AdrianaHoffmanMD

Summary

• I am a third-year pediatric resident, starting neonatology fellowship in July of this year. My journey into research started shortly into my undergraduate career. My basic science research experiences in medical school helped me to define my path to neonatology. I have worked with translational research in pulmonary development using a rodent model of SIDS, assessing hyperoxia and hypoxia effects on pulmonary function. My experiences have led to several posters, an oral presentation at a national conference and a first author manuscript published in the journal of Respiratory Physiology & Neurobiology. During my pediatric residency I had opportunities to gain additional experience with clinical research while still keeping myself active in the laboratory. My first clinical project in residency evaluated the risk factors and pathogenicity of E. Coli sepsis through retrospective review. My second clinical project was comparing the development of physiologic maturity of small-for-gestational and appropriate-for-gestational age infants. With each of my projects, I am assured that as part of the career I envision for myself, I would like to pursue translational and basic science research and develop as a physician scientist. Therefore, I intend to pursue basic science research in lung development and injury, especially as it pertains to perinatal inflammation. Going forward, I would like to focus on lung development and preventing mortality from lung pathologies that affect preterm infants, particularly BPD. Specifically, I would like to research the effects of placental inflammation on lung development and injury. I would like to focus on the interplay of perinatal inflammation and development of BPD. The proposal and training outlined in this application will enhance my skills for a successful career as an early-career physician scientist.