AlexKentsisMDPhD

PubMed

• BPDCN MYB fusions regulate cell cycle genes, impair differentiation, and induce myeloid-dendritic cell leukemia.
  Christopher Ag Booth, Juliette M Bouyssou, Katsuhiro Togami, Olivier Armand, Hembly G Rivas
  JCI Insight. 2024-12-20
• Toward a Unified Theory of Why Young People Develop Cancer.
  Alex Kentsis
  Cold Spring Harbor Perspectives in Medicine. 2024-10-01
• Pediatric Leukemia Roadmaps Are a Guide for Positive Metastatic Bone Sarcoma Trials.
  Damon R Reed, Asmin Tulpule, Jonathan Metts, Matteo Trucco, Mark Robertson-Tessi
  Journal of Clinical Oncology. 2024-09-01

Journal Articles

• DPP8/DPP9 Inhibitor-Induced Pyroptosis for Treatment of Acute Myeloid Leukemia  
  Alex Kentsis, MD, Nature
• High sensitivity quantitative proteomics using accumulated ion monitoring and automated multidimensional nano-flow chromatography  
  Cifani P, Kentsis A, Mol Cell Proteomics, 1/18/2017
• ProteoModlR for functional proteomic analysis  
  Cifani P, Shakiba M, Chhangawala S, Kentsis A, BMC Bioinformatics, 1/1/2017
• Intracardiac Low-grade Sarcoma Following Treatment for Ewing Sarcoma  
  Ortiz MV, Magnan H, Slotkin EK, Ambati SR, Chou AJ, Wexler LH, Meyers PA, Walsh MF, Heaton T, Girardi LN, Wolden SL, Price AP, Kennedy JA, Zehir A, Hameed M, Berger MF..., J Pediatr Hematol Oncol, 1/1/2017
• PGBD5 promotes site-specific oncogenic mutations in human tumors  
  Henssen AG, Koche R, Zhuang J, Jiang E, Reed C, Eisenberg A, Still E, MacArthur IC, Rodríguez-Fos E, Gonzalez S, Puiggròs M, Blackford AN, Mason CE, de Stanchina E, Gö..., Nature Genetics, 1/1/2017
• Towards comprehensive and quantitative proteomics for diagnostic and therapy of human disease  
  Cifani P, Kentsis A, Proteomics, 1/1/2017
• Genomics of primary chemoresistance and remission induction failure in pediatric and adult acute myeloid leukemia  
  Brown F, Cifani P, Drill E, He J, Still E, Zhong S, Balasubramanian S, Pavlick D, Yilmazel B, Knapp K, Alonzo TA, Meshinchi S, Stone R, Kornblau SM, Marcucci G, Gamis ..., Br J Haematol, 1/1/2017
• A case report of concurrent embryonal rhabdomyosarcoma and diffuse large B-cell lymphoma in an adult without identifiable cancer predisposition  
  Mathias MD, Ortiz MV, Magnan H, Ambati SR, Slotkin EK, Chou AJ, Walsh MF, Offit K, Moskowitz C, Kentsis A, Wexler LH, Biomark Res, 1/1/2017
• Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors  
  Henssen AG, Reed C, Jiang E, Garcia HD, von Stebut J, MacArthur IC, Hundsdoerfer P, Kim JH, de Stanchina E, Kuwahara Y, Hosoi H, Ganem NJ, Dela Cruz F, Kung KL, Schult..., Science Transl Med, 1/1/2017
• Characterization of Deletions of the HBA and HBB Loci by Array Comparative Genomic Hybridization  
  Sabath DE, Bender MA, Sankaran VG, Vamos E, Kentsis A, Yi HS, Greisman HA, J Mol Diagn, 1/1/2016
• Osteosarcoma with apparent Ewing sarcoma gene rearrangement  
  Mathias M, Chou AJ, Meyers P, Shukla N, Hameed M, Agaram N, Wang L, Berger MF, Walsh M, Kentsis A, J Hematol Oncol, 1/1/2016
• Integrating genomics into clinical pediatric oncology using the molecular tumor board at the Memorial Sloan Kettering Cancer Center  
