AlexanderR.JudkinsMD

PubMed

• 411 citations
  Akt-Dependent Metabolic Reprogramming Regulates Tumor Cell Histone Acetylation
  Joyce V. Lee, Alessandro Carrer, Supriya Shah, Nathaniel W. Snyder, Shuanzeng Wei
  Cell Metabolism. 2014-08-05
• 560 citations
  The Genetic Landscape of the Childhood Cancer Medulloblastoma
  D. Williams Parsons, Meng Li, Xiaosong Zhang, Siân Jones, Rebecca J. Leary
  Science. 2011-01-28
• 351 citations
  Hypoxia Induces Production of L-2-Hydroxyglutarate
  Andrew M. Intlekofer, Raymond G. DeMatteo, Sriram Venneti, Lydia W.S. Finley, Chao Lu
  Cell Metabolism. 2015-08-04

Journal Articles

• A Sensitive and Specific Histopathologic Prognostic Marker for H3F3A K27M Mutant Pediatric Glioblastomas  
  Venneti S, Judkins AR, Santi, M, Felicella, MM, Yarilin D, Phillips JJ, Sullivan LM, Martinez D, Perry A, Lewis PW, Thompson CB, Judkins, AR, Acta Neuropathologica, 7/30/2014
• Akt-Dependent Metabolic Reprogramming Regulates Tumor Cell Histone Acetylation  
  Lee JV, Carrer A, Shah S, Snyder N, Wei S, Venneti S, Worth A, Yuan ZF, Lim HW, Liu S, Jackson E, Aiello N, Haas N, Rebbeck, Judkins AR, Won KJ, Chodosh LA, Garcia BA,..., Cell Metabolism, 1/1/2014
• Pathology and Diagnosis of SMARCB1-deficient Tumors  
  Margol AS, Judkins AR, Cancer Genetics, 1/1/2014
• PID1 (NYGGF4), a New Growth-inhibitory Gene in Embryonal Brain Tumors and Gliomas  
  Erdeich-Epstein A., Robison N, Ren X, Zhou H, Xu J, Davidson T, Schur M, Gilles FH, Ji L, Malvar J, Shackleford G, Margol A, Krieger M, Judkins AR, Jones DTW, Pfister ..., Clin Cancer Res, 1/1/2014
• Evaluation of Histone 3 Lysine 27 Trimethylation (H3K27me3) And Enhancer of Zest 2 (EZH2) In Pediatric Glial and Glioneuronal Tumors Shows Decreased H3K27me3 in H3F3A ...  
  Venneti S, Garimella MT, Sullivan LM, Martinez D, Hsue JT, Heguy A, Santi M, Thompson CB, Judkins AR, Brain Pathol, 9/1/2013
• Epithelioid Sarcoma Is Associated with a High Percentage of SMARCB1 Deletions  
  Sullivan LM, Folpe AL, Pawel BR, Judkins AR, Biegel JA, Mod Pathol, 3/1/2013
• Histone3lysine 9 Trimethylation (H3K9me3)is Differentially Associated with Isocitrate Dehydrogenase 1 (IDH1)R132H Mutations in Oligodendrogliomas and High-grade Astroc...  
  Venneti S, Felicella MM, Coyne T, Phillips JJ, Gorovets D, Huse JT, Kofler J, Lu C, Tihan T, Sullivan LM, Santi M, Judkins AR, Perry A, Thompson CB, J Neuropathol Exp Neurol, 1/1/2013
• The Alternative Lengthening of Telomere Phenotype Is Significantly Associated with Loss of ATRX Expression in High-grade Pediatric and Adult Astrocycomas: A Multi-inst...  
