/1/1999
• p27KIP1 Deletions in Childhood Acute Lymphoblastic Leukemia  
  Komuro H, Valentine MB, Rubnitz JE, Saito M, Raimondi SC, Carroll AJ, Yi T, Sherr CJ, Look AT, Neoplasia, 1/1/1999
• Three Molecular Determinants of Malignant Conversion and Their Potential as Therapeutic Targets  
  Dome JS, Look AT, Curr Opin Oncol, 1/1/1999
• Prognostic Significance of Age, MYCN Oncogene Amplification, Tumor Cell Ploidy, and Histology in 110 Infants with Stage D(S) Neuroblastoma: The Pediatric Oncology Grou...  
  Katzenstein HM, Bowman LC, Brodeur GM, Thorner PS, Joshi VV, Smith EI, Look AT, Rowe ST, Nash MB, Holbrook T, Alvarado C, Rao PV, Castleberry RP, Cohn SL, J. Clin. Oncol., 1/1/1998
• Prognostic Significance of Sex in Childhood B-precursor Acute Lymphoblastic Leukemia: A Pediatric Oncology Group Study  
  Shuster JJ, Wacker P, Pullen J, Humbert J, Land VJ, Mahoney DH, Lauer S, Look AT, Borowitz MJ, Carroll AJ, Camitta B, J. Clin. Oncol., 1/1/1998
• Chromosomal Localization of the Human Smoothened Gene (SMOH) To 7q32 3 by Fluorescence in Situ Hybridization and Radiation Hybrid Mapping  
  Sublett JE, Entrekin RE, Look AT, Reardon DA, Genomics, 1/1/1998
• The AD1 and AD2 Transactivation Domains of E2A Are Essential for the Antiapoptotic Activity of the Chimeric Oncoprotein E2A-HLF  
  Inukai T, Inaba T, Ikushima S, Look AT, Mol. Cell. Biol, 1/1/1998
• Join now to see all

