AlanPaulKnutsenMD

PubMed

• 160 citations
  Immune reconstitution and survival of 100 SCID patients post-hematopoietic cell transplant: a PIDTC natural history study.
  Jennifer Heimall, Brent R. Logan, Morton J. Cowan, Luigi D. Notarangelo, Linda M. Griffith
  Blood. 2017-12-21
• 59 citations
  Thymosin-alpha1 stimulates maturation of CD34+ stem cells into CD3+4+ cells in an in vitro thymic epithelia organ coculture model.
  Alan P. Knutsen, John J. Freeman, Kathleen R. Mueller, Stanford T. Roodman, John D. Bouhasin
  International Journal of Immunopharmacology. 1999-01-25
• 128 citations
  Allergic Bronchopulmonary Aspergillosis in Asthma and Cystic Fibrosis
  Alan P. Knutsen, Raymond G. Slavin
  Clinical & Developmental Immunology. 2011-04-05

Journal Articles

• Inflammatory cytokines in a child with hypogammaglobulinemia and lymphoid nodular hyperplasia treated with oral budesonide.  
  Jordan T, Foy T, Knutsen AP, Pediatr Allergy Immunol Pulmonol 23:147-150
• Transient hypogammaglobulinemia of infancy.  
  Knutsen AP, Clinical Decision Support
• Allergic bronchopulmonary aspergillosis.  
  Knutsen AP, Clinical Decision Support
• Case report: Misdiagnosis of asthma in a boy with aortic ring.  
  Sturm JM, Knutsen AP, Ann Allergy Asthma Immunol 108:291-293
• Fungal Diseases of the Lower Airway Task Force. Fungi and allergic lower respiratory diseases.  
  Knutsen AP, Bush RK, Demain JG, Denning DW, Dixit A, Fairs A, Greenberger PA, Kariuki B, Kita H, Kurup VP, Moss RB, Niven RM, Pashley CH, Slavin RG, Vijay HM, Wardlaw AJ, J Allergy Clin Immunol 129:280-291
• Requirement of NEMO for nucleosomal IKK? activity and NF-?B directed gene expression.  
  Temmerman ST, Ma CA, Zhao Y, Keenan J, Aksentijevich I, Turner M, Brown MR, Fessler M, Knutsen AP, Shapiro R, Jain A, J Clin Invest 122(1):315-326
• Interpreting absent T cell receptor excision circles (TRECs) in newborns with DiGeorge anomaly: importance of assessing naïve T cell markers.  
  Knutsen AP, Baker MW, Markert ML, J Allergy Clin Immunol 128(6):1375-1376
• Association of selective antibody deficiency in children with mannose binding lectin deficiency.  
  Lotz DR, Knutsen AP, Pediatr Allergy Immunol Pulmonol 23:265-271
• Understanding subcutaneous immunoglobulin therapies for primary immunodeficiency diseases.  
  Knutsen AP, Siegel J, Pharm Practice News
• Pathophysiology of Fungal Diseases of the Lower Airways.  
  Kita H, Knutsen AP, Fungal Diseases of the Lower Airways Task Force Report
• Introduction of Fungal Diseases of the Lower Airways.  
  Bush, Demain JG, Knutsen AP, Slavin RG, Fungal Diseases of the Lower Airways Task Force Report
• Improved quality of life, increased IgG trough levels and freedom from infections in adults and children with primary immunodeficiency diseases treated with a licensed...  
  Berger M, Murphy E, Riley P, Bergman G, and the VIRTUE Trial Investigators, Southern Medical J 103(9):856-863
• Gastric ulcer is a new presentation for varicella in common variable immunodeficiency.  
  Milligan KL, Jain A, Garret JS, Knutsen AP, Pediatrics
• Efficacy and safety of Privigen in pediatric and juvenile patients with primary immunodeficiency.  
  Church JA, Borte M, Taki H, Nelson RP, Sleasman JW, Knutsen AP, Le Gall E, Debre M, Bichler J, Pediatr Asthma Allergy Immunol 22:53-61
• HLA-DR, IL-4RA, and IL-10: Genetic risk factors in allergic bronchopulmonary aspergillosis.  
  Knutsen AP, Kariuki B, Santigo L, Bellone C, Slavin RG, Shah MR, Pediatr Asthma Allergy Immunol 21:185-190
• IgPro10 in PID study group. Safety and efficacy of Privigen, a novel 10% liquid immunoglobulin preparation for intravenous use, in patients with primary immunodeficie...  