  Abedalthagafi M, Phillips J, Kim G, Mueller S, Haas-Kogan D, Marshall R, Croul S, Santi M, Cheng J, Zhou S, Sullivan L, Martinez-Lage M, Judkins AR, Perry A, Mod Pathol, 1/1/2013
• PDGFRA Amplification Is Common in Pediatric and Adult High-grade Astrocytomas and Identifies a Poor Prognostic Group in IDH1 Mutant Glioblastoma  
  Phillips JJ, Aranda D, Ellison DW, Judkins AR, Croul SE, Brat DJ, Ligon KL, Horbinski C, Venneti S, Zadeh G, Santi M, Zhou S, Appin CL, Sioletic S, Sullivan LM, Martin..., Brain Pathol, 1/1/2013
• Outcome of Infants and Young Children with Newly Diagnosed Ependymoma Treated on the "Head Start" III Prospective Clinical Trial  
  Venkatramani R, Ji L, Lasky J, Haley K, Judkins AR, Sposto R, Olshefski R, Garvin J, Tekautz T, Kennedy G, Rassekh SR, Moore T, Gardner S, Allen J, Shore R, Moertel C,..., J Neurooncol, 1/1/2013
• Intracranial Sarcoma Metastasizing along Distal Shunt Tubing  
  Heuer GG, Orlova KA, Pollock AN, Guzman MA, Judkins AR, Storm PB, Pediatric Neurosurgery, 8/1/2012
• Definition of Genetic Events Directing the Development of Distinct Types of Brain Tumors from Postnatal Neural Stem/Progenitor Cells  
  Hertwig F, Meyer K, Braun S, Ek S, Spang R, Pfenninger C, Artner I, Prost G, Chen X, Biegel JA, Judkins AR, Englund E, Nuber U, Cancer Research, 7/1/2012
• Surgical Treatment of Brain Tumors in Infants Younger than Six Months of Age and Review of the Literature  
  Lang SS, Beslow LA, Gabel B, Judkins AR, Fisher MJ, Sutton LN, Storm PB, Heuer GG, World Neurosurgery, 7/1/2012
• Spinal Cord Ependymomas and Myxopapillaryependymomas in the First Two Decades of Life: A Clinicopathological and Immunohistochemical Characterization of 19 Cases  
  Santi M, Stephen J, Sievert A, Madsen P, Judkins AR, Resnick A, Storm P, Rushing E, Journal of Neurosurgery: Pediatrics, 6/1/2012
• Epithelioid Malignant Peripheral Nerve Sheath Tumor Arising in a Schwannoma, in a Patient With "Neuroblastoma-like" Schwannomatoisis and a Novel Germlike SMARCB1 Mutation  
  Carter J, O'Hara C, Dundas G, Gilchrist D, Collins M, Eaton K, Judkins AR, Biegel JA, Folpe A, Am J Surg Pathol, 1/1/2012
• A Visual Latent Semantic Approach for Automatic Analysis and Interpretation of Anaplastic Medullobastoma Virtual Slides  
  Cruz-Roa A, Gonzalet F, Galaro J, Judkins AR, Ellison D, Baccon J, Madabhushi A, Romero E, Med Image Comput Assist Interv, 1/1/2012
• Pulmonary Edema and Cardian Dysfuntion after Resection of a Fourth Ventricle Tumor in a Toddler: Case Report  
  Heuer G, Fenning R, Brown M, Kilbaught T, Guzman M, Judkins AR, Rorke-Adams L, Sutton L, Storm P, Childs Nerv Syst, 9/1/2011
• p16 INK4A and p14 ARF Tumor Suppressor Pathways Are Deregulated in Malignant Rhabdoid Tumors  
  Venneti S, Le P, Martinez D, Eaton KW, Shyam N, Jordan-Sciutto KL, Pawel B, Biegel JA, Judkins AR, J Neuropathol Exp Neurol, 1/1/2011
• The Relationship among Hypoxia, Proliferation, and Outcome in Patients with De Novo Glioblastoma: A Pilot Study  
  Evans SM, Jenkins KW, Chen HI, Jenkins WT, Judy KD, Hwang W, Lustig RA, Judkins AR, Grady MS, Hahn SM, Koch CJ, Clin Transl Oncol, 6/1/2010
• Coexisting Follicular and Mantle Cell Lymphoma with Each Having an in Situ Component: A Novel, Curious, and Complex Consultation Case of Coincidental, Composite, Colon...  
