Alessandro Iannaccone MD MS, FARVO

Ophthalmology•Chapel Hill, NC

Retinal Disease

Professor of Ophthalmology Director, Center for Retinal Degenerations and Ophthalmic Genetic Diseases

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2226 Nelson HwySte 200Chapel Hill, NC 27517
Phone+1 984-974-2020
Fax+1 919-684-9016

Summary

Developing Gene-Specific Molecular Approaches to Treat Inherited Retinal Disease

Launching gene-specific clinical trials on inherited retinal disease at the Duke Center for Retinal Degenerations and Ophthalmic Genetic Diseases

Education & Training

University of Tennessee Health Science CenterMS, Epidemiology, 2000 - 2003
University of Tennessee College of MedicineFellowship, Pediatric Retinal and Optic Nerve Diseases, 1996 - 1998
University of Pennsylvania Health SystemFellowship, Surgical Retina and Vitreous, 1995 - 1996
Sapienza University of RomeClass of 1989

Certifications & Licensure

NC State Medical License 2016 - 2025
TN State Medical License 1998 - 2016

Clinical Trials

Safety and Efficacy of rAAV-hRS1 in Patients With X-linked Retinoschisis (XLRS) Start of enrollment: 2015 May 01
Completed
Phase 1, Phase 2
RST-001 Phase I/II Trial for Advanced Retinitis Pigmentosa Start of enrollment: 2015 Dec 14
COMPLETED
PHASE1, PHASE2
Safety and Efficacy Trial of AAV Gene Therapy in Patients With CNGB3 Achromatopsia (A Clarity Clinical Trial) Start of enrollment: 2016 Apr 11
Active, not recruiting
Phase 1, Phase 2
Clinical Evaluation of Patients With X-linked Retinitis Pigmentosa (XLRP) Start of enrollment: 2017 Dec 01
Completed
Safety and Efficacy of rAAV2tYF-GRK1-RPGR in Subjects With X-linked Retinitis Pigmentosa Caused by RPGR Mutations Start of enrollment: 2018 Apr 16
Active, not recruiting
Phase 1, Phase 2
The Dark-Adapted Retinal Function Response in Choroideremia (DARC) Study Start of enrollment: 2023 May 01
Withdrawn
Not Applicable
Roles: Contact
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Publications & Presentations

PubMed

Corrigendum to "Baseline Visual Field Findings in the RUSH2A Study: Associated Factors and Correlation With Other Measures of Disease Severity" [Am J Ophthalmol 2020;2...
Jacque L Duncan, Wendi Liang, Maureen G Maguire, Isabelle Audo, Allison R Ayala
American Journal of Ophthalmology. 2025-03-07
Subretinal Gene Therapy Drug AGTC-501 for XLRP Phase 1/2 Multicenter Study (HORIZON): 24-Month Safety and Efficacy Results.
Paul Yang, David Birch, Andreas Lauer, Robert Sisk, Rajiv Anand
American Journal of Ophthalmology. 2025-03-01
1 citations
Characterising the refractive error in paediatric patients with congenital stationary night blindness: a multicentre study.
Austin D Igelman, Elizabeth White, Alaa Tayyib, Lesley Everett, Ajoy Vincent
The British Journal of Ophthalmology. 2025-01-28

Journal Articles

Murine Retinal Citrullination Declines with Age and Is Mainly Dependent on Peptidyl Arginine Deiminase 4 (PAD4)
Alessandro Iannaccone, MD, Investigative Ophthalmology and Visual Science

Grant Support

Autoimmunity and Age-Related Macular DegenerationNational Eye Institute2012–2015
Auto-Antibodies As Serum Biomarkers For Age-Related Macular DegenerationNational Eye Institute2009–2010
Clinical Epidemiology Of Retinal DegenerationsNational Eye Institute2001–2005

Committees

Member, ARVO Advocacy and Outreach Committee 2015 - 2018

Professional Memberships

American Academy of Ophthalmology - AAO
Member
Association for Research in Vision and Ophthalmology - ARVO
Fellow
North Carolina Society of Eye Physicians and Surgeons - NCSEPS
Member
International Society for Genetic Eye Disease and Retinoblastoma - ISGEDR
Member
International Society for Clinical Electrophysiology of Vision - ISCEV
Member

Other Languages

Italian, Spanish, Portuguese