  Stein MR, Nelson RP, Church JA, Wasserman RL, Borte M, Vermylen C, Bichler J, J Clin Immunol. 29:137-144
• Antibody deficiency with normal immunoglobulins.  
  Knutsen AP, Encyclopedia of Molecular Mechanisms of Disease
• Fifty Years Ago in The Journal of Pediatrics: The circulating eosinophil level in the newborn infant following normal and difficult labor.  
  Knutsen AP, J Pediatr 153:776
• Oligoclonal T- and B-cells in an Amish girl with atypical RAG-1 deficient severe combined immunodeficiency.  
  Knutsen AP, Pediatr Asthma Allergy Immunol 21:145-148
• Omalizumab treatment in children with severe asthma at a Children’s Medical Center.  
  Campbell JM, Wofford JD, Knutsen AP, Pediatr Asthma Allergy Immunol 21:129-136
• Evolution of IgG subclass deficiency into common variable immunodeficiency in a child with pulmonary interstitial glycogenosis.  
  Knutsen AP, Becker BA, Pediatr Asthma Allergy Immunol 21:191-194
• Development of common variable immunodeficiency in an 8-year-old boy treated with rituximab for idiopathic thrombocytopenia.  
  Gentner J, Knutsen AP, Pediatr Asthma Allergy Immunol 21:99-104
• Development of common variable immunodeficiency in an 8-year-old boy treated with rituximab for idiopathic thrombocytopenia.  
  Gentner J, Knutsen AP, Pediatr Asthma Allergy Immunol 21:99-104
• Decreased CD27+ mature B cells in DiGeorge anomaly.  
  Campbell JM, Knutsen AP, Pediatr Allergy Asthma Immunol 21:6-13
• Complement receptor deficiencies.  
  Knutsen AP, eMedicine 6:1-8
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Books/Book Chapters

• Textbook of Pediatric Advanced Cardiorespiratory & Trauma Support for Life/Pediatric Advanced Life Support. 
  Chapter: Management of chronic asthma in pediatrics. 
  Page 13 - 18Gray HC, Knutsen APEditors: AJ Scalzo.Edition 8th,
• Kendig’s Disorders of the Respiratory tract in Children. 
  Chapter: Environmental exposures in the normal host 
  Page 858 - 876Knutsen AP, Temprano J, Wooldridge JL, Bhatla D, Slavin RGEditors: Wilmott R, Boat T, Bush V, Chernick V, Deterding RR, Ratjen F.Saunders Elsevier Inc, PhiladelphiaEdition 8th,
• PACTS for Life Textbook: Pediatric Advanced Cardiopulmonary and Trauma Support for Life. 
  Chapter: Treatment of anaphylaxis 
  Lotz DR, Knutsen APEditors: AJ Scalzo.
• PACTS for Life Textbook: Pediatric Advanced Cardiopulmonary and Trauma Support for Life. 
  Chapter: Acute asthma 
  Lotz D, Gray H, Knutsen APEditors: AJ Scalzo.
• Allergy Frontiers: Clinical Manifestations. 
  Chapter: Allergic bronchopulmonary aspergillosis 
  Page 351 - 366Kurup VP, Knutsen AP
• Trends in Diphtheria Research. 
  Chapter: IL-4 alpha chain receptor (IL-4Ra) polymorphisms: Genetic risk factors in the development of allergic bronchopulmonary aspergillosis 
  Page 37 - 62Warrier MR, Chauhan B, Slavin RG, Knutsen APNova Science Publishers, Inc
• Kendig’s Disorders of the Respiratory tract in Children. 
  Chapter: Hypersensitivity pneumonitis and eosinophilic pulmonary diseases 
  Page 686 - 704Knutsen AP, Amin RS, Temprano J, Wilmott RWEditors: Chernick V, Boat T, Wilmott R, Bush V.Saunders Elsevier Inc, PhiladelphiaEdition 7th,
• Mold Allergy, Biology and Pathogenesis. 
  Chapter: Aspergillus antigens and immunodiagnosis of allergic bronchopulmonary aspergillosis 
  Page 137 - 146Kurup VP, Knutsen AP, Moss RBEditors: Kurup VP.Research Signpost, Kerala, India
• Mold Allergy, Biology and Pathogenesis. 