  Roullet MR, Martinez D, Ma L, Fowler MH, McPhail ED, Judkins AR, Arber DA, Bagg A, Am J Clin Pathol, 3/1/2010
• Immunoprofile of Mesenchymal Chondrosarcoma: Aberrant Desmin and EMA Expression, Retention of INI1, and Negative Estrogen Receptor in 22 Female-predominant Central Ner...  
  Fanburg-Smith JC, Auerbach A, Marwaha JS, Wang Z, Santi M, Judkins AR, Rushing, EJ, Ann Diag Pathol, 2/1/2010
• Ependymoblastoma: Dear, Damned, Distracting Diagnosis, Farewell!  
  Judkins AR, Ellison DW, Brain Pathol, 1/1/2010
• Digital Pathology: A Tool for 21st Century Neuropathology  
  Guzman M, Judkins AR, Brain Pathol, 4/1/2009
• Computer and Internet Based Tools for Neuropathology in the 21st Century  
  Judkins A R, Brain Pathol, 4/1/2009
• Genomic Analysis Using High Density SNP Based Oligonucleotide Arrays and MLPA Provides a Comprehensive Analysis of INI-1 / SMARCB1 in Malignant Rhabdoid Tumors  
  Jackson EM, Sievert AJ, Gai X, Hakonarson H, Judkins AR, Tooke L, Perin JC, Xie H, Shaikh T, Biegel JA, Clin Cancer Res, 3/1/2009
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Books/Book Chapters

• Molecular Pathoogy of Nervous System Tumors: Biological Stratification and Targeted Therapies 
  Chapter: Choroid Plexus Tumors 
  Venneti S, Hasselblatt M, Wolff J, Judkins AREditors: Karajannis M, Zagzag D.Springer, Arlington, VA2014
• Molecular Pathoogy of Nervous System Tumors: Biological Stratification and Targeted Therapies 
  Chapter: Atypical Teratoid Rhabdoid Tumors 
  Venneti S, Kalpana G, Judkins AR, Gardner SEditors: Karajannis M, Zagzag D.Springer, Arlington, VA2014
• Non-neoplastic Disease of the Central Nervous System. First Non-Neoplastic Disease Fascicle Series 
  Louis DN, Frosch MP, Mena H, Rushing EJ, Judkins ARArmed Forces Institute of Pathology / American Registry of Pathology, Silver Spring, MD2010
• World Health Organization Classification of Tumors. Pathology & Genetics: Tumors of the Nervous System 
  Chapter: Atypical Teratoid / Rhabdoid Tumor 
  Judkins AR, Eberhart CE, Wesseling PEditors: Cavenee W, Louis DN, Ohgaki H, Wiestler O.IARC Press, Lyon, FranceEdition 4th,2007
• World Health Organization Classification of Tumors. Pathology & Genetics: Tumors of the Nervous System 
  Chapter: CNS Primitive Neuroectodermal Tumour (PNET) 
  McLendon RE, Judkins AR, Fuller G, Sarkar C, Ng HEditors: Cavenee W, Louis DN, Ohgaki H, Wiestler O.IARC Press, Lyon, FranceEdition 4th,2007
• World Health Organization Classification of Tumors. Pathology & Genetics: Tumors of the Nervous System 
  Chapter: Rhabdoid Tumor Predisposition Syndrome (RTPS) 
  Wesseling P, Biegel JA, Eberhart C, Judkins AREditors: CaveneeW, Louis DN, Ohgaki H, Wiestler O.IARC Press, Lyon, FranceEdition 4th,2007
• Pathology & Genetics. Developmental Neuropathology 
  Chapter: Dandy Walker Malformation 
  Page 95 - 99Judkins AREditors: Golden JA, Harding BN.ISN Neuropath Press, Basel2004
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Abstracts/Posters

• Whole Genome Copy Number Analysis of Formalin Fixed Paraffin Embedded Samples Identifies Major Genomic Aberrations in Medulloblastoma
  Robison N, Margol A, Shukla A, KennedyR, Fung E, Judkins AR, Asgharzadeh S, Cancer Genomics Consortium/Cytogenomics Array Group Summer Meeting, Chicago, IL, 8/1/2014