Books/Book Chapters

• Oncology of Infancy and Childhood 
  Page 331.0 - 402.0Clark JJ, Berman JN, Look ATEditors: Orkin SH, Fisher DE, Look AT, Lux SE, Ginsburg D, Nathan DG.W.B. Saunders, Philadelphia, PA2009
• Molecular Biology of B Cells 
  Chapter: Chromosomal Translocations in B Cell Leukemias and Lymphomas 
  Page 1891. - 1900.Ferrando A. and Look ATEditors: Honjo T, Alt FW, Neuberger M.Elsevier Academic Press, London, UK2004
• Hematology of Infancy and Childhood 
  Chapter: Myeloid Leukemia, Myelodysplasia, and Myeloproliferative Disease in Children 
  Page 1167. - 1209.Bennett CM, Hsu K and Look ATEditors: Nathan DG, Orkin SH, Ginsburg D, Look AT.W.B. Saunders, Philadelphia, PAEdition 6th,2003
• Hematopoiesis: A Developmental Approach 
  Chapter: Aberrant Control of Cell Fate in the Leukemias and Lymphomas 
  Page 672.0 - 688.0Look ATOxford University Press, New York, NY2000
• The Genetic Basis of Human Cancer 
  Chapter: Genes Altered by Chromosomal Translocations in Leukemias and Lymphoma 
  Page 109.0 - 141.0Look ATEditors: Vogelstein B and Kinzler KW.New York, NY1998
• Principles and Practice of Pediatric Oncology 
  Chapter: Molecular Basis of Childhood Cancer 
  Page 37.0 - 74.0Look AT and Kirsch IREditors: Pizzo PA and Poplack DG.J. B. Lippincott Co., Philadelphia, PAEdition 3rd,1997
• Leukemia: Advances in Research and Treatment 
  Chapter: MLL Fusion Genes in the 11q23 Acute Leukemias 
  Page 72.0 - 92.0Downing JR and Look ATEditors: Freireich EJ.1995
• Molecular Biology in Cancer Medicine 
  Chapter: Cytogenetic and Molecular Defects in the Acute Lymphoid Leukemias 
  Page 174.0 - 195.0Downing JR and Look ATEditors: Kurzrock R, Talpaz M.Martin Dunitz, London1995
• Leucocyte Typing V 
  Chapter: Report of the CD13 (Aminopeptidase N) Cluster Workshop 
  Page 988.0 - 989.0Ashmun RA, Holmes KV, Shapiro LH, Favaloro EJ, Razak K, deCrom RPG, Howard CJ, Look ATEditors: Schlossman SF, et al..Oxford University Press, Oxford1995
• Hematology: Basic Principles and Practice 
  Chapter: Pathobiology of the Acute Lymphoid Leukemia Cell 
  Page 763.0 - 776.0Look ATEditors: Benz EJ, Cohen HJ, Furie B, Hoffman R, Shattil SJ.Churchill Livingstone, New Department of Experimental Oncology1991
• Leukocyte Typing IV 
  Chapter: Report on the CD34 Cluster Workshop 
  Page 881.0 - 825.0Civin CI, Trischmann TM, Fackler MJ, Bernstein ID, Buhring H-J, Campos L, Greaves MF, Kamoun M, Katz DR, Landsdorp PM, Look AT, Seed B, Sutherland DR, Tindle RW, Uchan...Editors: Knapp W.Oxford University Press, Oxford1989
• Molecular Diagnostics of Human Cancer 
  Chapter: Human CSF-1 Receptor (C-fms Proto-oncogene Product) On Normal and Leukemic Myeloid Cells 
  Ashmun RA, Look AT, Roussel MR, Ohtuska M, Sherr CJCold Spring Harbor Laboratory1989
• Leukocyte Typing IV 
  Chapter: Summary of the Myeloid Workshop Transfectoma Studies 
  Page 880.0 - 886.0Stockinger H, Ashmun RA, Dougherty G, Franklin WA, Goyert SM, Hogarth M, Humphries K, Jose DG, Kasinrerk W, Landsdorp PM, Look AT, Pilkington G, Seed B, Tesio L, Willi...Editors: Knapp W.Oxford University Press, Oxford1989
• Leukocyte Typing IV 
  Chapter: Summary of the CD14 Cluster Workshop 
  Page 789.0 - 794.0Goyert SM, Tesio L, Ashman LK, Ball E, Bazil V, Garrido F, Hogg N, Horejsi V, Howell A, Jayaram Y, Look AT, Ruiz-Cabello F, Schmitt D, Schneider M, van der Schoot CEEditors: Knapp W.Oxford University Press, Oxford1989
• Leukocyte Typing IV 
  Chapter: Monoclonal Antibodies to the Human CSF-1 Receptor (C-fms Proto-oncogene Product) Define a New Myeloid Cluster Group 
  Page 941.0 - 943.0Ashmun RA, Look AT, Roussel MF, Ohtsuka M, Sherr CJEditors: Knapp W.Oxford University Press, Oxford1989
• Leukocyte Typing IV 
  Chapter: Report of the CD33 Cluster Group Workshop: Biochemical and Genetic Characterization of gp67 
  Page 814.0 - 816.0Peiper SC, LeBoeuf RD, Hughes CB, Prasthofer EF, Borowitz MJ, Dewtter-Dambuyant, Katz DR, Walker WS, Ashmun RA, Look ATEditors: Knapp W.Oxford University Press, Oxford1989
• Leukocyte Typing IV 
  Chapter: Report of the CD13 (Aminopeptidase N) Cluster Workshop 
  Page 784.0 - 787.0Look AT, Ashmun RA, Shapiro LH, O'Connell PJ, Gerkis V, d'Apice AJ, Sagawa K, Peiper SCEditors: Knapp W.Oxford University Press, Oxford1989
• Mechanisms of Action and Therapeutic Applications of Biologicals in Cancer and Immune Deficiency Disorders 
  Chapter: Expression of CSF-1 Receptors on Human Leukemic Blasts 
  Page 39.0 - 55.0Ashmun RA, Look AT, Roussel MF, Ohtsuka M, Sherr CJAlan R. Liss Inc.1989
• Constellations of Genetic Abnormalities Predict Clinical Outcome in Childhood Malignancies 
  Look AT1989
• Biology of Human Leukemia 
  Chapter: Genetic Abnormalities in Human Leukemia 
  Look ATEditors: Mauer AM.Johns Hopkins University Press1989
• Leukocyte Typing III 
  Chapter: DNA Mediated Transfer of the Gene Encoding p67, a Myeloid Differentiation Antigen Recognized by the MY9, L1B2, and L4F3 Monoclonal Antibodies 
  Page 622.0 - 625.0Peiper SC, Lemons RS, Ashmun RA, Look ATOxford University Press, Oxford1987
• Leukocyte Typing III 
  Chapter: Binding of Independently Derived Monoclonal Antibodies to Unique Human Myeloid Differentiation Antigens 
  Page 626.0 - 629.0Look AT, Peiper SC, Ashmun RAEditors: McMichael AJ, et al..Oxford University Press, Oxford1987
• Cancer Biology and Therapeutics 
  Chapter: Relationships of Cell Biology to Therapy in Childhood Leukemia 
  Page 161.0 - 172.0Look AT, Williams DL, Simone JVEditors: Cory JG, Szentivanyi A.Plenum Publishing, New York1986
• Leukocyte Typing 
  Chapter: Changes in Cell Surface Antigen Expression during Myelocytic and Monocytic Cell Differentiation 
  Page 442.0 - 446.0Mirro J, Melvin S, Metzger D, Look AT, Murphy SBEditors: Bernard A, Boumsell L.Springer Verlag1984
• New Approaches in Cancer Therapy 
  Chapter: VP 16 213 and 5 Azacytidine for Remission Induction of Refractory Acute Nonlymphocytic Leukemia 
  Dahl GV, Look AT, Rivera GEditors: Cortes Funes H, Rozencweig M.Raven Press, New York1982
• Join now to see all