  Page 209 - 235Knutsen APEditors: Kurup VP.Immune responses in allergic bronchopulmonary aspergillosis and fungal allergy, Kerala, India
• Fungal Immunology from an Organ Perspective. 
  Chapter: Fungal hypersensitivity in the lungs 
  Page 241 - 264Kurup VP, Knutsen APEditors: Gary Huffnagle and Paul Fidel.Kluwer Publishers
• Allergy and Immunology Review Board Manual. 
  Chapter: Antibody Deficiencies, Complement Deficiencies, and Severe Combined Immunodeficiency 
  Knutsen AP, William LWEditors: Knutsen AP, William LW.Turner White Communications, Inc
• Characterization of immune parameters in humans potentially exposed to dioxin. 
  Knutsen AP, Roodman ST, Slavin RG, Miller R, Stein GFJefferson City, Missouri
• Textbook of Pediatric Advanced Cardiorespiratory & Trauma Support for Life/Pediatric Advanced Life Support. 
  Chapter: Management of acute asthma in pediatrics 
  Page 1 - 12Gray HC, Knutsen APEditors: AJ Scalzo.Edition 8th,
• Nezelof syndrome. NORD Guide to Rare Disorders. 
  Insel RA, Scheer BG, Knutsen APLippincott William & Wilkins, Philadelphia, PA
• PACTS for Life Textbook: Pediatric Advanced Cardiopulmonary and Trauma Support for Life. 
  Chapter: Anaphylaxis 
  Page 19 - 23Knutsen APEditors: AJ Scalzo.
• PACTS for Life Textbook: Pediatric Advanced Cardiopulmonary and Trauma Support for Life. 
  Chapter: Acute asthma 
  Page 1 - 13Knutsen APEditors: AJ Scalzo.
• Manual of Allergy and Immunology: Diagnosis and Therapy. 
  Chapter: Immunodeficiency Diseases 
  Page 397 - 424Knutsen AP, Fischer TJEditors: Glen J. Lawlor, Jr., Thomas J. Fischer, and Daniel C. Adelman.Little, Brown and Company, BostonEdition Thir,
• Sinusitis: Pathophysiology and Treatment. 
  Chapter: Systemic and mucosal immunodeficiency 
  Page 283 - 303Knutsen APEditors: Druce HM.Marcel Dekker, N.Y
• Cystic Fibrosis. Infection, Immunopathology, and Host Response. 
  Chapter: Allergic bronchopulmonary aspergillosis in patients with cystic fibrosis 
  Page 103 - 118Knutsen AP, Slavin RGEditors: Moss RB.Humana Press Inc
• Manual of Allergy and Immunology: Diagnosis and Therapy. 
  Chapter: Immunodeficiency Diseases 
  Page 356 - 379Knutsen AP, Fischer TJEditors: Lawlor GJ, Jr. and Fischer TJ.Little, Brown and CompanyEdition Seco,
• Primary Immunodeficiencies. 
  Chapter: Immunoglobulin synthesis by cord and maternal blood mononuclear cells and their effect on synthesis by normal adult cells 
  Page 13 - 22Knutsen AP, Buckley RHEditors: Seligmann M and Hitzig WH.Elsevier/North Holland Biomedical Press
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Abstracts/Posters

• Increased sensitivity to IL-4 stimulation in patients with allergic bronchopulmonary aspergillosis.
  Knutsen AP, Khan S, McClennan, J Allergy Clin Immunol 107:S252
• Interleukin-4 receptor a (IL-4Ra) gene polymorphisms: another risk factor for the development of allergic bronchopulmonary aspergillosis (ABPA).
  Warrier MR, Vakamudy K, Smick JK, Chauhan B, Chauhan AK, Knutsen AP, Clin Invest Med 27: 147A
• Increased sensitivity to IL-4 in cystic fibrosis patients with allergic bronchopulmonary aspergillosis.
  Smick J, Kurup VP, Hutchinson PS, Knutsen AP, J Allergy Clin Immunol 113:S285
• T cell cytokine synthesis in cystic fibrosis patients with allergic bronchopulmonary Aspergillosis.
  Knutsen AP, Smick J, Hutchinson PS, Kurup VP, J Allergy Clin Immunol 113:S278
• Interleukin-4 receptor a (IL-4Ra) gene polymorphisms in cystic fibrosis patients with allergic bronchopulmonary aspergillosis.