• Reduction in H3K27me3 Is a Molecular and Prognostic Surrogate in Pediatric Glioblastomas
  Venneti S, Santi M, Felicella Madden M, Sullivan LM, Dolgalev I, Martinez D, Perry A, Lewis PW, Allis DC, Thompson CB, Judkins AR, 16th International Symposium on Pediatric Neuro-Oncology(ISPNO), Singapore, 7/2/2014
• Histopathologic Evaluation of H3K27me3 is a Prognostic Biomarker for Pediatric Glioblastomas
  Venneti S, Santi M, Felicella Madden M, Sullivan LM, Dolgalev I, Martinez D, Perry A, Lewis PW, Allis DC, Thompson CB, Judkins AR, 20th International Conference on Brain Tumor Research and Therapy (ICBRT20), Lake Tahoe, CA, 7/1/2014
• Evaluation of H3K27me3 and EZH2 in Pediatric Glial and Glioneuronal Tumors Shows Decreased H3K27me3 in H3F3A K27M Mutant GBM
  Venneti S, Garimella MT, Sullivan LM, Martinez D, Huse JT, Heguy A, Santi M, Thompson CB, Judkins AR, Fourth Quadrennial Meeting of the World Federation of Neuro-Oncology, hosted by the Society for Neuro-Oncology, San Francsico, CA, 11/1/2013
• Evaluation of H3K27me3 and EZH2 in Pediatric Glial and Glioneuronal Tumors Shows Decreased H3K27me3 in H3F3A K27M Mutant Glioblastomas
  Venneti S, Garimella MT, Sullivan LM, Martinez D, Huse JT, Heguy A, Santi M, Thompson CB, Judkins AR, Chromatin and Epigenetics in Cancer, AACR, American Association of Neuropathologists, Atlanta, GA, 2013; Charleston, SC, 2013, 6/22/2013
• Histone3 K9 Trimethylation (H3K9me3) Is Differntially Associated with Isocitrate Dehydrogenase Mutations in Oligodendrogliomas and Astrocytomas
  Venneti S, Madden ME, Coyne T, Phillips JJ, Gorovets D, Huse JT, Kofler J, Lu C, Tihan T, Sullivan LM, Santi M, Judkins AR, Perry A, Thompson CB, 17th Annual Scientific Meeting and Education Day of the Society for Neuro-Oncology (SNO), Washington DC, 11/1/2012
• Patterns of Repressive Histone3K9 Trimethylation in Isocitrate Dehydrogenase R132H Positive and Negative Gliomas
  Venneti S, Madden ME, Coyne T, Phillips JJ, Gorovets D, Huse JT, Lu C, Tihan T, Sullivan LM, Santi M, Judkins AR, Thompson CB, Perry A, 87th Annual meeting of the American Association of Neuropathologists, Chicago, IL, 6/23/2012
• Malignant Rhabdoid Tumors Express the Germ Cell Specific Markers VASA and Nanos
  Venneti S, Le P, Martinez D, Pawel B, Judkins AR, Annual Meeting of American Association of Neuropathologists Annual Meeting, Chicago, IL, 6/1/2012
• Histone3 K9 Trimethylation (H3K9me3) Is Differntially Associated with Isocitrate Dehydrogenase Mutations in Oligodendrogliomas and Astrocytomas
  Venneti S, Madden ME, Coyne T, Phillips JJ, Gorovets D, Huse JT, Kofler J, Lu C, Tihan T, Sullivan LM, Santi M, Judkins AR, Perry A, Thompson CB, Annual Meeting of American Association for Neuropathologists (AANP), Chicago, 6/1/2012
• Malignant Rhabdoid Tumors Express Stem Cell Factors, Which Relate to the Expression of EZH2 and Id Proteins
  Venneti S, Le P, Martinez D, Xie SX, Sullivan LM, Rorke-Adams LB, Pawel B, Judkins AR, American Association of Neuropathologists Annual Meeting, Seattle, WA, 6/23/2011
• Segmentation of Nodular Medulloblastoma Using Random Walker and Hierarchical Normalized Cuts