  Ortiz MV, Kobos R, Walsh M, Slotkin EK, Roberts S, Berger MF, Hameed M, Solit D, Ladanyi M, Shukla N, Kentsis A, Pediatric Blood and Cancer, 1/1/2016
• Forward genetic screen of human transposase genomic rearrangements  
  Henssen AG, Jiang E, Zhuang J, Pinello L, Socci ND, Koche R, Gonen M, Villasante CM, Armstrong SA, Bauer DE, Weng Z, Kentsis A, BMC Genomics, 1/1/2016
• Transposon mapping using flanking sequence exponential anchored (FLEA) PCR  
  Henssen A, Carson J, Kentsis A, Protocol Exchange, 1/22/2015
• Native proteome extraction protocol using poloxamer-based adaptive focused sonication  
  Dhabaria A, Cifani P, Reed C, Kentsis A, Protocol Exchange, 1/14/2015
• Fabrication of nanoelectrospray emitters for LC-MS  
  Cifani P, Dhabaria A, Kentsis A, Protocol Exchange, 1/9/2015
• Fabrication of capillary columns with integrated frits for mass spectrometry  
  Dhabaria A, Cifani P, Kentsis A, Protocol Exchange, 1/2/2015
• MStern blotting - high throughput PVDF membrane-based proteomic sample preparation for 96-well plates  
  Berger ST, Ahmed S, Muntel J, Cuevas Polo N, Bachur R, Kentsis A, Steen J, Steen H, Mol Cell Proteomics, 1/1/2015
• Advancing Urinary Protein Biomarker Discovery by Data-Independent Acquisition on a Quadrupole-Orbitrap Mass Spectrometer  
  Muntel J, Xuan Y, Berger ST, Reiter L, Bachur R, Kentsis A, Steen H, J Proteome Res, 1/1/2015
• A high-efficiency cellular extraction system for biological proteomics  
  Dhabaria A, Cifani P, Reed C, Steen H, Kentsis A, J Proteome Res, 1/1/2015
• High expression of myocyte enhancer factor 2C (MEF2C) is associated with adverse-risk features and poor outcome in pediatric acute myeloid leukemia: a report from the ...  
  Laszlo GS, Alonzo TA, Gudgeon CJ, Harrington KH, Kentsis A, Gerbing RB, Wang YC, Ries RE, Raimondi SC, Hirsch BA, Gamis AS, Meshinchi S, Walter RB, J Hematol Oncol, 1/1/2015
• Targeting oncogenic interleukin-7 receptor signaling with N-acetylcysteine in T-cell acute lymphoblastic leukemia  
  Mansour MR, Reed C, Eisenberg AR, Tseng JC, Twizere JC, Daakour S, Yoda A, Rodig SJ, Tal N, Shochat C, Berezovskaya A, DeAngelo DJ, Sallan SE, Weinstock DM, Izraeli S,..., Br J Haematol, 1/1/2015
• Genomic DNA transposition induced by human PGBD5  
  Henssen AG, Henaff E, Jiang E, Eisenberg AR, Carson JR, Villasante CM, Ray M, Still E, Burns M, Gandara J, Feschotte C, Mason CE, Kentsis A, eLife, 1/1/2015
• Therapeutic re-activation of protein phosphatase 2A in acute myeloid leukemia  
  Ramaswamy K, Spitzer B, Kentsis A, Front Oncol, 1/1/2015
• Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia  
  Gutierrez A, Pan L, Groen RW, Baleydier F, Kentsis A, Marineau J, Grebliunaite R, Kozakewich E, Reed C, Pflumio F, Poglio S, Uzan B, Clemons P, Verplank L, An F, Burba..., J Clin Invest, 1/1/2014
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Books/Book Chapters

• Nathan & Oski’s Hematology of Infancy and Childhood, and Orkin: Oncology of Infancy and Childhood 
  Chapter: Genetics and Epigenetics of Childhood Cancers. 
  Kentsis A, Roberts CW2013