  Warrier MR, Smick JK, Chauhan B, Chauhan AK, Knutsen AP, J Allergy Clin Immunol 113:S278
• Th1/Th2 T cell sensitivity to rice in an infant.
  Gray HC, Becker BA, Knutsen AP, J Allergy Clin Immunol 113:S156
• Th1/Th2 T cells and cytokine synthesis in cystic fibrosis patients with allergic bronchopulmonary aspergillosis.
  Knutsen AP, Hutchinson PS, Smick J, Kurup VP, J Allergy Clin Immunol 111:S312
• Increased sensitivity to IL-4 in cystic fibrosis patients with allergic bronchopulmonary aspergillosis.
  Knutsen AP, Hutchinson PS, Smick J, Kurup VP, J Allergy Clin Immunol 111:S293
• IgE response to recombinant allergens in patients sensitized to Aspergillus in asthmatics and cystic fibrosis.
  Kurup V, Knutsen A, Greenberger P, Castillo L, Elms N, Fink JN, J Allergy Clin Immunol 111:S204
• IL-4 sensitivity and Th2 T cells in cystic fibrosis patients with allergic bronchopulmonary aspergillosis.
  Knutsen AP, Hutcheson PS, Kurup V, J Allergy Clin Immunol 109:S343
• The prevalence of latex allergy in a high risk population and the prevalence of clinical cross reactivity of foods with similar antigenic structure.
  Suffian LV, Glass TA, Becker BA, Pittman T, Knutsen AP, J Allergy Clin Immunol 107:S118
• Coexistence of IL-4R single nucleotide polymorphisms and HLA-DR2/DR5 in allergic bronchopulmonary aspergillosis.
  Knutsen AP, Smick JK, Hutcheson PS, Slavin RG, J Allergy Clin Immunol 115:S117
• Female patient with an autosomal recessive B cell immune deficiency manifested by hypogammaglobulinemia, absent B cells, T cell functional abnormalities, pyoderma, and...
  Becker BA, Sullivan KE, Knutsen AP, J Allergy Clin Immunol 105:S224
• Unrelated umbilical cord blood stem cell transplantation in severe T- and B-cell immune deficiency disorders.
  AP Knutsen, DA Wall, J Allergy Clin Immunol 105:S265
• Increased sensitivity to IL-4 and mutations of IL-4Ra in patients with allergic bronchopulmonary aspergillosis and atopy.
  McClellan JS, A White, Chatilla TA, Roodman ST, Knutsen AP, J Allergy Clin Immunol 105:S303
• Increased sensitivity to IL-4 in patients with allergic bronchopulmonary aspergillosis.
  McClellan JS, Roodman ST, Knutsen AP, J Allergy Clin Immunol 103:S16
• Aspergillus sensitivity in CF patients receiving DNAse.
  Hutcheson PS, Rejent AJ, Knutsen AP, Slavin RG, J Allergy Clin Immunol 101:S118
• Natural history of selective antibody deficiency to bacterial polysaccharide antigens in children.
  Wolpert J, Knutsen AP, J Allergy Clin Immunol 101:S71
• Cord blood stem transplantation in severe combined immunodeficiency.
  Knutsen AP, Wall D, J Allergy Clin Immunol 101:S101
• Cord blood as an alternative donor hematopoietic stem cell source in children with non-malignant disorders: single institution experience.
  Wall DA, Gale GB, Chu J-Y, Knutsen AP, Steffen M, Wasserman KM, Fallon RJ, Am Soc Pediatr Hematol Oncol
• Expression of macrophage markers by a population of T cells present in the synovial fluid of juvenile rheumatoid arthritis patients.
  Khalkhali-Ellis Z, Roodman ST, Knutsen AP, Mueller KR, Chauhan B, Moore TL, Hendrix MJC, J Allergy Clin Immunol 99:S237
• Efficacy and safety of Privigen in children with primary immunodeficiency.
  Church JA, Borte M, Taki H, Nelson RP, Sleasman JW, Knutsen AP, Le Gall E, Debre M, Bichler J, European Society for Paediatric Infectious Diseases, 26th Annual Meeting 2008, Graz
• Mesalamine treatment for colitis in ectodermal dysplasia with immunodeficiency.