  Tchikindas L, Sparks R, Baccon J, Ellison D, Judkins AR, Madabhushi A, Bioengineering Conference (NEBEC), 2011 IEEE 37th Annual Northeast, Troy, NY, 4/1/2011
• A Texture-based Classifier to Discriminate Anaplastic from Non-anaplastic Medulloblastoma
  Lai Y, Viswanath SE, Baccon J, Ellison D, Judkins AR, Madabhushi A, Bioengineering Conference (NEBEC), 2011 IEEE 37th Annual Northeast, Troy, NY, 4/1/2011
• p16 INK4A and P14 ARF Tumor Suppressor Pathways Are Dysregulated in Malignant Rhabdoid Tumors
  Venneti S, Lee P, Martinez D, Biegel JA, Judkins AR, Brain Pathol, XVIIth International Congress of Neuropathology, Salzburg, Austria, 9/11/2010
• Genetic Predisposition to Rhabdoid Tumor due to Germline Deletions and Mutations of the INI1/SMARCB1 Gene
  Biegel JA, Tooke L, Wainwright L, Judkins AR, Eaton K, Neuro-Oncology, 14th International Symposium on Pediatric Neuro-Oncology, Vienna, Austria, 6/20/2010
• Molecular Characterization and Targeting of Pediatric Low Grade Gliomas
  Sievert AJ, Judkins AR, Biegel JA, Storm PB, Phillips PC, Resnick AC, Neuro-Oncology, 14th International Symposium on Pediatric Neuro-Oncology, Vienna, Austria, 6/20/2010
• MicroRNA-9 and MicroRNA-200a Differentiate CNS Hemangioblastomas from Metastatic Clear Cell Renal Cell Carcinomas to the Brain
  Venneti S, Aihua L, Tobias J, Baldwin D, Judkins AR, Mourelatos Z, Lal P, Journal of Neuropathology and Experiemental Neurology, American Association of Neuropathologists Annual Meeting, Philadelphia, PA, 6/10/2010
• MiRNA-9 and MiRNA-200a Distinguish Hemangioblastomas from Metastatic Clear Cell Renal Cell Carcinomas in the CNS
  Venneti S, Boateng LA, Friedman JR, Baldwin DA, Tobias JW, Judkins AR, Mourelatos Z, Lal P, American Association of Neuropathologists Annual Meeting, Philadelphia, PA, 6/10/2010
• Claudin 6: A New Marker of Non-cns Malignant Rhabdoid Tumors and Atypical Teratoid/rhabdoid Tumors
  Sullivan LM, Pawel BP, Le PM, Doran W, Martinez D, Biegel JA, Judkins AR, Mod Pathol, Society for Pediatric Pathology Spring Meeting, Washington D.C., 3/20/2010
• Pathological Subtypes of Polymicrogyria and Brain Development
  Judkins AR, Dobyns W, Golden JA, 83rd Annual Meeting of the American Association of Neuropathologists (AANP), Washington, DC, 4/28/2007
• An Animal Model to Study Retinal Hemorrhages in Nonimpact Brain Injury
  Binenbaum G, Forbes BJ, Reghupathi R, Judkins AR, Rorke L, Margulies SS, Journal of American Association for Pediatric Ophthalmology and Strabismus, American Association for Pediatric Ophthalmology and Strabismus Annual Meeting, Seattle, Washington, 4/11/2007
• Gliomatosis Cerebri: A Pediatric Case Series and Review of the Literature
  Armstrong GT, Phillips PC, Roke-Adams LB, Judkins AR, Localio AR, Fisher MJ, American Society of Clinical Oncology Annual Meeting, Atlanta, GA, 6/2/2006
• Development and Validation of a Neuroblastoma Tissue Microarray
  Pawel BR, Maris JD, Martinez D, Cole K, Ferrante H, Judkins AR, Advances in Neuroblastoma Research, Los Angeles, CA, 5/1/2006
• Malignant Rhabdoid Tumors with a Non-rhabdoid Phenotype: Expanding The Concept of Malignant Rhabdoid Tumor