Lectures

• Therapeutic Disassembly of Leukemogenic Enhancer Complexes 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Functional Profiling of Patient AML Stem Cells Reveals Mechanisms of Epigenetic Plasticity Controlling Therapy Resistance 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• On the Causes of Childhood Cancer: Mechanisms and Therapy of Site-Specific Oncogenic Mutations by the Human DNA Transposase PGBD5 
  Johns Hopkins University School of Medicine - 1/1/2017
• Recent discoveries, therapies, and clinical implementation of rational pediatric oncology 
  Weill Cornell Medical College, New York, NY - 1/1/2017
• Functional proteomics of therapy resistance and aberrant gene control in acute myeloid leukemia 
  Cambridge, MA - 1/1/2017
• Mechanism and function of human piggybac transposable element derived PGBD5 
  Big Sky, MT - 1/1/2017
• Towards Comprehensive and Quantitative Proteomics for Diagnosis and Therapy of Childhood Disease 
  Boston, MA - 1/1/2016
• Human Tumorigenesis Induced by an Endogenous DNA Transposase in Renal Tumors 
  Toronto, Canada - 1/1/2016
• Human Tumorigenesis Induced by an Endogenous DNA Transposase in Embryonal Tumors 
  New York, NY - 1/1/2016
• Functional proteomics of acute myeloid leukemia 
  Orlando, FL - 1/1/2015
• Therapeutic targeting of leukemogenic interleukin-7 receptor in acute lymphoblastic leukemia 
  Dallas, TX - 1/1/2014
• Tumorigenesis by endogenous DNA transposons in rhabdoid tumors 
  Washington, DC - 1/1/2014
• Functional proteomics for improved therapy of acute myeloid leukemia 
  Philadelphia, PA - 1/1/2014
• Urine proteomics of renal tumors for discovery of new prognostic markers and therapeutic targets 
  Bethesda, MD - 1/1/2013
• Urine proteomics for discovery of markers of human disease 
  Boston, MA - 1/1/2013
• Enzyme-linked immunosorbent assay of urine leucine-rich alpha-2-glycoprotein discriminates patients with acute appendicitis and correlates with appendicitis severity 
  Denver, CO - 1/1/2011
• Toward translational proteomics 
  Children’s Hospital Boston, Boston, MA - 1/1/2011
• Urine proteomics for profiling of human disease using high accuracy mass spectrometry 
  Erice, Sicily - 1/1/2010
• Discovery and validation of urine markers of acute pediatrics appendicitis using high accuracy mass spectrometry 
  Baltimore, MD - 1/1/2009
• Protein stability calculations using Monte Carlo and graph manifold learning 
  New York, NY - 1/1/2006
• Control of biochemical reactions through supramolecular RING domain self-assembly 
  Erice, Sicily - 1/1/2003
• Biochemical properties of promyelocytic leukemia protein PML 
  San Francisco, CA - 1/1/2002
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Other

• Whole-genome sequencing in medicine: New knowledge, new responsibilities. 
  Kentsis A, Vector, Children’s Hospital Boston’s science and Clinical Innovation Blog
  1/24/2012
• Proteomics 2011. 
  Kentsis A, Vector, Children’s Hospital Boston’s science and Clinical Innovation Blog
  1/29/2011
• Patients and genes: Getting personal through information technology. 
  Kentsis A, Vector, Children’s Hospital Boston’s science and Clinical Innovation Blog
  1/30/2010
• Personalized rational medicine for all. 
  Kentsis A, Vector, Children’s Hospital Boston’s science and Clinical Innovation Blog
  1/22/2010
• Smart cancer drugs need smart clinical trials. 
  Kentsis A, Vector, Children’s Hospital Boston’s science and Clinical Innovation Blog
  1/5/2010
• Self-organization of biological systems, Ph.D. Dissertation. 
  Kentsis A
  New York University, New York, NY - 1/1/2004
• Folding and specification of native protein structure, S.M. Thesis. 
  Kentsis A
  University of Chicago, Chicago, IL - 1/1/1998
• Between light and eye: Goethe’s science of color and the polar phenomenology of nature. 
  Kentsis A
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