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Office
Division of Lymphoma
1500 East Duarte Road
Duarte, CA 91010Phone+1 626-256-4673Fax+1 626-389-3058
Summary
- I earned my medical degree and PhD at Yaroslavl State Medical Academy in Russia and completed a fellowship in hematology/oncology at Tufts Medical Center, in Boston, Massachusetts. I am a physician-scientist with background in molecular biology and oncologic drug development and expertise in cancer cell signaling. I lead an independent research program in hematologic malignancies which bridges the understanding of blood cancer biology with early clinical evaluation of novel therapeutics.
As a leader of the Lymphoma Center at the City of Hope National Medical Center, I guide an effort in experimental therapeutics in lymphoid malignancies. In addition to pre-clinical focus on evaluation of novel targets in the ubiquitin-proteasome system (1) and oncogenic role of cyclin-dependent kinase-9 (2), my group performs correlative science on multiple clinical trials. I received peer-reviewed funding from the National Cancer Institute, Leukemia and Lymphoma Society, American Society of Hematology, Lymphoma Research Foundation and SWOG, and serve as Translational Medicine Chair at SWOG Lymphoma Committee.
Clinically, I am a practicing medical oncologist specializing in the care of patients with CLL and lymphoma. Building on our group's pre-clinical discoveries, we launched multiple early-phase clinical trials with novel agents targeting Nedd8-activating enzyme, BTK, PI3K and SYK. As a member of industry and SWOG committees, I participate in drug development on a global scale.
Education & Training
- Tufts Medical CenterFellowship, Hematology and Medical Oncology, 2007 - 2010
- Brown UniversityResidency, Internal Medicine, 2004 - 2007
- Yaroslavl Med AcadClass of 1997
Certifications & Licensure
- NH State Medical License 2010 - Present
- CA State Medical License 2019 - 2025
- OR State Medical License 2014 - 2023
- RI State Medical License 2005 - 2007
- American Board of Internal Medicine Hematology
- American Board of Internal Medicine Medical Oncology
Awards, Honors, & Recognition
- Leukemia and Lymphoma Society Scholar LLS, 2018
Clinical Trials
- Copanlisib and Nivolumab in Treating Patients With Richter's Transformation or Transformed Indolent Non-Hodgkin Lymphoma Start of enrollment: 2019 Feb 26
Roles: Contact, Principal Investigator
- Acalabrutinib for the Treatment of Relapsed or Refractory Autoimmune Hemolytic Anemia in Patients With Chronic Lymphocytic Leukemia Start of enrollment: 2021 Mar 16
Roles: Principal Investigator, Contact
- Copanlisib and Venetoclax for the Treatment of Relapsed or Refractory Mantle Cell Lymphoma Start of enrollment: 2022 Jun 29
Roles: Contact, Principal Investigator
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Publications & Presentations
PubMed
- Navigating the changing landscape of BTK-targeted therapies for B cell lymphomas and chronic lymphocytic leukaemia.Michele D Stanchina, Skye Montoya, Alexey V Danilov, Jorge J Castillo, Alvaro J Alencar
Nature Reviews. Clinical Oncology. 2024-12-01 - Bruton Tyrosine Kinase Degraders in B-Cell Malignancies.Tiana Huynh, Sonia Rodriguez-Rodriguez, Alexey V Danilov
Molecular Cancer Therapeutics. 2024-05-02 - 3 citationsT Cell-intrinsic Immunomodulatory Effects of TAK-981 (Subasumstat), a SUMO-activating Enzyme Inhibitor, in Chronic Lymphocytic Leukemia.Vi Lam, Carly Roleder, Tingting Liu, Nur Bruss, Scott Best
Molecular Cancer Therapeutics. 2023-09-05
Press Mentions
- Fixed-Duration Oral Doublet for Fit CLL Wins in Frontline SettingDecember 9th, 2024
- Promising Results with Epcoritamab Monotherapy in Relapsed/Refractory CLLDecember 8th, 2024
- Investigational Epcoritamab (DuoBody® CD3xCD20) Monotherapy Achieves High Overall and Complete Response Rates in Clinical Trial of Patients with Relapsed or Refractory (R/R) Chronic Lymphocytic Leukemia (CLL) in Preliminary AnalysisDecember 8th, 2024
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