  Milligan KL, Jain AK, Siegfried EC, Foy TM, Knutsen AP, CIS
• The Role Of Skin Prick Testing And Specific IgE To Boiled Versus Unheated Cow Milk In Cow Milk Allergic Children.
  Hong JC, Knutsen AP, AAAAI
• Vitamin D Levels In Children With Eosinophilic Esophagitis and Gastroesophageal Reflux.
  Waterhouse K, Katta A, Teckman J, Foy T, Derdoy J, Jain A, Knutsen A, Becker B, J Allergy Clin Immunol;127:AB107
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Lectures

• B cell Immunodeficiency. 
  CGCMC Pediatric Grand Rounds, St. Louis, MO
• Pulmonary Disease Impact on Stem Cell. 
  Louisiana State University/Jeffrey Modell Foundation Center Conference, New Orleans, LA
• Humoral Immunodeficiencies in Children. 
  University of Missouri Pediatric Grand Rounds Columbia, MO
• Antibody deficiencies: diagnosis and management. 
  Alabama State Allergy Immunology Meeting Destin, FL
• Treatment of moderate-severe asthma. 
  Philippine Medical Association, St. Louis, MO
• Diagnosis and management of fungal allergy. 
  50th ICAAC Meeting Boston, MA
• Genetics of Alternaria-sensitive asthma. 
  Immunobiology Research Conference, St. Louis, MO
• Treatment options for allergic asthma. 
  ALA, Decatur, IL
• Primary Immunodeficiency Disorders. 
  Louisville Allergy Society, Louisville, KY
• CPC – CVID, Evans syndrome. 
  CGCMC Pediatric Grand Rounds, St. Louis, MO
• Lung Manifestations of Immunodeficiencies in Children. 
  Louisiana State University/Jeffrey Modell Foundation Center Conference, New Orleans, LA
• Indoor Molds and Respiratory Disorders. 
  AAAAI Annual Meeting, San Francisco, CA
• Umbilical Cord Blood Stem Cell Transplantation in Primary Immunodeficiency Disorders. 
  Texas Children’s, Houston, TX
• Diagnosis & Treatment of Common Primary Immunodeficiencies in the Office Setting. 
  Houston Allergy Society, Houston, TX
• Diagnosis and Management of Antibody Immunodeficiencies. 
  Minnesota Allergy Society, Minneapolis, MN
• Gammaglobulin Therapy in Immunodeficiency. 
  1st Annual JMF Conference Primary Immunodeficiency, St. Louis, MO
• Diagnosis and Management of Antibody Immunodeficiencies. 
  3rd Annual Allergy/Asthma/ENT Conference, Asthma & Immunology, San Antonio, TX
• Overview of Primary Immunodeficiency Diseases. 
  Immune Deficiency Foundation, St. Louis, MO
• The Hyper-IgE Disorders. 
  2nd Annual JMF Conference Primary Immunodeficiency, St. Louis, MO
• Diseases of Immune Dysregulation (IPEX, HLH, ALPS). 
  2nd Annual JMF Conference Primary Immunodeficiency, St. Louis, MO
• Umbilical Cord Blood Stem Cell Transplantation in Primary Immunodeficiency Disorders. 
  Dr. Lehrer’s Clinical Immunology Series, Tulane, New Orleans, LA
• Immunology of ABPA. 
  53rd AAAAI Annual Meeting, San Francisco, CA
• Immunopathogenesis of ABPA. 
  CFF Consensus Conference, Bethesda, MA
• Allergic bronchopulmonary Aspergillosis. 
  AAAAI 58th Annual Meeting, New Orleans, LA
• Lymphocytes and Pathogenesis of ABPA. 
  16th Annual Cystic Fibrosis Meeting, New Orleans, LA
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Other

• Methods of promoting T-cell differentiation from stem cells using thymosin-alpha-1 
  Knutsen AP, Reference #: 2062-143 (1-97)
• IgG subclass deficiency 
  Knutsen AP, Lemmon JK
  http://www.uptodate.com/contents/igg-subclass-deficiency
  UpToDate, Wolters Kluwer Health - 2012-05-11
• IgG subclasses: Physical properties, genetics, and biologic functions 
  Knutsen AP, Lemmon JK
  http://www.uptodate.com/contents/igg-subclasses-physical-properties-genetics-and-biologic-functions
  UpToDate, Wolters Kluwer Health - 2012-05-11