Abstracts/Posters

• Therapy of Childhood Leukemia -understanding Success and Failure
  Simone JV, Rivera GK, Look AT, Crist WM, Proc of 20th Anniversary Symposium, Children's Cancer Association of Japan, 1/1/1989

Lectures

• Phase I Study of the Selinexor in Relapsed/Refractory Childhood Acute Leukemia 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Emerging features of Super-Enhancers in T-Cell acute Leukemia 
  Boston University School of Medicine - 1/1/2015
• Inherited and Somatically Acquired Super-Enhancers in Development Cancers 
  Denver, Colorado - 1/1/2015
• Pediatric Cancer: Basic Science III 
  Philadelphia - 1/1/2015
• Zebrafish Models to Dissect Human Cancers 
  Bar Harbor, Maine - 1/1/2015
• Oncogene Regulation by Super-enhance Formulation 
  1/1/2015
• A Zebrafish Model of Myelodysplastic Syndrome Produced Through tet2 Genomic Editing 
  Pacific Grove, CA - 1/1/2015
• A Zebrafish Model of Myeloid Malignacy Produced Through tet2 and asxl1 Genomic Editing 
  Hawaii - 1/1/2015
• Central Role for Super-Enhancers in T-cell Leukemia 
  Berlin, Germany - 1/1/2015
• Central Role of Super-enhancers in T-Cell Acute Leukemia 
  Berlin, Germany - 1/1/2015
• Targeting Pathway Addiction to the TYK2 Kinase in T-cell Acute Lymphoblastic Leukemia 
  Moores UCSD Cancer Center, University of California, San Diego - 1/1/2014
• The Interface of GWAS and Zebrafish-LMO1 Controls the Rate of Neuroblastoma 
  San Diego - 1/1/2014
• Targeting of Nuclear Export in Primary AML Cells 
  New York - 1/1/2014
• Faithful Zebrafish Models of High Risk Neuroblastoma Promise New Advances in Personalized Medicine 
  Halifax, NS, Canada - 1/1/2014
• Zebrafish Models to Dissect Cancer 
  Bar Harbor, Maine - 1/1/2014
• Core Transcriptional Regulatory Circuit Controlled by the TAL1 Complex in Human T-cell Acute Lymphoblastic Leukemia 
  Univeristy of Pennslyvania Perelman School of Medicine ,Philadelphia, PA - 1/1/2013
• Aberrant Expression of Hepatocyte Growth Factor Induces Autocrine MET Activation in Acute Myeloid Leukemia 
  Van Andel Institute Grand Rapids, Michigan - 1/1/2013
• MYBL2 Is a Sub-haploinsufficient Tumor Suppressor Gene in Myeloid Malignancy 
  Maui , Hawaii - 1/1/2013
• Autocrine Activation of MET and Strategies to Overcome Adaptation for the Targeted Therapy of Acute Myeloid Leukemia 
  Washington, D.C. - 1/1/2013
• Role of the LMO1 Oncogene in Neuroblastoma Pathogenesis 
  Barcelona, Spain, 2013; Murcia, Spain, 2013 - 1/1/2013
• ALK Mutations and Mechanisms of Transformation in Neuroblastoma 
  Heidelberg, Germany - 1/1/2013
• MYBL2 is a Tumor Suppressor Gene in Myelodysplastic Syndromes 
  Stanford University School of Medicine, Stanford, California - 1/1/2012
• New Advances Molecular Pathogenesis and Pathway Dependence in T-cell ALL 
  Stowers Institute for Medical Research, Kansas City, Missouri - 1/1/2012
• Addiction to a Non-Canonical Interferon Receptor-TYK2-STAT1 Pathway in Human T-ALL 
  Memorial Sloan-Kettering Cancer Center, New York, New York - 1/1/2011
• Recent Advances in T-ALL: Addiction to a Non-Canonical Interferon Receptor-TYK2-STAT1 Pathway 
  University of Chicago Comprehensive Cancer Center, Chicago, Illinois - 1/1/2011
• Join now to see all