  Kreiger PA, Judkins AR, Russo PA, Biegel JA, Wang L, Kozakewich H, Vujanic GM, Pawel BP, Society of Pediatric Pathology Annual Meeting, Atlanta, GA, 2/11/2006
• Characterization of Neurodegenerative Disease Radioligands by Tissue Microarray Analysis
  Skovronsky D, Judkins AR, Kung MP, Forman M, Martinez D, Hou C, Zhuang ZP, Kung HF, Alzheimer's Association 9th International Conference on Alzheimer's Disease and Related Disorders, Philadelphia, PA, 7/17/2004
• Evidence of Common Molecular Origins of Cortical Tuber and Chordoma in a Tuberous Sclerosis Patient
  Roy S, Smith ML, Sutton LL, Judkins AR, 80th Annual Meeting of the American Association of Neuropathologists, Cleveland, OH, 6/24/2004
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Lectures

• AT/RT and Related Tumors: Pathology and Diagnosis of SMARCB1-deficient Neoplasms 
  Portland, OR - 6/1/2014
• Fundamentals of Image-based Rad/Path Correlation Issues 
  Oak Brook, IL - 4/1/2014
• Pathology and Diagnosis of SMARCB1-deficient Tumours 
  Institut Curie, Paris, France - 12/1/2013
• Pathology: Innovating our Future for the 21st Century 
  University of New Mexico School of Medicine, Albuquerque, NM - 5/1/2013
• Neuropathology 
  Atlanta, GA - 3/1/2013
• Neuropathology/Molecular Biology 
  Toronto, Canada - 6/1/2012
• Expression of SMARCB1/INI1: An Evolving Tool for Tumor Diagnostics, Discovery and Development 
  Los Angeles, CA - 4/1/2012
• Embryonal, Neuronal and Mixed Glioneuronal Neoplasms 
  (Inova Fairfax Hospital), Bethesda, MD - 2/1/2012
• Pediatric Neuropathology Update 
  San Antonio, TX - 2/1/2011
• Embryonal, Neuronal and Mixed Glioneuronal Tumors 
  (Inova Fairfax Hospital), Arlington, VA - 2/1/2011
• INI-1: Syndromes and Diagnostic Applications 
  Philadelphia, PA - 6/1/2010
• Neuronal and Mixed Neuronal-Glial and Embryonal Tumors 
  (Armed Forces Institute of Pathology), Bethesda, MD - 2/1/2010
• Pathology, Seeing and Understanding: Opportunities and Challenges for the 21st Century 
  Children's Hospital Los Angeles, Los Angeles, CA - 2/1/2010
• Digital Pathology: Opportunities and Challenges 
  University of California San Francisco Medical Center, San Francisco, CA, 2009; Mayo Clinic, Rochest - 8/1/2009
• Digital Pathology: A Tool for 21st Century Neuropathology 
  Boston, MA - 3/7/2009
• Digital Pathology Clinical Interface Issues: The CHOP Experience 
  San Diego, CA - 10/1/2008
• Pathology of the Developing Cerebellum 
  San Diego, CA - 4/1/2008
• Immunohistochemical Detection of INI1 Expression: A New Tool for Old Challenges in CNS and Pediatric Pathology 
  Yale University School of Medicine, Department of Pathology, New Haven, CT, 2007; Children's Nationa - 2/1/2008
• Immunohistochemistry of INI1 Expression: A New Tool for Old Challenges 
  Stanford University, Department of Pathology, Palo Alto, CA, 2006; University of Pittsburgh, Departm - 4/1/2007
• Neuropathology and Differential Diagnosis of Inflicted Neurotrauma in Infancy 
  Kyoto, Japan - 6/1/2006
• Tissue Microarrays: A Novel Research Tool 
  Children's Hospital of Philadelphia, Philadelphia, PA, 2004; University of Pennsylvania Medical Cent - 2/1/2005
• The Tissue Microarray Core Facility 
  Philadelphia, PA - 5/1/2004
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